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The map label for this gene is htrA [H]

Identifier: 17229500

GI number: 17229500

Start: 2401466

End: 2402716

Strand: Reverse

Name: htrA [H]

Synonym: all2008

Alternate gene names: 17229500

Gene position: 2402716-2401466 (Counterclockwise)

Preceding gene: 17229503

Following gene: 17229499

Centisome position: 37.46

GC content: 44.68

Gene sequence:

>1251_bases
ATGAAGACATATAATGGCGAAGCAAACAAGATTCATACTTCGAGTTTGCCCCACAAGGGGGGCAGTAGTGCGATTTTGAT
GCTGCTGGGTGGGGTAACAGCTATGTTTCTAGGAAGCTGCTCCTTTCTACCCACAAGGACAATACAATCCCAAGCCAATC
AATCTCAGCCCCAGTCTAATGATAATAGTCCAGCAATTGTCCCTCCAGCTATTTTTTCATCCACCGGCGACCCTAATTTT
GTCGTCGGAGTAGTACAAAAAGTGGGAGGGGCTGTAGTTCGGATTGATTCTGCCAGAACAGTAACTTCCAGGGTTCCAAA
TGAATTTAATGATCCTTTTTTCCGCCGCTTTTTCGGAGATGGAGTGCCAGCACAACCAAGACAGCGAGTAGAAAGGGGTA
GCGGTTCAGGTTTTATTATTAGTTCCTCTGGTCAAATTTTAACTAATGCCCATGTTGTTGATGGTGCTGATGAGGTAACA
GTTACCCTCAAGGATGGTAGGAGTTTTGATGGTAAGGTACTTGGTGAAGACCCGGTAACGGATGTAGCCGTCATTCAAAT
AAACGCTAATAACTTGCCAACTGTCGCTGTCGGTAATTCTGAAGTTTTACAACCAGGTGAAGCAGTTATTGCAATTGGTA
ATCCTCTAGGCTTGAATAATAGTGTTACGTCAGGAATTATCAGCGCCACAGGTCGTTCTGGTAGTGATATTGGCGCAAGT
GATAAGCGCGTTGACTATTTGCAAACAGACGCGGCGATTAATCCTGGTAACTCTGGCGGCCCCCTGCTCAATGCTCGCGG
TCAGGTAATTGGTATGAACACAGCTATTATCCAAGGCGCTCAAGGTTTGGGATTTGCTATTCCTATCAACACTGTGCAGA
AAGTCTCTCAGGAATTAATCACTCAAGGTAAGGTAGATCATCCCTATTTGGGTGTACAGATGGCAACCCTCACGCCACAA
GTTAAGGAAAGAATTAACGAAAGATTTGGCGATCGCATCAATATTACAGCAGATAGAGGCGTTTTACTAGTTCGTATTGT
CCCTGGCTCTCCCGCCGCCAATGCTGGACTTAGACCAGGAGATATCATTCAAAGCATTAATAATCAATCTGTAACAACCG
TTGAACAAGTCCAAAAAATTGTAGAAAATAGCCAAATTGGCCAACCTTTACAAATTCAAATAGAACGCAATGGCCAAACA
ACACAAGTAAACGTCAGTCCAGCACCTTTACCTGCGCGGAGAGAGGGGTAG

Upstream 100 bases:

>100_bases
CCACGCAAAGAGTCTTGTTGCATAAGTCCGAATCAAGTTCAGACAAACCCAGTAGGCAACATCCTAGCACTCACTGACCA
ACACGGAGAAACAAAGACAC

Downstream 100 bases:

>100_bases
GGATTGGGTATTGGGGATTGGGGACTGGGGACTGGGGTCAAAATCCATAGCTAAGTATAGTTTACGATTAATCAAAATTA
CTAGCTGTAAAGCGTAAAGC

Product: serine proteinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKTYNGEANKIHTSSLPHKGGSSAILMLLGGVTAMFLGSCSFLPTRTIQSQANQSQPQSNDNSPAIVPPAIFSSTGDPNF
VVGVVQKVGGAVVRIDSARTVTSRVPNEFNDPFFRRFFGDGVPAQPRQRVERGSGSGFIISSSGQILTNAHVVDGADEVT
VTLKDGRSFDGKVLGEDPVTDVAVIQINANNLPTVAVGNSEVLQPGEAVIAIGNPLGLNNSVTSGIISATGRSGSDIGAS
DKRVDYLQTDAAINPGNSGGPLLNARGQVIGMNTAIIQGAQGLGFAIPINTVQKVSQELITQGKVDHPYLGVQMATLTPQ
VKERINERFGDRINITADRGVLLVRIVPGSPAANAGLRPGDIIQSINNQSVTTVEQVQKIVENSQIGQPLQIQIERNGQT
TQVNVSPAPLPARREG

Sequences:

>Translated_416_residues
MKTYNGEANKIHTSSLPHKGGSSAILMLLGGVTAMFLGSCSFLPTRTIQSQANQSQPQSNDNSPAIVPPAIFSSTGDPNF
VVGVVQKVGGAVVRIDSARTVTSRVPNEFNDPFFRRFFGDGVPAQPRQRVERGSGSGFIISSSGQILTNAHVVDGADEVT
VTLKDGRSFDGKVLGEDPVTDVAVIQINANNLPTVAVGNSEVLQPGEAVIAIGNPLGLNNSVTSGIISATGRSGSDIGAS
DKRVDYLQTDAAINPGNSGGPLLNARGQVIGMNTAIIQGAQGLGFAIPINTVQKVSQELITQGKVDHPYLGVQMATLTPQ
VKERINERFGDRINITADRGVLLVRIVPGSPAANAGLRPGDIIQSINNQSVTTVEQVQKIVENSQIGQPLQIQIERNGQT
TQVNVSPAPLPARREG
>Mature_416_residues
MKTYNGEANKIHTSSLPHKGGSSAILMLLGGVTAMFLGSCSFLPTRTIQSQANQSQPQSNDNSPAIVPPAIFSSTGDPNF
VVGVVQKVGGAVVRIDSARTVTSRVPNEFNDPFFRRFFGDGVPAQPRQRVERGSGSGFIISSSGQILTNAHVVDGADEVT
VTLKDGRSFDGKVLGEDPVTDVAVIQINANNLPTVAVGNSEVLQPGEAVIAIGNPLGLNNSVTSGIISATGRSGSDIGAS
DKRVDYLQTDAAINPGNSGGPLLNARGQVIGMNTAIIQGAQGLGFAIPINTVQKVSQELITQGKVDHPYLGVQMATLTPQ
VKERINERFGDRINITADRGVLLVRIVPGSPAANAGLRPGDIIQSINNQSVTTVEQVQKIVENSQIGQPLQIQIERNGQT
TQVNVSPAPLPARREG

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=335, Percent_Identity=36.1194029850746, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI22129776, Length=339, Percent_Identity=33.9233038348083, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI7019477, Length=343, Percent_Identity=36.734693877551, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI24308541, Length=314, Percent_Identity=35.6687898089172, Blast_Score=176, Evalue=4e-44,
Organism=Escherichia coli, GI1789629, Length=330, Percent_Identity=37.2727272727273, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1786356, Length=351, Percent_Identity=36.4672364672365, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1789630, Length=326, Percent_Identity=34.9693251533742, Blast_Score=167, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24646839, Length=363, Percent_Identity=36.3636363636364, Blast_Score=192, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 43602; Mature: 43602

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTYNGEANKIHTSSLPHKGGSSAILMLLGGVTAMFLGSCSFLPTRTIQSQANQSQPQSN
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCC
DNSPAIVPPAIFSSTGDPNFVVGVVQKVGGAVVRIDSARTVTSRVPNEFNDPFFRRFFGD
CCCCEEECHHHHCCCCCCCCEEHHHHHHCCEEEEECCCCHHHHHCCCCCCCHHHHHHHCC
GVPAQPRQRVERGSGSGFIISSSGQILTNAHVVDGADEVTVTLKDGRSFDGKVLGEDPVT
CCCCCHHHHHHCCCCCEEEEECCCCEEEEEEEECCCCEEEEEEECCCCCCCEECCCCCCC
DVAVIQINANNLPTVAVGNSEVLQPGEAVIAIGNPLGLNNSVTSGIISATGRSGSDIGAS
EEEEEEEECCCCCEEEECCHHHCCCCCEEEEECCCCCCCCCHHCCCEEECCCCCCCCCCC
DKRVDYLQTDAAINPGNSGGPLLNARGQVIGMNTAIIQGAQGLGFAIPINTVQKVSQELI
CCCEEEEECCCCCCCCCCCCCEEECCCCEEECCHHEEECCCCCEEEEEHHHHHHHHHHHH
TQGKVDHPYLGVQMATLTPQVKERINERFGDRINITADRGVLLVRIVPGSPAANAGLRPG
HCCCCCCCEECEEEECCCHHHHHHHHHHCCCEEEEEECCCEEEEEEECCCCCCCCCCCHH
DIIQSINNQSVTTVEQVQKIVENSQIGQPLQIQIERNGQTTQVNVSPAPLPARREG
HHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MKTYNGEANKIHTSSLPHKGGSSAILMLLGGVTAMFLGSCSFLPTRTIQSQANQSQPQSN
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCC
DNSPAIVPPAIFSSTGDPNFVVGVVQKVGGAVVRIDSARTVTSRVPNEFNDPFFRRFFGD
CCCCEEECHHHHCCCCCCCCEEHHHHHHCCEEEEECCCCHHHHHCCCCCCCHHHHHHHCC
GVPAQPRQRVERGSGSGFIISSSGQILTNAHVVDGADEVTVTLKDGRSFDGKVLGEDPVT
CCCCCHHHHHHCCCCCEEEEECCCCEEEEEEEECCCCEEEEEEECCCCCCCEECCCCCCC
DVAVIQINANNLPTVAVGNSEVLQPGEAVIAIGNPLGLNNSVTSGIISATGRSGSDIGAS
EEEEEEEECCCCCEEEECCHHHCCCCCEEEEECCCCCCCCCHHCCCEEECCCCCCCCCCC
DKRVDYLQTDAAINPGNSGGPLLNARGQVIGMNTAIIQGAQGLGFAIPINTVQKVSQELI
CCCEEEEECCCCCCCCCCCCCEEECCCCEEECCHHEEECCCCCEEEEEHHHHHHHHHHHH
TQGKVDHPYLGVQMATLTPQVKERINERFGDRINITADRGVLLVRIVPGSPAANAGLRPG
HCCCCCCCEECEEEECCCHHHHHHHHHHCCCEEEEEECCCEEEEEEECCCCCCCCCCCHH
DIIQSINNQSVTTVEQVQKIVENSQIGQPLQIQIERNGQTTQVNVSPAPLPARREG
HHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]