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The map label for this gene is cadA

Identifier: 170755351

GI number: 170755351

Start: 594333

End: 596561

Strand: Direct

Name: cadA

Synonym: CLD_0267

Alternate gene names: 170755351

Gene position: 594333-596561 (Clockwise)

Preceding gene: 170757102

Following gene: 170756515

Centisome position: 15.02

GC content: 29.74

Gene sequence:

>2229_bases
ATGATTATAAAAAAGAAATTGCTTTTAAAAGGCTTACATTGTGCCAATTGTGCAGCGAAAATAGAACGAGCTGTGCAAAA
GCTAAATATAATAGAGGAAGCTAACTATAATTTTAATAATTCAACTTTGATTATTAACTTAGAAGAAACTCATAAAGACA
GTATTATAAAAACAATACAAGAAATAGTAGATAGAATAGAACCCGGGGTAAAGGTAATAGATAAAGAAAATTTAAAAAGA
ACAGTAGTGCATGCCCCTGTTAAAAATAGTAGTAATTTAAAGATGCAGAATAATAAAGAGGAAAATTTGAAATTAGATAA
AAAAGAAAATAGTTATGAGCACAATCATGATCATAGTCATGGACACAGTCATGATGGAGAAGATAGTGACGAGTTAGAAA
AGAAGACTCTTATAAGAATTATTTCAGGAGTGGTTTTATTAATTTTAGCTACCGTATTGAAATCTAAAGAAACTTTGTCT
ATAGGTCTATATTTAGCTTCATATGTATTAATTGGAGGTAAGGTAATATTAAGTTCTATAAGAAATATATCTAAAGGACA
AGTATTTGATGAGAACTTTTTAATGGCTGTTGCAACTGTAGCGGCTATAGGAGTAAAACAGTATCCAGAAGCAGTAGCGG
TTATGCTATTTTATGAAGTAGGGGAGTTCTTACAAGATAAAGCTGTTAATAAATCTAGAAAATCTATAACATCACTTATG
AATATAAGACCTGACTATGCCAATTTAGTTAGAGGTGAAGATATAGAAGTAGTTTCTCCAGAAGATATTAATATAGATGA
TATTATAATGGTAAAACCGGGAGAAAAAATTCCTCTAGATGGTATAGTTGTAGAAGGACAATCTTTTGTAGATACATCAG
CTATAACAGGTGAATCTTTAATAAGTGAAGTTTCAAAAGATAGTAATGTATTAAGTGGATATATAAACAAAAATGGTGTT
ATAAAAATAAAAATTACAAAAACCTTTGGAGAATCTACAGTGTCCAAAATATTGGAATTAACAGAAAACGCATCAGCTAC
TAAGGCAAATACAGAAAAATTTATAACAAAGTTCGCCAGATATTATACTCCTGTAGTTGTTTTTGCTGCTTTAGCTTTAT
CAGTAATTCCTACACTAATACTAAAAGATCCAGATATATCTAAATGGATTTATAGAGCAGCTGTATTTTTAGTAGTATCT
TGTCCATGTGCTTTAGTAATATCAATACCTTTAAGCTTCTTTGCTGGTATTGGAGGGGCATCTAAAAAAGGCGTTTTAAT
AAAAACAGGAACAGCATTAGAAGCTCTAAATGATGCAGATACAATAGTATTTGATAAAACAGGAACTCTAACTAAAGGTG
TGTTTAAAGTATCAAAAATTGAGTCAGAAGAAGGAGTAAATACAGAAGAATTAATAGAATATGCGGCTTTAGTAGAAAGT
TATTCTAATCACCCTATCGCAAAATCTATACTAAAGTATTATGAAAAAACCATAGATAATAAAAGAATAGAAGGTTATGA
AGAAATAGTTGCAAGAGGTGTAACTGCTTATATTGATGGCAAAAAAGTTTATGCTGGTAACAATAAATTAATGGAAGAAT
TAAATATTAACTATAAAAAAGCTCAAGAGGATGGAGTAATCCTTTATATAGCATTAGAAGATAAGTATATAGGTTATATA
GTTATAAACGACGAAATAAAGAAAGATTCAAAAGAAACAATAAAATCATTAAAAGATATAGGCATAAAAAAAGCAGCTAT
GCTTACAGGAGATAGAAAATCTACAGCTAATAATATAGGGACTTTTCTAGGAATGGATGAAATATACTCAGAACTTTTAC
CACAGGAAAAGGTAGAAAAGATGCAGACCTTAAAGTCTAAAACATCTAAAGATGGAAAAATTGTTTTTGTAGGAGATGGA
GTAAATGATGCTCCAGTATTAGCTATGTCAGATATAGGGGTATCCATGGGAGGATTAGGATCTGATGCAGCTATAGAAGC
ATCTGATTTAGTTTTAATGTCTGATGAGCCATCAAAATTAGTAGATGCTATAAAAATAGCAAGAAAAACTCATAAAATAG
TATGGCAAAATATAATTATAGTTTTAATAATTAAGTTTGCAGTATTAGCTCTAGCTATAATGGGAAAAAGTACTATGTGG
ATGGCTGTCTTTGCCGATGTAGGTGTGGCTTTAATAGCAGTAATAAATGCATTAAGAATACTAAAATAA

Upstream 100 bases:

>100_bases
ACTAGAACACATAATGCATAGATAAAATTAAGTTTAATATTTTATTGTAATTTTAGAAATTTTGATTTTTTAATAATTAT
TTTAGAAGGATGGTGGGATT

Downstream 100 bases:

>100_bases
AAATTTACTAAAATAATAACTTTCTAAAGAACAATAGGAACGAATGATTTTAAAGAAAAATATTTAATTATATTTATATA
GTTTCAGTTAAGTAATTTTA

Product: cadmium-translocating P-type ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 742; Mature: 742

Protein sequence:

>742_residues
MIIKKKLLLKGLHCANCAAKIERAVQKLNIIEEANYNFNNSTLIINLEETHKDSIIKTIQEIVDRIEPGVKVIDKENLKR
TVVHAPVKNSSNLKMQNNKEENLKLDKKENSYEHNHDHSHGHSHDGEDSDELEKKTLIRIISGVVLLILATVLKSKETLS
IGLYLASYVLIGGKVILSSIRNISKGQVFDENFLMAVATVAAIGVKQYPEAVAVMLFYEVGEFLQDKAVNKSRKSITSLM
NIRPDYANLVRGEDIEVVSPEDINIDDIIMVKPGEKIPLDGIVVEGQSFVDTSAITGESLISEVSKDSNVLSGYINKNGV
IKIKITKTFGESTVSKILELTENASATKANTEKFITKFARYYTPVVVFAALALSVIPTLILKDPDISKWIYRAAVFLVVS
CPCALVISIPLSFFAGIGGASKKGVLIKTGTALEALNDADTIVFDKTGTLTKGVFKVSKIESEEGVNTEELIEYAALVES
YSNHPIAKSILKYYEKTIDNKRIEGYEEIVARGVTAYIDGKKVYAGNNKLMEELNINYKKAQEDGVILYIALEDKYIGYI
VINDEIKKDSKETIKSLKDIGIKKAAMLTGDRKSTANNIGTFLGMDEIYSELLPQEKVEKMQTLKSKTSKDGKIVFVGDG
VNDAPVLAMSDIGVSMGGLGSDAAIEASDLVLMSDEPSKLVDAIKIARKTHKIVWQNIIIVLIIKFAVLALAIMGKSTMW
MAVFADVGVALIAVINALRILK

Sequences:

>Translated_742_residues
MIIKKKLLLKGLHCANCAAKIERAVQKLNIIEEANYNFNNSTLIINLEETHKDSIIKTIQEIVDRIEPGVKVIDKENLKR
TVVHAPVKNSSNLKMQNNKEENLKLDKKENSYEHNHDHSHGHSHDGEDSDELEKKTLIRIISGVVLLILATVLKSKETLS
IGLYLASYVLIGGKVILSSIRNISKGQVFDENFLMAVATVAAIGVKQYPEAVAVMLFYEVGEFLQDKAVNKSRKSITSLM
NIRPDYANLVRGEDIEVVSPEDINIDDIIMVKPGEKIPLDGIVVEGQSFVDTSAITGESLISEVSKDSNVLSGYINKNGV
IKIKITKTFGESTVSKILELTENASATKANTEKFITKFARYYTPVVVFAALALSVIPTLILKDPDISKWIYRAAVFLVVS
CPCALVISIPLSFFAGIGGASKKGVLIKTGTALEALNDADTIVFDKTGTLTKGVFKVSKIESEEGVNTEELIEYAALVES
YSNHPIAKSILKYYEKTIDNKRIEGYEEIVARGVTAYIDGKKVYAGNNKLMEELNINYKKAQEDGVILYIALEDKYIGYI
VINDEIKKDSKETIKSLKDIGIKKAAMLTGDRKSTANNIGTFLGMDEIYSELLPQEKVEKMQTLKSKTSKDGKIVFVGDG
VNDAPVLAMSDIGVSMGGLGSDAAIEASDLVLMSDEPSKLVDAIKIARKTHKIVWQNIIIVLIIKFAVLALAIMGKSTMW
MAVFADVGVALIAVINALRILK
>Mature_742_residues
MIIKKKLLLKGLHCANCAAKIERAVQKLNIIEEANYNFNNSTLIINLEETHKDSIIKTIQEIVDRIEPGVKVIDKENLKR
TVVHAPVKNSSNLKMQNNKEENLKLDKKENSYEHNHDHSHGHSHDGEDSDELEKKTLIRIISGVVLLILATVLKSKETLS
IGLYLASYVLIGGKVILSSIRNISKGQVFDENFLMAVATVAAIGVKQYPEAVAVMLFYEVGEFLQDKAVNKSRKSITSLM
NIRPDYANLVRGEDIEVVSPEDINIDDIIMVKPGEKIPLDGIVVEGQSFVDTSAITGESLISEVSKDSNVLSGYINKNGV
IKIKITKTFGESTVSKILELTENASATKANTEKFITKFARYYTPVVVFAALALSVIPTLILKDPDISKWIYRAAVFLVVS
CPCALVISIPLSFFAGIGGASKKGVLIKTGTALEALNDADTIVFDKTGTLTKGVFKVSKIESEEGVNTEELIEYAALVES
YSNHPIAKSILKYYEKTIDNKRIEGYEEIVARGVTAYIDGKKVYAGNNKLMEELNINYKKAQEDGVILYIALEDKYIGYI
VINDEIKKDSKETIKSLKDIGIKKAAMLTGDRKSTANNIGTFLGMDEIYSELLPQEKVEKMQTLKSKTSKDGKIVFVGDG
VNDAPVLAMSDIGVSMGGLGSDAAIEASDLVLMSDEPSKLVDAIKIARKTHKIVWQNIIIVLIIKFAVLALAIMGKSTMW
MAVFADVGVALIAVINALRILK

Specific function: Couples the hydrolysis of ATP with the transport of cadmium, zinc and cobalt out of the cell. Does not seem to transport copper [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=594, Percent_Identity=27.9461279461279, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI55743073, Length=558, Percent_Identity=28.1362007168459, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI115529486, Length=319, Percent_Identity=29.7805642633229, Blast_Score=155, Evalue=1e-37,
Organism=Escherichia coli, GI1789879, Length=744, Percent_Identity=29.4354838709677, Blast_Score=302, Evalue=6e-83,
Organism=Escherichia coli, GI1786691, Length=734, Percent_Identity=25.4768392370572, Blast_Score=255, Evalue=6e-69,
Organism=Escherichia coli, GI1786914, Length=546, Percent_Identity=26.1904761904762, Blast_Score=136, Evalue=5e-33,
Organism=Escherichia coli, GI2367363, Length=529, Percent_Identity=22.117202268431, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17556548, Length=576, Percent_Identity=28.6458333333333, Blast_Score=193, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17559224, Length=259, Percent_Identity=27.7992277992278, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71997275, Length=191, Percent_Identity=28.2722513089005, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71997262, Length=191, Percent_Identity=28.2722513089005, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=546, Percent_Identity=28.5714285714286, Blast_Score=216, Evalue=9e-57,
Organism=Saccharomyces cerevisiae, GI6319772, Length=602, Percent_Identity=27.906976744186, Blast_Score=180, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6325221, Length=634, Percent_Identity=23.6593059936909, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321430, Length=634, Percent_Identity=23.0283911671924, Blast_Score=107, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6321271, Length=218, Percent_Identity=31.651376146789, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321432, Length=160, Percent_Identity=31.875, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221329854, Length=309, Percent_Identity=30.0970873786408, Blast_Score=137, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24668708, Length=158, Percent_Identity=29.746835443038, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281366617, Length=158, Percent_Identity=29.746835443038, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24668704, Length=158, Percent_Identity=29.746835443038, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24668696, Length=158, Percent_Identity=29.746835443038, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161085803, Length=158, Percent_Identity=29.746835443038, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281366676, Length=254, Percent_Identity=26.7716535433071, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45553437, Length=246, Percent_Identity=27.6422764227642, Blast_Score=67, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24648576, Length=246, Percent_Identity=27.6422764227642, Blast_Score=67, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45553435, Length=246, Percent_Identity=27.6422764227642, Blast_Score=67, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45553439, Length=246, Percent_Identity=27.6422764227642, Blast_Score=67, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281362164, Length=246, Percent_Identity=27.6422764227642, Blast_Score=67, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24648582, Length=246, Percent_Identity=27.6422764227642, Blast_Score=67, Evalue=7e-11,
Organism=Drosophila melanogaster, GI45553441, Length=246, Percent_Identity=27.6422764227642, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24648580, Length=246, Percent_Identity=27.6422764227642, Blast_Score=66, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24648578, Length=246, Percent_Identity=27.6422764227642, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.3; =3.6.3.5 [H]

Molecular weight: Translated: 81469; Mature: 81469

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIKKKLLLKGLHCANCAAKIERAVQKLNIIEEANYNFNNSTLIINLEETHKDSIIKTIQ
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHH
EIVDRIEPGVKVIDKENLKRTVVHAPVKNSSNLKMQNNKEENLKLDKKENSYEHNHDHSH
HHHHHHCCCCEEECCCCCHHHEEECCCCCCCCCEECCCCCCCCEECCCCCCCCCCCCCCC
GHSHDGEDSDELEKKTLIRIISGVVLLILATVLKSKETLSIGLYLASYVLIGGKVILSSI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
RNISKGQVFDENFLMAVATVAAIGVKQYPEAVAVMLFYEVGEFLQDKAVNKSRKSITSLM
HCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NIRPDYANLVRGEDIEVVSPEDINIDDIIMVKPGEKIPLDGIVVEGQSFVDTSAITGESL
HCCCCHHHHCCCCCEEEECCCCCCCCCEEEECCCCCCCCCCEEECCCCCCCHHHCCHHHH
ISEVSKDSNVLSGYINKNGVIKIKITKTFGESTVSKILELTENASATKANTEKFITKFAR
HHHHHCCCCHHHHEECCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
YYTPVVVFAALALSVIPTLILKDPDISKWIYRAAVFLVVSCPCALVISIPLSFFAGIGGA
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SKKGVLIKTGTALEALNDADTIVFDKTGTLTKGVFKVSKIESEEGVNTEELIEYAALVES
CCCCEEEECCCHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
YSNHPIAKSILKYYEKTIDNKRIEGYEEIVARGVTAYIDGKKVYAGNNKLMEELNINYKK
HCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEECCCEEEECCHHHHHHHCCCCEE
AQEDGVILYIALEDKYIGYIVINDEIKKDSKETIKSLKDIGIKKAAMLTGDRKSTANNIG
CCCCCEEEEEEEECCEEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHH
TFLGMDEIYSELLPQEKVEKMQTLKSKTSKDGKIVFVGDGVNDAPVLAMSDIGVSMGGLG
HHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCC
SDAAIEASDLVLMSDEPSKLVDAIKIARKTHKIVWQNIIIVLIIKFAVLALAIMGKSTMW
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
MAVFADVGVALIAVINALRILK
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIIKKKLLLKGLHCANCAAKIERAVQKLNIIEEANYNFNNSTLIINLEETHKDSIIKTIQ
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHH
EIVDRIEPGVKVIDKENLKRTVVHAPVKNSSNLKMQNNKEENLKLDKKENSYEHNHDHSH
HHHHHHCCCCEEECCCCCHHHEEECCCCCCCCCEECCCCCCCCEECCCCCCCCCCCCCCC
GHSHDGEDSDELEKKTLIRIISGVVLLILATVLKSKETLSIGLYLASYVLIGGKVILSSI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
RNISKGQVFDENFLMAVATVAAIGVKQYPEAVAVMLFYEVGEFLQDKAVNKSRKSITSLM
HCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NIRPDYANLVRGEDIEVVSPEDINIDDIIMVKPGEKIPLDGIVVEGQSFVDTSAITGESL
HCCCCHHHHCCCCCEEEECCCCCCCCCEEEECCCCCCCCCCEEECCCCCCCHHHCCHHHH
ISEVSKDSNVLSGYINKNGVIKIKITKTFGESTVSKILELTENASATKANTEKFITKFAR
HHHHHCCCCHHHHEECCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
YYTPVVVFAALALSVIPTLILKDPDISKWIYRAAVFLVVSCPCALVISIPLSFFAGIGGA
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SKKGVLIKTGTALEALNDADTIVFDKTGTLTKGVFKVSKIESEEGVNTEELIEYAALVES
CCCCEEEECCCHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
YSNHPIAKSILKYYEKTIDNKRIEGYEEIVARGVTAYIDGKKVYAGNNKLMEELNINYKK
HCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEECCCEEEECCHHHHHHHCCCCEE
AQEDGVILYIALEDKYIGYIVINDEIKKDSKETIKSLKDIGIKKAAMLTGDRKSTANNIG
CCCCCEEEEEEEECCEEEEEEECCCCCCCHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHH
TFLGMDEIYSELLPQEKVEKMQTLKSKTSKDGKIVFVGDGVNDAPVLAMSDIGVSMGGLG
HHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCC
SDAAIEASDLVLMSDEPSKLVDAIKIARKTHKIVWQNIIIVLIIKFAVLALAIMGKSTMW
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
MAVFADVGVALIAVINALRILK
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]