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The map label for this gene is eriC [C]

Identifier: 17229571

GI number: 17229571

Start: 2486176

End: 2487936

Strand: Direct

Name: eriC [C]

Synonym: alr2079

Alternate gene names: 17229571

Gene position: 2486176-2487936 (Clockwise)

Preceding gene: 17229568

Following gene: 17229573

Centisome position: 38.76

GC content: 44.69

Gene sequence:

>1761_bases
GTGTTGTTTTTAGCCGTACTCATTGGCGGTGGCACTGGTATGGGGGTGGTGACTTTTCACTATTTGATTGAGCTGATTCA
CCACCTGATGCTAGAAAATCTGATGGGTGCAATTGGTGTTTGGGGCGCTTGGACATTAGCTCTTGTCCCCATTTTAGGAG
GGCTAATAGTTGGATTTATGCGCTGGCGTACACAAGACTTTGGCCCCGGACTATCCTCACTCATTGCCGCTTCTGAGGGT
GGCGAAATCAAAGGACAATTACGTCCTGTTACAAAAATGTTAGCGGCTGCCGTTTCTTTGGGGAGTGGTGCTTCTTTGGG
GCCAGAGGGGCCAAGTGTGGAAATTGGCGCTAATTTCGGAATGCTGTTGTCCTTAATATTACAAGTTTCGCAAGAACGTC
AGCGTTTACTTTTAGGTGCTGGCGCGGCCGCTGGCTTGGCGGCGGGATTTAATGCGCCAATTGCCGGGGTATTTTTTGCC
TTAGAAGTAGTCATGGGCGCAACATCTTTTGCCACTTCCGCCGTGAGTGTAGTGCTGTTGGCGGCGGTAGTAGCGGCTTT
AATTGCACAAATTGGTTTAGGGGCGCAACCTGCTTTTGCTTTACCTGTTTACCAAGTCCGCAGCCCTTTGGAATTGCCCC
TTTATCTGGGTTTGGGGTTGGGTGCTAGTTTGGTTTCTGTAGCTTATAAACAATCTATTAATTGGGGAAAAGCTTGTTTT
GCCGGTTCGATTCCTGGGTTTAAATTTTTAGATAAAATTCCTCAGCCAATTCACCCTATCATTGGGGGTTTCATTATTGG
CATAGTAGCTTTAAAATTCCCACAAATTTTGGGCATCGGTTATGGCACAGTACAAGCGATGCTGCAAGATGTCAAATTTT
CTCTAGATTTGTTATTGATATTGTTGGTTTTAAAGTTGCTGATAACAGCCATTAGTGCGGGTAGTGGTTTTGTTGGCGGT
TTGTTTGCGCCGGCAATGTTTTTAGGTGCTTCATTGGGTTCAGCTTATGCTAAGATTCTCACACTCATAGCGCCAGGAAT
TGGCGAATATATGGCAGCACCTCCGGCTTATGCAATGGTAGGTATGGCTGCCGTCCTAGCTGGAAGTGTGAGAGCGCCTT
TGACCTCAATTTTAATGTTATTTGAACTTACCCGCGATTACCGAATTGTTTTACCTTTAATGGCGGCTGTGGGTTTAAGT
GTATGGCTAGTAGAAAGGATTAAACCAAATACGAATTCTCATACCAATTTACAGCAAATTGGTCTTTCAATTCCGAAAGA
CCAAAAAGTAGAAATTTTGCAGCAAATTTTAGTAGAGGATGCTATGCTTGCTTGCCCAAAAAAGCTATCTGCGACTTTGG
GCATTTTAGAAGCTGCTAGGGAAATGATCAGCGATCGCACACGCAGTGCTTTAGTTATTGATGATGCAGAACAACTAGTT
GGGATTATCTCCCTAGAAGACCTCAACCGTACTCTTTCTGTATGGCAAAATTACCCGAATTCTGCAAGTGAAATCCAAAG
TAATTTCACCCATCAAAGCATCATCGATATCTGTACAAAAGAGATCCTCTATGCTTGGCGTGATGAACCTTTGTCTGAGG
CTTTAGACCGCATGGAGGTTAGAGGTTTGCATCAGTTACCTGTGGTAGCACGAGACAACCATGACCATATTCTAGGGTTG
CTAGATAGGGAGCAAATTGCATTAACGTGTAACTTGGCAGTCACACGCCAGACACTTTACCGTTTGGTCAGTAGTCATTA
G

Upstream 100 bases:

>100_bases
CACTGAGCTAAGGAAGGTAACAGAACCATCTGCTTTTCCTACACCTTCCTCCCAAGTAACACATCTCATTAACCGATTTC
AACTTTCCCCAGAAACTATC

Downstream 100 bases:

>100_bases
TCATTGGTCATTGGAAAAATCAACAACTGACAACTAACTATTAATTATGCTGTAGCTTCTGCGATTTCGAGGATTTCTCT
TTCTTCGCCATCTACTTGTC

Product: hypothetical protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 586; Mature: 586

Protein sequence:

>586_residues
MLFLAVLIGGGTGMGVVTFHYLIELIHHLMLENLMGAIGVWGAWTLALVPILGGLIVGFMRWRTQDFGPGLSSLIAASEG
GEIKGQLRPVTKMLAAAVSLGSGASLGPEGPSVEIGANFGMLLSLILQVSQERQRLLLGAGAAAGLAAGFNAPIAGVFFA
LEVVMGATSFATSAVSVVLLAAVVAALIAQIGLGAQPAFALPVYQVRSPLELPLYLGLGLGASLVSVAYKQSINWGKACF
AGSIPGFKFLDKIPQPIHPIIGGFIIGIVALKFPQILGIGYGTVQAMLQDVKFSLDLLLILLVLKLLITAISAGSGFVGG
LFAPAMFLGASLGSAYAKILTLIAPGIGEYMAAPPAYAMVGMAAVLAGSVRAPLTSILMLFELTRDYRIVLPLMAAVGLS
VWLVERIKPNTNSHTNLQQIGLSIPKDQKVEILQQILVEDAMLACPKKLSATLGILEAAREMISDRTRSALVIDDAEQLV
GIISLEDLNRTLSVWQNYPNSASEIQSNFTHQSIIDICTKEILYAWRDEPLSEALDRMEVRGLHQLPVVARDNHDHILGL
LDREQIALTCNLAVTRQTLYRLVSSH

Sequences:

>Translated_586_residues
MLFLAVLIGGGTGMGVVTFHYLIELIHHLMLENLMGAIGVWGAWTLALVPILGGLIVGFMRWRTQDFGPGLSSLIAASEG
GEIKGQLRPVTKMLAAAVSLGSGASLGPEGPSVEIGANFGMLLSLILQVSQERQRLLLGAGAAAGLAAGFNAPIAGVFFA
LEVVMGATSFATSAVSVVLLAAVVAALIAQIGLGAQPAFALPVYQVRSPLELPLYLGLGLGASLVSVAYKQSINWGKACF
AGSIPGFKFLDKIPQPIHPIIGGFIIGIVALKFPQILGIGYGTVQAMLQDVKFSLDLLLILLVLKLLITAISAGSGFVGG
LFAPAMFLGASLGSAYAKILTLIAPGIGEYMAAPPAYAMVGMAAVLAGSVRAPLTSILMLFELTRDYRIVLPLMAAVGLS
VWLVERIKPNTNSHTNLQQIGLSIPKDQKVEILQQILVEDAMLACPKKLSATLGILEAAREMISDRTRSALVIDDAEQLV
GIISLEDLNRTLSVWQNYPNSASEIQSNFTHQSIIDICTKEILYAWRDEPLSEALDRMEVRGLHQLPVVARDNHDHILGL
LDREQIALTCNLAVTRQTLYRLVSSH
>Mature_586_residues
MLFLAVLIGGGTGMGVVTFHYLIELIHHLMLENLMGAIGVWGAWTLALVPILGGLIVGFMRWRTQDFGPGLSSLIAASEG
GEIKGQLRPVTKMLAAAVSLGSGASLGPEGPSVEIGANFGMLLSLILQVSQERQRLLLGAGAAAGLAAGFNAPIAGVFFA
LEVVMGATSFATSAVSVVLLAAVVAALIAQIGLGAQPAFALPVYQVRSPLELPLYLGLGLGASLVSVAYKQSINWGKACF
AGSIPGFKFLDKIPQPIHPIIGGFIIGIVALKFPQILGIGYGTVQAMLQDVKFSLDLLLILLVLKLLITAISAGSGFVGG
LFAPAMFLGASLGSAYAKILTLIAPGIGEYMAAPPAYAMVGMAAVLAGSVRAPLTSILMLFELTRDYRIVLPLMAAVGLS
VWLVERIKPNTNSHTNLQQIGLSIPKDQKVEILQQILVEDAMLACPKKLSATLGILEAAREMISDRTRSALVIDDAEQLV
GIISLEDLNRTLSVWQNYPNSASEIQSNFTHQSIIDICTKEILYAWRDEPLSEALDRMEVRGLHQLPVVARDNHDHILGL
LDREQIALTCNLAVTRQTLYRLVSSH

Specific function: Selective chloride channel [C]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=292, Percent_Identity=29.4520547945205, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI87081943, Length=327, Percent_Identity=30.2752293577982, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71996455, Length=482, Percent_Identity=25.3112033195021, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71996452, Length=482, Percent_Identity=25.3112033195021, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71980828, Length=468, Percent_Identity=23.2905982905983, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980824, Length=468, Percent_Identity=23.2905982905983, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71980820, Length=479, Percent_Identity=22.964509394572, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24665008, Length=472, Percent_Identity=25, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 62178; Mature: 62178

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFLAVLIGGGTGMGVVTFHYLIELIHHLMLENLMGAIGVWGAWTLALVPILGGLIVGFM
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RWRTQDFGPGLSSLIAASEGGEIKGQLRPVTKMLAAAVSLGSGASLGPEGPSVEIGANFG
HHHCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCHH
MLLSLILQVSQERQRLLLGAGAAAGLAAGFNAPIAGVFFALEVVMGATSFATSAVSVVLL
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAVVAALIAQIGLGAQPAFALPVYQVRSPLELPLYLGLGLGASLVSVAYKQSINWGKACF
HHHHHHHHHHHCCCCCCCHHCCHHHHCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCHHHH
AGSIPGFKFLDKIPQPIHPIIGGFIIGIVALKFPQILGIGYGTVQAMLQDVKFSLDLLLI
CCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LLVLKLLITAISAGSGFVGGLFAPAMFLGASLGSAYAKILTLIAPGIGEYMAAPPAYAMV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHH
GMAAVLAGSVRAPLTSILMLFELTRDYRIVLPLMAAVGLSVWLVERIKPNTNSHTNLQQI
HHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
GLSIPKDQKVEILQQILVEDAMLACPKKLSATLGILEAAREMISDRTRSALVIDDAEQLV
CCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHH
GIISLEDLNRTLSVWQNYPNSASEIQSNFTHQSIIDICTKEILYAWRDEPLSEALDRMEV
HHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RGLHQLPVVARDNHDHILGLLDREQIALTCNLAVTRQTLYRLVSSH
CCHHHCCCEEECCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLFLAVLIGGGTGMGVVTFHYLIELIHHLMLENLMGAIGVWGAWTLALVPILGGLIVGFM
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RWRTQDFGPGLSSLIAASEGGEIKGQLRPVTKMLAAAVSLGSGASLGPEGPSVEIGANFG
HHHCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCHH
MLLSLILQVSQERQRLLLGAGAAAGLAAGFNAPIAGVFFALEVVMGATSFATSAVSVVLL
HHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAVVAALIAQIGLGAQPAFALPVYQVRSPLELPLYLGLGLGASLVSVAYKQSINWGKACF
HHHHHHHHHHHCCCCCCCHHCCHHHHCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCHHHH
AGSIPGFKFLDKIPQPIHPIIGGFIIGIVALKFPQILGIGYGTVQAMLQDVKFSLDLLLI
CCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LLVLKLLITAISAGSGFVGGLFAPAMFLGASLGSAYAKILTLIAPGIGEYMAAPPAYAMV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHH
GMAAVLAGSVRAPLTSILMLFELTRDYRIVLPLMAAVGLSVWLVERIKPNTNSHTNLQQI
HHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
GLSIPKDQKVEILQQILVEDAMLACPKKLSATLGILEAAREMISDRTRSALVIDDAEQLV
CCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHH
GIISLEDLNRTLSVWQNYPNSASEIQSNFTHQSIIDICTKEILYAWRDEPLSEALDRMEV
HHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RGLHQLPVVARDNHDHILGLLDREQIALTCNLAVTRQTLYRLVSSH
CCHHHCCCEEECCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]