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The map label for this gene is ffh [H]

Identifier: 17229444

GI number: 17229444

Start: 2335694

End: 2337166

Strand: Direct

Name: ffh [H]

Synonym: alr1952

Alternate gene names: 17229444

Gene position: 2335694-2337166 (Clockwise)

Preceding gene: 17229438

Following gene: 17229445

Centisome position: 36.42

GC content: 48.74

Gene sequence:

>1473_bases
ATGTTTGACGCATTAGCAGACCGTTTAGAATCCGCCTGGAAAAAGCTGCGCGGGCAAGATAAAATTTCTGAATCTAACAT
TCAAGATGCTTTGCGAGAAGTGCGCCGCGCCCTGTTGGAAGCAGATGTTAACCTCCAAGTAGTCAAAGATTTTATTAGCG
AAGTTGAAGCCAAGGCGCAGGGAGCCGAAGTTATTAGCGGCGTGCGACCTGACCAGCAGTTCATCAAGATTGTTTACGAT
GAGCTAGTACAGGTGATGGGGGAAGAGAATGTTCCCCTGGCGGAAGTGGAACAAAAGCCCACAATTGTTTTGATGGCTGG
TTTACAAGGTACTGGTAAAACCACAGCCACCGCCAAATTAGCTTTACATTTACGGAAATTAGAACGCAGTTGCTTGTTGG
TAGCCACAGACGTATATCGTCCAGCCGCGATTGACCAGTTGCTCACATTAGGTAAACAAATTGACGTACCAGTATTTGAA
CTGGGAAGCGATGCAGACCCTGTAGAAATTGCTCGTCAAGGTGTGGAACGTGCCAAAGCAGAGGGCGTGAACACGGTCAT
CATTGATACAGCAGGTCGTCTGCAAATTGACGAAGACATGATGGCGGAATTAGCCAGAATAAAAGAAACCGTCCAACCCC
ACGAAACGTTGCTGGTGGTGGATTCGATGACTGGTCAAGAAGCCGCCAACCTCACCCGCACCTTTCATGAGCAAATAGGT
ATTACTGGGGCAATTCTCACCAAGATGGATGGTGATAGCCGTGGTGGTGCGGCGTTGTCGGTACGGCAAATTTCAGGAGC
GCCGATTAAGTTTGTGGGTGTGGGGGAAAAAGTCGAAGCCCTACAACCCTTTTATCCAGACCGCATGGCTTCCCGAATTC
TGGGTATGGGTGATGTGCTGACATTGGTAGAAAAAGCCCAGGAAGAGTTCGATTTAGCTGATGCTGAGAAAATGCAGGAG
AAAATCCTGTCAGCGAAGTTTGACTTTACCGACTTTGTCAAGCAACTGCGGATGCTGAAAAATATGGGATCGCTGGGGGG
TCTCCTCAAAATGATTCCGGGGATGGGTAAACTCTCAGATGATCAGCTAAAGCAGGGAGAAACCCAACTCAAGCGGTGTG
AAGCGATGATTAATTCCATGACAATGCAGGAACGCCGCGACCCTGATTTATTGGCAAGTTCGCCCAACCGACGGCGACGG
ATTGCGTCTGGCTCTGGTTATAAAGAAGCAGATGTGAATAAACTAGTGGCTGATTTCCAAAAAATGCGATCGCTCATGCA
GCAAATGGGTCAAGGTAATTTCCCAGGAATGCCCGGAATGTTTGGCGGTGGCGGTGGTGGAATGGGTAATATGTTCGGTG
GTGGTAGTAACCGTCCCGCAGCCCCTGGCTGGCGCGGCTACAATAGCGGCGGTGCAGGCACAAAGAAGAAAAAACCCAAA
GACAAAAAGAAAAAAGGTTTTGGAAATCTGTAG

Upstream 100 bases:

>100_bases
AAAAACTACTAAGCTGGTAAATAGCACATTATAAAAATTTCTGAATCGCATTCCATAGCTGGTTCGGACACCCCATTGGC
TCAATAACTGTAACTAAGAT

Downstream 100 bases:

>100_bases
CCAACTGTCAAAGATTAGGGTTTTGACTATGGGCTATGGACTTTTGACTAATGACCAATAGCACTAAACCCTTAGCAAGT
GTTAAAATTAGCATTTCAAT

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MFDALADRLESAWKKLRGQDKISESNIQDALREVRRALLEADVNLQVVKDFISEVEAKAQGAEVISGVRPDQQFIKIVYD
ELVQVMGEENVPLAEVEQKPTIVLMAGLQGTGKTTATAKLALHLRKLERSCLLVATDVYRPAAIDQLLTLGKQIDVPVFE
LGSDADPVEIARQGVERAKAEGVNTVIIDTAGRLQIDEDMMAELARIKETVQPHETLLVVDSMTGQEAANLTRTFHEQIG
ITGAILTKMDGDSRGGAALSVRQISGAPIKFVGVGEKVEALQPFYPDRMASRILGMGDVLTLVEKAQEEFDLADAEKMQE
KILSAKFDFTDFVKQLRMLKNMGSLGGLLKMIPGMGKLSDDQLKQGETQLKRCEAMINSMTMQERRDPDLLASSPNRRRR
IASGSGYKEADVNKLVADFQKMRSLMQQMGQGNFPGMPGMFGGGGGGMGNMFGGGSNRPAAPGWRGYNSGGAGTKKKKPK
DKKKKGFGNL

Sequences:

>Translated_490_residues
MFDALADRLESAWKKLRGQDKISESNIQDALREVRRALLEADVNLQVVKDFISEVEAKAQGAEVISGVRPDQQFIKIVYD
ELVQVMGEENVPLAEVEQKPTIVLMAGLQGTGKTTATAKLALHLRKLERSCLLVATDVYRPAAIDQLLTLGKQIDVPVFE
LGSDADPVEIARQGVERAKAEGVNTVIIDTAGRLQIDEDMMAELARIKETVQPHETLLVVDSMTGQEAANLTRTFHEQIG
ITGAILTKMDGDSRGGAALSVRQISGAPIKFVGVGEKVEALQPFYPDRMASRILGMGDVLTLVEKAQEEFDLADAEKMQE
KILSAKFDFTDFVKQLRMLKNMGSLGGLLKMIPGMGKLSDDQLKQGETQLKRCEAMINSMTMQERRDPDLLASSPNRRRR
IASGSGYKEADVNKLVADFQKMRSLMQQMGQGNFPGMPGMFGGGGGGMGNMFGGGSNRPAAPGWRGYNSGGAGTKKKKPK
DKKKKGFGNL
>Mature_490_residues
MFDALADRLESAWKKLRGQDKISESNIQDALREVRRALLEADVNLQVVKDFISEVEAKAQGAEVISGVRPDQQFIKIVYD
ELVQVMGEENVPLAEVEQKPTIVLMAGLQGTGKTTATAKLALHLRKLERSCLLVATDVYRPAAIDQLLTLGKQIDVPVFE
LGSDADPVEIARQGVERAKAEGVNTVIIDTAGRLQIDEDMMAELARIKETVQPHETLLVVDSMTGQEAANLTRTFHEQIG
ITGAILTKMDGDSRGGAALSVRQISGAPIKFVGVGEKVEALQPFYPDRMASRILGMGDVLTLVEKAQEEFDLADAEKMQE
KILSAKFDFTDFVKQLRMLKNMGSLGGLLKMIPGMGKLSDDQLKQGETQLKRCEAMINSMTMQERRDPDLLASSPNRRRR
IASGSGYKEADVNKLVADFQKMRSLMQQMGQGNFPGMPGMFGGGGGGMGNMFGGGSNRPAAPGWRGYNSGGAGTKKKKPK
DKKKKGFGNL

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=446, Percent_Identity=32.0627802690583, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI226371618, Length=388, Percent_Identity=31.701030927835, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=34.375, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI23308697, Length=300, Percent_Identity=28.3333333333333, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI295424842, Length=300, Percent_Identity=28.3333333333333, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1788963, Length=426, Percent_Identity=50.7042253521127, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1789874, Length=264, Percent_Identity=32.9545454545455, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17539958, Length=448, Percent_Identity=29.0178571428571, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI193206261, Length=297, Percent_Identity=28.6195286195286, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6325345, Length=474, Percent_Identity=31.8565400843882, Blast_Score=234, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6320498, Length=311, Percent_Identity=22.508038585209, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17647949, Length=448, Percent_Identity=32.3660714285714, Blast_Score=237, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24641198, Length=305, Percent_Identity=26.5573770491803, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 53388; Mature: 53388

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDALADRLESAWKKLRGQDKISESNIQDALREVRRALLEADVNLQVVKDFISEVEAKAQ
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GAEVISGVRPDQQFIKIVYDELVQVMGEENVPLAEVEQKPTIVLMAGLQGTGKTTATAKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEECCCCCCCCHHHHHH
ALHLRKLERSCLLVATDVYRPAAIDQLLTLGKQIDVPVFELGSDADPVEIARQGVERAKA
HHHHHHHHHHHEEEEHHHCCHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHHHHHHH
EGVNTVIIDTAGRLQIDEDMMAELARIKETVQPHETLLVVDSMTGQEAANLTRTFHEQIG
CCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHC
ITGAILTKMDGDSRGGAALSVRQISGAPIKFVGVGEKVEALQPFYPDRMASRILGMGDVL
CCHHHHEECCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHCCCCHHHHHHHHHCCHHHH
TLVEKAQEEFDLADAEKMQEKILSAKFDFTDFVKQLRMLKNMGSLGGLLKMIPGMGKLSD
HHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCH
DQLKQGETQLKRCEAMINSMTMQERRDPDLLASSPNRRRRIASGSGYKEADVNKLVADFQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHH
KMRSLMQQMGQGNFPGMPGMFGGGGGGMGNMFGGGSNRPAAPGWRGYNSGGAGTKKKKPK
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DKKKKGFGNL
HHHHCCCCCC
>Mature Secondary Structure
MFDALADRLESAWKKLRGQDKISESNIQDALREVRRALLEADVNLQVVKDFISEVEAKAQ
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GAEVISGVRPDQQFIKIVYDELVQVMGEENVPLAEVEQKPTIVLMAGLQGTGKTTATAKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCEEEEECCCCCCCCHHHHHH
ALHLRKLERSCLLVATDVYRPAAIDQLLTLGKQIDVPVFELGSDADPVEIARQGVERAKA
HHHHHHHHHHHEEEEHHHCCHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHHHHHHH
EGVNTVIIDTAGRLQIDEDMMAELARIKETVQPHETLLVVDSMTGQEAANLTRTFHEQIG
CCCCEEEEECCCCEEECHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHC
ITGAILTKMDGDSRGGAALSVRQISGAPIKFVGVGEKVEALQPFYPDRMASRILGMGDVL
CCHHHHEECCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHCCCCHHHHHHHHHCCHHHH
TLVEKAQEEFDLADAEKMQEKILSAKFDFTDFVKQLRMLKNMGSLGGLLKMIPGMGKLSD
HHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCH
DQLKQGETQLKRCEAMINSMTMQERRDPDLLASSPNRRRRIASGSGYKEADVNKLVADFQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHH
KMRSLMQQMGQGNFPGMPGMFGGGGGGMGNMFGGGSNRPAAPGWRGYNSGGAGTKKKKPK
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DKKKKGFGNL
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]