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The map label for this gene is neuC [H]

Identifier: 170756742

GI number: 170756742

Start: 2888976

End: 2890127

Strand: Reverse

Name: neuC [H]

Synonym: CLD_1853

Alternate gene names: 170756742

Gene position: 2890127-2888976 (Counterclockwise)

Preceding gene: 170757542

Following gene: 170757489

Centisome position: 73.02

GC content: 36.55

Gene sequence:

>1152_bases
ATGAGAAAAGTATGTGTAGTTACAGGAACAAGAGCAGAATATGGATTGCTTAGAAACATATTGGTGAAAATAAAGGATTC
AAATAATTTGAGACTCCATCTAGTAGTTACAGGTGCACATTTGTCAGAGGACTATGGTTGCACAGTAGACGAAATAGAAA
GTGACGGATTCGCCATAGACGAAAAATTGCCAATATTGATGAATGGTAATAGTAAAAGCGTTATAGCTAAAGAAATGGGA
ATGCTGATGATTCAGCTTTCTCAAACCTTTGAAAGGTTAAAACCAGACATGCTGCTTGTTCTAGGTGACAGATATGAAAT
ATTTGCAGCGACGTCAACTGCAATGGCAATGAACATACCTATTGCTCACATATCTGGTGGAGAAATTACAGAGGGCCTGG
TCGATGAGCAGATCAGGCATGCAATAACAAAAATGTCGCATGTTCATTTTCCAGGAGCTGAACCATATGTGAAAAACATA
ATGAATATGGGGGAAGAGTCATGGAGAATTTTCAATGCAGGTGATCCTGGAATTGAGAACATTAAACTTACCAAGTTATT
CAATAGGGAAGAATTAAAGGCTGAACTGAATATGGAGGTTGATGAAGATACGTTACTTGTTACATATCATCCAGTGACGC
TGGAACCTAACAGGCTTCCGTATCAAGTGGAAAATTTAATCAAGGCATTGAATGCAATAAATAAAAAGATGATAGTAACG
TATCCTAATTCAGACAATGGTAGCGACTACATAATAAAGAAGCTACAGGAATTTGCAAAAATTAATTCCAATGTTCACTT
GTTTAAAAATTTAGGCATTACCAGATATTTAAGTGTTATGAAACTATGTGGTGCTGTAGTTGGAAACTCATCCAGCGCAT
TAGTTGAAGCACCATATTTGAAAGTACCTGTTGTAAACATAGGGAACAGGCAGAAGGGAAGGCTTATGGCAGAAAACATT
ATAAGCTGTAGCAATAAGTATGAAGATGTTGTAAAAGCTGTAAACAAGGCATTAAGCAGTGAGTTCAGGGAAAGGGTTAA
GAGATCTAAAAGTCTGTATGGAGAAGGAAATACCAGTGAAGAAATAGTCAAGGTGCTGGAAAGCATCGAAATTAATGATG
AATTATTAAAAAAGAAACTTGTTTGGAGTTGA

Upstream 100 bases:

>100_bases
AATATAATGGCATTAGCCAGATACAGGGGAAGCAGTGTTTCCAGACAATTTGCTGAAGCATTCATGTTGGTTAGAGACAT
ATGTTAAAGGAGAGTTCATA

Downstream 100 bases:

>100_bases
TAACATGTCAGTATTAATAATTGCAGAAGCGGGAGTCAATCATAATGGAGATGTCAAAATAGCAAAAGAACTTGTGGACA
TGGCTGTTGAATGTGGAGCA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MRKVCVVTGTRAEYGLLRNILVKIKDSNNLRLHLVVTGAHLSEDYGCTVDEIESDGFAIDEKLPILMNGNSKSVIAKEMG
MLMIQLSQTFERLKPDMLLVLGDRYEIFAATSTAMAMNIPIAHISGGEITEGLVDEQIRHAITKMSHVHFPGAEPYVKNI
MNMGEESWRIFNAGDPGIENIKLTKLFNREELKAELNMEVDEDTLLVTYHPVTLEPNRLPYQVENLIKALNAINKKMIVT
YPNSDNGSDYIIKKLQEFAKINSNVHLFKNLGITRYLSVMKLCGAVVGNSSSALVEAPYLKVPVVNIGNRQKGRLMAENI
ISCSNKYEDVVKAVNKALSSEFRERVKRSKSLYGEGNTSEEIVKVLESIEINDELLKKKLVWS

Sequences:

>Translated_383_residues
MRKVCVVTGTRAEYGLLRNILVKIKDSNNLRLHLVVTGAHLSEDYGCTVDEIESDGFAIDEKLPILMNGNSKSVIAKEMG
MLMIQLSQTFERLKPDMLLVLGDRYEIFAATSTAMAMNIPIAHISGGEITEGLVDEQIRHAITKMSHVHFPGAEPYVKNI
MNMGEESWRIFNAGDPGIENIKLTKLFNREELKAELNMEVDEDTLLVTYHPVTLEPNRLPYQVENLIKALNAINKKMIVT
YPNSDNGSDYIIKKLQEFAKINSNVHLFKNLGITRYLSVMKLCGAVVGNSSSALVEAPYLKVPVVNIGNRQKGRLMAENI
ISCSNKYEDVVKAVNKALSSEFRERVKRSKSLYGEGNTSEEIVKVLESIEINDELLKKKLVWS
>Mature_383_residues
MRKVCVVTGTRAEYGLLRNILVKIKDSNNLRLHLVVTGAHLSEDYGCTVDEIESDGFAIDEKLPILMNGNSKSVIAKEMG
MLMIQLSQTFERLKPDMLLVLGDRYEIFAATSTAMAMNIPIAHISGGEITEGLVDEQIRHAITKMSHVHFPGAEPYVKNI
MNMGEESWRIFNAGDPGIENIKLTKLFNREELKAELNMEVDEDTLLVTYHPVTLEPNRLPYQVENLIKALNAINKKMIVT
YPNSDNGSDYIIKKLQEFAKINSNVHLFKNLGITRYLSVMKLCGAVVGNSSSALVEAPYLKVPVVNIGNRQKGRLMAENI
ISCSNKYEDVVKAVNKALSSEFRERVKRSKSLYGEGNTSEEIVKVLESIEINDELLKKKLVWS

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI298566312, Length=382, Percent_Identity=32.7225130890052, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI190014632, Length=382, Percent_Identity=32.7225130890052, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4885285, Length=382, Percent_Identity=32.7225130890052, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI298566325, Length=350, Percent_Identity=30.8571428571429, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI298566315, Length=327, Percent_Identity=27.82874617737, Blast_Score=132, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: NA

Molecular weight: Translated: 42947; Mature: 42947

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKVCVVTGTRAEYGLLRNILVKIKDSNNLRLHLVVTGAHLSEDYGCTVDEIESDGFAID
CCEEEEEECCCHHHHHHHHHHEEEECCCCEEEEEEEEECCCCCCCCCCHHHCCCCCEEEC
EKLPILMNGNSKSVIAKEMGMLMIQLSQTFERLKPDMLLVLGDRYEIFAATSTAMAMNIP
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCEEEEECC
IAHISGGEITEGLVDEQIRHAITKMSHVHFPGAEPYVKNIMNMGEESWRIFNAGDPGIEN
EEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHEEEEECCCCCCCC
IKLTKLFNREELKAELNMEVDEDTLLVTYHPVTLEPNRLPYQVENLIKALNAINKKMIVT
EEEEEECCHHHHHHHCCCEECCCEEEEEEECEEECCCCCCHHHHHHHHHHHHCCCEEEEE
YPNSDNGSDYIIKKLQEFAKINSNVHLFKNLGITRYLSVMKLCGAVVGNSSSALVEAPYL
CCCCCCCHHHHHHHHHHHHHHCCCEEEEHHCCHHHHHHHHHHHHHHHCCCCCCEEECCEE
KVPVVNIGNRQKGRLMAENIISCSNKYEDVVKAVNKALSSEFRERVKRSKSLYGEGNTSE
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
EIVKVLESIEINDELLKKKLVWS
HHHHHHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure
MRKVCVVTGTRAEYGLLRNILVKIKDSNNLRLHLVVTGAHLSEDYGCTVDEIESDGFAID
CCEEEEEECCCHHHHHHHHHHEEEECCCCEEEEEEEEECCCCCCCCCCHHHCCCCCEEEC
EKLPILMNGNSKSVIAKEMGMLMIQLSQTFERLKPDMLLVLGDRYEIFAATSTAMAMNIP
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCEEEEECC
IAHISGGEITEGLVDEQIRHAITKMSHVHFPGAEPYVKNIMNMGEESWRIFNAGDPGIEN
EEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHEEEEECCCCCCCC
IKLTKLFNREELKAELNMEVDEDTLLVTYHPVTLEPNRLPYQVENLIKALNAINKKMIVT
EEEEEECCHHHHHHHCCCEECCCEEEEEEECEEECCCCCCHHHHHHHHHHHHCCCEEEEE
YPNSDNGSDYIIKKLQEFAKINSNVHLFKNLGITRYLSVMKLCGAVVGNSSSALVEAPYL
CCCCCCCHHHHHHHHHHHHHHCCCEEEEHHCCHHHHHHHHHHHHHHHCCCCCCEEECCEE
KVPVVNIGNRQKGRLMAENIISCSNKYEDVVKAVNKALSSEFRERVKRSKSLYGEGNTSE
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
EIVKVLESIEINDELLKKKLVWS
HHHHHHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]