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The map label for this gene is icd

Identifier: 17229319

GI number: 17229319

Start: 2192333

End: 2193754

Strand: Direct

Name: icd

Synonym: alr1827

Alternate gene names: 17229319

Gene position: 2192333-2193754 (Clockwise)

Preceding gene: 17229314

Following gene: 17229320

Centisome position: 34.18

GC content: 44.73

Gene sequence:

>1422_bases
ATGTACAACAAGATTACCCCCCCTACAACCGGAGAAAAAATTACCTTCAAAAATGGTGAGCCGGTTGTGCCTGACAATCC
AATTATCCCCTTTATTCGGGGCGATGGAACAGGAATTGATATTTGGCCGGCTACAGAAAAAGTACTAGATGCGGCGGTAG
CCAAAGCGTATCAAGGCAAGCGTAAAATTAGCTGGTTTAAGGTTTACGCTGGGGATGAAGCCTGTGATTTATACGGGACT
TATCAGTATTTACCAGAGGATACATTAACAGCCATTAGGGAATATGGTGTGGCAATTAAAGGGCCTTTGACTACCCCTGT
CGGTGGTGGTATCCGTTCCTTAAATGTGGCACTCAGACAAATTTTTGACCTATATGCCTGTGTACGTCCTTGCCGTTATT
ATGCAGGTACACCCTCACCCCACAAAAATCCTGAAAAACTTGATGTAATTGTCTATCGGGAAAACACGGAAGATATTTAT
TTAGGGATTGAGTGGAAACAAGGTAGTGAAATAGGCGATCGCCTCATCTCTATCCTCAACAAAGAACTCATCCCCGCCAC
CCCAGAACACGGTAAAAAGCAAATCCCCCTCGATTCTGGTATAGGGATCAAACCCATCAGTAAAACAGGTTCCCAGCGCC
TAGTACGCCGCGCCATTAAACACGCCCTCACATTACCCAAAGACAAGCAACAAGTGACTTTGGTGCATAAGGGTAACATC
ATGAAGTACACCGAAGGCGCTTTCCGTGATTGGGGTTACGAATTAGCTACAAGTGAGTTCCGCCAAGAGACTGTCACTGA
ACGGGAATCTTGGATTTTAAGCAACAAGGAGAAAAACCCGAACATTTCCTTGGAAGACAACGCCCGTCAAATTGACCCTG
GTTTTGATGCCCTTACTCCAGAGAAAAAGGCGCAAATTGTCAAGGAAGTAGAAACAGTTCTTAACTCAATTTGGGAAAGC
CACGGTAACGGTAAGTGGAAAGAAAAAGTGTTAGTCAATGACCGGATTGCTGACAGTATCTTTCAACAAATCCAAACCAG
ACCAGATGAGTATTCAATTCTGGCGACAATGAACTTAAACGGCGATTACTTGTCTGATGCGGCGGCTGCTATTGTCGGCG
GCTTAGGAATGGGGCCAGGGGCAAATATTGGCGATTCCTGCGCTGTGTTTGAAGCCACTCATGGTACAGCACCTAAACAC
GCTGGCTTAGACAGAATTAACCCAGGTTCAGTCATTTTATCTGGGGTAATGATGTTGGAGTATATGGGTTGGCAAGAAGC
CGCAGACCTAATTAAGAAAGGTTTAAGCGATGCGATCGCTAACAGTCAAGTCACCTATGATTTAGCTAGATTACTCGAAC
CACCAGTTGAACCTCTAAAATGTTCTGAATTTGCCGACGCAATTATCAAACATTTTGGTTAA

Upstream 100 bases:

>100_bases
GAAAGTAGAGGCGAAAACAACAAAAAATCCTAATCCCCAGTACCCAATCCTCAATCCCCAATCCCCAATACACAACGTAT
CTTTGTGGAGTGTGTGAAAT

Downstream 100 bases:

>100_bases
TTAACCTGAGTTCGGGATAAGGAAAGGGACAGGTAGTAAGCTGAAAATAGTGTTAAACCCAGCAACCTGTCCTACTGATG
AAGTGCCATTAACTAAATCT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MYNKITPPTTGEKITFKNGEPVVPDNPIIPFIRGDGTGIDIWPATEKVLDAAVAKAYQGKRKISWFKVYAGDEACDLYGT
YQYLPEDTLTAIREYGVAIKGPLTTPVGGGIRSLNVALRQIFDLYACVRPCRYYAGTPSPHKNPEKLDVIVYRENTEDIY
LGIEWKQGSEIGDRLISILNKELIPATPEHGKKQIPLDSGIGIKPISKTGSQRLVRRAIKHALTLPKDKQQVTLVHKGNI
MKYTEGAFRDWGYELATSEFRQETVTERESWILSNKEKNPNISLEDNARQIDPGFDALTPEKKAQIVKEVETVLNSIWES
HGNGKWKEKVLVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAIVGGLGMGPGANIGDSCAVFEATHGTAPKH
AGLDRINPGSVILSGVMMLEYMGWQEAADLIKKGLSDAIANSQVTYDLARLLEPPVEPLKCSEFADAIIKHFG

Sequences:

>Translated_473_residues
MYNKITPPTTGEKITFKNGEPVVPDNPIIPFIRGDGTGIDIWPATEKVLDAAVAKAYQGKRKISWFKVYAGDEACDLYGT
YQYLPEDTLTAIREYGVAIKGPLTTPVGGGIRSLNVALRQIFDLYACVRPCRYYAGTPSPHKNPEKLDVIVYRENTEDIY
LGIEWKQGSEIGDRLISILNKELIPATPEHGKKQIPLDSGIGIKPISKTGSQRLVRRAIKHALTLPKDKQQVTLVHKGNI
MKYTEGAFRDWGYELATSEFRQETVTERESWILSNKEKNPNISLEDNARQIDPGFDALTPEKKAQIVKEVETVLNSIWES
HGNGKWKEKVLVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAIVGGLGMGPGANIGDSCAVFEATHGTAPKH
AGLDRINPGSVILSGVMMLEYMGWQEAADLIKKGLSDAIANSQVTYDLARLLEPPVEPLKCSEFADAIIKHFG
>Mature_473_residues
MYNKITPPTTGEKITFKNGEPVVPDNPIIPFIRGDGTGIDIWPATEKVLDAAVAKAYQGKRKISWFKVYAGDEACDLYGT
YQYLPEDTLTAIREYGVAIKGPLTTPVGGGIRSLNVALRQIFDLYACVRPCRYYAGTPSPHKNPEKLDVIVYRENTEDIY
LGIEWKQGSEIGDRLISILNKELIPATPEHGKKQIPLDSGIGIKPISKTGSQRLVRRAIKHALTLPKDKQQVTLVHKGNI
MKYTEGAFRDWGYELATSEFRQETVTERESWILSNKEKNPNISLEDNARQIDPGFDALTPEKKAQIVKEVETVLNSIWES
HGNGKWKEKVLVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAIVGGLGMGPGANIGDSCAVFEATHGTAPKH
AGLDRINPGSVILSGVMMLEYMGWQEAADLIKKGLSDAIANSQVTYDLARLLEPPVEPLKCSEFADAIIKHFG

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family

Homologues:

Organism=Homo sapiens, GI5031777, Length=140, Percent_Identity=37.1428571428571, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI28178838, Length=136, Percent_Identity=31.6176470588235, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1787381, Length=474, Percent_Identity=52.7426160337553, Blast_Score=477, Evalue=1e-136,
Organism=Escherichia coli, GI1788101, Length=141, Percent_Identity=30.4964539007092, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI87081683, Length=115, Percent_Identity=34.7826086956522, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71986051, Length=209, Percent_Identity=34.4497607655502, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25144293, Length=113, Percent_Identity=35.3982300884956, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17505779, Length=110, Percent_Identity=34.5454545454545, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324709, Length=453, Percent_Identity=28.476821192053, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322097, Length=144, Percent_Identity=34.0277777777778, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324291, Length=154, Percent_Identity=31.1688311688312, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24643270, Length=447, Percent_Identity=30.4250559284116, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24643268, Length=447, Percent_Identity=30.4250559284116, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24661184, Length=126, Percent_Identity=43.6507936507937, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): IDH_NOSS1 (P50214)

Other databases:

- EMBL:   X77654
- EMBL:   BA000019
- PIR:   A55591
- PIR:   AE2034
- RefSeq:   NP_485867.1
- ProteinModelPortal:   P50214
- STRING:   P50214
- GeneID:   1105419
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr1827
- NMPDR:   fig|103690.1.peg.2134
- eggNOG:   COG0538
- HOGENOM:   HBG518924
- OMA:   RDWGYEL
- PhylomeDB:   P50214
- ProtClustDB:   PRK07362
- BioCyc:   NSP103690:ALR1827-MONOMER
- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439
- Gene3D:   G3DSA:3.40.718.10
- PANTHER:   PTHR11835
- PANTHER:   PTHR11835:SF1
- TIGRFAMs:   TIGR00183

Pfam domain/function: PF00180 Iso_dh

EC number: =1.1.1.42

Molecular weight: Translated: 52228; Mature: 52228

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00470 IDH_IMDH

Important sites: BINDING 104-104 BINDING 113-113 BINDING 115-115 BINDING 119-119 BINDING 129-129 BINDING 153-153 BINDING 407-407 BINDING 446-446 BINDING 450-450

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNKITPPTTGEKITFKNGEPVVPDNPIIPFIRGDGTGIDIWPATEKVLDAAVAKAYQGK
CCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHCCC
RKISWFKVYAGDEACDLYGTYQYLPEDTLTAIREYGVAIKGPLTTPVGGGIRSLNVALRQ
CCEEEEEEEECCCHHHHCHHHHHCCHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHH
IFDLYACVRPCRYYAGTPSPHKNPEKLDVIVYRENTEDIYLGIEWKQGSEIGDRLISILN
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHH
KELIPATPEHGKKQIPLDSGIGIKPISKTGSQRLVRRAIKHALTLPKDKQQVTLVHKGNI
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCE
MKYTEGAFRDWGYELATSEFRQETVTERESWILSNKEKNPNISLEDNARQIDPGFDALTP
EEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCC
EKKAQIVKEVETVLNSIWESHGNGKWKEKVLVNDRIADSIFQQIQTRPDEYSILATMNLN
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEHHHHHHHHHHHHHHCCCCCEEEEEEEECC
GDYLSDAAAAIVGGLGMGPGANIGDSCAVFEATHGTAPKHAGLDRINPGSVILSGVMMLE
CCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
YMGWQEAADLIKKGLSDAIANSQVTYDLARLLEPPVEPLKCSEFADAIIKHFG
HCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MYNKITPPTTGEKITFKNGEPVVPDNPIIPFIRGDGTGIDIWPATEKVLDAAVAKAYQGK
CCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCEEEECCCHHHHHHHHHHHHHCCC
RKISWFKVYAGDEACDLYGTYQYLPEDTLTAIREYGVAIKGPLTTPVGGGIRSLNVALRQ
CCEEEEEEEECCCHHHHCHHHHHCCHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHH
IFDLYACVRPCRYYAGTPSPHKNPEKLDVIVYRENTEDIYLGIEWKQGSEIGDRLISILN
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHH
KELIPATPEHGKKQIPLDSGIGIKPISKTGSQRLVRRAIKHALTLPKDKQQVTLVHKGNI
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCE
MKYTEGAFRDWGYELATSEFRQETVTERESWILSNKEKNPNISLEDNARQIDPGFDALTP
EEECCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCC
EKKAQIVKEVETVLNSIWESHGNGKWKEKVLVNDRIADSIFQQIQTRPDEYSILATMNLN
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEHHHHHHHHHHHHHHCCCCCEEEEEEEECC
GDYLSDAAAAIVGGLGMGPGANIGDSCAVFEATHGTAPKHAGLDRINPGSVILSGVMMLE
CCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
YMGWQEAADLIKKGLSDAIANSQVTYDLARLLEPPVEPLKCSEFADAIIKHFG
HCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8169222; 11759840