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The map label for this gene is folP

Identifier: 170756530

GI number: 170756530

Start: 939202

End: 940389

Strand: Direct

Name: folP

Synonym: CLD_3744

Alternate gene names: 170756530

Gene position: 939202-940389 (Clockwise)

Preceding gene: 170755668

Following gene: 170757743

Centisome position: 23.73

GC content: 30.22

Gene sequence:

>1188_bases
ATGATTATAGAATTAAATAAAAATAGTTTCCCAGAAGAGTTCAATAAGATAGAAGTACATGAGGGTAGTGTGAATATATT
TATGAATAAAAATAGTATTACCCCTTTAAAAATTTTTAATGTGCTAGCTCCTGCGGCCAATATAATAAAGCAAGAAATGC
TGGCTTTAGGTGGAGATTGTGCTGTAAATAAATATTGTATAAATTGCAAAGTGGAAACTTCAGATATAATTTTATTAGGA
ACCAAAAGACAATACAAAAAATTATTGCAAAAGCTTAAATGCATGACTTTTTTTAGAATAGAAGAAATAGTAGGGGAATT
AGAAAATTATATTAACAATCATAAAAAAATTAAAACGGTTTTAAGAGATGGAAGAGAAATAAACTATGAGAATTTAAAGG
TTATGGGAATTATAAATTGTACTCCAGATTCTTTTTATGAGGGTTCTAGAAAAAATTCTATAGAAGAAGCTTTAAATTCT
GCAGAAAAGATGTTAAAAGAAGGTGCAGAAATTTTAGATATAGGTGGAGAATCCACAAGACCAGGCTCTGACCCAGTAGA
TGAAGAGGAAGAAATAAAAAGAGTAGTTCCTGTTATAAGAGAGATAAAGAATAAATTTAAGGATGTCATAATTTCCATAG
ATACTTATAGAGCAAATACGGCAAAGGCTGCCATAGAGGCAGGGGCAGATATTGTAAATGATATAAGTGCTATGAAGTAT
GATGAAAATATGGTGAAAGTAGTTAAAGAATACAATGTACCTGTAATACTTATGCATGTAAAAGGAAAACCAAAGGATAT
GCAAATAGATCCAGTTTATGAGAATTTAATGAAAGAAATTCATCTTTATTTTAATGAGAGAATAGAGTACTGCAAATCTC
ATGGCATAACAGAGGATAAAATAATATTAGATCCAGGCATAGGTTTTGGAAAAACTGTAGAGCATAATCTAAAAATAATG
AACAGAATAGAAGAATTGAAAAGCTTTAATCTTCCAGTACTTTTAGCAGCCTCAAGAAAAGCTACCATAGGAAAAGTTTT
AGGAGACTTACCTACAGAAGAAAGATTAGAAGGAACCATAGCTTTATCCTGTTTAGCTGTAGATTCAGGACTTCAAATGG
TGAGAGTACATGATGTAAAAGAAAATACAAGAGCCATAAGAATGTTAGAGGCAGTAAGAAAAATATAA

Upstream 100 bases:

>100_bases
TAAAGAATTTATGAGAAATAATTAAAGTAAATTTCAGTTTGAGATAGTTCAATGTTTATATAGCTTAACAGAATGGTTAT
AAAGAAAAGGGGCGTTAAAA

Downstream 100 bases:

>100_bases
ATTATATTATAAAAATATATTTTAAAATCTAAAAAGTATAATCAAAATTAAATTATAATTTAAATTGCATCTTCTGATTT
TTAGGGCTGTAAGATAAATT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MIIELNKNSFPEEFNKIEVHEGSVNIFMNKNSITPLKIFNVLAPAANIIKQEMLALGGDCAVNKYCINCKVETSDIILLG
TKRQYKKLLQKLKCMTFFRIEEIVGELENYINNHKKIKTVLRDGREINYENLKVMGIINCTPDSFYEGSRKNSIEEALNS
AEKMLKEGAEILDIGGESTRPGSDPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKAAIEAGADIVNDISAMKY
DENMVKVVKEYNVPVILMHVKGKPKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDKIILDPGIGFGKTVEHNLKIM
NRIEELKSFNLPVLLAASRKATIGKVLGDLPTEERLEGTIALSCLAVDSGLQMVRVHDVKENTRAIRMLEAVRKI

Sequences:

>Translated_395_residues
MIIELNKNSFPEEFNKIEVHEGSVNIFMNKNSITPLKIFNVLAPAANIIKQEMLALGGDCAVNKYCINCKVETSDIILLG
TKRQYKKLLQKLKCMTFFRIEEIVGELENYINNHKKIKTVLRDGREINYENLKVMGIINCTPDSFYEGSRKNSIEEALNS
AEKMLKEGAEILDIGGESTRPGSDPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKAAIEAGADIVNDISAMKY
DENMVKVVKEYNVPVILMHVKGKPKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDKIILDPGIGFGKTVEHNLKIM
NRIEELKSFNLPVLLAASRKATIGKVLGDLPTEERLEGTIALSCLAVDSGLQMVRVHDVKENTRAIRMLEAVRKI
>Mature_395_residues
MIIELNKNSFPEEFNKIEVHEGSVNIFMNKNSITPLKIFNVLAPAANIIKQEMLALGGDCAVNKYCINCKVETSDIILLG
TKRQYKKLLQKLKCMTFFRIEEIVGELENYINNHKKIKTVLRDGREINYENLKVMGIINCTPDSFYEGSRKNSIEEALNS
AEKMLKEGAEILDIGGESTRPGSDPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKAAIEAGADIVNDISAMKY
DENMVKVVKEYNVPVILMHVKGKPKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDKIILDPGIGFGKTVEHNLKIM
NRIEELKSFNLPVLLAASRKATIGKVLGDLPTEERLEGTIALSCLAVDSGLQMVRVHDVKENTRAIRMLEAVRKI

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=272, Percent_Identity=41.9117647058824, Blast_Score=238, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6324073, Length=318, Percent_Identity=34.9056603773585, Blast_Score=164, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 44717; Mature: 44717

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIELNKNSFPEEFNKIEVHEGSVNIFMNKNSITPLKIFNVLAPAANIIKQEMLALGGDC
CEEEECCCCCCHHHCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
AVNKYCINCKVETSDIILLGTKRQYKKLLQKLKCMTFFRIEEIVGELENYINNHKKIKTV
EECEEEEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRDGREINYENLKVMGIINCTPDSFYEGSRKNSIEEALNSAEKMLKEGAEILDIGGESTR
HHCCCCCCCCCEEEEEEEECCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCC
PGSDPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKAAIEAGADIVNDISAMKY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCHHHHHHHHHHHH
DENMVKVVKEYNVPVILMHVKGKPKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDK
HHHHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IILDPGIGFGKTVEHNLKIMNRIEELKSFNLPVLLAASRKATIGKVLGDLPTEERLEGTI
EEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCHHHHCCEE
ALSCLAVDSGLQMVRVHDVKENTRAIRMLEAVRKI
EEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIIELNKNSFPEEFNKIEVHEGSVNIFMNKNSITPLKIFNVLAPAANIIKQEMLALGGDC
CEEEECCCCCCHHHCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
AVNKYCINCKVETSDIILLGTKRQYKKLLQKLKCMTFFRIEEIVGELENYINNHKKIKTV
EECEEEEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRDGREINYENLKVMGIINCTPDSFYEGSRKNSIEEALNSAEKMLKEGAEILDIGGESTR
HHCCCCCCCCCEEEEEEEECCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCC
PGSDPVDEEEEIKRVVPVIREIKNKFKDVIISIDTYRANTAKAAIEAGADIVNDISAMKY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCHHHHHHHHHHHH
DENMVKVVKEYNVPVILMHVKGKPKDMQIDPVYENLMKEIHLYFNERIEYCKSHGITEDK
HHHHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IILDPGIGFGKTVEHNLKIMNRIEELKSFNLPVLLAASRKATIGKVLGDLPTEERLEGTI
EEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHCCCCCHHHHCCEE
ALSCLAVDSGLQMVRVHDVKENTRAIRMLEAVRKI
EEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]