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The map label for this gene is icd [H]

Identifier: 170755526

GI number: 170755526

Start: 531912

End: 532910

Strand: Direct

Name: icd [H]

Synonym: CLD_0324

Alternate gene names: 170755526

Gene position: 531912-532910 (Clockwise)

Preceding gene: 170756378

Following gene: 170755089

Centisome position: 13.44

GC content: 32.33

Gene sequence:

>999_bases
ATGAAACACAATATAACTTTAATACCAGGAGATGGTATAGGACCAGAAGTAACTGAAGCTGCAAGGAAAGTTATAGATGC
AGTAGGAGTAGATATTAATTGGCATGTAGTAGAGGCTGGGGAAAAAGTTTTAGATCAATATGGAACTCCCCTTCCAGACT
ATGTTTTAGATAGTATAAAGGAGACTAAAGTAGCATTGAAGGGTCCAGTAACTACTCCTGTAGGAAAGGGATTTAGAAGT
GTTAATGTTACTTTAAGAAAAAGCTTAAATTTATATGCAAATATAAGACCTGTAAAAAGTTATAAAGGAATAAAATCTAG
ATATGAAAATGTGGATTTAATAATTGTGAGGGAAAACACAGAAGATTTATATGCGGGAATTGAGCATATGATAGGTGATG
ATATAGCAGAAAGTATAAAGGTAATTACTAAAAAGGCTAGTGATAGAATAGTAGATTATGCTTTTGATATGGCAAGAAAA
GAAAATAGAAATAAGGTAACTGCAGTGCACAAGGCTAACATAATGAAATTATCAGATGGATTATTTTTAAATTGTGCAAA
GGAAGTTGCTAGTAAAAATAAGGATATTGATTTTGAAGATGTAATAGTAGATGCTATGGCCATGAAATTAGTTTTAAATC
CAGAAAAATATGATGTTTTAGTAATGCCTAATTTATATGGTGATATTTTATCAGACATGGCAGCAGGTTTAGTTGGTGGA
TTAGGATTACTTCCAGGAGCTAATATAGGATATGAGGGAGCTGTGTTTGAAGCAGCCCATGGTGCAGCACCTGATATTGC
AGGAAAAAATAAAGCTAATCCAACAGCTTGTATACTAAGTGGCGCCATGATGTTAAACTATATCGGTGAAAATGAAAAAG
CTAAAAAAATAGAAAATGCTATAGAAAAAGTATTTGTAGAAGGAAAATGTCTTACAGAGGATTTAGGTGGAAGTTCTACA
ACAGAAGAATTTACAAAGGCAATTATAGAAAATCTTTAA

Upstream 100 bases:

>100_bases
ATAGACAAAAGAAGATGATTTTAAAGGGCGGATTATTAAATTTAATAAAAAGTTCTCAACAATAGCTACAAAAATTTGGT
TAAGTTTTCGGAGGGATATG

Downstream 100 bases:

>100_bases
ATTACTATATAATTCTTAATTTGTTATTACCTTTTAATTAGATATAAATTTTAGATCTCCTTTTTAAATTATATTTAAGT
TTTTCTTATGATTTTAAGAT

Product: isocitrate/isopropylmalate family dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKHNITLIPGDGIGPEVTEAARKVIDAVGVDINWHVVEAGEKVLDQYGTPLPDYVLDSIKETKVALKGPVTTPVGKGFRS
VNVTLRKSLNLYANIRPVKSYKGIKSRYENVDLIIVRENTEDLYAGIEHMIGDDIAESIKVITKKASDRIVDYAFDMARK
ENRNKVTAVHKANIMKLSDGLFLNCAKEVASKNKDIDFEDVIVDAMAMKLVLNPEKYDVLVMPNLYGDILSDMAAGLVGG
LGLLPGANIGYEGAVFEAAHGAAPDIAGKNKANPTACILSGAMMLNYIGENEKAKKIENAIEKVFVEGKCLTEDLGGSST
TEEFTKAIIENL

Sequences:

>Translated_332_residues
MKHNITLIPGDGIGPEVTEAARKVIDAVGVDINWHVVEAGEKVLDQYGTPLPDYVLDSIKETKVALKGPVTTPVGKGFRS
VNVTLRKSLNLYANIRPVKSYKGIKSRYENVDLIIVRENTEDLYAGIEHMIGDDIAESIKVITKKASDRIVDYAFDMARK
ENRNKVTAVHKANIMKLSDGLFLNCAKEVASKNKDIDFEDVIVDAMAMKLVLNPEKYDVLVMPNLYGDILSDMAAGLVGG
LGLLPGANIGYEGAVFEAAHGAAPDIAGKNKANPTACILSGAMMLNYIGENEKAKKIENAIEKVFVEGKCLTEDLGGSST
TEEFTKAIIENL
>Mature_332_residues
MKHNITLIPGDGIGPEVTEAARKVIDAVGVDINWHVVEAGEKVLDQYGTPLPDYVLDSIKETKVALKGPVTTPVGKGFRS
VNVTLRKSLNLYANIRPVKSYKGIKSRYENVDLIIVRENTEDLYAGIEHMIGDDIAESIKVITKKASDRIVDYAFDMARK
ENRNKVTAVHKANIMKLSDGLFLNCAKEVASKNKDIDFEDVIVDAMAMKLVLNPEKYDVLVMPNLYGDILSDMAAGLVGG
LGLLPGANIGYEGAVFEAAHGAAPDIAGKNKANPTACILSGAMMLNYIGENEKAKKIENAIEKVFVEGKCLTEDLGGSST
TEEFTKAIIENL

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=336, Percent_Identity=48.2142857142857, Blast_Score=328, Evalue=4e-90,
Organism=Homo sapiens, GI28178821, Length=339, Percent_Identity=45.7227138643068, Blast_Score=269, Evalue=2e-72,
Organism=Homo sapiens, GI28178816, Length=339, Percent_Identity=45.4277286135693, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI4758582, Length=334, Percent_Identity=42.814371257485, Blast_Score=264, Evalue=7e-71,
Organism=Homo sapiens, GI28178838, Length=303, Percent_Identity=44.5544554455446, Blast_Score=254, Evalue=8e-68,
Organism=Homo sapiens, GI28178819, Length=200, Percent_Identity=50.5, Blast_Score=184, Evalue=1e-46,
Organism=Escherichia coli, GI1787381, Length=389, Percent_Identity=39.0745501285347, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI87081683, Length=331, Percent_Identity=35.3474320241692, Blast_Score=181, Evalue=6e-47,
Organism=Escherichia coli, GI1788101, Length=357, Percent_Identity=32.4929971988796, Blast_Score=175, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71986051, Length=324, Percent_Identity=49.3827160493827, Blast_Score=328, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI25144293, Length=336, Percent_Identity=40.7738095238095, Blast_Score=255, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17505779, Length=333, Percent_Identity=40.8408408408408, Blast_Score=250, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI17550882, Length=337, Percent_Identity=40.0593471810089, Blast_Score=249, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6324709, Length=335, Percent_Identity=48.0597014925373, Blast_Score=331, Evalue=8e-92,
Organism=Saccharomyces cerevisiae, GI6324291, Length=335, Percent_Identity=45.6716417910448, Blast_Score=290, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6322097, Length=349, Percent_Identity=42.6934097421203, Blast_Score=254, Evalue=9e-69,
Organism=Saccharomyces cerevisiae, GI6319830, Length=358, Percent_Identity=32.9608938547486, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24643270, Length=328, Percent_Identity=53.6585365853659, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24643268, Length=328, Percent_Identity=53.6585365853659, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24661184, Length=334, Percent_Identity=48.8023952095808, Blast_Score=337, Evalue=9e-93,
Organism=Drosophila melanogaster, GI281362242, Length=337, Percent_Identity=45.6973293768546, Blast_Score=257, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24648872, Length=337, Percent_Identity=45.6973293768546, Blast_Score=257, Evalue=6e-69,
Organism=Drosophila melanogaster, GI161078633, Length=333, Percent_Identity=39.6396396396396, Blast_Score=242, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24650122, Length=333, Percent_Identity=39.6396396396396, Blast_Score=242, Evalue=2e-64,
Organism=Drosophila melanogaster, GI161078635, Length=333, Percent_Identity=39.6396396396396, Blast_Score=242, Evalue=2e-64,
Organism=Drosophila melanogaster, GI161078637, Length=333, Percent_Identity=39.6396396396396, Blast_Score=242, Evalue=2e-64,
Organism=Drosophila melanogaster, GI161078639, Length=328, Percent_Identity=39.6341463414634, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI20130355, Length=330, Percent_Identity=34.8484848484849, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI45550436, Length=247, Percent_Identity=25.9109311740891, Blast_Score=95, Evalue=7e-20,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 35999; Mature: 35999

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHNITLIPGDGIGPEVTEAARKVIDAVGVDINWHVVEAGEKVLDQYGTPLPDYVLDSIK
CCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHH
ETKVALKGPVTTPVGKGFRSVNVTLRKSLNLYANIRPVKSYKGIKSRYENVDLIIVRENT
HHHEEECCCCCCCCCCCCCEEEHEEEECCCEEEECEEHHHHHHHHHHHCCCEEEEEECCC
EDLYAGIEHMIGDDIAESIKVITKKASDRIVDYAFDMARKENRNKVTAVHKANIMKLSDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCC
LFLNCAKEVASKNKDIDFEDVIVDAMAMKLVLNPEKYDVLVMPNLYGDILSDMAAGLVGG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEECCCCEEEEECCHHHHHHHHHHHHHHHHH
LGLLPGANIGYEGAVFEAAHGAAPDIAGKNKANPTACILSGAMMLNYIGENEKAKKIENA
HHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
IEKVFVEGKCLTEDLGGSSTTEEFTKAIIENL
HHHHHHCCCEEHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKHNITLIPGDGIGPEVTEAARKVIDAVGVDINWHVVEAGEKVLDQYGTPLPDYVLDSIK
CCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHH
ETKVALKGPVTTPVGKGFRSVNVTLRKSLNLYANIRPVKSYKGIKSRYENVDLIIVRENT
HHHEEECCCCCCCCCCCCCEEEHEEEECCCEEEECEEHHHHHHHHHHHCCCEEEEEECCC
EDLYAGIEHMIGDDIAESIKVITKKASDRIVDYAFDMARKENRNKVTAVHKANIMKLSDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEECCC
LFLNCAKEVASKNKDIDFEDVIVDAMAMKLVLNPEKYDVLVMPNLYGDILSDMAAGLVGG
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEECCCCEEEEECCHHHHHHHHHHHHHHHHH
LGLLPGANIGYEGAVFEAAHGAAPDIAGKNKANPTACILSGAMMLNYIGENEKAKKIENA
HHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
IEKVFVEGKCLTEDLGGSSTTEEFTKAIIENL
HHHHHHCCCEEHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1539996 [H]