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The map label for this gene is ycbM [H]

Identifier: 170754637

GI number: 170754637

Start: 2477657

End: 2478568

Strand: Reverse

Name: ycbM [H]

Synonym: CLD_2288

Alternate gene names: 170754637

Gene position: 2478568-2477657 (Counterclockwise)

Preceding gene: 170757056

Following gene: 170757060

Centisome position: 62.62

GC content: 26.43

Gene sequence:

>912_bases
ATGAATTGGATATTAATAATTATTATAATAATACTATCTATACTATTATTAAATGATAAAATAAAAACTAAAAGGATTAC
TGCAAAATTAAATGAGATTCTTAAAAAAAATTCAAGAGAAAGAATAAAATTTTATAATTTAAGTACAAATAAGAAGGAAC
TTGTTAGAGAAATTAATATTTTTCTTGATAAATACCAGAGTATTTCTATTGATAATAAAAATTATAAAGAACATCACCAA
AAAATGATTTCGAATATTTCTCATGATATAAGAACTCCACTTACTGCTCTTATGGGATATGTTGACCTTCTTTCAGATAA
TTCTATTACAAAAGAAAAGAAGGAAGAATATATCAGTATTATTAGAGAAAGAGGCACTGCTTTAAAGGATCTTATGGAAG
AGTTTTTTCAAATGGCAAAGCTCGAATGTAATGATGTAGAGATAACTATTGAAAAATTTAATATATCCGAAGTAGTAAGA
AAGAATATAATTACTTTTATGAATGAAATAAATGAAAGAAATATAACTCCTGAGATAAACATAGGCGATGAAGAGATTTT
TGCTTTAGGGGATAAAAATTATACGAGTAGAATCATAACCAACCTTATTTCAAATAGTCTAAAATATGGATATGAAGGAA
AAGTTATTGGTATTGATTTAAAAGAAGATAATAAGTGGGTAACTCTTAGTATATGGGACAAAGGAAAGGGTATCGATAAA
AATGAGCTTCCTTATATTTTTGATAGATTATATACAGGGGAGAAGTCTAGAAATAGAAGTTTTCAAGGCAGCGGTCTTGG
ACTTAGTATAGTAAAGAATATGGCTCAGCATATGAATGGAAGTATAACTGCTCAAAGCATACCCTATGAGAAAACTATAT
TTACAATAAAGATTCCAAAGTCTAATAGTTAA

Upstream 100 bases:

>100_bases
ATATGAGAAGACTTAGAAGTAAAATCGAGGATGATCCCAATAACCCTAAACTTATAGAAACTGTTTGGGGAATAGGATAC
AAATTAACAGGTGATAGATA

Downstream 100 bases:

>100_bases
AATTGACTAAACATGCTAAAAATATTAGATGAAATTACTAAACTATTGTATAGCTTTTTATATAATTCTTAATAAATATC
TAAAAGGTATTTAATTTAAT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MNWILIIIIIILSILLLNDKIKTKRITAKLNEILKKNSRERIKFYNLSTNKKELVREINIFLDKYQSISIDNKNYKEHHQ
KMISNISHDIRTPLTALMGYVDLLSDNSITKEKKEEYISIIRERGTALKDLMEEFFQMAKLECNDVEITIEKFNISEVVR
KNIITFMNEINERNITPEINIGDEEIFALGDKNYTSRIITNLISNSLKYGYEGKVIGIDLKEDNKWVTLSIWDKGKGIDK
NELPYIFDRLYTGEKSRNRSFQGSGLGLSIVKNMAQHMNGSITAQSIPYEKTIFTIKIPKSNS

Sequences:

>Translated_303_residues
MNWILIIIIIILSILLLNDKIKTKRITAKLNEILKKNSRERIKFYNLSTNKKELVREINIFLDKYQSISIDNKNYKEHHQ
KMISNISHDIRTPLTALMGYVDLLSDNSITKEKKEEYISIIRERGTALKDLMEEFFQMAKLECNDVEITIEKFNISEVVR
KNIITFMNEINERNITPEINIGDEEIFALGDKNYTSRIITNLISNSLKYGYEGKVIGIDLKEDNKWVTLSIWDKGKGIDK
NELPYIFDRLYTGEKSRNRSFQGSGLGLSIVKNMAQHMNGSITAQSIPYEKTIFTIKIPKSNS
>Mature_303_residues
MNWILIIIIIILSILLLNDKIKTKRITAKLNEILKKNSRERIKFYNLSTNKKELVREINIFLDKYQSISIDNKNYKEHHQ
KMISNISHDIRTPLTALMGYVDLLSDNSITKEKKEEYISIIRERGTALKDLMEEFFQMAKLECNDVEITIEKFNISEVVR
KNIITFMNEINERNITPEINIGDEEIFALGDKNYTSRIITNLISNSLKYGYEGKVIGIDLKEDNKWVTLSIWDKGKGIDK
NELPYIFDRLYTGEKSRNRSFQGSGLGLSIVKNMAQHMNGSITAQSIPYEKTIFTIKIPKSNS

Specific function: Member of the two-component regulatory system ycbM/ycbL. Probably activates ycbL by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=224, Percent_Identity=29.9107142857143, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788393, Length=224, Percent_Identity=27.6785714285714, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1786600, Length=253, Percent_Identity=25.296442687747, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87081816, Length=269, Percent_Identity=25.2788104089219, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786783, Length=297, Percent_Identity=23.5690235690236, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI145693157, Length=218, Percent_Identity=25.6880733944954, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=27.1111111111111, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790861, Length=220, Percent_Identity=23.6363636363636, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI48994928, Length=221, Percent_Identity=26.6968325791855, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=304, Percent_Identity=26.6447368421053, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=23.6842105263158, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=26.457399103139, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=20.1834862385321, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1789149, Length=223, Percent_Identity=23.3183856502242, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787894, Length=224, Percent_Identity=24.5535714285714, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1789403, Length=280, Percent_Identity=22.8571428571429, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=22.2707423580786, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 35166; Mature: 35166

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWILIIIIIILSILLLNDKIKTKRITAKLNEILKKNSRERIKFYNLSTNKKELVREINI
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHH
FLDKYQSISIDNKNYKEHHQKMISNISHDIRTPLTALMGYVDLLSDNSITKEKKEEYISI
HHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IRERGTALKDLMEEFFQMAKLECNDVEITIEKFNISEVVRKNIITFMNEINERNITPEIN
HHHCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEE
IGDEEIFALGDKNYTSRIITNLISNSLKYGYEGKVIGIDLKEDNKWVTLSIWDKGKGIDK
CCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCC
NELPYIFDRLYTGEKSRNRSFQGSGLGLSIVKNMAQHMNGSITAQSIPYEKTIFTIKIPK
CCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCEEEEEEEECCC
SNS
CCC
>Mature Secondary Structure
MNWILIIIIIILSILLLNDKIKTKRITAKLNEILKKNSRERIKFYNLSTNKKELVREINI
CCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHH
FLDKYQSISIDNKNYKEHHQKMISNISHDIRTPLTALMGYVDLLSDNSITKEKKEEYISI
HHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IRERGTALKDLMEEFFQMAKLECNDVEITIEKFNISEVVRKNIITFMNEINERNITPEIN
HHHCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEE
IGDEEIFALGDKNYTSRIITNLISNSLKYGYEGKVIGIDLKEDNKWVTLSIWDKGKGIDK
CCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCC
NELPYIFDRLYTGEKSRNRSFQGSGLGLSIVKNMAQHMNGSITAQSIPYEKTIFTIKIPK
CCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCEEEEEEEECCC
SNS
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704254; 9384377 [H]