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The map label for this gene is ubiE [C]

Identifier: 17229295

GI number: 17229295

Start: 2164274

End: 2165116

Strand: Direct

Name: ubiE [C]

Synonym: alr1803

Alternate gene names: 17229295

Gene position: 2164274-2165116 (Clockwise)

Preceding gene: 17229293

Following gene: 17229297

Centisome position: 33.74

GC content: 45.31

Gene sequence:

>843_bases
ATGAGTGCAACACTTTACCAACAAATTCAGCAATTTTACGATGCTTCCTCTGGGCTGTGGGAAGAGATTTGGGGCGAACA
TATGCACCACGGCTATTATGGTGCAGACGGTACTGAACAAAAAAACCGCCGTCAGGCGCAAATTGATTTAATTGAAGAAT
TACTCACTTGGGCAGGAGTACAAACAGCAGAAAATATACTAGATGTGGGTTGTGGTATTGGTGGTAGTTCTCTGTATTTG
GCAGGAAAGTTGAATGCTAAAGCTACAGGAATTACCCTGAGTCCAGTGCAAGCCGCTAGAGCCACAGAAAGAGCCAAGGA
AGCTGGTTTAAGTGGTAGAAGTCAGTTTTTAGTGGCAAATGCCCAAGCAATGCCTTTTGATGATAATTCTTTTGACTTGG
TGTGGTCGCTAGAAAGTGGCGAACATATGCCAGATAAAACCAAGTTTTTGCAAGAGTGTTATCGAGTCTTGAAACCGGGC
GGTAAGTTAATCATGGTGACATGGTGTCATCGTCCCACTGATAAAACACCACTGACGGCTGATGAAAAAAAACACCTAGA
AGATATTTATCGGGTGTATTGTTTGCCTTATGTAATTTCGTTGCCGGAGTATGAAGCGATCGCACGTCAACTACCATTAA
ATAATATCCGCACCGCCGACTGGTCGCAATCCGTCGCCCAATTTTGGAACATAGTCATCGATTCCGCCTTTACCCCCCAA
GCAATATTCGGCTTACTCCGCGCAGGTTGGACTACCATCCAAGGAGCCTTATCACTAGGCTTAATGCGTCGCGGCTATGA
GCGCGGGTTAATTCGGTTTGGGTTGCTTTGTGGGGATAAGTGA

Upstream 100 bases:

>100_bases
CTCTGAGGAAGCAAAAACTTTCTTATTTAATTAAAAACACACATGGTAGCCTACGAATATGTTTTTTTAATTTCTGTTTT
GTATTAACACTGCTTTTTTC

Downstream 100 bases:

>100_bases
CAACTGATGATTGATGACTGTTGACTGCTGACTGACAACTGACTACTGACCACGCTTAATTAAACTGGCGACGACTGTAG
CCAATTCTGTGGGTTCAATG

Product: gamma-tocopherol methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MSATLYQQIQQFYDASSGLWEEIWGEHMHHGYYGADGTEQKNRRQAQIDLIEELLTWAGVQTAENILDVGCGIGGSSLYL
AGKLNAKATGITLSPVQAARATERAKEAGLSGRSQFLVANAQAMPFDDNSFDLVWSLESGEHMPDKTKFLQECYRVLKPG
GKLIMVTWCHRPTDKTPLTADEKKHLEDIYRVYCLPYVISLPEYEAIARQLPLNNIRTADWSQSVAQFWNIVIDSAFTPQ
AIFGLLRAGWTTIQGALSLGLMRRGYERGLIRFGLLCGDK

Sequences:

>Translated_280_residues
MSATLYQQIQQFYDASSGLWEEIWGEHMHHGYYGADGTEQKNRRQAQIDLIEELLTWAGVQTAENILDVGCGIGGSSLYL
AGKLNAKATGITLSPVQAARATERAKEAGLSGRSQFLVANAQAMPFDDNSFDLVWSLESGEHMPDKTKFLQECYRVLKPG
GKLIMVTWCHRPTDKTPLTADEKKHLEDIYRVYCLPYVISLPEYEAIARQLPLNNIRTADWSQSVAQFWNIVIDSAFTPQ
AIFGLLRAGWTTIQGALSLGLMRRGYERGLIRFGLLCGDK
>Mature_279_residues
SATLYQQIQQFYDASSGLWEEIWGEHMHHGYYGADGTEQKNRRQAQIDLIEELLTWAGVQTAENILDVGCGIGGSSLYLA
GKLNAKATGITLSPVQAARATERAKEAGLSGRSQFLVANAQAMPFDDNSFDLVWSLESGEHMPDKTKFLQECYRVLKPGG
KLIMVTWCHRPTDKTPLTADEKKHLEDIYRVYCLPYVISLPEYEAIARQLPLNNIRTADWSQSVAQFWNIVIDSAFTPQA
IFGLLRAGWTTIQGALSLGLMRRGYERGLIRFGLLCGDK

Specific function: Catalyzes the methylation of the lipid moiety of the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycoserosates to form phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI48994983, Length=163, Percent_Identity=28.2208588957055, Blast_Score=68, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI25143945, Length=293, Percent_Identity=27.3037542662116, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17561380, Length=112, Percent_Identity=34.8214285714286, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323635, Length=171, Percent_Identity=30.4093567251462, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 31310; Mature: 31179

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATLYQQIQQFYDASSGLWEEIWGEHMHHGYYGADGTEQKNRRQAQIDLIEELLTWAGV
CCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCH
QTAENILDVGCGIGGSSLYLAGKLNAKATGITLSPVQAARATERAKEAGLSGRSQFLVAN
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEECHHHHHHHHHHHHHCCCCCCCEEEEEC
AQAMPFDDNSFDLVWSLESGEHMPDKTKFLQECYRVLKPGGKLIMVTWCHRPTDKTPLTA
CCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCC
DEKKHLEDIYRVYCLPYVISLPEYEAIARQLPLNNIRTADWSQSVAQFWNIVIDSAFTPQ
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCHH
AIFGLLRAGWTTIQGALSLGLMRRGYERGLIRFGLLCGDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SATLYQQIQQFYDASSGLWEEIWGEHMHHGYYGADGTEQKNRRQAQIDLIEELLTWAGV
CHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCH
QTAENILDVGCGIGGSSLYLAGKLNAKATGITLSPVQAARATERAKEAGLSGRSQFLVAN
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEECHHHHHHHHHHHHHCCCCCCCEEEEEC
AQAMPFDDNSFDLVWSLESGEHMPDKTKFLQECYRVLKPGGKLIMVTWCHRPTDKTPLTA
CCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCC
DEKKHLEDIYRVYCLPYVISLPEYEAIARQLPLNNIRTADWSQSVAQFWNIVIDSAFTPQ
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCHH
AIFGLLRAGWTTIQGALSLGLMRRGYERGLIRFGLLCGDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]