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The map label for this gene is phoP [H]

Identifier: 170754525

GI number: 170754525

Start: 433948

End: 434634

Strand: Direct

Name: phoP [H]

Synonym: CLD_0399

Alternate gene names: 170754525

Gene position: 433948-434634 (Clockwise)

Preceding gene: 170756714

Following gene: 170754453

Centisome position: 10.96

GC content: 31.0

Gene sequence:

>687_bases
ATGGATAAAATATTAATAGTGGAAGATGAGAGCTCTATAAGAGGCTTTGTAAAAGTAAATTTAAAGATGAACAATTTTGA
TGTAATAGAAGCAGAAACAGGAGAAGAAGGGATAGAAAAAGCAAGGAAACATAAACCAGATGTAGTTGTATTAGATATTA
TGCTGCCAGGTGTAGACGGACTAGAGGTGTGCAAAACTCTAAGACAGGAGTTTCCTAATATGGGAATAATAATGCTTACT
GCTAAAAGCCAAGATACAGATAAAGTTTCAGGTCTAGAATATGGAGCAGATGACTATATAATAAAACCCTTTAATCCTTT
AGAACTTACTTTGAGAATAAAAGCTATACTAAGAAGAGTTAATGCAGTAAAGGAAAGTGATGATAATATAATAACTGGAG
GTCCATTTAAAATAGATCTTTATTCCAAAAAAATCCATAAAAATGAAGAAGAAATAGATATAACCCCGACAGAGTATTTA
CTTATGAAAATATTTATTGAAAATCCAGGGAAAGCTTTTAATAGAGATGAGTTATTGGATTTAGTTTGGGGCTATGATTT
TATGGGAGATTCTAAAATTGTAGATGTAAACATAAGAAGACTAAGATCAAAAATAGAAGAAACACCATCTGAGCCTAAAT
TTATAAAAACTGTATGGGGAACAGGTTATAGATGGCAAAACACTTAA

Upstream 100 bases:

>100_bases
TATATATCTTAAATTATAGTTAAAAGTTGTAAAAAGGGTGAGTTTTACAATATACTAAAGATATTAAAGTGGAATACTAA
AACAAAATTGAGGTGAAGCC

Downstream 100 bases:

>100_bases
GGAGTTATTATGAGTAAAATAAGTGTAAAAAGAAGACTAATGGTAAATTTTATATTAATTATAATAATAAGTGTTTTTAT
ACTAGAATTTTTATTAATTC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MDKILIVEDESSIRGFVKVNLKMNNFDVIEAETGEEGIEKARKHKPDVVVLDIMLPGVDGLEVCKTLRQEFPNMGIIMLT
AKSQDTDKVSGLEYGADDYIIKPFNPLELTLRIKAILRRVNAVKESDDNIITGGPFKIDLYSKKIHKNEEEIDITPTEYL
LMKIFIENPGKAFNRDELLDLVWGYDFMGDSKIVDVNIRRLRSKIEETPSEPKFIKTVWGTGYRWQNT

Sequences:

>Translated_228_residues
MDKILIVEDESSIRGFVKVNLKMNNFDVIEAETGEEGIEKARKHKPDVVVLDIMLPGVDGLEVCKTLRQEFPNMGIIMLT
AKSQDTDKVSGLEYGADDYIIKPFNPLELTLRIKAILRRVNAVKESDDNIITGGPFKIDLYSKKIHKNEEEIDITPTEYL
LMKIFIENPGKAFNRDELLDLVWGYDFMGDSKIVDVNIRRLRSKIEETPSEPKFIKTVWGTGYRWQNT
>Mature_228_residues
MDKILIVEDESSIRGFVKVNLKMNNFDVIEAETGEEGIEKARKHKPDVVVLDIMLPGVDGLEVCKTLRQEFPNMGIIMLT
AKSQDTDKVSGLEYGADDYIIKPFNPLELTLRIKAILRRVNAVKESDDNIITGGPFKIDLYSKKIHKNEEEIDITPTEYL
LMKIFIENPGKAFNRDELLDLVWGYDFMGDSKIVDVNIRRLRSKIEETPSEPKFIKTVWGTGYRWQNT

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=37.7777777777778, Blast_Score=177, Evalue=5e-46,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=37.7777777777778, Blast_Score=171, Evalue=4e-44,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=38.3259911894273, Blast_Score=170, Evalue=7e-44,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=36.1607142857143, Blast_Score=156, Evalue=9e-40,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=37.9912663755458, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=34.2342342342342, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=37.3873873873874, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=33.7777777777778, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=33.9366515837104, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=29.8642533936652, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=32.1428571428571, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=30.9734513274336, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=29.3103448275862, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788550, Length=125, Percent_Identity=32, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790299, Length=102, Percent_Identity=36.2745098039216, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=30.5785123966942, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26139; Mature: 26139

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKILIVEDESSIRGFVKVNLKMNNFDVIEAETGEEGIEKARKHKPDVVVLDIMLPGVDG
CCCEEEEECCCCCEEEEEEEEEECCEEEEECCCCHHHHHHHHHCCCCEEEEEEEECCCCH
LEVCKTLRQEFPNMGIIMLTAKSQDTDKVSGLEYGADDYIIKPFNPLELTLRIKAILRRV
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHH
NAVKESDDNIITGGPFKIDLYSKKIHKNEEEIDITPTEYLLMKIFIENPGKAFNRDELLD
HHHHCCCCCEEECCCEEEEEEHHHHCCCCCEEECCHHHHEEEEEEECCCCCCCCHHHHHH
LVWGYDFMGDSKIVDVNIRRLRSKIEETPSEPKFIKTVWGTGYRWQNT
HHHCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCEEEEECCCCEEECCC
>Mature Secondary Structure
MDKILIVEDESSIRGFVKVNLKMNNFDVIEAETGEEGIEKARKHKPDVVVLDIMLPGVDG
CCCEEEEECCCCCEEEEEEEEEECCEEEEECCCCHHHHHHHHHCCCCEEEEEEEECCCCH
LEVCKTLRQEFPNMGIIMLTAKSQDTDKVSGLEYGADDYIIKPFNPLELTLRIKAILRRV
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHH
NAVKESDDNIITGGPFKIDLYSKKIHKNEEEIDITPTEYLLMKIFIENPGKAFNRDELLD
HHHHCCCCCEEECCCEEEEEEHHHHCCCCCEEECCHHHHEEEEEEECCCCCCCCHHHHHH
LVWGYDFMGDSKIVDVNIRRLRSKIEETPSEPKFIKTVWGTGYRWQNT
HHHCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCEEEEECCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]