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The map label for this gene is napA [H]

Identifier: 170757789

GI number: 170757789

Start: 3059728

End: 3060945

Strand: Reverse

Name: napA [H]

Synonym: CLD_1714

Alternate gene names: 170757789

Gene position: 3060945-3059728 (Counterclockwise)

Preceding gene: 170756836

Following gene: 170755658

Centisome position: 77.33

GC content: 31.03

Gene sequence:

>1218_bases
TTGTTATCTTATGAATTCTTATTAGATCTTGCGCTTATATTATTAAGTACAAAAGTTTTAGGTATGGTCACTAAAAAATT
ACACATGCCTAAGGTTGTAGGTGCATTATTAGCAGGTCTTATACTAGGACCATGTGTACTGAATATAGTACATGAAACTG
ACTTTCTAGCGAAAATGGCCCAACTAGGAGTAATTATTTTAATGTTTTCAGCAGGCTTACAAACAGATCTTAAGGAATTA
AAAAAATGTGGTAGGGCTTCCTTGATTATTGCTATATTAGGAACAGTTGTCCCTTTATTAGGAGGATACTTTGTATCAGC
ACTATTTTTTGATTCTAATGGGATCTTTGATATAACTTCAAAAGCATTTATTAAGAATTTTTTTATTGGGGTAATATTAA
CTGCTACTTCTGTTAGTATTACTGTTGAAACTTTGCAAGAACTAGGCAGATTGAAAACACGTTCTGGAACAGCTATATTA
GGGGCAGCAATTATTGATGATATTTTAGGAATAATCATTTTAACTATAGTTACAAGTTCTACAGATAATTCAACAAGTAT
TAATTTAGTACTTCTAAAAATTGTAGCATTCTTTATATTATCTACTATCTGTGGAGTAGTGTTGCATCACATTTTCAATA
AAATTTATAAACGTTATGGTAATATAAGTGGAATTTCAGCTGTTACATTTTCTTTTTGTCTAATTATGGCCTTTATTGCA
GAGCACTTTTTTGGTGTAGCAGATATAACAGGTGCTTTTATAGCTGGAGTTATTATTTCAAATACGTCTTTTCGTGAGCA
TGTAGAAAAAAATTTCGAAGTAATTTCCTATATGCTTTTATCTCCCGTATTTTTTGCCAGTATAGGTTTAAATACAACAA
TGAAGCATATGAATAATAAAATGAGGTTGTTTACAATTGCATTATTACTAATGGCGATATTAGCAAAAGTCATAGGGTGT
TTTATAGGAGGAAGAATTTGCAAATACACATATGCTGAATCTCTTAGAATCGGAATTGGAATGATATCACGTGGAGAAGT
TGCCCTAATAATTGCAAAGAAAGGTGCCGCATTAGGTTTGATAGAAGCACAATTCTTCGGATCGATAGTTTTTGTAGTTA
TAGCAACTACCCTTATAACACCTATATTATTAAAGATGGTGTATAGTACTAAATTCAATGATATTAAAGCATATGATTCC
TTGCATAGTGCTGCTTAA

Upstream 100 bases:

>100_bases
TTTTGAAAAAAGGTATCTATAAAATTTAATTGAACTTAGTGTTACAATTTTGCTTAACTAAGTCAAAACCTATAATAATA
CTTTAAAGGAGGAGTTAAAT

Downstream 100 bases:

>100_bases
TATTCATGAATAAGATAAATTTTATCCTAGAAACTTTATAAATACTTTCAAAGGCAGAACTTAATTTATATATATCTTAA
CCTTTCAATGATTCAACTAG

Product: monovalent cation:proton antiporter-2 (CPA2) family protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MLSYEFLLDLALILLSTKVLGMVTKKLHMPKVVGALLAGLILGPCVLNIVHETDFLAKMAQLGVIILMFSAGLQTDLKEL
KKCGRASLIIAILGTVVPLLGGYFVSALFFDSNGIFDITSKAFIKNFFIGVILTATSVSITVETLQELGRLKTRSGTAIL
GAAIIDDILGIIILTIVTSSTDNSTSINLVLLKIVAFFILSTICGVVLHHIFNKIYKRYGNISGISAVTFSFCLIMAFIA
EHFFGVADITGAFIAGVIISNTSFREHVEKNFEVISYMLLSPVFFASIGLNTTMKHMNNKMRLFTIALLLMAILAKVIGC
FIGGRICKYTYAESLRIGIGMISRGEVALIIAKKGAALGLIEAQFFGSIVFVVIATTLITPILLKMVYSTKFNDIKAYDS
LHSAA

Sequences:

>Translated_405_residues
MLSYEFLLDLALILLSTKVLGMVTKKLHMPKVVGALLAGLILGPCVLNIVHETDFLAKMAQLGVIILMFSAGLQTDLKEL
KKCGRASLIIAILGTVVPLLGGYFVSALFFDSNGIFDITSKAFIKNFFIGVILTATSVSITVETLQELGRLKTRSGTAIL
GAAIIDDILGIIILTIVTSSTDNSTSINLVLLKIVAFFILSTICGVVLHHIFNKIYKRYGNISGISAVTFSFCLIMAFIA
EHFFGVADITGAFIAGVIISNTSFREHVEKNFEVISYMLLSPVFFASIGLNTTMKHMNNKMRLFTIALLLMAILAKVIGC
FIGGRICKYTYAESLRIGIGMISRGEVALIIAKKGAALGLIEAQFFGSIVFVVIATTLITPILLKMVYSTKFNDIKAYDS
LHSAA
>Mature_405_residues
MLSYEFLLDLALILLSTKVLGMVTKKLHMPKVVGALLAGLILGPCVLNIVHETDFLAKMAQLGVIILMFSAGLQTDLKEL
KKCGRASLIIAILGTVVPLLGGYFVSALFFDSNGIFDITSKAFIKNFFIGVILTATSVSITVETLQELGRLKTRSGTAIL
GAAIIDDILGIIILTIVTSSTDNSTSINLVLLKIVAFFILSTICGVVLHHIFNKIYKRYGNISGISAVTFSFCLIMAFIA
EHFFGVADITGAFIAGVIISNTSFREHVEKNFEVISYMLLSPVFFASIGLNTTMKHMNNKMRLFTIALLLMAILAKVIGC
FIGGRICKYTYAESLRIGIGMISRGEVALIIAKKGAALGLIEAQFFGSIVFVVIATTLITPILLKMVYSTKFNDIKAYDS
LHSAA

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Escherichia coli, GI1786232, Length=379, Percent_Identity=23.2189973614776, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786685, Length=389, Percent_Identity=24.4215938303342, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789749, Length=410, Percent_Identity=22.4390243902439, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322367, Length=413, Percent_Identity=26.634382566586, Blast_Score=120, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 43820; Mature: 43820

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSYEFLLDLALILLSTKVLGMVTKKLHMPKVVGALLAGLILGPCVLNIVHETDFLAKMA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGVIILMFSAGLQTDLKELKKCGRASLIIAILGTVVPLLGGYFVSALFFDSNGIFDITS
HHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
KAFIKNFFIGVILTATSVSITVETLQELGRLKTRSGTAILGAAIIDDILGIIILTIVTSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
TDNSTSINLVLLKIVAFFILSTICGVVLHHIFNKIYKRYGNISGISAVTFSFCLIMAFIA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EHFFGVADITGAFIAGVIISNTSFREHVEKNFEVISYMLLSPVFFASIGLNTTMKHMNNK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCH
MRLFTIALLLMAILAKVIGCFIGGRICKYTYAESLRIGIGMISRGEVALIIAKKGAALGL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEECCCCEEEEEEECCCEEHH
IEAQFFGSIVFVVIATTLITPILLKMVYSTKFNDIKAYDSLHSAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MLSYEFLLDLALILLSTKVLGMVTKKLHMPKVVGALLAGLILGPCVLNIVHETDFLAKMA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGVIILMFSAGLQTDLKELKKCGRASLIIAILGTVVPLLGGYFVSALFFDSNGIFDITS
HHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHH
KAFIKNFFIGVILTATSVSITVETLQELGRLKTRSGTAILGAAIIDDILGIIILTIVTSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
TDNSTSINLVLLKIVAFFILSTICGVVLHHIFNKIYKRYGNISGISAVTFSFCLIMAFIA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
EHFFGVADITGAFIAGVIISNTSFREHVEKNFEVISYMLLSPVFFASIGLNTTMKHMNNK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCH
MRLFTIALLLMAILAKVIGCFIGGRICKYTYAESLRIGIGMISRGEVALIIAKKGAALGL
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEECCCCEEEEEEECCCEEHH
IEAQFFGSIVFVVIATTLITPILLKMVYSTKFNDIKAYDSLHSAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]