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The map label for this gene is fruA [H]

Identifier: 170757049

GI number: 170757049

Start: 2135867

End: 2136307

Strand: Reverse

Name: fruA [H]

Synonym: CLD_2634

Alternate gene names: 170757049

Gene position: 2136307-2135867 (Counterclockwise)

Preceding gene: 170756738

Following gene: 170756497

Centisome position: 53.97

GC content: 28.57

Gene sequence:

>441_bases
ATGGAATTAAATGAATTAATAAAAGAAAGCACTATAGAATTAAATGTAGCGGCAAAGGATAAAGAGGATCTTATTAATAA
AATGATTGATGTTTTAGTAAAAGATGGAGCAGTTCTTGATAAGGATAAATTTAAAGAGGATATTTATCATAGGGAATCTT
TAAGTAATACAGGCATAGGTTTTGGAATTGCTATACCACATGCTAAATCTATAGCTGTAAAGGAACCTCGTATTGCAGTA
GGGATACTTAAAGATACTGTGGATTATGATTCAATAGACGGAGATCCAGTAAATATGATATTCATGATAGCAGTAAATGA
TATGCAAAGTGATCTTCATCTAAAAGCATTAGCTAACTTATCAAGAAAATTAATGCATGAAGATTTCAGAGGAAAGATCT
TAAATGTAAAATCAAAATCTGAAATATTAGAAATAATTTAA

Upstream 100 bases:

>100_bases
TAATTATAATTTATAATAGCATTGAAGAATATTGTTAAACTTAAGATAAAAAAACAATAATTTACAAGGTATCTAAGATA
AGGGGATGAATAAAATAATT

Downstream 100 bases:

>100_bases
GTTGCTTATAAACAGAGTTCTTGGCTTCAGAGGGAGTTTTTACTCCCACTAAAGATTAGGAAATGGTTATCCAGAGACAT
AGCCGCTCTTTACCCCACTT

Product: PTS system, fructose family, IIA component

Products: NA

Alternate protein names: EIIABC-Fru; Fructose-specific phosphotransferase enzyme IIA component; EII-Fru; PTS system fructose-specific EIIA component; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MELNELIKESTIELNVAAKDKEDLINKMIDVLVKDGAVLDKDKFKEDIYHRESLSNTGIGFGIAIPHAKSIAVKEPRIAV
GILKDTVDYDSIDGDPVNMIFMIAVNDMQSDLHLKALANLSRKLMHEDFRGKILNVKSKSEILEII

Sequences:

>Translated_146_residues
MELNELIKESTIELNVAAKDKEDLINKMIDVLVKDGAVLDKDKFKEDIYHRESLSNTGIGFGIAIPHAKSIAVKEPRIAV
GILKDTVDYDSIDGDPVNMIFMIAVNDMQSDLHLKALANLSRKLMHEDFRGKILNVKSKSEILEII
>Mature_146_residues
MELNELIKESTIELNVAAKDKEDLINKMIDVLVKDGAVLDKDKFKEDIYHRESLSNTGIGFGIAIPHAKSIAVKEPRIAV
GILKDTVDYDSIDGDPVNMIFMIAVNDMQSDLHLKALANLSRKLMHEDFRGKILNVKSKSEILEII

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1762

COG function: function code GT; Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1786951, Length=148, Percent_Identity=28.3783783783784, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI48994992, Length=142, Percent_Identity=30.2816901408451, Blast_Score=79, Evalue=1e-16,
Organism=Escherichia coli, GI2367327, Length=123, Percent_Identity=26.8292682926829, Blast_Score=79, Evalue=1e-16,
Organism=Escherichia coli, GI1788726, Length=127, Percent_Identity=28.3464566929134, Blast_Score=69, Evalue=9e-14,
Organism=Escherichia coli, GI1789597, Length=105, Percent_Identity=34.2857142857143, Blast_Score=60, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 16346; Mature: 16346

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELNELIKESTIELNVAAKDKEDLINKMIDVLVKDGAVLDKDKFKEDIYHRESLSNTGIG
CCHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCE
FGIAIPHAKSIAVKEPRIAVGILKDTVDYDSIDGDPVNMIFMIAVNDMQSDLHLKALANL
EEEECCCCCCEEECCCCEEEEEHHHCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHH
SRKLMHEDFRGKILNVKSKSEILEII
HHHHHHHHHCCEEECCCCHHHHHHCC
>Mature Secondary Structure
MELNELIKESTIELNVAAKDKEDLINKMIDVLVKDGAVLDKDKFKEDIYHRESLSNTGIG
CCHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCE
FGIAIPHAKSIAVKEPRIAVGILKDTVDYDSIDGDPVNMIFMIAVNDMQSDLHLKALANL
EEEECCCCCCEEECCCCEEEEEHHHCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHH
SRKLMHEDFRGKILNVKSKSEILEII
HHHHHHHHHCCEEECCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]