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The map label for this gene is adk2

Identifier: 17227564

GI number: 17227564

Start: 72595

End: 73149

Strand: Direct

Name: adk2

Synonym: alr0068

Alternate gene names: 17227564

Gene position: 72595-73149 (Clockwise)

Preceding gene: 17227560

Following gene: 17227565

Centisome position: 1.13

GC content: 43.6

Gene sequence:

>555_bases
GTGAGATTAGTGATTCTGGGAGGTTCAGGGTCGGGAAAAAGCACTCAAGCACAAAGGCTTTGCAGTCATTTAGAAATTAC
TCAGATTTCTACGGGCGAGATTTTACGGGAAGCTATTTCCCATCTTAGTGAATTAGGTCGTCATGCCCAACCTTACATGA
TTAAAGGGGAACTAGTCCCTGACGAAATGATCATTGAACTAATCCGATTGCGTCTGAAAAAGTCTGATGTAATTGATGGC
TGGGTTTTGGAAGGTTATCCGCGTACTGCCTTCCAAGCTGAAGAGTTGGACTTTTTGCTTGATGAGTTGGGGCAGAAATT
AGATTGGGCAATTTATTTACAAGTACCGGAAGCAGTGATGGTGAGTCGTTCTTTGGGGCGTTCTCTACCAGATGACCAAC
CTGAAATTGTGCAGCGTCGAGTAGAGATTTTTTACGATCGCACTGTTCCTATTTTAGAGTATTACGACCGTCGCCGCCGC
CTGTTGACAATTAACGGTGATCAGTCCCCGGAATTAGTATTGCAAAGTATCCTCAAACTACTTTTAGTAACTTAG

Upstream 100 bases:

>100_bases
CCCCGACTCATACTCTTTGGCTAAATGTTAGATTTCTGACAGGGTTGGGCAAAACAAATTTATTATGTTTTAAATATTAC
TGGTTGAGGAGTGAATTGTT

Downstream 100 bases:

>100_bases
AGTTTTTAGCTATCTTAAAACTTTCGGGAATTTATCTGACTGTAGGCATGAGATCACAACCTCACACAGTACTTAATGTT
TTGCACCACTAAGGTAACTT

Product: adenylate kinase

Products: NA

Alternate protein names: AK 2; ATP-AMP transphosphorylase 2

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MRLVILGGSGSGKSTQAQRLCSHLEITQISTGEILREAISHLSELGRHAQPYMIKGELVPDEMIIELIRLRLKKSDVIDG
WVLEGYPRTAFQAEELDFLLDELGQKLDWAIYLQVPEAVMVSRSLGRSLPDDQPEIVQRRVEIFYDRTVPILEYYDRRRR
LLTINGDQSPELVLQSILKLLLVT

Sequences:

>Translated_184_residues
MRLVILGGSGSGKSTQAQRLCSHLEITQISTGEILREAISHLSELGRHAQPYMIKGELVPDEMIIELIRLRLKKSDVIDG
WVLEGYPRTAFQAEELDFLLDELGQKLDWAIYLQVPEAVMVSRSLGRSLPDDQPEIVQRRVEIFYDRTVPILEYYDRRRR
LLTINGDQSPELVLQSILKLLLVT
>Mature_184_residues
MRLVILGGSGSGKSTQAQRLCSHLEITQISTGEILREAISHLSELGRHAQPYMIKGELVPDEMIIELIRLRLKKSDVIDG
WVLEGYPRTAFQAEELDFLLDELGQKLDWAIYLQVPEAVMVSRSLGRSLPDDQPEIVQRRVEIFYDRTVPILEYYDRRRR
LLTINGDQSPELVLQSILKLLLVT

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=209, Percent_Identity=32.0574162679426, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI7524346, Length=209, Percent_Identity=32.0574162679426, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI19923437, Length=203, Percent_Identity=30.0492610837438, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI28144897, Length=180, Percent_Identity=32.7777777777778, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI28144899, Length=180, Percent_Identity=32.7777777777778, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4502011, Length=184, Percent_Identity=29.8913043478261, Blast_Score=95, Evalue=3e-20,
Organism=Homo sapiens, GI22749187, Length=204, Percent_Identity=29.4117647058824, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI310110345, Length=203, Percent_Identity=30.0492610837438, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI53832003, Length=203, Percent_Identity=30.0492610837438, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI8051579, Length=203, Percent_Identity=30.0492610837438, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI53832001, Length=203, Percent_Identity=30.0492610837438, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI7706497, Length=190, Percent_Identity=23.6842105263158, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1786680, Length=188, Percent_Identity=32.9787234042553, Blast_Score=110, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17552384, Length=188, Percent_Identity=28.7234042553192, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17567503, Length=173, Percent_Identity=28.3236994219653, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17533833, Length=183, Percent_Identity=25.1366120218579, Blast_Score=76, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=25.5434782608696, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI25147457, Length=187, Percent_Identity=26.7379679144385, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=213, Percent_Identity=28.6384976525822, Blast_Score=101, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6321018, Length=200, Percent_Identity=31.5, Blast_Score=95, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6322828, Length=192, Percent_Identity=28.6458333333333, Blast_Score=79, Evalue=3e-16,
Organism=Drosophila melanogaster, GI22026816, Length=208, Percent_Identity=29.3269230769231, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17737899, Length=204, Percent_Identity=28.921568627451, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24645822, Length=204, Percent_Identity=28.921568627451, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI221459597, Length=190, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21356893, Length=190, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24663208, Length=186, Percent_Identity=29.0322580645161, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17647141, Length=186, Percent_Identity=29.0322580645161, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD2_NOSS1 (Q8Z0M3)

Other databases:

- EMBL:   BA000019
- PIR:   AD1815
- RefSeq:   NP_484112.1
- ProteinModelPortal:   Q8Z0M3
- SMR:   Q8Z0M3
- STRING:   Q8Z0M3
- GeneID:   1103665
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr0068
- NMPDR:   fig|103690.1.peg.379
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   EMQKYIL
- ProtClustDB:   CLSK287207
- BioCyc:   NSP103690:ALR0068-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 21055; Mature: 21055

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVILGGSGSGKSTQAQRLCSHLEITQISTGEILREAISHLSELGRHAQPYMIKGELVP
CEEEEEECCCCCCCHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
DEMIIELIRLRLKKSDVIDGWVLEGYPRTAFQAEELDFLLDELGQKLDWAIYLQVPEAVM
HHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHH
VSRSLGRSLPDDQPEIVQRRVEIFYDRTVPILEYYDRRRRLLTINGDQSPELVLQSILKL
HHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
LLVT
HHCC
>Mature Secondary Structure
MRLVILGGSGSGKSTQAQRLCSHLEITQISTGEILREAISHLSELGRHAQPYMIKGELVP
CEEEEEECCCCCCCHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
DEMIIELIRLRLKKSDVIDGWVLEGYPRTAFQAEELDFLLDELGQKLDWAIYLQVPEAVM
HHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCHHHH
VSRSLGRSLPDDQPEIVQRRVEIFYDRTVPILEYYDRRRRLLTINGDQSPELVLQSILKL
HHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
LLVT
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840