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The map label for this gene is msbA [H]

Identifier: 170755105

GI number: 170755105

Start: 2471898

End: 2473229

Strand: Reverse

Name: msbA [H]

Synonym: CLD_2294

Alternate gene names: 170755105

Gene position: 2473229-2471898 (Counterclockwise)

Preceding gene: 170757575

Following gene: 170756159

Centisome position: 62.48

GC content: 30.93

Gene sequence:

>1332_bases
ATGAAAGAAAAAAATTGGTTAATAACAGTTTTGTCCTTTGCTAAAGAATGCAAAATGAAAATGATTATTTCCGTATTATG
TGCAATAATCAGCGTTATAGGTGGACTCTTGCCTTATGTAGGAGTTTATCAAATAATAATTTTATTTTTTAATGGAAGAC
AGACAGTAAAGGACATATTGTTTTGGTCGGCAATATGTCTTGCTGGATATGTGGTGAAGCTTGTTTTTTATGATATATCG
ACTACCTTAGCACATTTTTCTGCATATACCATATTAGAGAATATGCGACTTAAGATTGCCGATAGGTTAATGAAAGCTCC
ACTTGGTACAGTGTTAAATCAACCCATAGGAAAGATAAAAAATATAATTGTAGATCGGGTAGAAACTATCGAGCTTCCCT
TGGCTCATATGATACCAGAAGGAATTTCTAATCTATTTTTACCTATAGGTGTGTTTATCTATATTATTATGATAGATTGG
CGTATGGCACTGGCGTCAATGATTACAATACCTATAGCCATTATAGCATATGGATTTATGATGAAGACCTTTAGTAAACA
GTATAAGAATTATATGGAGTCTAGTAATTATGTAAATAGTGTTATTGTAGAATATGTAGAAGGAATCGAAGTCATTAAAG
CTTTTAATCGTTCCTCATCCTCTTATGAAAAATTTGAAAAAGCAGTAGAAGATTTTAAGGTATATACATTAAACTGGTTT
AAAAGTACTTGGAAACTCATGAATTTTGGTGGCGCAGCTTTACCATCAACTTTACTTGGGACTATGCCTATTGGAATGTA
CTTGTATATAAATGGGTCTTTAACTCCGGCAGATCTTACAATGTGCCTTATATTATCTTTAGGAATTGTAGCACCATTAA
CTAGTTTTACAGTATTTATAAATGATGCTAAAGCTATAGAATTTGCTGTAAAAGATGCCTATGAATTTTTAAATTTAAAG
GAACTTGAAAATCCATTAGAGCCAGTGAATATTTGTAGATATGATATTGAGCTTAAAGATGTGTTTTTTTCCTATAATAC
TTATGAAGATGATAATTTAAATAGAGAAAATAATTATGTACTTAATAATATTAATTTAAAACTTCCTGAAGGAAAATTTA
CAGCTTTGGTTGGCCCTTCAGGAGGTGGAAAATCTACGGTTGCAAGATTGATTACACGATTTTGGGATGTGAGCAAAGGA
GAGATTAAAATTGGTGGTATTAATATCAAAAAATTTCCTTTGTCACAGCTTGCTGACACAGTTAGTTTTGTAACTCAGGA
TAATTTTTTATTCAATTATTCAATTGCGGAAAATCTACAATATGCAATTTGA

Upstream 100 bases:

>100_bases
GGATTAGTTAATTTTAACTAATCCCTATAAGTATTTTTAGAGGCTTATATAAGTAAGGAGTATTTTAAATTCTAAAATTT
AAAAGAGGTGAAAGAGTAAA

Downstream 100 bases:

>100_bases
TTGCTAGATTCTATGATGTGGACAAAGGCAGTATCTCCATAGGAGGGATTAACATAAAAGATATAACCTGCGATAGTCTT
TTAAAGAATATAAGTATGGT

Product: ABC transporter, ATP-binding transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MKEKNWLITVLSFAKECKMKMIISVLCAIISVIGGLLPYVGVYQIIILFFNGRQTVKDILFWSAICLAGYVVKLVFYDIS
TTLAHFSAYTILENMRLKIADRLMKAPLGTVLNQPIGKIKNIIVDRVETIELPLAHMIPEGISNLFLPIGVFIYIIMIDW
RMALASMITIPIAIIAYGFMMKTFSKQYKNYMESSNYVNSVIVEYVEGIEVIKAFNRSSSSYEKFEKAVEDFKVYTLNWF
KSTWKLMNFGGAALPSTLLGTMPIGMYLYINGSLTPADLTMCLILSLGIVAPLTSFTVFINDAKAIEFAVKDAYEFLNLK
ELENPLEPVNICRYDIELKDVFFSYNTYEDDNLNRENNYVLNNINLKLPEGKFTALVGPSGGGKSTVARLITRFWDVSKG
EIKIGGINIKKFPLSQLADTVSFVTQDNFLFNYSIAENLQYAI

Sequences:

>Translated_443_residues
MKEKNWLITVLSFAKECKMKMIISVLCAIISVIGGLLPYVGVYQIIILFFNGRQTVKDILFWSAICLAGYVVKLVFYDIS
TTLAHFSAYTILENMRLKIADRLMKAPLGTVLNQPIGKIKNIIVDRVETIELPLAHMIPEGISNLFLPIGVFIYIIMIDW
RMALASMITIPIAIIAYGFMMKTFSKQYKNYMESSNYVNSVIVEYVEGIEVIKAFNRSSSSYEKFEKAVEDFKVYTLNWF
KSTWKLMNFGGAALPSTLLGTMPIGMYLYINGSLTPADLTMCLILSLGIVAPLTSFTVFINDAKAIEFAVKDAYEFLNLK
ELENPLEPVNICRYDIELKDVFFSYNTYEDDNLNRENNYVLNNINLKLPEGKFTALVGPSGGGKSTVARLITRFWDVSKG
EIKIGGINIKKFPLSQLADTVSFVTQDNFLFNYSIAENLQYAI
>Mature_443_residues
MKEKNWLITVLSFAKECKMKMIISVLCAIISVIGGLLPYVGVYQIIILFFNGRQTVKDILFWSAICLAGYVVKLVFYDIS
TTLAHFSAYTILENMRLKIADRLMKAPLGTVLNQPIGKIKNIIVDRVETIELPLAHMIPEGISNLFLPIGVFIYIIMIDW
RMALASMITIPIAIIAYGFMMKTFSKQYKNYMESSNYVNSVIVEYVEGIEVIKAFNRSSSSYEKFEKAVEDFKVYTLNWF
KSTWKLMNFGGAALPSTLLGTMPIGMYLYINGSLTPADLTMCLILSLGIVAPLTSFTVFINDAKAIEFAVKDAYEFLNLK
ELENPLEPVNICRYDIELKDVFFSYNTYEDDNLNRENNYVLNNINLKLPEGKFTALVGPSGGGKSTVARLITRFWDVSKG
EIKIGGINIKKFPLSQLADTVSFVTQDNFLFNYSIAENLQYAI

Specific function: Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation [H]

COG id: COG1132

COG function: function code V; ABC-type multidrug transport system, ATPase and permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI156105685, Length=387, Percent_Identity=24.031007751938, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI9955966, Length=306, Percent_Identity=25.4901960784314, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI45243524, Length=306, Percent_Identity=25.4901960784314, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI21536378, Length=406, Percent_Identity=24.6305418719212, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI42490749, Length=257, Percent_Identity=26.8482490272374, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI9961250, Length=341, Percent_Identity=26.3929618768328, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4505771, Length=341, Percent_Identity=26.3929618768328, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI9961252, Length=341, Percent_Identity=26.3929618768328, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI171184400, Length=284, Percent_Identity=25.3521126760563, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI9955963, Length=115, Percent_Identity=36.5217391304348, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI73747915, Length=306, Percent_Identity=21.5686274509804, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI73747917, Length=306, Percent_Identity=21.5686274509804, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI9955968, Length=302, Percent_Identity=24.5033112582781, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI42741659, Length=377, Percent_Identity=23.0769230769231, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI9665248, Length=417, Percent_Identity=23.2613908872902, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI255708477, Length=449, Percent_Identity=22.271714922049, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI148612844, Length=449, Percent_Identity=22.271714922049, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1787143, Length=402, Percent_Identity=24.3781094527363, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1786654, Length=365, Percent_Identity=22.7397260273973, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786653, Length=311, Percent_Identity=25.08038585209, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1787113, Length=360, Percent_Identity=22.2222222222222, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787112, Length=378, Percent_Identity=21.1640211640212, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17569145, Length=454, Percent_Identity=23.3480176211454, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17543740, Length=365, Percent_Identity=25.4794520547945, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17565938, Length=364, Percent_Identity=25, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193209708, Length=396, Percent_Identity=25.2525252525253, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17533971, Length=362, Percent_Identity=23.2044198895028, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI115535101, Length=333, Percent_Identity=23.7237237237237, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI212646699, Length=317, Percent_Identity=26.813880126183, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI193211015, Length=296, Percent_Identity=27.027027027027, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193211017, Length=296, Percent_Identity=27.027027027027, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193202349, Length=383, Percent_Identity=24.2819843342037, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71996809, Length=296, Percent_Identity=27.3648648648649, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17569143, Length=324, Percent_Identity=23.4567901234568, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17541710, Length=369, Percent_Identity=24.6612466124661, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71984940, Length=462, Percent_Identity=25.974025974026, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71996550, Length=258, Percent_Identity=25.1937984496124, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115533592, Length=366, Percent_Identity=21.8579234972678, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI115534520, Length=308, Percent_Identity=22.4025974025974, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71992290, Length=365, Percent_Identity=21.0958904109589, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI32563727, Length=377, Percent_Identity=21.7506631299735, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17567269, Length=365, Percent_Identity=23.013698630137, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17511077, Length=377, Percent_Identity=21.7506631299735, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71992285, Length=287, Percent_Identity=24.390243902439, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25146777, Length=458, Percent_Identity=22.2707423580786, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17558664, Length=366, Percent_Identity=24.3169398907104, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193208177, Length=374, Percent_Identity=22.192513368984, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17567265, Length=375, Percent_Identity=22.9333333333333, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323217, Length=364, Percent_Identity=23.3516483516484, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323959, Length=367, Percent_Identity=25.8855585831063, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324985, Length=277, Percent_Identity=25.6317689530686, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322640, Length=124, Percent_Identity=33.8709677419355, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641565, Length=337, Percent_Identity=24.6290801186944, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI85726357, Length=394, Percent_Identity=24.3654822335025, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357907, Length=368, Percent_Identity=24.7282608695652, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24659289, Length=388, Percent_Identity=23.9690721649485, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136662, Length=380, Percent_Identity=24.2105263157895, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24653245, Length=120, Percent_Identity=34.1666666666667, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281363262, Length=120, Percent_Identity=34.1666666666667, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI23397593, Length=367, Percent_Identity=21.2534059945504, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45551501, Length=372, Percent_Identity=24.7311827956989, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357851, Length=372, Percent_Identity=24.7311827956989, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45551502, Length=372, Percent_Identity=24.7311827956989, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45552363, Length=379, Percent_Identity=21.3720316622691, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45552343, Length=379, Percent_Identity=21.3720316622691, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017940
- InterPro:   IPR011917
- InterPro:   IPR001140
- InterPro:   IPR011527
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00664 ABC_membrane; PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 50054; Mature: 50054

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS50929 ABC_TM1F

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCEEEEEEHHCCCCCCC
>Mature Secondary Structure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HHHHCCCCEEEEEEHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA