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The map label for this gene is tuaD [H]

Identifier: 17228154

GI number: 17228154

Start: 762102

End: 763487

Strand: Direct

Name: tuaD [H]

Synonym: alr0658

Alternate gene names: 17228154

Gene position: 762102-763487 (Clockwise)

Preceding gene: 17228153

Following gene: 17228159

Centisome position: 11.88

GC content: 45.82

Gene sequence:

>1386_bases
ATGCGTGTTTGTGTAATTGGTACTGGTTATGTTGGCTTGGTAACAGGAGCTTGCTTGGCTCACATCGGACATGATGTGAT
TTGCATAGATAACAACGAAGAAAAAGTCAAGATCATGAAGGCCGGGCAATCACCAATTTTTGAGCCTGGACTTTCAGAAA
TTATGCAGTCGGCGATCCAATCCGGCAAGATTCAATTTTCTACCGATTTGGCAGCAGGTGTAGCCCACGGAGAAATCTTA
TTTATTGCTGTTGGTACTCCACCATTACCCACCGGTGAAAGCGACACCCGCTATGTAGAAGCTGTAGCCCGTGGTATCGG
TGCTAACCTCAACGGTGGTTATAAAGTAATTGTTAATAAATCTACAGTACCCATCGGTTCCGGCGACTGGGTAAGAATGA
TCGTTCTGGATGGGATTGCAGAACGTCAAAAAACCCTCGTAACCGCAGGTGGTAGTGTTGAGGATAAATTACCCGAATTA
CCTCAGTTTGATGTAGTTAGTAACCCAGAATTCTTGCGAGAAGGTTCAGCAGTATACGACACATTTAACCCAGACCGCAT
TGTTTTGGGAGGTAATAGCTCCAGAGCGATCGCGGCAATGCAAGAATTATACGCCCCAATTGTCGAGCGCAAATTTGCAG
AAAACCAATCTTTACCACCAGTACCCATTCTGGCTACAGACCTCAGTTCCGCAGAAATGATTAAATATGCGGCGAACGCT
TTCTTAGCCACTAAGATTAGTTTTATTAACGAAGTAGCTAATATTTGCGATCGTGTCGGTGCAGATGTTACCCAAGTTGC
CAAAGGTATCGGTTTAGACTCCCGTATTGGTAACAAATTCTTACAAGCTGGTATTGGTTGGGGTGGTTCCTGTTTCCCCA
AAGACGTAGCTGCACTGATTCACACCGCCGACGACTACGGTTATGAAGCCCAGCTATTAAAATCTGCTGTTAGCGTCAAC
GAGCGTCAACGCTTGATTGCTTTAGAAAAACTGCAACAAGTCCTGAAAATCCTCAAAGGCAAAACTGTTGGGTTACTCGG
TTTAACCTTTAAGCCCGACACCGACGACTTACGTGATGCACCAGCATTGAACTTAATTGAGCAACTGAACCGCTTAGGCG
CTAAAGTTAAAGCCTACGACCCCATAGTGTCCCAAACAGGTATGCGTCATGGTCTTTCTGGCGTATTAGTAGAAACCGAT
GCTGAACGTTTGGCTGATGGCTGTGATGCGTTGGTACTTGTGACAGAATGGCAGCAATTTAGCGGTCTTGACTACGCCAA
AATGGCCAAACTAATGAATAACCCCGTCGTTATTGACGGTCGTAACTTCCTTGACCCTGAGACTCTGGTACGGGCTGGAT
TCCAGTACGTAGGCGTTGGCAGATAG

Upstream 100 bases:

>100_bases
TGAGCAGGTATTTCGGCAACAGTACAGCATGAAAAAGTGTAAATGTCATCTTGACAAATCTTTGTTTTAAAAGTAACCCC
CTAGTGAGGAGTTCAACAAA

Downstream 100 bases:

>100_bases
GTAAGTATCTTATTTGCACAAGAAGTTTGAGTGATTAAATAACTCTCAATACCGCTTAGTATTTCTAGGCGGTATTTAAT
TTTGCGACTAATCTTGTGCA

Product: UDP-glucose dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MRVCVIGTGYVGLVTGACLAHIGHDVICIDNNEEKVKIMKAGQSPIFEPGLSEIMQSAIQSGKIQFSTDLAAGVAHGEIL
FIAVGTPPLPTGESDTRYVEAVARGIGANLNGGYKVIVNKSTVPIGSGDWVRMIVLDGIAERQKTLVTAGGSVEDKLPEL
PQFDVVSNPEFLREGSAVYDTFNPDRIVLGGNSSRAIAAMQELYAPIVERKFAENQSLPPVPILATDLSSAEMIKYAANA
FLATKISFINEVANICDRVGADVTQVAKGIGLDSRIGNKFLQAGIGWGGSCFPKDVAALIHTADDYGYEAQLLKSAVSVN
ERQRLIALEKLQQVLKILKGKTVGLLGLTFKPDTDDLRDAPALNLIEQLNRLGAKVKAYDPIVSQTGMRHGLSGVLVETD
AERLADGCDALVLVTEWQQFSGLDYAKMAKLMNNPVVIDGRNFLDPETLVRAGFQYVGVGR

Sequences:

>Translated_461_residues
MRVCVIGTGYVGLVTGACLAHIGHDVICIDNNEEKVKIMKAGQSPIFEPGLSEIMQSAIQSGKIQFSTDLAAGVAHGEIL
FIAVGTPPLPTGESDTRYVEAVARGIGANLNGGYKVIVNKSTVPIGSGDWVRMIVLDGIAERQKTLVTAGGSVEDKLPEL
PQFDVVSNPEFLREGSAVYDTFNPDRIVLGGNSSRAIAAMQELYAPIVERKFAENQSLPPVPILATDLSSAEMIKYAANA
FLATKISFINEVANICDRVGADVTQVAKGIGLDSRIGNKFLQAGIGWGGSCFPKDVAALIHTADDYGYEAQLLKSAVSVN
ERQRLIALEKLQQVLKILKGKTVGLLGLTFKPDTDDLRDAPALNLIEQLNRLGAKVKAYDPIVSQTGMRHGLSGVLVETD
AERLADGCDALVLVTEWQQFSGLDYAKMAKLMNNPVVIDGRNFLDPETLVRAGFQYVGVGR
>Mature_461_residues
MRVCVIGTGYVGLVTGACLAHIGHDVICIDNNEEKVKIMKAGQSPIFEPGLSEIMQSAIQSGKIQFSTDLAAGVAHGEIL
FIAVGTPPLPTGESDTRYVEAVARGIGANLNGGYKVIVNKSTVPIGSGDWVRMIVLDGIAERQKTLVTAGGSVEDKLPEL
PQFDVVSNPEFLREGSAVYDTFNPDRIVLGGNSSRAIAAMQELYAPIVERKFAENQSLPPVPILATDLSSAEMIKYAANA
FLATKISFINEVANICDRVGADVTQVAKGIGLDSRIGNKFLQAGIGWGGSCFPKDVAALIHTADDYGYEAQLLKSAVSVN
ERQRLIALEKLQQVLKILKGKTVGLLGLTFKPDTDDLRDAPALNLIEQLNRLGAKVKAYDPIVSQTGMRHGLSGVLVETD
AERLADGCDALVLVTEWQQFSGLDYAKMAKLMNNPVVIDGRNFLDPETLVRAGFQYVGVGR

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=489, Percent_Identity=34.9693251533742, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI296040438, Length=390, Percent_Identity=35.8974358974359, Blast_Score=216, Evalue=5e-56,
Organism=Homo sapiens, GI296040443, Length=319, Percent_Identity=36.9905956112853, Blast_Score=193, Evalue=3e-49,
Organism=Escherichia coli, GI1788340, Length=389, Percent_Identity=29.8200514138817, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI48994968, Length=431, Percent_Identity=26.6821345707657, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17560350, Length=484, Percent_Identity=35.3305785123967, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI17136908, Length=489, Percent_Identity=32.9243353783231, Blast_Score=263, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 49385; Mature: 49385

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVCVIGTGYVGLVTGACLAHIGHDVICIDNNEEKVKIMKAGQSPIFEPGLSEIMQSAIQ
CEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHH
SGKIQFSTDLAAGVAHGEILFIAVGTPPLPTGESDTRYVEAVARGIGANLNGGYKVIVNK
CCCEEEECHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEC
STVPIGSGDWVRMIVLDGIAERQKTLVTAGGSVEDKLPELPQFDVVSNPEFLREGSAVYD
CCCCCCCCCEEEEEEHHHHHHHHHEEEECCCCCHHHCCCCCCCCCCCCHHHHHCCCCEEE
TFNPDRIVLGGNSSRAIAAMQELYAPIVERKFAENQSLPPVPILATDLSSAEMIKYAANA
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHH
FLATKISFINEVANICDRVGADVTQVAKGIGLDSRIGNKFLQAGIGWGGSCFPKDVAALI
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
HTADDYGYEAQLLKSAVSVNERQRLIALEKLQQVLKILKGKTVGLLGLTFKPDTDDLRDA
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHCC
PALNLIEQLNRLGAKVKAYDPIVSQTGMRHGLSGVLVETDAERLADGCDALVLVTEWQQF
HHHHHHHHHHHHCCCEECCCCHHHHHHHHCCCCCEEEECCHHHHHCCCCEEEEEECHHHH
SGLDYAKMAKLMNNPVVIDGRNFLDPETLVRAGFQYVGVGR
CCCCHHHHHHHHCCCEEECCCCCCCHHHHHHCCCCEECCCC
>Mature Secondary Structure
MRVCVIGTGYVGLVTGACLAHIGHDVICIDNNEEKVKIMKAGQSPIFEPGLSEIMQSAIQ
CEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHH
SGKIQFSTDLAAGVAHGEILFIAVGTPPLPTGESDTRYVEAVARGIGANLNGGYKVIVNK
CCCEEEECHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEC
STVPIGSGDWVRMIVLDGIAERQKTLVTAGGSVEDKLPELPQFDVVSNPEFLREGSAVYD
CCCCCCCCCEEEEEEHHHHHHHHHEEEECCCCCHHHCCCCCCCCCCCCHHHHHCCCCEEE
TFNPDRIVLGGNSSRAIAAMQELYAPIVERKFAENQSLPPVPILATDLSSAEMIKYAANA
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHH
FLATKISFINEVANICDRVGADVTQVAKGIGLDSRIGNKFLQAGIGWGGSCFPKDVAALI
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
HTADDYGYEAQLLKSAVSVNERQRLIALEKLQQVLKILKGKTVGLLGLTFKPDTDDLRDA
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHCC
PALNLIEQLNRLGAKVKAYDPIVSQTGMRHGLSGVLVETDAERLADGCDALVLVTEWQQF
HHHHHHHHHHHHCCCEECCCCHHHHHHHHCCCCCEEEECCHHHHHCCCCEEEEEECHHHH
SGLDYAKMAKLMNNPVVIDGRNFLDPETLVRAGFQYVGVGR
CCCCHHHHHHHHCCCEEECCCCCCCHHHHHHCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]