Click here to switch to the map view.

The map label for this gene is pepP [H]

Identifier: 17229438

GI number: 17229438

Start: 2328360

End: 2329727

Strand: Direct

Name: pepP [H]

Synonym: alr1946

Alternate gene names: 17229438

Gene position: 2328360-2329727 (Clockwise)

Preceding gene: 17229437

Following gene: 17229444

Centisome position: 36.3

GC content: 47.22

Gene sequence:

>1368_bases
ATGGGTTCTCTAGCTGATACTTTGCGCGATCGCCGTCAAAAATTAGCCCACCTCATCGATTTTCCCGCGATTTTATGGTC
AGGTGGTAGCAATGCGCGCAATTTTCCCGCCAATCGTTTTCCGTTTCGGGCTAGCAGTCACTTCCTCTATTTTGCTGGCT
TACCCCTACCCAACGCCGCAATTTACCTAAAAGCAGGTAAGTTAACATTATTTATCGATGATCCTGCACCCGGTAGCGCC
CTATGGCATGGAGAAACGCCAAAACGTGAGGAAATAGCTGAAACTATTGGTGCGGATGCAGCTCAACCCTTATCAGAATT
AACGCCTTTCCTGGAAGGTGCAGCCACTATTGCCGTCCAAGATGCTACAACTTGGACGCAGCAATCCCAACTACTGAACA
GATGGGTTTTACCGCAAGGTCAGCCAGAAGGAATTGATTTAGAATTAGCGAAAGCGATCGTTACCTTACGCCTCACCCAC
GACACAGGCGCATTAGCTGAGTTACGCAAAGCTGCAACTGTGAGTGTAGCAGCCCACAAAGCCGGCATGGCAGCCACCAC
CAACGCCAAAATAGAAGCAGAAATTAGAGCCGCAATGGAAAGCGTTTTCCTGGCTCACAACATGACGACTGCTTATAACA
GTATTGTCACAGTCCACGGTGAAGTCTTACACAACGAACAGTATCACCATCCTCTGCAACCAGGGGATTTATTACTAGCC
GATGTCGGCGGCGAAACAGAATTAGGTTGGGCTGCTGATATTACCCGTACCTGGCCTGTGTCTGGTAAATTTTCTCCCAC
ACAACGGGATATATATGATGTAGTCTTAGCAGCCCATGATACCTGCATTGCCAACATCCGCCCTGGTGTGGAGTATGCAG
AGATTCATCTATTAGGGGCTAGGGTTATTGCCGAAGGTTTGGTAAATTTAGGCATTTTGCGAGGTAATCCCGAAGATTTA
GTAGAAAAAGATGCCCATGCTTTATTTTTCCCCCACGGTATCGGTCATCTCTTGGGTTTGGATGTCCACGATATGGAAGA
CTTGGGCGATTTAGCCGGCTATGAAGAAGGGAAGAAAAGGAGCGATCGCTTCGGCTTAGGCTACCTCCGTTTAAATCGTC
CCCTACGTACAGGAATGTTAGTCACAATTGAACCCGGATTCTACCAAGTTCCCGCCATCTTAAACGATGAAAAAACTCGC
TCAAGATATCAATACACAGTCAATTGGGAACGCCTATCACAATTTACCGATGTCCGAGGAATCCGCATTGAAGATGATGT
TTTAGTTACAGATACAGGCAGCGAAGTCCTCACCGCCGCCTTGCCAAATGACGCTGATACCATAGAACATCTAGTTAATC
AAATTTGA

Upstream 100 bases:

>100_bases
CCAAACAGGGAAAATGACAAAGATGATGATGATCAAGAGCCAGAAAATGACAGCCAGGATAATGATAAAGAAGATAACGA
TTAAATAGCGATAACTAATT

Downstream 100 bases:

>100_bases
GGCGTTGCTGAATCAGAGGATGAAATTTGATGTGCTGAAATTTCAAACTCTTTATTTTGAATTTTGTTGGCGTTCGCGGT
AGCGTCTCGTAGAGAAGCCT

Product: aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MGSLADTLRDRRQKLAHLIDFPAILWSGGSNARNFPANRFPFRASSHFLYFAGLPLPNAAIYLKAGKLTLFIDDPAPGSA
LWHGETPKREEIAETIGADAAQPLSELTPFLEGAATIAVQDATTWTQQSQLLNRWVLPQGQPEGIDLELAKAIVTLRLTH
DTGALAELRKAATVSVAAHKAGMAATTNAKIEAEIRAAMESVFLAHNMTTAYNSIVTVHGEVLHNEQYHHPLQPGDLLLA
DVGGETELGWAADITRTWPVSGKFSPTQRDIYDVVLAAHDTCIANIRPGVEYAEIHLLGARVIAEGLVNLGILRGNPEDL
VEKDAHALFFPHGIGHLLGLDVHDMEDLGDLAGYEEGKKRSDRFGLGYLRLNRPLRTGMLVTIEPGFYQVPAILNDEKTR
SRYQYTVNWERLSQFTDVRGIRIEDDVLVTDTGSEVLTAALPNDADTIEHLVNQI

Sequences:

>Translated_455_residues
MGSLADTLRDRRQKLAHLIDFPAILWSGGSNARNFPANRFPFRASSHFLYFAGLPLPNAAIYLKAGKLTLFIDDPAPGSA
LWHGETPKREEIAETIGADAAQPLSELTPFLEGAATIAVQDATTWTQQSQLLNRWVLPQGQPEGIDLELAKAIVTLRLTH
DTGALAELRKAATVSVAAHKAGMAATTNAKIEAEIRAAMESVFLAHNMTTAYNSIVTVHGEVLHNEQYHHPLQPGDLLLA
DVGGETELGWAADITRTWPVSGKFSPTQRDIYDVVLAAHDTCIANIRPGVEYAEIHLLGARVIAEGLVNLGILRGNPEDL
VEKDAHALFFPHGIGHLLGLDVHDMEDLGDLAGYEEGKKRSDRFGLGYLRLNRPLRTGMLVTIEPGFYQVPAILNDEKTR
SRYQYTVNWERLSQFTDVRGIRIEDDVLVTDTGSEVLTAALPNDADTIEHLVNQI
>Mature_454_residues
GSLADTLRDRRQKLAHLIDFPAILWSGGSNARNFPANRFPFRASSHFLYFAGLPLPNAAIYLKAGKLTLFIDDPAPGSAL
WHGETPKREEIAETIGADAAQPLSELTPFLEGAATIAVQDATTWTQQSQLLNRWVLPQGQPEGIDLELAKAIVTLRLTHD
TGALAELRKAATVSVAAHKAGMAATTNAKIEAEIRAAMESVFLAHNMTTAYNSIVTVHGEVLHNEQYHHPLQPGDLLLAD
VGGETELGWAADITRTWPVSGKFSPTQRDIYDVVLAAHDTCIANIRPGVEYAEIHLLGARVIAEGLVNLGILRGNPEDLV
EKDAHALFFPHGIGHLLGLDVHDMEDLGDLAGYEEGKKRSDRFGLGYLRLNRPLRTGMLVTIEPGFYQVPAILNDEKTRS
RYQYTVNWERLSQFTDVRGIRIEDDVLVTDTGSEVLTAALPNDADTIEHLVNQI

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=438, Percent_Identity=31.0502283105023, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI260593663, Length=438, Percent_Identity=29.2237442922374, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI260593665, Length=305, Percent_Identity=35.0819672131148, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI11559925, Length=478, Percent_Identity=27.8242677824268, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1789275, Length=433, Percent_Identity=30.2540415704388, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1790282, Length=287, Percent_Identity=32.404181184669, Blast_Score=119, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17508215, Length=448, Percent_Identity=29.2410714285714, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71989583, Length=395, Percent_Identity=24.8101265822785, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6321118, Length=422, Percent_Identity=28.1990521327014, Blast_Score=163, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6320922, Length=450, Percent_Identity=24, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI21357079, Length=449, Percent_Identity=31.1804008908686, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI19920384, Length=448, Percent_Identity=26.7857142857143, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49860; Mature: 49729

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSLADTLRDRRQKLAHLIDFPAILWSGGSNARNFPANRFPFRASSHFLYFAGLPLPNAA
CCCHHHHHHHHHHHHHHHHHCCHHEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCE
IYLKAGKLTLFIDDPAPGSALWHGETPKREEIAETIGADAAQPLSELTPFLEGAATIAVQ
EEEEECEEEEEECCCCCCCEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEE
DATTWTQQSQLLNRWVLPQGQPEGIDLELAKAIVTLRLTHDTGALAELRKAATVSVAAHK
CCCHHHHHHHHHHHHCCCCCCCCCCCHHHEEEEEEEEEECCCCHHHHHHHHHHEEEHHHH
AGMAATTNAKIEAEIRAAMESVFLAHNMTTAYNSIVTVHGEVLHNEQYHHPLQPGDLLLA
CCCEEECCCEEHHHHHHHHHHHHHHHCCHHHHCCEEEEEHHHHCCCCCCCCCCCCCEEEE
DVGGETELGWAADITRTWPVSGKFSPTQRDIYDVVLAAHDTCIANIRPGVEYAEIHLLGA
ECCCCCCCCEEECCCEECCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCEEEEEEHHH
RVIAEGLVNLGILRGNPEDLVEKDAHALFFPHGIGHLLGLDVHDMEDLGDLAGYEEGKKR
HHHHHHHHHEEEECCCHHHHHHCCCCEEEECCCHHHHHCCCCCCHHHHHHHCCCCCCCCC
SDRFGLGYLRLNRPLRTGMLVTIEPGFYQVPAILNDEKTRSRYQYTVNWERLSQFTDVRG
CCCCCEEEEEECCCHHCCEEEEECCCCEECCEEECCCCCCCEEEEEEEHHHHHHHHCCCC
IRIEDDVLVTDTGSEVLTAALPNDADTIEHLVNQI
EEEECCEEEECCCCCEEEEECCCCHHHHHHHHHCC
>Mature Secondary Structure 
GSLADTLRDRRQKLAHLIDFPAILWSGGSNARNFPANRFPFRASSHFLYFAGLPLPNAA
CCHHHHHHHHHHHHHHHHHCCHHEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCE
IYLKAGKLTLFIDDPAPGSALWHGETPKREEIAETIGADAAQPLSELTPFLEGAATIAVQ
EEEEECEEEEEECCCCCCCEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEE
DATTWTQQSQLLNRWVLPQGQPEGIDLELAKAIVTLRLTHDTGALAELRKAATVSVAAHK
CCCHHHHHHHHHHHHCCCCCCCCCCCHHHEEEEEEEEEECCCCHHHHHHHHHHEEEHHHH
AGMAATTNAKIEAEIRAAMESVFLAHNMTTAYNSIVTVHGEVLHNEQYHHPLQPGDLLLA
CCCEEECCCEEHHHHHHHHHHHHHHHCCHHHHCCEEEEEHHHHCCCCCCCCCCCCCEEEE
DVGGETELGWAADITRTWPVSGKFSPTQRDIYDVVLAAHDTCIANIRPGVEYAEIHLLGA
ECCCCCCCCEEECCCEECCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCEEEEEEHHH
RVIAEGLVNLGILRGNPEDLVEKDAHALFFPHGIGHLLGLDVHDMEDLGDLAGYEEGKKR
HHHHHHHHHEEEECCCHHHHHHCCCCEEEECCCHHHHHCCCCCCHHHHHHHCCCCCCCCC
SDRFGLGYLRLNRPLRTGMLVTIEPGFYQVPAILNDEKTRSRYQYTVNWERLSQFTDVRG
CCCCCEEEEEECCCHHCCEEEEECCCCEECCEEECCCCCCCEEEEEEEHHHHHHHHCCCC
IRIEDDVLVTDTGSEVLTAALPNDADTIEHLVNQI
EEEECCEEEECCCCCEEEEECCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]