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The map label for this gene is napA [H]

Identifier: 17227587

GI number: 17227587

Start: 93059

End: 94516

Strand: Direct

Name: napA [H]

Synonym: alr0091

Alternate gene names: 17227587

Gene position: 93059-94516 (Clockwise)

Preceding gene: 17227584

Following gene: 17227588

Centisome position: 1.45

GC content: 46.09

Gene sequence:

>1458_bases
ATGCAGTTTTTCAATGCAATCAACTTCGCTTTTCCTCTGCTGGCCAGCACAACTGAAGCCGCAGACAGTTCAATGGTTGT
CGCCGCAGTCTTGCTGAGTTTAGTGGTAGTTTACCTAGCTAGCAAAGTTGGTGGCGAGTTATCCAACCGAGTGGGTTTAC
CACCTGTCTTAGGCGAACTTTTAGGTGGTGTGGTCGTGGGTGTTTCTGTTCTGCACCTGTTGGTGTTCCCTGAAGGTGGT
GCAGACGGTTCCAGTTCTATGATTATGACCTTCCTCCAAACTACGGCTGGTTTAAGTCCAGAAGCGACACCAGCCGTATT
TACAGCCCAATCAGAAGTGATTTCTGTTTTAGCTGAACTGGGTGTGATCATCCTACTGTTTGAAATTGGCTTAGAGTCAA
ACTTAAAAGACTTGATGGCAGTTGGTGTCCAAGCTTTAGTAGTCGCAGTGGTGGGGGTTACAGTCCCATTTGCCGCCGGG
ACTATAGGCTTGATGACTTTGTTTGGTATCGATGCTGTACCCGCAATCTTTGCTGGGGCAGCTTTAACGGCTACCAGTAT
CGGGATTACCTCTAAGGTACTCTCAGAAATAGGAAGGCTCAATTCCAAAGAAGGACAGATAATTCTGGGTGCGGCTGTAA
TTGACGACGTACTGGGAATTATTGTCTTAGCGGTGGTTGCCAGCCTCGCTAAAGAAGGGACTGTAGATGTAGGTCAAGTC
ATCTATCTGATTATTAGTGCTAGTGGCTTTCTTTTGGGTGCGATTGTCTTGGGTAATGTTTTCAACAAAACCTTTGTCGC
GATCGCTGATATGCTCAAAACACGAGGTGAACTAGTAATACCAGCTTTCATCTTCGCTTTTGTTATGGCATATCTCGCTG
CCATCATCCATTTAGAAGCCATTCTTGGCGCTTTTGCCGCAGGTTTAGTTCTGGAAGAAACAGACAAGCGCAAAGAGCTA
CAAAGGCAAGTTTGCCCCATTGCTGATATGTTAGTGCCAATTTTCTTCGTTACCGTAGGTGCGAAAACTGATTTAGGCGT
ACTTAACCCAGCCATCCCCAGCAATCGGGAAGGGTTAATTATGGCAAGTTTCCTGATCATGGTCGCTATCTTCGGTAAAG
TAATCACAGGCTTTAGCGTCTTTGGTCAATCCCAAATCAACCGCCTAGCGATTGGCGTGGGGATGATTCCTAGAGGTGAG
GTAGGGTTAGTATTTGCTGGTGTCGGTGCAGCCAGTGGCGCACTCTCTAAACCGTTAGGGGCAGCAATCATCATGATGGT
TATCCTGACAACTTTTCTCGCTCCCCCTTTATTAAGATTCGTTTTTCCAGACTCAGATGATGGGATAGACGACTCAGCAC
AATTGATTTTAGATGGTTCCACGGGGAAACAATTAGCTATAGAAACACCATCTTCTGTTGTATCTACTGCCAAGGATAGT
GGGAATGTAAGTTCTTAA

Upstream 100 bases:

>100_bases
TTAGTCCGCCAAACATCATTTATCGCACCTGAACGAAGTGTATTTTCCATAAAAGAGTAAAAATGGAATAGAAGGATGTT
CACGTAACAACGCGTAACAA

Downstream 100 bases:

>100_bases
AGTAGGGGTGCAGAGTGCTGTAGGCAGATGGAATGTTTTTCCCTAAGTTTATCCCCCTTGCACCCTGCTCCCTGCTCCCG
TGGCTTTTCTACTCCCCATC

Product: Na+/H+-exchanging protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MQFFNAINFAFPLLASTTEAADSSMVVAAVLLSLVVVYLASKVGGELSNRVGLPPVLGELLGGVVVGVSVLHLLVFPEGG
ADGSSSMIMTFLQTTAGLSPEATPAVFTAQSEVISVLAELGVIILLFEIGLESNLKDLMAVGVQALVVAVVGVTVPFAAG
TIGLMTLFGIDAVPAIFAGAALTATSIGITSKVLSEIGRLNSKEGQIILGAAVIDDVLGIIVLAVVASLAKEGTVDVGQV
IYLIISASGFLLGAIVLGNVFNKTFVAIADMLKTRGELVIPAFIFAFVMAYLAAIIHLEAILGAFAAGLVLEETDKRKEL
QRQVCPIADMLVPIFFVTVGAKTDLGVLNPAIPSNREGLIMASFLIMVAIFGKVITGFSVFGQSQINRLAIGVGMIPRGE
VGLVFAGVGAASGALSKPLGAAIIMMVILTTFLAPPLLRFVFPDSDDGIDDSAQLILDGSTGKQLAIETPSSVVSTAKDS
GNVSS

Sequences:

>Translated_485_residues
MQFFNAINFAFPLLASTTEAADSSMVVAAVLLSLVVVYLASKVGGELSNRVGLPPVLGELLGGVVVGVSVLHLLVFPEGG
ADGSSSMIMTFLQTTAGLSPEATPAVFTAQSEVISVLAELGVIILLFEIGLESNLKDLMAVGVQALVVAVVGVTVPFAAG
TIGLMTLFGIDAVPAIFAGAALTATSIGITSKVLSEIGRLNSKEGQIILGAAVIDDVLGIIVLAVVASLAKEGTVDVGQV
IYLIISASGFLLGAIVLGNVFNKTFVAIADMLKTRGELVIPAFIFAFVMAYLAAIIHLEAILGAFAAGLVLEETDKRKEL
QRQVCPIADMLVPIFFVTVGAKTDLGVLNPAIPSNREGLIMASFLIMVAIFGKVITGFSVFGQSQINRLAIGVGMIPRGE
VGLVFAGVGAASGALSKPLGAAIIMMVILTTFLAPPLLRFVFPDSDDGIDDSAQLILDGSTGKQLAIETPSSVVSTAKDS
GNVSS
>Mature_485_residues
MQFFNAINFAFPLLASTTEAADSSMVVAAVLLSLVVVYLASKVGGELSNRVGLPPVLGELLGGVVVGVSVLHLLVFPEGG
ADGSSSMIMTFLQTTAGLSPEATPAVFTAQSEVISVLAELGVIILLFEIGLESNLKDLMAVGVQALVVAVVGVTVPFAAG
TIGLMTLFGIDAVPAIFAGAALTATSIGITSKVLSEIGRLNSKEGQIILGAAVIDDVLGIIVLAVVASLAKEGTVDVGQV
IYLIISASGFLLGAIVLGNVFNKTFVAIADMLKTRGELVIPAFIFAFVMAYLAAIIHLEAILGAFAAGLVLEETDKRKEL
QRQVCPIADMLVPIFFVTVGAKTDLGVLNPAIPSNREGLIMASFLIMVAIFGKVITGFSVFGQSQINRLAIGVGMIPRGE
VGLVFAGVGAASGALSKPLGAAIIMMVILTTFLAPPLLRFVFPDSDDGIDDSAQLILDGSTGKQLAIETPSSVVSTAKDS
GNVSS

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786685, Length=416, Percent_Identity=26.9230769230769, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322367, Length=420, Percent_Identity=26.4285714285714, Blast_Score=119, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 49760; Mature: 49760

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFFNAINFAFPLLASTTEAADSSMVVAAVLLSLVVVYLASKVGGELSNRVGLPPVLGEL
CCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHH
LGGVVVGVSVLHLLVFPEGGADGSSSMIMTFLQTTAGLSPEATPAVFTAQSEVISVLAEL
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHEEHHHHHHHHHHHH
GVIILLFEIGLESNLKDLMAVGVQALVVAVVGVTVPFAAGTIGLMTLFGIDAVPAIFAGA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALTATSIGITSKVLSEIGRLNSKEGQIILGAAVIDDVLGIIVLAVVASLAKEGTVDVGQV
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
IYLIISASGFLLGAIVLGNVFNKTFVAIADMLKTRGELVIPAFIFAFVMAYLAAIIHLEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHH
ILGAFAAGLVLEETDKRKELQRQVCPIADMLVPIFFVTVGAKTDLGVLNPAIPSNREGLI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHH
MASFLIMVAIFGKVITGFSVFGQSQINRLAIGVGMIPRGEVGLVFAGVGAASGALSKPLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEEECCCCCCCCCCHHH
AAIIMMVILTTFLAPPLLRFVFPDSDDGIDDSAQLILDGSTGKQLAIETPSSVVSTAKDS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEECCHHHHHHCCCC
GNVSS
CCCCC
>Mature Secondary Structure
MQFFNAINFAFPLLASTTEAADSSMVVAAVLLSLVVVYLASKVGGELSNRVGLPPVLGEL
CCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHH
LGGVVVGVSVLHLLVFPEGGADGSSSMIMTFLQTTAGLSPEATPAVFTAQSEVISVLAEL
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHEEHHHHHHHHHHHH
GVIILLFEIGLESNLKDLMAVGVQALVVAVVGVTVPFAAGTIGLMTLFGIDAVPAIFAGA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALTATSIGITSKVLSEIGRLNSKEGQIILGAAVIDDVLGIIVLAVVASLAKEGTVDVGQV
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
IYLIISASGFLLGAIVLGNVFNKTFVAIADMLKTRGELVIPAFIFAFVMAYLAAIIHLEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHH
ILGAFAAGLVLEETDKRKELQRQVCPIADMLVPIFFVTVGAKTDLGVLNPAIPSNREGLI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHH
MASFLIMVAIFGKVITGFSVFGQSQINRLAIGVGMIPRGEVGLVFAGVGAASGALSKPLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEEECCCCCCCCCCHHH
AAIIMMVILTTFLAPPLLRFVFPDSDDGIDDSAQLILDGSTGKQLAIETPSSVVSTAKDS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEECCHHHHHHCCCC
GNVSS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]