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The map label for this gene is yycG [H]

Identifier: 17228042

GI number: 17228042

Start: 637970

End: 639349

Strand: Direct

Name: yycG [H]

Synonym: alr0546

Alternate gene names: 17228042

Gene position: 637970-639349 (Clockwise)

Preceding gene: 17228041

Following gene: 17228043

Centisome position: 9.95

GC content: 41.01

Gene sequence:

>1380_bases
ATGAGCCTGAATCAGCGATCACCTACGGTGGGCGGAACGCCATCGCTCTGGCATCAAACTCACACACCACAAACTATTTT
GCCCAAAACTCCTGTGTACTTGGAAACAGCGACGGAATTAGCTTCTCATCAAGAGTTTGACACAGCAGCGAAACTCCATC
GCACGGAAGAAGAATTGCGATGGTATCGCATGATGTACGATAATATACCTACTATATATTTCAGTTTGGATGCGGCTGGG
CTAATTTTAACTGTCAATCATTTCGGAGCGAATTTTCTAGGATACACACCAGAACAATTGTTACAACAGCCCATTGCTCA
ATTATTTGCTCAATCAGACCAAGCAAGACTGTCTAATGCTGTCATAAGTCTTTGCAAGACTGCGCCTCATGATGCTGTTA
ACTATGGCAATTTTCAGTTAAAAAAAATTATCGACGGTATAAAATCTGTTAAGGTCACATTGCGACTAATACCTAATGAA
GGAAAGTCTCTCGCCAAAAATTTGACGATTTTGATGCTTTGCGAGGCCATCACCTCTCTAGAACCAGGCGTAGCAAGTCA
AGAAGATGGGAATAATTTAGTTCAAAACTTACCACAACTGCAATCACATCCAGCTCAGTTAAAGGAACTAGAAAGCCTTA
ACCACTTGCAAGAAGAATTTTTTAGCACTGTTTCCCACGAACTGCGAACACCGCTAACTAATATGAAGATGGCGATTCAA
ATGCTGGGAATTACGCTGCATCGGGAGCATAATTTGTTCTCGGCAACAACAAAACCAACAAATGAAGGCTCAAAAGCTGC
TTGTTATTTTAATATTTTAGAAAATGAGTGCGATCGCCAAATAAATCTTATTAATAACTTCCTAGAATTACAGCGCCTCG
ATACTAACGCTAAACCTTGGGTACTAGAGACAATTCACATACCGCAATGGCTATGGCGTGTAGTGGAGGAATTTAAAAGC
CGCAATTTCGATATTTGTAAGCAGAAATTACACATCAGCATCAGCCCTGCTCTGGCAACATTAACGTCCAATCCGTGCAG
CTTGGAACGCATTTTGATAGAACTGCTCACCAATGCGTGTAAATTTAGCCCGCCAGAGGGAGAAATTACAGTTACAGCCC
AAATAAAATCTCAAAATATTCTTTTGCAAGTGATTAATTCTGGTGTAGAAATCCCTCAATCTGAATTACCCCACATTTTT
GATAAATTTTATCGTATTCCCAGCAATGACCCCGGAAAGCAGGGAGGCACAGGACTAGGGTTGGCACTAGTACAAAAACT
CATCAAACAATTAGGAGGAACAATAGAAGTAGAAAGCGGATCAAATCGTACCTGTTTTAGTATCCAACTGGTGCTTCCAC
AACCCAAAATAGTTGAGTGA

Upstream 100 bases:

>100_bases
AAGTTGAACAAAAGGCACAAGACTTTTTATTTGGCAAAAAAAGAATTTAAAATTTGTTGTTTCCCATTCACTTCAGCCCT
TGAGCGTCAGTTTAAACCTT

Downstream 100 bases:

>100_bases
AGGAAGTAGGGGCAGGGAGCAGAGGGAAAATATCTGACTCAAGACTCAGCACCGACTAACCCCCGTTACAGCTCACAGCA
CTTATGACTCAGAACTCCCT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSLNQRSPTVGGTPSLWHQTHTPQTILPKTPVYLETATELASHQEFDTAAKLHRTEEELRWYRMMYDNIPTIYFSLDAAG
LILTVNHFGANFLGYTPEQLLQQPIAQLFAQSDQARLSNAVISLCKTAPHDAVNYGNFQLKKIIDGIKSVKVTLRLIPNE
GKSLAKNLTILMLCEAITSLEPGVASQEDGNNLVQNLPQLQSHPAQLKELESLNHLQEEFFSTVSHELRTPLTNMKMAIQ
MLGITLHREHNLFSATTKPTNEGSKAACYFNILENECDRQINLINNFLELQRLDTNAKPWVLETIHIPQWLWRVVEEFKS
RNFDICKQKLHISISPALATLTSNPCSLERILIELLTNACKFSPPEGEITVTAQIKSQNILLQVINSGVEIPQSELPHIF
DKFYRIPSNDPGKQGGTGLGLALVQKLIKQLGGTIEVESGSNRTCFSIQLVLPQPKIVE

Sequences:

>Translated_459_residues
MSLNQRSPTVGGTPSLWHQTHTPQTILPKTPVYLETATELASHQEFDTAAKLHRTEEELRWYRMMYDNIPTIYFSLDAAG
LILTVNHFGANFLGYTPEQLLQQPIAQLFAQSDQARLSNAVISLCKTAPHDAVNYGNFQLKKIIDGIKSVKVTLRLIPNE
GKSLAKNLTILMLCEAITSLEPGVASQEDGNNLVQNLPQLQSHPAQLKELESLNHLQEEFFSTVSHELRTPLTNMKMAIQ
MLGITLHREHNLFSATTKPTNEGSKAACYFNILENECDRQINLINNFLELQRLDTNAKPWVLETIHIPQWLWRVVEEFKS
RNFDICKQKLHISISPALATLTSNPCSLERILIELLTNACKFSPPEGEITVTAQIKSQNILLQVINSGVEIPQSELPHIF
DKFYRIPSNDPGKQGGTGLGLALVQKLIKQLGGTIEVESGSNRTCFSIQLVLPQPKIVE
>Mature_458_residues
SLNQRSPTVGGTPSLWHQTHTPQTILPKTPVYLETATELASHQEFDTAAKLHRTEEELRWYRMMYDNIPTIYFSLDAAGL
ILTVNHFGANFLGYTPEQLLQQPIAQLFAQSDQARLSNAVISLCKTAPHDAVNYGNFQLKKIIDGIKSVKVTLRLIPNEG
KSLAKNLTILMLCEAITSLEPGVASQEDGNNLVQNLPQLQSHPAQLKELESLNHLQEEFFSTVSHELRTPLTNMKMAIQM
LGITLHREHNLFSATTKPTNEGSKAACYFNILENECDRQINLINNFLELQRLDTNAKPWVLETIHIPQWLWRVVEEFKSR
NFDICKQKLHISISPALATLTSNPCSLERILIELLTNACKFSPPEGEITVTAQIKSQNILLQVINSGVEIPQSELPHIFD
KFYRIPSNDPGKQGGTGLGLALVQKLIKQLGGTIEVESGSNRTCFSIQLVLPQPKIVE

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=227, Percent_Identity=28.1938325991189, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1786783, Length=263, Percent_Identity=26.2357414448669, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789149, Length=286, Percent_Identity=26.9230769230769, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=29.1304347826087, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1786912, Length=248, Percent_Identity=27.0161290322581, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI48994928, Length=256, Percent_Identity=26.953125, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=247, Percent_Identity=25.1012145748988, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786600, Length=252, Percent_Identity=25.7936507936508, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790436, Length=252, Percent_Identity=26.984126984127, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI145693157, Length=254, Percent_Identity=27.5590551181102, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790300, Length=257, Percent_Identity=27.6264591439689, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788393, Length=292, Percent_Identity=22.6027397260274, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51429; Mature: 51298

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLNQRSPTVGGTPSLWHQTHTPQTILPKTPVYLETATELASHQEFDTAAKLHRTEEELR
CCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
WYRMMYDNIPTIYFSLDAAGLILTVNHFGANFLGYTPEQLLQQPIAQLFAQSDQARLSNA
HHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
VISLCKTAPHDAVNYGNFQLKKIIDGIKSVKVTLRLIPNEGKSLAKNLTILMLCEAITSL
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHC
EPGVASQEDGNNLVQNLPQLQSHPAQLKELESLNHLQEEFFSTVSHELRTPLTNMKMAIQ
CCCCCCCCCCCHHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
MLGITLHREHNLFSATTKPTNEGSKAACYFNILENECDRQINLINNFLELQRLDTNAKPW
HHHHHEECCCCCEECCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VLETIHIPQWLWRVVEEFKSRNFDICKQKLHISISPALATLTSNPCSLERILIELLTNAC
EEEEECHHHHHHHHHHHHHHCCHHHHHHHHEEEECHHHHHHCCCCHHHHHHHHHHHHHHH
KFSPPEGEITVTAQIKSQNILLQVINSGVEIPQSELPHIFDKFYRIPSNDPGKQGGTGLG
CCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCHHHCCHHHHHHHCCCCCCCCCCCCCCHH
LALVQKLIKQLGGTIEVESGSNRTCFSIQLVLPQPKIVE
HHHHHHHHHHHCCEEEEECCCCCEEEEEEEECCCCCCCC
>Mature Secondary Structure 
SLNQRSPTVGGTPSLWHQTHTPQTILPKTPVYLETATELASHQEFDTAAKLHRTEEELR
CCCCCCCCCCCCCHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
WYRMMYDNIPTIYFSLDAAGLILTVNHFGANFLGYTPEQLLQQPIAQLFAQSDQARLSNA
HHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
VISLCKTAPHDAVNYGNFQLKKIIDGIKSVKVTLRLIPNEGKSLAKNLTILMLCEAITSL
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHC
EPGVASQEDGNNLVQNLPQLQSHPAQLKELESLNHLQEEFFSTVSHELRTPLTNMKMAIQ
CCCCCCCCCCCHHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
MLGITLHREHNLFSATTKPTNEGSKAACYFNILENECDRQINLINNFLELQRLDTNAKPW
HHHHHEECCCCCEECCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VLETIHIPQWLWRVVEEFKSRNFDICKQKLHISISPALATLTSNPCSLERILIELLTNAC
EEEEECHHHHHHHHHHHHHHCCHHHHHHHHEEEECHHHHHHCCCCHHHHHHHHHHHHHHH
KFSPPEGEITVTAQIKSQNILLQVINSGVEIPQSELPHIFDKFYRIPSNDPGKQGGTGLG
CCCCCCCCEEEEEEECCCHHHHHHHHCCCCCCHHHCCHHHHHHHCCCCCCCCCCCCCCHH
LALVQKLIKQLGGTIEVESGSNRTCFSIQLVLPQPKIVE
HHHHHHHHHHHCCEEEEECCCCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9829949; 10878122; 11758928 [H]