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The map label for this gene is crp [H]

Identifier: 17228114

GI number: 17228114

Start: 718010

End: 718738

Strand: Direct

Name: crp [H]

Synonym: alr0618

Alternate gene names: 17228114

Gene position: 718010-718738 (Clockwise)

Preceding gene: 17228113

Following gene: 17228118

Centisome position: 11.19

GC content: 43.9

Gene sequence:

>729_bases
ATGCAGGCCTCCCTGGAACAAATTTCACGAATTATTGTGTTTGTGGGTATAGAAACCTCAGACAAGGAAAGTTTGCAACC
TTACACTCAGGTGCAAGGCTACAAGAAAGGAGAGATTATTCTCCATGAAGGCGATCGCCTGGCTGCTAAGTTATATGCTG
TAGTTAGTGGCTCCATTCAAGTCACCAAAACAGCAACCACAGGAAAAGAAACTATTTTACGGGGACTGAATGCTGGGGAA
ATGTTCGCCGCCCCTGCATTGTTAGGAGATAGCATTGCGCCTGCAACTGTGACTGCTGAATCTGATTGCGAAATTCTCAC
TGTCCAACGGGATGCTTTATTACAAGCCATCCAAAGTAATCCAGAAATTGCTTTACGAATGTTGATGGTGTTTAATACTC
GGATTCAGCAACTACATGAAACAGTTCATGGGTTAGTTTCGGAAAGGGCAATTGTTCGCCTAGCTAGGTTAATCCAATAT
TTCGCCACGGAATCGGGAACTGAACCAAGTCCACAAGGTCAAATTTTAAAAATCAAGTTATCTTACTATCGGATGGCTCG
CAGCATTGGTATTACTTATGAAGAATGCGTGCGGTTAATTAAAACACTCAATTCAGTTGTTGCCTATAGTCGAGGCGGCA
AAATCATTATATTGGATGCCGAGAAATTGAATGCGATCGCCTACGGTGGGGCGCAGCCCATCGCGTCGGGGAATATCGAA
GAGATTTGA

Upstream 100 bases:

>100_bases
ATCAAGTTAAAAGGAGGCAGGAGATGGGGAGTGGTAAGGCTTGTGAAACTTCCTTCATCATGGCTCCTCCTGCCTCCTGC
CCCCTTAAATCAGGCTAATT

Downstream 100 bases:

>100_bases
CAGTCTTTAGGAGGCTGCTAAAGCTCCTAAGTTTAATTTATCTTGTTCACGAGCCGCGACAACTAAAACTAAACACAGCG
CTGCAACAGCTTTTTGCCAT

Product: hypothetical protein

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MQASLEQISRIIVFVGIETSDKESLQPYTQVQGYKKGEIILHEGDRLAAKLYAVVSGSIQVTKTATTGKETILRGLNAGE
MFAAPALLGDSIAPATVTAESDCEILTVQRDALLQAIQSNPEIALRMLMVFNTRIQQLHETVHGLVSERAIVRLARLIQY
FATESGTEPSPQGQILKIKLSYYRMARSIGITYEECVRLIKTLNSVVAYSRGGKIIILDAEKLNAIAYGGAQPIASGNIE
EI

Sequences:

>Translated_242_residues
MQASLEQISRIIVFVGIETSDKESLQPYTQVQGYKKGEIILHEGDRLAAKLYAVVSGSIQVTKTATTGKETILRGLNAGE
MFAAPALLGDSIAPATVTAESDCEILTVQRDALLQAIQSNPEIALRMLMVFNTRIQQLHETVHGLVSERAIVRLARLIQY
FATESGTEPSPQGQILKIKLSYYRMARSIGITYEECVRLIKTLNSVVAYSRGGKIIILDAEKLNAIAYGGAQPIASGNIE
EI
>Mature_242_residues
MQASLEQISRIIVFVGIETSDKESLQPYTQVQGYKKGEIILHEGDRLAAKLYAVVSGSIQVTKTATTGKETILRGLNAGE
MFAAPALLGDSIAPATVTAESDCEILTVQRDALLQAIQSNPEIALRMLMVFNTRIQQLHETVHGLVSERAIVRLARLIQY
FATESGTEPSPQGQILKIKLSYYRMARSIGITYEECVRLIKTLNSVVAYSRGGKIIILDAEKLNAIAYGGAQPIASGNIE
EI

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of one or more genes involved in the induction of competence [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=197, Percent_Identity=26.9035532994924, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 26380; Mature: 26380

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50042 CNMP_BINDING_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQASLEQISRIIVFVGIETSDKESLQPYTQVQGYKKGEIILHEGDRLAAKLYAVVSGSIQ
CCCHHHHHCEEEEEEEECCCCHHHCCCHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCEE
VTKTATTGKETILRGLNAGEMFAAPALLGDSIAPATVTAESDCEILTVQRDALLQAIQSN
EEEECCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCEEECCCCCCEEEECHHHHHHHHHCC
PEIALRMLMVFNTRIQQLHETVHGLVSERAIVRLARLIQYFATESGTEPSPQGQILKIKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEH
SYYRMARSIGITYEECVRLIKTLNSVVAYSRGGKIIILDAEKLNAIAYGGAQPIASGNIE
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCEEEECCCCCCCCCCCC
EI
CC
>Mature Secondary Structure
MQASLEQISRIIVFVGIETSDKESLQPYTQVQGYKKGEIILHEGDRLAAKLYAVVSGSIQ
CCCHHHHHCEEEEEEEECCCCHHHCCCHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCEE
VTKTATTGKETILRGLNAGEMFAAPALLGDSIAPATVTAESDCEILTVQRDALLQAIQSN
EEEECCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCEEECCCCCCEEEECHHHHHHHHHCC
PEIALRMLMVFNTRIQQLHETVHGLVSERAIVRLARLIQYFATESGTEPSPQGQILKIKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEH
SYYRMARSIGITYEECVRLIKTLNSVVAYSRGGKIIILDAEKLNAIAYGGAQPIASGNIE
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCEEEECCCCCCCCCCCC
EI
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1542653; 7542800 [H]