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The map label for this gene is yycG [H]

Identifier: 17229733

GI number: 17229733

Start: 2692248

End: 2693381

Strand: Direct

Name: yycG [H]

Synonym: alr2241

Alternate gene names: 17229733

Gene position: 2692248-2693381 (Clockwise)

Preceding gene: 17229732

Following gene: 17229734

Centisome position: 41.98

GC content: 40.65

Gene sequence:

>1134_bases
ATGAATCCTATCCAAATTTTGATAGTTGAAGATGAGCAACTAGTGGCTGATGACCTGAGAGAAACTCTAGAATATTTGGG
GTACGGTGTGCCTGCCTTAGTAGCATCTGGAGAAGAAGCTATTCTCATGGCAGGAATCTTGCGACCTGACCTAGTGCTGA
TGGACATCAGATTAGAGGGTAAAATCGATGGCATAGAAGCCTCTTTTGCCATCCAGTCTCGCTTTGGTTTACCTGTCGTT
TACCTAACTGCTAATGCCGACCGCGCAACACTAGAGCGAGCTAAGGCTTCCCATCCTTTTGGTTATATTTTAAAACCCTT
CGATGAAAGAATATTAGCTACCACAATAGAGATTGCCATTTCCCGACATCAAACAGAAGTTGAAGTAAAAGAAGCACTAA
TGGCTGCCAAAAATAGTCAGCAAATTGCTGAATCCAAAAACCAGATGAAATCACAACATCTCTACATGGCAGCACATGAG
TTTCGTAACCCTTTAACTACAATTAAGCTCAGTGCCGAAATGTTGAATACCTATGGCGAGAAGATGTCAGAGGAAAAAAA
ACAAAAACATATCGACCGCATTGAATCTGCCACGGATAGCTTGACGAATCTGCTAGAGAATATACTCACACTTGGTAGAG
CCGAAGCTGAAAATTTTGTATTGAACCCCACGCTGATAGAGGTAGTAAGTTTCTGTGAAGAAATAGTCGAGTCTTTACGG
TTAACATTGAAAGAACAGTATGAAATTAATTTTGTCACAGATACTAAAAGTTGTATTGCCTGCTTAGATGAACAGCTACT
GTGGCATTTACTAAATAACTTACTTTCTAACGCAGTCAAGTACTCACCCAGAGGTAGTACTATTTTGCTGCGGCTGACTT
GCGACGAAAGTGATGTATATTTTCAAATTAAAGACCAAGGTGTAGGTATTCCCCCAGAATTTCAAGCTAAACTATTTGAA
CCTTTTCAACGTGCTGCCAATGTTGCCACGATTCCTGGCACAGGATTAGGGCTAGCAATTGTTAAGCAATGTGTCGATTT
GCATCAGGGTACGATATCTATTGATACTACCTTAGGTCAAGGCACAAGTTTCGTAGTTAAACTACCACTGAAGGTAGATT
CAATATCGGCTTAA

Upstream 100 bases:

>100_bases
AGAAATCTTAAAAAAGATCAAAGAAATTTATAATTTAAGCAAAAATTTTCAGGATATAAATCTGAATAAGCGATAAATCT
AATCAACTAGAAAATTAAAT

Downstream 100 bases:

>100_bases
TTTTGATAAAAATAGCGCTTTTCGAGTTGATGAAGTATATCGTCAAAATCGTCAAATTTGCAATCATTTATCCATAGCAA
TCTAATTTTAGCCCTGTAAT

Product: two-component hybrid sensor and regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MNPIQILIVEDEQLVADDLRETLEYLGYGVPALVASGEEAILMAGILRPDLVLMDIRLEGKIDGIEASFAIQSRFGLPVV
YLTANADRATLERAKASHPFGYILKPFDERILATTIEIAISRHQTEVEVKEALMAAKNSQQIAESKNQMKSQHLYMAAHE
FRNPLTTIKLSAEMLNTYGEKMSEEKKQKHIDRIESATDSLTNLLENILTLGRAEAENFVLNPTLIEVVSFCEEIVESLR
LTLKEQYEINFVTDTKSCIACLDEQLLWHLLNNLLSNAVKYSPRGSTILLRLTCDESDVYFQIKDQGVGIPPEFQAKLFE
PFQRAANVATIPGTGLGLAIVKQCVDLHQGTISIDTTLGQGTSFVVKLPLKVDSISA

Sequences:

>Translated_377_residues
MNPIQILIVEDEQLVADDLRETLEYLGYGVPALVASGEEAILMAGILRPDLVLMDIRLEGKIDGIEASFAIQSRFGLPVV
YLTANADRATLERAKASHPFGYILKPFDERILATTIEIAISRHQTEVEVKEALMAAKNSQQIAESKNQMKSQHLYMAAHE
FRNPLTTIKLSAEMLNTYGEKMSEEKKQKHIDRIESATDSLTNLLENILTLGRAEAENFVLNPTLIEVVSFCEEIVESLR
LTLKEQYEINFVTDTKSCIACLDEQLLWHLLNNLLSNAVKYSPRGSTILLRLTCDESDVYFQIKDQGVGIPPEFQAKLFE
PFQRAANVATIPGTGLGLAIVKQCVDLHQGTISIDTTLGQGTSFVVKLPLKVDSISA
>Mature_377_residues
MNPIQILIVEDEQLVADDLRETLEYLGYGVPALVASGEEAILMAGILRPDLVLMDIRLEGKIDGIEASFAIQSRFGLPVV
YLTANADRATLERAKASHPFGYILKPFDERILATTIEIAISRHQTEVEVKEALMAAKNSQQIAESKNQMKSQHLYMAAHE
FRNPLTTIKLSAEMLNTYGEKMSEEKKQKHIDRIESATDSLTNLLENILTLGRAEAENFVLNPTLIEVVSFCEEIVESLR
LTLKEQYEINFVTDTKSCIACLDEQLLWHLLNNLLSNAVKYSPRGSTILLRLTCDESDVYFQIKDQGVGIPPEFQAKLFE
PFQRAANVATIPGTGLGLAIVKQCVDLHQGTISIDTTLGQGTSFVVKLPLKVDSISA

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=254, Percent_Identity=30.3149606299213, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1786600, Length=248, Percent_Identity=29.8387096774194, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1786912, Length=240, Percent_Identity=28.75, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082128, Length=225, Percent_Identity=30.2222222222222, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786783, Length=225, Percent_Identity=30.6666666666667, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788713, Length=229, Percent_Identity=27.0742358078603, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788549, Length=273, Percent_Identity=27.8388278388278, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789149, Length=267, Percent_Identity=26.5917602996255, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87081816, Length=267, Percent_Identity=26.5917602996255, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1790346, Length=260, Percent_Identity=27.6923076923077, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789808, Length=239, Percent_Identity=28.8702928870293, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790861, Length=211, Percent_Identity=28.9099526066351, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI48994928, Length=240, Percent_Identity=25.8333333333333, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1789403, Length=218, Percent_Identity=29.8165137614679, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790551, Length=269, Percent_Identity=27.8810408921933, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788279, Length=212, Percent_Identity=29.7169811320755, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787894, Length=253, Percent_Identity=27.6679841897233, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788393, Length=249, Percent_Identity=25.3012048192771, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=25.3393665158371, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41865; Mature: 41865

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIQILIVEDEQLVADDLRETLEYLGYGVPALVASGEEAILMAGILRPDLVLMDIRLEG
CCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEECCCCCCEEEEEEEECC
KIDGIEASFAIQSRFGLPVVYLTANADRATLERAKASHPFGYILKPFDERILATTIEIAI
CCCCCCCEEEECCCCCCEEEEEECCCCHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHH
SRHQTEVEVKEALMAAKNSQQIAESKNQMKSQHLYMAAHEFRNPLTTIKLSAEMLNTYGE
HCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHH
KMSEEKKQKHIDRIESATDSLTNLLENILTLGRAEAENFVLNPTLIEVVSFCEEIVESLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHH
LTLKEQYEINFVTDTKSCIACLDEQLLWHLLNNLLSNAVKYSPRGSTILLRLTCDESDVY
HHHHHCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEEECCCCEE
FQIKDQGVGIPPEFQAKLFEPFQRAANVATIPGTGLGLAIVKQCVDLHQGTISIDTTLGQ
EEECCCCCCCCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCC
GTSFVVKLPLKVDSISA
CCEEEEEECEEECCCCC
>Mature Secondary Structure
MNPIQILIVEDEQLVADDLRETLEYLGYGVPALVASGEEAILMAGILRPDLVLMDIRLEG
CCCEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEECCCCCCEEEEEEEECC
KIDGIEASFAIQSRFGLPVVYLTANADRATLERAKASHPFGYILKPFDERILATTIEIAI
CCCCCCCEEEECCCCCCEEEEEECCCCHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHH
SRHQTEVEVKEALMAAKNSQQIAESKNQMKSQHLYMAAHEFRNPLTTIKLSAEMLNTYGE
HCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHH
KMSEEKKQKHIDRIESATDSLTNLLENILTLGRAEAENFVLNPTLIEVVSFCEEIVESLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHH
LTLKEQYEINFVTDTKSCIACLDEQLLWHLLNNLLSNAVKYSPRGSTILLRLTCDESDVY
HHHHHCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEEEECCCCEE
FQIKDQGVGIPPEFQAKLFEPFQRAANVATIPGTGLGLAIVKQCVDLHQGTISIDTTLGQ
EEECCCCCCCCCHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHCCCEEEEEEECCC
GTSFVVKLPLKVDSISA
CCEEEEEECEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9829949; 10878122; 11758928 [H]