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The map label for this gene is mutL

Identifier: 170757624

GI number: 170757624

Start: 1914712

End: 1916712

Strand: Reverse

Name: mutL

Synonym: CLD_2841

Alternate gene names: 170757624

Gene position: 1916712-1914712 (Counterclockwise)

Preceding gene: 170755080

Following gene: 170756578

Centisome position: 48.42

GC content: 25.29

Gene sequence:

>2001_bases
ATGAGGAAAATAAATTTATTAGATTTAGAAACTACAAATAAAATAGCTGCAGGAGAAGTTATAGAAAGACCCTTTTCTGT
AGTAAAAGAATTAGTAGAAAATAGTATAGATGCCGGTGCCAAAAATATAACCATAGAAATAGAAGATGGAGGACAAAAGC
TTATAAAGATAATAGATGATGGAGAAGGTATTTATCCTATTGATATAAAAAATGCTTTTCTTCCTCATGCTACAAGTAAA
ATAAATTCTATAGAGGATATATACAAAATAAGTACTATGGGCTTTAGAGGTGAAGCACTAGCTAGCATTTCTTCCGTATC
AAAAACTAAACTTAAAAGTAGAGTTGACTCTTATAATTTTGGAAAAGAAATATATATAGAGGGTGGCAAAATAGAGTACT
TAAAAGATACAGGTTGCAATGTTGGCACTACTATAGAAGTTTCTGATTTATTTTATAATGTCCCTGCAAGACTTAAATTT
TTGAAAAGTGCAAGAAGTGATAGTAGTTCTATATCAGATATTGTGAATAGGTTTATATTAGCCCATCCAGATATATCTTT
TAATTTAATAAATAAGGGAAAGCAAAGTATAAAGAGTTATGGTACCGGAAATTTAAAGGACTCTATACGATGTGTATATA
ATAAAACAATAAGTGAAAACCTTATAAACTTCGAAAGTCATAAAGATATAATATCTGTATATGGATTTATAGGTAAGACT
GAAATAAGCCGTAAAAGCAGAACAAATCAAAGTATATTTGTAAACAAGCGATATGTTAAAAGTAAATTTATAACTGCTGC
AGTAGAAAATGCTTTTAAATCCTTTTTAACAGTAAATAGCTATCCTTTCTTTGTAATATTTATAGATATTTTTCCGGAAT
ATATTGATGTAAATGTACATCCTACTAAATCAGAAGTTAAATTTAAAGATGAGAGAGCAATGTTTAAAACTATATTTGAT
GCAGTTCATGAAGCTATAAAAGGAGAATTAAAAGAATCTTTTACAAACTTCTTTAATAAAGAAGATATTAATATATATGA
TTCTGAAAAATCTATAACTGAACCCATAAAACTAGAGAAAGAAGAAGTACAAATACCAATAGATTTAAATAGTAATAATA
AAATTGATATTTTTGGTAATAATATAAATAAACTACCTAACAATACAGAACTTCTTAAAAATATAGGTGTTAAAGCAAAA
AATACACTTGAAAATAATAATGATTTCTATACTTCTAAACAAAATGAAATATACTATGCTAATAAAAATGATGAATGTTT
AAATTCATGTAATAAAGATAACTATAGCAAAATAGAAAAGTCATTACAAAAAGATAATAAAAATCCAGATACCTTATATC
TAAATGAGCATAATACAAATTCTTCATCTATAAATATTAAAGAAAATAAACCTAATAATTTTTATGTAGATATGAAAATA
ATAGGACAGTTTAATAATACATATATATTAATAGAAAAGGATAAAGAACTTTATATAATAGATCAACATGCAGCTCATGA
AAAAGTGTTATTTGAGAAATTCAAATCCGAAATAGAAAAAGGATATGTAATAAGTCAGATTTTATTATCTCCTGTAGTTA
TAGAACTTTCAGAAGATGAATTTAATATATACGAAGAAAACAAGGATATTTTTAAGAATTCGGGTTTTTCAGTGGAAACT
TTTGGAGAATACACTATAAATATAAAAGAAGTACCTTTAATTCTAGGTAAACCCAATGTAGAAAATCTCTTTATGGATAT
ACTTTATAATTTAAAAAATATGAAGTCTAAAGAAACTTCTACAATAAAATATAATGCCATTGCTACACTGGCATGCAAAT
CCGCAGTTAAAGCTAATGACAACTTAAAAGAAGAAGAAATAAAAAAATTAATAGAAGACATGCTTATATTAAATAATCCA
TATACTTGTCCCCATGGAAGACCTACTATGATTAAATTTACATTAAAAGATTTAGAAAAAAAATTTAAAAGAATACAATG
A

Upstream 100 bases:

>100_bases
ATATTAATACATACAAAATCCTATAATTTTTATTAACCTAGTACCATTTATAAGTGGTACTAATCTATATAATAAAATTA
TAAGCTATGTGGTGATTTAA

Downstream 100 bases:

>100_bases
GGGGGATAAGGAAAAATGATAGATTTATTAATAATTGCAGGTCCTACAGCAGTAGGGAAAACAGATATTTCCATAAAACT
TGCAGAAAAACTAAATGGAG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDDGEGIYPIDIKNAFLPHATSK
INSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNFGKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKF
LKSARSDSSSISDIVNRFILAHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKT
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVHPTKSEVKFKDERAMFKTIFD
AVHEAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEKEEVQIPIDLNSNNKIDIFGNNINKLPNNTELLKNIGVKAK
NTLENNNDFYTSKQNEIYYANKNDECLNSCNKDNYSKIEKSLQKDNKNPDTLYLNEHNTNSSSINIKENKPNNFYVDMKI
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKSEIEKGYVISQILLSPVVIELSEDEFNIYEENKDIFKNSGFSVET
FGEYTINIKEVPLILGKPNVENLFMDILYNLKNMKSKETSTIKYNAIATLACKSAVKANDNLKEEEIKKLIEDMLILNNP
YTCPHGRPTMIKFTLKDLEKKFKRIQ

Sequences:

>Translated_666_residues
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDDGEGIYPIDIKNAFLPHATSK
INSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNFGKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKF
LKSARSDSSSISDIVNRFILAHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKT
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVHPTKSEVKFKDERAMFKTIFD
AVHEAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEKEEVQIPIDLNSNNKIDIFGNNINKLPNNTELLKNIGVKAK
NTLENNNDFYTSKQNEIYYANKNDECLNSCNKDNYSKIEKSLQKDNKNPDTLYLNEHNTNSSSINIKENKPNNFYVDMKI
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKSEIEKGYVISQILLSPVVIELSEDEFNIYEENKDIFKNSGFSVET
FGEYTINIKEVPLILGKPNVENLFMDILYNLKNMKSKETSTIKYNAIATLACKSAVKANDNLKEEEIKKLIEDMLILNNP
YTCPHGRPTMIKFTLKDLEKKFKRIQ
>Mature_666_residues
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDDGEGIYPIDIKNAFLPHATSK
INSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNFGKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKF
LKSARSDSSSISDIVNRFILAHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKT
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVHPTKSEVKFKDERAMFKTIFD
AVHEAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEKEEVQIPIDLNSNNKIDIFGNNINKLPNNTELLKNIGVKAK
NTLENNNDFYTSKQNEIYYANKNDECLNSCNKDNYSKIEKSLQKDNKNPDTLYLNEHNTNSSSINIKENKPNNFYVDMKI
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKSEIEKGYVISQILLSPVVIELSEDEFNIYEENKDIFKNSGFSVET
FGEYTINIKEVPLILGKPNVENLFMDILYNLKNMKSKETSTIKYNAIATLACKSAVKANDNLKEEEIKKLIEDMLILNNP
YTCPHGRPTMIKFTLKDLEKKFKRIQ

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=34.2424242424242, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI4505911, Length=357, Percent_Identity=28.8515406162465, Blast_Score=145, Evalue=2e-34,
Organism=Homo sapiens, GI189458898, Length=357, Percent_Identity=28.8515406162465, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI4505913, Length=344, Percent_Identity=26.453488372093, Blast_Score=133, Evalue=7e-31,
Organism=Homo sapiens, GI310128478, Length=344, Percent_Identity=26.453488372093, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI189458896, Length=355, Percent_Identity=28.7323943661972, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI263191589, Length=241, Percent_Identity=29.4605809128631, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI310128480, Length=299, Percent_Identity=24.0802675585284, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI91992162, Length=459, Percent_Identity=25.2723311546841, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI91992160, Length=459, Percent_Identity=25.2723311546841, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1790612, Length=597, Percent_Identity=29.1457286432161, Blast_Score=239, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=32.2981366459627, Blast_Score=166, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17562796, Length=351, Percent_Identity=28.2051282051282, Blast_Score=140, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323819, Length=333, Percent_Identity=36.036036036036, Blast_Score=200, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6324247, Length=353, Percent_Identity=30.3116147308782, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323063, Length=348, Percent_Identity=26.1494252873563, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6325093, Length=756, Percent_Identity=22.8835978835979, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17136968, Length=334, Percent_Identity=33.5329341317365, Blast_Score=198, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=25.2100840336134, Blast_Score=117, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 76159; Mature: 76159

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1 ; PS00583 PFKB_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDD
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEC
GEGIYPIDIKNAFLPHATSKINSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNF
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
GKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKFLKSARSDSSSISDIVNRFIL
CCEEEEECCEEEEEECCCCCCCCEEEEHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHEE
AHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKT
ECCCCEEEHHHHHHHHHHHCCCCCCHHHHHEEHHCHHHHHHHCCCHHHHHHHHHHHHCCC
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVH
HHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCCHHEEEEC
PTKSEVKFKDERAMFKTIFDAVHEAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEK
CCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEECC
EEVQIPIDLNSNNKIDIFGNNINKLPNNTELLKNIGVKAKNTLENNNDFYTSKQNEIYYA
CCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEE
NKNDECLNSCNKDNYSKIEKSLQKDNKNPDTLYLNEHNTNSSSINIKENKPNNFYVDMKI
CCCHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEEE
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKSEIEKGYVISQILLSPVVIELSEDE
EECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEECCCC
FNIYEENKDIFKNSGFSVETFGEYTINIKEVPLILGKPNVENLFMDILYNLKNMKSKETS
CEEEECCHHHHHCCCCEEEECCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCC
TIKYNAIATLACKSAVKANDNLKEEEIKKLIEDMLILNNPYTCPHGRPTMIKFTLKDLEK
EEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHH
KFKRIQ
HHHHCC
>Mature Secondary Structure
MRKINLLDLETTNKIAAGEVIERPFSVVKELVENSIDAGAKNITIEIEDGGQKLIKIIDD
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEC
GEGIYPIDIKNAFLPHATSKINSIEDIYKISTMGFRGEALASISSVSKTKLKSRVDSYNF
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
GKEIYIEGGKIEYLKDTGCNVGTTIEVSDLFYNVPARLKFLKSARSDSSSISDIVNRFIL
CCEEEEECCEEEEEECCCCCCCCEEEEHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHEE
AHPDISFNLINKGKQSIKSYGTGNLKDSIRCVYNKTISENLINFESHKDIISVYGFIGKT
ECCCCEEEHHHHHHHHHHHCCCCCCHHHHHEEHHCHHHHHHHCCCHHHHHHHHHHHHCCC
EISRKSRTNQSIFVNKRYVKSKFITAAVENAFKSFLTVNSYPFFVIFIDIFPEYIDVNVH
HHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEEECCCHHEEEEC
PTKSEVKFKDERAMFKTIFDAVHEAIKGELKESFTNFFNKEDINIYDSEKSITEPIKLEK
CCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEECC
EEVQIPIDLNSNNKIDIFGNNINKLPNNTELLKNIGVKAKNTLENNNDFYTSKQNEIYYA
CCEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEECCCCEEEEE
NKNDECLNSCNKDNYSKIEKSLQKDNKNPDTLYLNEHNTNSSSINIKENKPNNFYVDMKI
CCCHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEEE
IGQFNNTYILIEKDKELYIIDQHAAHEKVLFEKFKSEIEKGYVISQILLSPVVIELSEDE
EECCCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEECCCC
FNIYEENKDIFKNSGFSVETFGEYTINIKEVPLILGKPNVENLFMDILYNLKNMKSKETS
CEEEECCHHHHHCCCCEEEECCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCC
TIKYNAIATLACKSAVKANDNLKEEEIKKLIEDMLILNNPYTCPHGRPTMIKFTLKDLEK
EEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHH
KFKRIQ
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA