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The map label for this gene is flp [H]

Identifier: 170756630

GI number: 170756630

Start: 915102

End: 916550

Strand: Direct

Name: flp [H]

Synonym: CLD_3766

Alternate gene names: 170756630

Gene position: 915102-916550 (Clockwise)

Preceding gene: 170755814

Following gene: 170754897

Centisome position: 23.12

GC content: 41.34

Gene sequence:

>1449_bases
ATGAAAAAGACTATTGTTTTTGTATTAACGATACTTATATTATTCTCAGGATTCCCAACACAAGGTTGTCCGTTGTCAAA
TGCGCAATCTGCGGCAATACAAGCGTTGCTGGATGATGCCTGTCGTATATCAGGTGTGCCAGGAATGTCAATTTCAATAC
TTGCTGATGATGAAGTATTCTACTTTTCTTCTGGGTATGCAGATCGTGAAAAGGGACTGTCGGCAAGTGAAAATACGCTA
TATGAGCTGGCTTCGGTCAGCAAAGCTTTTACGGGCATAGGTATTCTGATGATGGAAAAACAAGGACTGCTGTCAATGAC
TGACCCCATCCAAAAGTATTTACCTTGGTTTACGTTAAAGCATCAGGGGAAACCCATTGATATGCAAAGTATTACACTCA
ATAACTTTTTACACCATACTAGCGGCTTAACAAATGGCAGTCACAGTCAAATCATTCCACAAGGCAATACGCCAGAGATG
TTGCGAAAAACCGTAGAAATGCTCGTAGATGCTGAATTGTCATTCTATCCTGGTGAGCAGTATAATTACGGAACTGTTAA
TTATGACGTATTAGGTCTGGTTATTGAAATTGTGTCGGGTCAGAGCTATGAAGACTACATGAAAAAGCAAGTGTTTCAGC
CGTTAGGGCTACACCAGACGTATGTTTACAAAGAAGATGCTCAAGCTACTGGACAATTGGCACAGGGCTACCGCTCTTCC
TTCTTTATGACGACCCCATATGATGCACCAGATTATGCTGGGAATAAACCCGCGGGCTACATCATTTCTTGCGCTAAAGA
TATGGCGCGTTGGATGGGCATACAGATGGGTATTGTTCAGGATATACCCGAAATATTCCATGAGATTATCGAGAAGTCCC
ATCATGGGGACATGTCTGTTCCAGATGTCAACGGAATGTTTTATGCGGTGGGGTGGTCAGTAAATTCCGAACAAACAATT
ATTGAACACTCGGGGGGCAACCCGAATTTTGCAACCGAAGTGGCAATACTGCCAAACGAACGCACAGCCGTTTGCTTGCT
GACCAACGGCACAAATACCAATAGAAATTTAGTGTTAAAAATTAAGGAAATATTGGATGGTAATCTTTCTCAGTCATACG
AGATAAGCGGCACACAGTTTCTTGACATCACTTTGTCGTCTGCCACAATTATTTGTTGCCTGTTGGCGGTTCTGTTCTTT
CTTTTAGGATTACGGAGAAAGAAAATGAATGAGCGGCAGCCAATGACAAAAAAGAGAATAATCGTAACAATTATTTTGCT
GATTGCTACGATTGTCCTGTGTATAATGTGCTTTGCCTTCGATTGGTCAACGATACTTATTTGGCAAACATATAGTGTTC
TTACAGCTTTGATTTCATCGGCATTATTAACTGGAAGCATTACATGGTTTGTATACACTCACCGATATAACACCTCGCTC
CGAAAATAA

Upstream 100 bases:

>100_bases
ACACAAAAATTAATAACAAATGAAAATTTATTAAATTCCAATTTGATATTGAGTAATATAAATTAGAATTTAGTTTAGTA
GTTGTAACTAAGGAGAATTT

Downstream 100 bases:

>100_bases
TCATAATGTTAAGTAATTAAATTCCAGCTTAAGGTTCAGTAATATAAATAGTAAATTTGTTTAATACACACTTATAGTGC
AATAAAATGGCATGTAAAAA

Product: beta-lactamase

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MKKTIVFVLTILILFSGFPTQGCPLSNAQSAAIQALLDDACRISGVPGMSISILADDEVFYFSSGYADREKGLSASENTL
YELASVSKAFTGIGILMMEKQGLLSMTDPIQKYLPWFTLKHQGKPIDMQSITLNNFLHHTSGLTNGSHSQIIPQGNTPEM
LRKTVEMLVDAELSFYPGEQYNYGTVNYDVLGLVIEIVSGQSYEDYMKKQVFQPLGLHQTYVYKEDAQATGQLAQGYRSS
FFMTTPYDAPDYAGNKPAGYIISCAKDMARWMGIQMGIVQDIPEIFHEIIEKSHHGDMSVPDVNGMFYAVGWSVNSEQTI
IEHSGGNPNFATEVAILPNERTAVCLLTNGTNTNRNLVLKIKEILDGNLSQSYEISGTQFLDITLSSATIICCLLAVLFF
LLGLRRKKMNERQPMTKKRIIVTIILLIATIVLCIMCFAFDWSTILIWQTYSVLTALISSALLTGSITWFVYTHRYNTSL
RK

Sequences:

>Translated_482_residues
MKKTIVFVLTILILFSGFPTQGCPLSNAQSAAIQALLDDACRISGVPGMSISILADDEVFYFSSGYADREKGLSASENTL
YELASVSKAFTGIGILMMEKQGLLSMTDPIQKYLPWFTLKHQGKPIDMQSITLNNFLHHTSGLTNGSHSQIIPQGNTPEM
LRKTVEMLVDAELSFYPGEQYNYGTVNYDVLGLVIEIVSGQSYEDYMKKQVFQPLGLHQTYVYKEDAQATGQLAQGYRSS
FFMTTPYDAPDYAGNKPAGYIISCAKDMARWMGIQMGIVQDIPEIFHEIIEKSHHGDMSVPDVNGMFYAVGWSVNSEQTI
IEHSGGNPNFATEVAILPNERTAVCLLTNGTNTNRNLVLKIKEILDGNLSQSYEISGTQFLDITLSSATIICCLLAVLFF
LLGLRRKKMNERQPMTKKRIIVTIILLIATIVLCIMCFAFDWSTILIWQTYSVLTALISSALLTGSITWFVYTHRYNTSL
RK
>Mature_482_residues
MKKTIVFVLTILILFSGFPTQGCPLSNAQSAAIQALLDDACRISGVPGMSISILADDEVFYFSSGYADREKGLSASENTL
YELASVSKAFTGIGILMMEKQGLLSMTDPIQKYLPWFTLKHQGKPIDMQSITLNNFLHHTSGLTNGSHSQIIPQGNTPEM
LRKTVEMLVDAELSFYPGEQYNYGTVNYDVLGLVIEIVSGQSYEDYMKKQVFQPLGLHQTYVYKEDAQATGQLAQGYRSS
FFMTTPYDAPDYAGNKPAGYIISCAKDMARWMGIQMGIVQDIPEIFHEIIEKSHHGDMSVPDVNGMFYAVGWSVNSEQTI
IEHSGGNPNFATEVAILPNERTAVCLLTNGTNTNRNLVLKIKEILDGNLSQSYEISGTQFLDITLSSATIICCLLAVLFF
LLGLRRKKMNERQPMTKKRIIVTIILLIATIVLCIMCFAFDWSTILIWQTYSVLTALISSALLTGSITWFVYTHRYNTSL
RK

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790593, Length=361, Percent_Identity=24.6537396121884, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082101, Length=187, Percent_Identity=26.7379679144385, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1786574, Length=362, Percent_Identity=23.7569060773481, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI115533026, Length=253, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17550934, Length=187, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17565630, Length=198, Percent_Identity=28.7878787878788, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 53675; Mature: 53675

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTIVFVLTILILFSGFPTQGCPLSNAQSAAIQALLDDACRISGVPGMSISILADDEVF
CCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEE
YFSSGYADREKGLSASENTLYELASVSKAFTGIGILMMEKQGLLSMTDPIQKYLPWFTLK
EEECCCCHHHCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHCCCEEEE
HQGKPIDMQSITLNNFLHHTSGLTNGSHSQIIPQGNTPEMLRKTVEMLVDAELSFYPGEQ
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCEECCCCC
YNYGTVNYDVLGLVIEIVSGQSYEDYMKKQVFQPLGLHQTYVYKEDAQATGQLAQGYRSS
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCC
FFMTTPYDAPDYAGNKPAGYIISCAKDMARWMGIQMGIVQDIPEIFHEIIEKSHHGDMSV
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCC
PDVNGMFYAVGWSVNSEQTIIEHSGGNPNFATEVAILPNERTAVCLLTNGTNTNRNLVLK
CCCCCEEEEEEECCCCCCEEEEECCCCCCCEEEEEEECCCCEEEEEEECCCCCCCEEEEE
IKEILDGNLSQSYEISGTQFLDITLSSATIICCLLAVLFFLLGLRRKKMNERQPMTKKRI
EHHHHCCCCCCCEECCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
IVTIILLIATIVLCIMCFAFDWSTILIWQTYSVLTALISSALLTGSITWFVYTHRYNTSL
HHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCC
RK
CC
>Mature Secondary Structure
MKKTIVFVLTILILFSGFPTQGCPLSNAQSAAIQALLDDACRISGVPGMSISILADDEVF
CCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEE
YFSSGYADREKGLSASENTLYELASVSKAFTGIGILMMEKQGLLSMTDPIQKYLPWFTLK
EEECCCCHHHCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHCCCEEEE
HQGKPIDMQSITLNNFLHHTSGLTNGSHSQIIPQGNTPEMLRKTVEMLVDAELSFYPGEQ
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCEECCCCC
YNYGTVNYDVLGLVIEIVSGQSYEDYMKKQVFQPLGLHQTYVYKEDAQATGQLAQGYRSS
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCC
FFMTTPYDAPDYAGNKPAGYIISCAKDMARWMGIQMGIVQDIPEIFHEIIEKSHHGDMSV
EEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCC
PDVNGMFYAVGWSVNSEQTIIEHSGGNPNFATEVAILPNERTAVCLLTNGTNTNRNLVLK
CCCCCEEEEEEECCCCCCEEEEECCCCCCCEEEEEEECCCCEEEEEEECCCCCCCEEEEE
IKEILDGNLSQSYEISGTQFLDITLSSATIICCLLAVLFFLLGLRRKKMNERQPMTKKRI
EHHHHCCCCCCCEECCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
IVTIILLIATIVLCIMCFAFDWSTILIWQTYSVLTALISSALLTGSITWFVYTHRYNTSL
HHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCC
RK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA