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The map label for this gene is ndhD

Identifier: 17227844

GI number: 17227844

Start: 398957

End: 400573

Strand: Direct

Name: ndhD

Synonym: alr0348

Alternate gene names: 17227844

Gene position: 398957-400573 (Clockwise)

Preceding gene: 17227843

Following gene: 17227849

Centisome position: 6.22

GC content: 45.21

Gene sequence:

>1617_bases
GTGATGAATCTCATTGAGTTTCCCTGGCTAACAGCCATAATTGCCTTACCCCTGGTGGCAGCCCTAGCCATCCCCATCAT
TCCCGACAAAGAAGGAAAAACGGTTCGTTGGTATGGATTGGGTGTCGCCTTTGCAGACTTTGCCTTAATGATTGCCGCTT
TCTGGCATTATTACGACTTCCAAAGTTCGAGTTACCAATTTGTTGAAAAATACGCTTGGGTTCCTCAAATAGGTTTGAAT
TGGTCTGTAGCAGTTGACGGCTTATCAATGCCCTTACTGTTGTTAACAGGCTTAATTAACACACTCGCAATCTTCGCGGC
TTGGAAAGTAACCAACAAGCCGCGATTATTTTATGGGTTGATGTTGGTGATGTACAGCGCCCAGTTAGGCGTGTTTGTTG
CCCAAGACTTGCTATTATTCTTCCTCATGTGGGAAATCGAGCTAGTTCCTGTCTACCTGCTGATTTCCATCTGGGGAGGT
CCCAAACGCCGTTATGCAGCGACCAAGTTCATCCTTTATACTGCTGCTGCTTCTATATTTATTCTCGTAGCCGGATTTGC
ACTCGCATTCTCTGGAGATACAGTTACTTTCGACATCGCAGCCCTGGGAATGAAAGAATATCCCAAAGCGATTGAATTAT
TAGCTTATGCAGGATTCTTGATTGCCTTTGGTGTCAAACTGCCAATTTTCCCTCTCCACACTTGGCTACCCGATGCTCAC
GGTGAAGCATCTGCCCCTGGTTCGATGATTCTGGCTGGTGTGTTGCTGAAAATGGGTGGTTATGCCCTCATTCGCTTCAA
CATGGAAATGTTGCCTGATGCCCATGTTTACTTTGCACCAGTCTTAGCAATATTGGGTGTAGTAAACATTGTTTATGGTG
CTTGCTGTGCCTTTGCTCAAACCAACCTCAAACGCCGTCTAGCTTACTCTTCAATCGCCCACATGGGTTTTGTGTTAATT
GGTCTAGCTTCCTACACAGAAATTGGTGTTAGTGGAGCAGTACTACAGATGGTTTCCCACGGTTTGGTTGCGGCTAGCTT
GTTCTTCTTAACTGGTGTGACTTACGAACGTACCCACACCTTATTGATGGACAAAATGGGTGGTATCGGTAAAATAATGC
CCAAAACCTTCGCTCTCTACACAGCCGGCGCAATGGCTTCTCTAGCATTACCCGGAATGAGTGGTTTCGTAGGTGAATTG
ATGGTGTTCATCGGTATCGCTACCAGCGATGTCTACAGTTCCAGTTTCAAAGTTGTAGTCGTCCTACTGTCAGCAGTGGG
TGTGATTCTGACTCCAATTTACTTATTGTCTATGTTGCGCCAAGTCTTCTACGGCAAACAAAGTGACGAGTTACATCTTG
ATGCTTTCGTCCCTGATGTGAAACCTCGTGAATTGTTCATCACTGCTTCTTTATTGCTTCCCATCATCGGTATCGGTTTG
TATCCCAAGTTGATTACCCAAACTTATGATGCGAAGACTGTAGAAATTGCCGCTCACGCTCGTCAAGTTTTACCAGTGGT
TGCAGGACAACAGCCATCAAGTCTGTACTCCCAGATTTTCACTGCACCAACACTGGCTAATGCTCAAGTTGAAAGTTTAG
TTAATATCTCTAAGTAA

Upstream 100 bases:

>100_bases
TAACCAAAATTTAATTTTTCAGAGATAAATAAAGTTTACAAAAGTAACAATTCCTTAATATAATGTAATTAAAAGCGAAA
AGAAAAAACGATTGTCAGAA

Downstream 100 bases:

>100_bases
ATATATCTCTCAGCAAGGGTGCTGAAAGTAAATCCTAAATATGACGGAAATTAGGGGTGGTTGCAAAACTACCCCTAAAA
TTTTATTGCACTGCGTGTGT

Product: NAD(P)H-quinone oxidoreductase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4 1; NDH-1, chain 4 1

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MMNLIEFPWLTAIIALPLVAALAIPIIPDKEGKTVRWYGLGVAFADFALMIAAFWHYYDFQSSSYQFVEKYAWVPQIGLN
WSVAVDGLSMPLLLLTGLINTLAIFAAWKVTNKPRLFYGLMLVMYSAQLGVFVAQDLLLFFLMWEIELVPVYLLISIWGG
PKRRYAATKFILYTAAASIFILVAGFALAFSGDTVTFDIAALGMKEYPKAIELLAYAGFLIAFGVKLPIFPLHTWLPDAH
GEASAPGSMILAGVLLKMGGYALIRFNMEMLPDAHVYFAPVLAILGVVNIVYGACCAFAQTNLKRRLAYSSIAHMGFVLI
GLASYTEIGVSGAVLQMVSHGLVAASLFFLTGVTYERTHTLLMDKMGGIGKIMPKTFALYTAGAMASLALPGMSGFVGEL
MVFIGIATSDVYSSSFKVVVVLLSAVGVILTPIYLLSMLRQVFYGKQSDELHLDAFVPDVKPRELFITASLLLPIIGIGL
YPKLITQTYDAKTVEIAAHARQVLPVVAGQQPSSLYSQIFTAPTLANAQVESLVNISK

Sequences:

>Translated_538_residues
MMNLIEFPWLTAIIALPLVAALAIPIIPDKEGKTVRWYGLGVAFADFALMIAAFWHYYDFQSSSYQFVEKYAWVPQIGLN
WSVAVDGLSMPLLLLTGLINTLAIFAAWKVTNKPRLFYGLMLVMYSAQLGVFVAQDLLLFFLMWEIELVPVYLLISIWGG
PKRRYAATKFILYTAAASIFILVAGFALAFSGDTVTFDIAALGMKEYPKAIELLAYAGFLIAFGVKLPIFPLHTWLPDAH
GEASAPGSMILAGVLLKMGGYALIRFNMEMLPDAHVYFAPVLAILGVVNIVYGACCAFAQTNLKRRLAYSSIAHMGFVLI
GLASYTEIGVSGAVLQMVSHGLVAASLFFLTGVTYERTHTLLMDKMGGIGKIMPKTFALYTAGAMASLALPGMSGFVGEL
MVFIGIATSDVYSSSFKVVVVLLSAVGVILTPIYLLSMLRQVFYGKQSDELHLDAFVPDVKPRELFITASLLLPIIGIGL
YPKLITQTYDAKTVEIAAHARQVLPVVAGQQPSSLYSQIFTAPTLANAQVESLVNISK
>Mature_538_residues
MMNLIEFPWLTAIIALPLVAALAIPIIPDKEGKTVRWYGLGVAFADFALMIAAFWHYYDFQSSSYQFVEKYAWVPQIGLN
WSVAVDGLSMPLLLLTGLINTLAIFAAWKVTNKPRLFYGLMLVMYSAQLGVFVAQDLLLFFLMWEIELVPVYLLISIWGG
PKRRYAATKFILYTAAASIFILVAGFALAFSGDTVTFDIAALGMKEYPKAIELLAYAGFLIAFGVKLPIFPLHTWLPDAH
GEASAPGSMILAGVLLKMGGYALIRFNMEMLPDAHVYFAPVLAILGVVNIVYGACCAFAQTNLKRRLAYSSIAHMGFVLI
GLASYTEIGVSGAVLQMVSHGLVAASLFFLTGVTYERTHTLLMDKMGGIGKIMPKTFALYTAGAMASLALPGMSGFVGEL
MVFIGIATSDVYSSSFKVVVVLLSAVGVILTPIYLLSMLRQVFYGKQSDELHLDAFVPDVKPRELFITASLLLPIIGIGL
YPKLITQTYDAKTVEIAAHARQVLPVVAGQQPSSLYSQIFTAPTLANAQVESLVNISK

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family

Homologues:

Organism=Homo sapiens, GI251831116, Length=383, Percent_Identity=31.0704960835509, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI251831117, Length=303, Percent_Identity=25.7425742574257, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1788613, Length=428, Percent_Identity=41.3551401869159, Blast_Score=309, Evalue=4e-85,
Organism=Escherichia coli, GI1788831, Length=302, Percent_Identity=29.8013245033113, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788827, Length=202, Percent_Identity=32.6732673267327, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1788614, Length=483, Percent_Identity=25.0517598343685, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788829, Length=403, Percent_Identity=25.5583126550869, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI2367154, Length=292, Percent_Identity=26.3698630136986, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI145693160, Length=302, Percent_Identity=31.4569536423841, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NU4C1_NOSS1 (Q8YZV7)

Other databases:

- EMBL:   BA000019
- PIR:   AC1850
- RefSeq:   NP_484392.1
- STRING:   Q8YZV7
- GeneID:   1103944
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr0348
- NMPDR:   fig|103690.1.peg.659
- eggNOG:   COG1008
- HOGENOM:   HBG643593
- OMA:   VDRTKQR
- PhylomeDB:   Q8YZV7
- ProtClustDB:   PRK12561
- BioCyc:   NSP103690:ALR0348-MONOMER
- HAMAP:   MF_00491
- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- PRINTS:   PR01437
- TIGRFAMs:   TIGR01972

Pfam domain/function: PF00361 Oxidored_q1

EC number: 1.6.5.3

Molecular weight: Translated: 58563; Mature: 58563

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xbb4e470)-; HASH(0xc27d4a4)-; HASH(0x9527764)-; HASH(0xd0fcf9c)-; HASH(0xcc0ac9c)-; HASH(0xc466efc)-; HASH(0xb38a88c)-; HASH(0xd0fa598)-; HASH(0xc97c5c4)-; HASH(0xce86f28)-; HASH(0xb26cf38)-; HASH(0xd20db00)-; HASH(0xcff8770)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNLIEFPWLTAIIALPLVAALAIPIIPDKEGKTVRWYGLGVAFADFALMIAAFWHYYDF
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCC
QSSSYQFVEKYAWVPQIGLNWSVAVDGLSMPLLLLTGLINTLAIFAAWKVTNKPRLFYGL
CCCHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
MLVMYSAQLGVFVAQDLLLFFLMWEIELVPVYLLISIWGGPKRRYAATKFILYTAAASIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
ILVAGFALAFSGDTVTFDIAALGMKEYPKAIELLAYAGFLIAFGVKLPIFPLHTWLPDAH
HHHHHHHHEECCCEEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHCCCCC
GEASAPGSMILAGVLLKMGGYALIRFNMEMLPDAHVYFAPVLAILGVVNIVYGACCAFAQ
CCCCCCHHHHHHHHHHHHCCEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TNLKRRLAYSSIAHMGFVLIGLASYTEIGVSGAVLQMVSHGLVAASLFFLTGVTYERTHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LLMDKMGGIGKIMPKTFALYTAGAMASLALPGMSGFVGELMVFIGIATSDVYSSSFKVVV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHH
VLLSAVGVILTPIYLLSMLRQVFYGKQSDELHLDAFVPDVKPRELFITASLLLPIIGIGL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHEEHHHHHHHHHHHCC
YPKLITQTYDAKTVEIAAHARQVLPVVAGQQPSSLYSQIFTAPTLANAQVESLVNISK
CHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCH
>Mature Secondary Structure
MMNLIEFPWLTAIIALPLVAALAIPIIPDKEGKTVRWYGLGVAFADFALMIAAFWHYYDF
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCC
QSSSYQFVEKYAWVPQIGLNWSVAVDGLSMPLLLLTGLINTLAIFAAWKVTNKPRLFYGL
CCCHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
MLVMYSAQLGVFVAQDLLLFFLMWEIELVPVYLLISIWGGPKRRYAATKFILYTAAASIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
ILVAGFALAFSGDTVTFDIAALGMKEYPKAIELLAYAGFLIAFGVKLPIFPLHTWLPDAH
HHHHHHHHEECCCEEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHCCCCC
GEASAPGSMILAGVLLKMGGYALIRFNMEMLPDAHVYFAPVLAILGVVNIVYGACCAFAQ
CCCCCCHHHHHHHHHHHHCCEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TNLKRRLAYSSIAHMGFVLIGLASYTEIGVSGAVLQMVSHGLVAASLFFLTGVTYERTHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LLMDKMGGIGKIMPKTFALYTAGAMASLALPGMSGFVGELMVFIGIATSDVYSSSFKVVV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHH
VLLSAVGVILTPIYLLSMLRQVFYGKQSDELHLDAFVPDVKPRELFITASLLLPIIGIGL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHEEHHHHHHHHHHHCC
YPKLITQTYDAKTVEIAAHARQVLPVVAGQQPSSLYSQIFTAPTLANAQVESLVNISK
CHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840