BacMap

Definition	Nostoc sp. PCC 7120, complete genome.
Accession	NC_003272
Length	6,413,771

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The map label for this gene is gmk [H]

Identifier: 17227602

GI number: 17227602

Start: 109372

End: 109971

Strand: Direct

Name: gmk [H]

Synonym: alr0106

Alternate gene names: 17227602

Gene position: 109372-109971 (Clockwise)

Preceding gene: 17227601

Following gene: 17227606

Centisome position: 1.71

GC content: 44.67

Gene sequence:

>600_bases
ATGATGCAAGTTTTATCCATCCAGAATTGTGCTACTACCAAAGAAAATCCGTTGTCAGGCAAGCTGATTATTTTAACCGG
GCCTAGTGGGGTCGGTAAAGGTACTTTAATGCGATCGCTCCTTCAGCGTCATCCGGAACTTTATTACTCTGTATCTGCAA
CAACCCGTCCTCCCCGTCCTGGGGAAGTAAATGGCGAAAGCTATTACTTTGTTAGCCGCAGTAAGTTTGAAGAATTAATT
GCTCAAGGTGAATTTCTTGAATCGGCAGAATTTGCGGGTAATTATTATGGCACTCCTCGTGAAGCCGTACTGAACCAAGT
TCAATCTGGTAAGTTAGTTGTGCTGGAAATTGAATTAGCAGGAGCAAGACAAATCCGTACCTCTTTCCCTGAAGCTCTGA
GTATTTTTATTCTGCCGCCTTCCTTTGAAGAGTTGGAAAACCGAATTCGGGGGCGTGGACAGGACTCAGAGGAAGCGATC
GCCCGTCGCTTACAACGTGCCAAAGAAGAGATTCAAGCTGCGGATGAATTTGATATTCAAATTGTGAATGACGATTTTGA
AGCCGCACTCCAGGCGATCGAAGTAGCCTTATTTGGATAA

Upstream 100 bases:

>100_bases
CAAATTCGTTAGTTAAGGTTTGCGCTGGTAACGTAGACTAGATTAAATTACTAACTTATCTAATGAATGCTCTTTCTTGA
TTAATTCACAGGTTTAACGG

Downstream 100 bases:

>100_bases
TCGATATTCTATAAAATCAAAGCCAAGCATTTTTTTAACCAAATAATAATCACTAAGGACACATGGAAAAGACGAGGTTT
TTCTTTTGTGTCCTTATCCT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MMQVLSIQNCATTKENPLSGKLIILTGPSGVGKGTLMRSLLQRHPELYYSVSATTRPPRPGEVNGESYYFVSRSKFEELI
AQGEFLESAEFAGNYYGTPREAVLNQVQSGKLVVLEIELAGARQIRTSFPEALSIFILPPSFEELENRIRGRGQDSEEAI
ARRLQRAKEEIQAADEFDIQIVNDDFEAALQAIEVALFG

Sequences:

>Translated_199_residues
MMQVLSIQNCATTKENPLSGKLIILTGPSGVGKGTLMRSLLQRHPELYYSVSATTRPPRPGEVNGESYYFVSRSKFEELI
AQGEFLESAEFAGNYYGTPREAVLNQVQSGKLVVLEIELAGARQIRTSFPEALSIFILPPSFEELENRIRGRGQDSEEAI
ARRLQRAKEEIQAADEFDIQIVNDDFEAALQAIEVALFG
>Mature_199_residues
MMQVLSIQNCATTKENPLSGKLIILTGPSGVGKGTLMRSLLQRHPELYYSVSATTRPPRPGEVNGESYYFVSRSKFEELI
AQGEFLESAEFAGNYYGTPREAVLNQVQSGKLVVLEIELAGARQIRTSFPEALSIFILPPSFEELENRIRGRGQDSEEAI
ARRLQRAKEEIQAADEFDIQIVNDDFEAALQAIEVALFG

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=179, Percent_Identity=41.8994413407821, Blast_Score=150, Evalue=6e-37,
Organism=Homo sapiens, GI4504221, Length=179, Percent_Identity=41.8994413407821, Blast_Score=150, Evalue=6e-37,
Organism=Homo sapiens, GI226874831, Length=179, Percent_Identity=41.8994413407821, Blast_Score=150, Evalue=6e-37,
Organism=Homo sapiens, GI38570142, Length=174, Percent_Identity=35.632183908046, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI21361598, Length=190, Percent_Identity=31.0526315789474, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI262118263, Length=180, Percent_Identity=31.6666666666667, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI262118255, Length=180, Percent_Identity=31.6666666666667, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI4505237, Length=180, Percent_Identity=31.6666666666667, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI262118259, Length=180, Percent_Identity=31.6666666666667, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI186700629, Length=180, Percent_Identity=28.8888888888889, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI186700627, Length=180, Percent_Identity=28.8888888888889, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI186972120, Length=180, Percent_Identity=28.8888888888889, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI52630447, Length=190, Percent_Identity=31.0526315789474, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI14780902, Length=196, Percent_Identity=32.6530612244898, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI21389483, Length=177, Percent_Identity=28.2485875706215, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI192447426, Length=178, Percent_Identity=30.3370786516854, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI111154074, Length=176, Percent_Identity=30.6818181818182, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI4557529, Length=178, Percent_Identity=30.3370786516854, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI21536464, Length=120, Percent_Identity=31.6666666666667, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI261862237, Length=125, Percent_Identity=32.8, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI119943108, Length=125, Percent_Identity=32.8, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI119943106, Length=125, Percent_Identity=32.8, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI148539578, Length=165, Percent_Identity=29.6969696969697, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI148539628, Length=165, Percent_Identity=29.6969696969697, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI218156270, Length=168, Percent_Identity=29.7619047619048, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI218156340, Length=168, Percent_Identity=29.7619047619048, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI218156338, Length=168, Percent_Identity=29.7619047619048, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI91199538, Length=168, Percent_Identity=29.7619047619048, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1790080, Length=181, Percent_Identity=51.9337016574586, Blast_Score=184, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI193203132, Length=174, Percent_Identity=45.9770114942529, Blast_Score=155, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17508835, Length=174, Percent_Identity=45.9770114942529, Blast_Score=155, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71988048, Length=176, Percent_Identity=30.6818181818182, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71988041, Length=176, Percent_Identity=30.6818181818182, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17557440, Length=180, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71984092, Length=172, Percent_Identity=31.9767441860465, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17556244, Length=124, Percent_Identity=34.6774193548387, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71982296, Length=101, Percent_Identity=32.6732673267327, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=181, Percent_Identity=42.5414364640884, Blast_Score=153, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21356141, Length=173, Percent_Identity=41.6184971098266, Blast_Score=130, Evalue=4e-31,
Organism=Drosophila melanogaster, GI221330162, Length=204, Percent_Identity=31.8627450980392, Blast_Score=93, Evalue=9e-20,
Organism=Drosophila melanogaster, GI221330164, Length=204, Percent_Identity=31.8627450980392, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221330166, Length=204, Percent_Identity=31.8627450980392, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45554481, Length=173, Percent_Identity=31.2138728323699, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI45554489, Length=173, Percent_Identity=31.2138728323699, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI85724806, Length=173, Percent_Identity=31.2138728323699, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI116007136, Length=173, Percent_Identity=31.2138728323699, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24640542, Length=173, Percent_Identity=31.2138728323699, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI161077626, Length=173, Percent_Identity=31.2138728323699, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI281362232, Length=180, Percent_Identity=28.8888888888889, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI161078485, Length=180, Percent_Identity=28.8888888888889, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648810, Length=180, Percent_Identity=28.8888888888889, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281362230, Length=180, Percent_Identity=28.8888888888889, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI161078487, Length=180, Percent_Identity=28.8888888888889, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648808, Length=180, Percent_Identity=28.8888888888889, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45551002, Length=218, Percent_Identity=27.9816513761468, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI85816281, Length=217, Percent_Identity=28.110599078341, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI85816106, Length=217, Percent_Identity=28.110599078341, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 22099; Mature: 22099

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMQVLSIQNCATTKENPLSGKLIILTGPSGVGKGTLMRSLLQRHPELYYSVSATTRPPRP
CCEEEECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCC
GEVNGESYYFVSRSKFEELIAQGEFLESAEFAGNYYGTPREAVLNQVQSGKLVVLEIELA
CCCCCCEEEEEEHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEEEC
GARQIRTSFPEALSIFILPPSFEELENRIRGRGQDSEEAIARRLQRAKEEIQAADEFDIQ
CCHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
IVNDDFEAALQAIEVALFG
EECCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MMQVLSIQNCATTKENPLSGKLIILTGPSGVGKGTLMRSLLQRHPELYYSVSATTRPPRP
CCEEEECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCC
GEVNGESYYFVSRSKFEELIAQGEFLESAEFAGNYYGTPREAVLNQVQSGKLVVLEIELA
CCCCCCEEEEEEHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEEEC
GARQIRTSFPEALSIFILPPSFEELENRIRGRGQDSEEAIARRLQRAKEEIQAADEFDIQ
CCHHHHHCCCCCEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEE
IVNDDFEAALQAIEVALFG
EECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA