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The map label for this gene is 17229756

Identifier: 17229756

GI number: 17229756

Start: 2723405

End: 2725036

Strand: Direct

Name: 17229756

Synonym: alr2264

Alternate gene names: NA

Gene position: 2723405-2725036 (Clockwise)

Preceding gene: 17229753

Following gene: 17229757

Centisome position: 42.46

GC content: 42.16

Gene sequence:

>1632_bases
ATGTTATTCAGCATATTGTGGATTTTAATCATGGGCTTTTTTGCAGGTCAAATTGCCCGTCGCTTAACAGCACCGCCGTT
AATTGGCATGATTCTAGTCGGGATTTTTGTAGGCCCCCAAGTTGGTAATGTCATCAGTCAAGATGTGCTTGGCGCTGCTG
ATGAATTAAGAACGGTGGCGGTGACAATTATCCTGATGAAAGCTGGGCTGGGATTGGACAGGGAAAAACTGGCCGAACAG
GGAAGTGTGGCATTGCGCTTGGGATTTCTACCTGCAACAACCGAAGCGATCGCCATTGCTATTGCTTCTATAATTATCTT
TAAATTTGATTTTCCTACTGGCTTACTTTTAGGTTGTGTCATTGGTGCTGAGTCGCCGGCGGTAATTGTGCCAGGAATGT
TGAGGCTGAAAAGTTTAGGCTTGGGAGTTACAAAAGGGATTCCCGATGCCATTTTGACAGGTAGTGCCTTATCTGATGTC
TTGCTATTACTTGTCTTTAGTCTATTGTTGAATTTCTTAGGTGATGGTGGTGTTGAGCAAATCACCCTTATAGGAGTATT
TACATTAAATACACTGTATTTACTCCCCATACAAATACTCATGCAAATCGTCTTGGGGTTGTTATTGGGGTATTTAGCTG
CGCGTTTAATAGTTTTGCTGTTAACAAAACAAAACTGGACACAAAATGTCGTTCAAGACACCGTAATTTCCGCAAGTTTA
GCTTTATTTTTAGTAATTATTGCTAATGCTCTACCTTACTTCTCCGGCTATTTAGCAACAATAGCAATGGGATTTTTCTT
AATTGAATTAGATGCTCCCTTAGCGAGAAGATTGCGCGGCGGATTCGATGGTTTATGGGTAGTAGCGGAGATTTTTTTGT
TTGTCTTGTTAGGGGCAACAATTCAACTACAAGTTTTAGAAAACATCTTGCTACCAGGAATTTTAATTCTGGCCATTGGT
TTATTTATTGGTCGAATGATTGGTTGGTATCTTTCAACTTTGGGTAGTAATTGGAACTGGCACGAAAGACTGTTTCTGCT
ACCAGGAAACTCAGCTAAAGCCACAGTGCAAGCTGCCATTGGGGCAATTCCCCTAGCCCAAGGTATTGCGGGAGGTGAGA
TAATTTTAGCGATCGCTGTGCTTTCAATTCTCATTACTGCACCCTTGGGCGCTTGGGCAACAACTGTCTTTGCACCTAAA
TTGTTAACGAGAGGAGAAGTTGACCCTACAAAAGTGACAATAGCTACACGTACTTTATTGCTAGCAGCAGTAGATACATC
CAGTTTAGCCACAGAGGTTTTAACCAAAGTTGCAGATTTAGCACGACGCAGTAACGGTGAGGCGATCGTTTTACACGTAG
TTAATACCTCGCATCGGCAAGATGTTGAACAAGTGCAAGCACAAGCAAAACAGCTATTATCAGATATTAGATATCAATTT
CTCACTGTTACTGGTGCTGTTCCCGAAGAAATTCTTCGCATTGCCGAGACATATAATGCAACGGCAATTGTGATGGGAAA
ACGGGGACATCAACCTTGGGAGAAAGTACTGATTGGCTCAGTATCCCAAGCTGTCTTAGAAAATAGTTCCATACCCGTCA
TCTTGCTGGACACCCGGCCAGAAAAAAATTAA

Upstream 100 bases:

>100_bases
TTTCTTGCTTGCTGCGGGAGGGTAGGAGTTTGTTGTATACATCACCTGGCTTCCTTGTAGTAAGTCTTGATCTACAAATC
GCAACACTGGCAGTCAAGGT

Downstream 100 bases:

>100_bases
ATCTGGCTGTACACAATTGATTAGATTACGGGAGACAGTTTACTCTGTTGTAGATATCGAAATTCAACAGAAGTTGGGAC
TATCTCCCCTTACTGCATAG

Product: Na+/H+-exchanging protein

Products: NA

Alternate protein names: MjNhaP1 [H]

Number of amino acids: Translated: 543; Mature: 543

Protein sequence:

>543_residues
MLFSILWILIMGFFAGQIARRLTAPPLIGMILVGIFVGPQVGNVISQDVLGAADELRTVAVTIILMKAGLGLDREKLAEQ
GSVALRLGFLPATTEAIAIAIASIIIFKFDFPTGLLLGCVIGAESPAVIVPGMLRLKSLGLGVTKGIPDAILTGSALSDV
LLLLVFSLLLNFLGDGGVEQITLIGVFTLNTLYLLPIQILMQIVLGLLLGYLAARLIVLLLTKQNWTQNVVQDTVISASL
ALFLVIIANALPYFSGYLATIAMGFFLIELDAPLARRLRGGFDGLWVVAEIFLFVLLGATIQLQVLENILLPGILILAIG
LFIGRMIGWYLSTLGSNWNWHERLFLLPGNSAKATVQAAIGAIPLAQGIAGGEIILAIAVLSILITAPLGAWATTVFAPK
LLTRGEVDPTKVTIATRTLLLAAVDTSSLATEVLTKVADLARRSNGEAIVLHVVNTSHRQDVEQVQAQAKQLLSDIRYQF
LTVTGAVPEEILRIAETYNATAIVMGKRGHQPWEKVLIGSVSQAVLENSSIPVILLDTRPEKN

Sequences:

>Translated_543_residues
MLFSILWILIMGFFAGQIARRLTAPPLIGMILVGIFVGPQVGNVISQDVLGAADELRTVAVTIILMKAGLGLDREKLAEQ
GSVALRLGFLPATTEAIAIAIASIIIFKFDFPTGLLLGCVIGAESPAVIVPGMLRLKSLGLGVTKGIPDAILTGSALSDV
LLLLVFSLLLNFLGDGGVEQITLIGVFTLNTLYLLPIQILMQIVLGLLLGYLAARLIVLLLTKQNWTQNVVQDTVISASL
ALFLVIIANALPYFSGYLATIAMGFFLIELDAPLARRLRGGFDGLWVVAEIFLFVLLGATIQLQVLENILLPGILILAIG
LFIGRMIGWYLSTLGSNWNWHERLFLLPGNSAKATVQAAIGAIPLAQGIAGGEIILAIAVLSILITAPLGAWATTVFAPK
LLTRGEVDPTKVTIATRTLLLAAVDTSSLATEVLTKVADLARRSNGEAIVLHVVNTSHRQDVEQVQAQAKQLLSDIRYQF
LTVTGAVPEEILRIAETYNATAIVMGKRGHQPWEKVLIGSVSQAVLENSSIPVILLDTRPEKN
>Mature_543_residues
MLFSILWILIMGFFAGQIARRLTAPPLIGMILVGIFVGPQVGNVISQDVLGAADELRTVAVTIILMKAGLGLDREKLAEQ
GSVALRLGFLPATTEAIAIAIASIIIFKFDFPTGLLLGCVIGAESPAVIVPGMLRLKSLGLGVTKGIPDAILTGSALSDV
LLLLVFSLLLNFLGDGGVEQITLIGVFTLNTLYLLPIQILMQIVLGLLLGYLAARLIVLLLTKQNWTQNVVQDTVISASL
ALFLVIIANALPYFSGYLATIAMGFFLIELDAPLARRLRGGFDGLWVVAEIFLFVLLGATIQLQVLENILLPGILILAIG
LFIGRMIGWYLSTLGSNWNWHERLFLLPGNSAKATVQAAIGAIPLAQGIAGGEIILAIAVLSILITAPLGAWATTVFAPK
LLTRGEVDPTKVTIATRTLLLAAVDTSSLATEVLTKVADLARRSNGEAIVLHVVNTSHRQDVEQVQAQAKQLLSDIRYQF
LTVTGAVPEEILRIAETYNATAIVMGKRGHQPWEKVLIGSVSQAVLENSSIPVILLDTRPEKN

Specific function: This is a Na(+)/H(+) antiporter. Can also transport lithium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI66793392, Length=373, Percent_Identity=31.0991957104558, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI47271479, Length=364, Percent_Identity=29.6703296703297, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI154937338, Length=304, Percent_Identity=30.5921052631579, Blast_Score=103, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI25152227, Length=437, Percent_Identity=25.858123569794, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17567635, Length=406, Percent_Identity=26.8472906403941, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI32566724, Length=175, Percent_Identity=32, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI20129297, Length=427, Percent_Identity=29.5081967213115, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI45550940, Length=427, Percent_Identity=29.5081967213115, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24649169, Length=378, Percent_Identity=28.8359788359788, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 58029; Mature: 58029

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFSILWILIMGFFAGQIARRLTAPPLIGMILVGIFVGPQVGNVISQDVLGAADELRTVA
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHH
VTIILMKAGLGLDREKLAEQGSVALRLGFLPATTEAIAIAIASIIIFKFDFPTGLLLGCV
HHHHHHHHCCCCCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHEECCCHHHHHHHH
IGAESPAVIVPGMLRLKSLGLGVTKGIPDAILTGSALSDVLLLLVFSLLLNFLGDGGVEQ
HCCCCCCEECCHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCE
ITLIGVFTLNTLYLLPIQILMQIVLGLLLGYLAARLIVLLLTKQNWTQNVVQDTVISASL
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ALFLVIIANALPYFSGYLATIAMGFFLIELDAPLARRLRGGFDGLWVVAEIFLFVLLGAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHCCCCCHHHHHHHHHHHHHHCCH
IQLQVLENILLPGILILAIGLFIGRMIGWYLSTLGSNWNWHERLFLLPGNSAKATVQAAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHH
GAIPLAQGIAGGEIILAIAVLSILITAPLGAWATTVFAPKLLTRGEVDPTKVTIATRTLL
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHH
LAAVDTSSLATEVLTKVADLARRSNGEAIVLHVVNTSHRQDVEQVQAQAKQLLSDIRYQF
HHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LTVTGAVPEEILRIAETYNATAIVMGKRGHQPWEKVLIGSVSQAVLENSSIPVILLDTRP
HEECCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCC
EKN
CCC
>Mature Secondary Structure
MLFSILWILIMGFFAGQIARRLTAPPLIGMILVGIFVGPQVGNVISQDVLGAADELRTVA
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHH
VTIILMKAGLGLDREKLAEQGSVALRLGFLPATTEAIAIAIASIIIFKFDFPTGLLLGCV
HHHHHHHHCCCCCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHEECCCHHHHHHHH
IGAESPAVIVPGMLRLKSLGLGVTKGIPDAILTGSALSDVLLLLVFSLLLNFLGDGGVEQ
HCCCCCCEECCHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCE
ITLIGVFTLNTLYLLPIQILMQIVLGLLLGYLAARLIVLLLTKQNWTQNVVQDTVISASL
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ALFLVIIANALPYFSGYLATIAMGFFLIELDAPLARRLRGGFDGLWVVAEIFLFVLLGAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHCCCCCHHHHHHHHHHHHHHCCH
IQLQVLENILLPGILILAIGLFIGRMIGWYLSTLGSNWNWHERLFLLPGNSAKATVQAAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHH
GAIPLAQGIAGGEIILAIAVLSILITAPLGAWATTVFAPKLLTRGEVDPTKVTIATRTLL
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHH
LAAVDTSSLATEVLTKVADLARRSNGEAIVLHVVNTSHRQDVEQVQAQAKQLLSDIRYQF
HHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LTVTGAVPEEILRIAETYNATAIVMGKRGHQPWEKVLIGSVSQAVLENSSIPVILLDTRP
HEECCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCC
EKN
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]