BacMap

Definition	Methylobacterium radiotolerans JCM 2831 chromosome, complete genome.
Accession	NC_010505
Length	6,077,833

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The map label for this gene is ccmA [H]

Identifier: 170752135

GI number: 170752135

Start: 6076233

End: 6076871

Strand: Direct

Name: ccmA [H]

Synonym: Mrad2831_5768

Alternate gene names: 170752135

Gene position: 6076233-6076871 (Clockwise)

Preceding gene: 170752133

Following gene: 170752136

Centisome position: 99.97

GC content: 75.74

Gene sequence:

>639_bases
GTGCGGCTCAGCGTGGACAATCTGGCCTGCCGCCGCTCCGGCCGCCGCATCTTCGCCAACCTGTCCTTCGCCCTCGGACC
CGGCGACGCCCTCGCGATCACCGGGCGGAACGGCGCGGGCAAGTCGAGCCTCCTCGCCATCCTCTCGGGCCGACTGCGGG
CGGATGCCGGGCGGATCGACGTCGCCGATGTCGGCGAGGCGAGTCTGCCCGAGTGCCTCCACGCCGTCGGCCACCGCGAC
GGGCTGAAGAGCTCTCTCACGGCGGGCGAGAACCTCCTGTTCGCCCAGCGGCTCCTGGGCGCGCCGCGTCTGGACCCGCG
CGCCGCGCTGGAGCGGCTCGGCCTCGGCCACGCGCACGACCTGCCGGTGGCCTATCTGTCGGCGGGTCAGCGGCGGCGCG
TGGCCCTGGCGCGGCTGCTGGTCTGCGCCCGCCCGCTCTGGCTCCTGGACGAGCCCACCGCCGCCCTCGACACGGCCTCG
CAGGCGGTGCTCGCCGAGCTGATGGAGGGCCATCGGGCCGGCGGCGGCCTCGTGATCGCCGCCACCCACCAGTCCCTCGG
CCTCGCCGGCGCTGCGGAACTGCGCATCGAGACCGCCGCCGCGGCACCGGTCGCGGACCTTCTGGAGGAGTGGGCGTGA

Upstream 100 bases:

>100_bases
CGCAGCTGAGCCGTGCGGTTCCGTTCCGCGCCGCGATCGGGCATGGAGTCGGCGATTCGCGGAGTGGCCGCGCGGTGGCG
GAACGAGGGCGGGGTATCGG

Downstream 100 bases:

>100_bases
TTCGCGCGGTCCTCGCCCTCATCGCCCGCGACCTGCGCCTCGCCGGCCGGGTCGGCGGGTCCGGCGCCCTGTCGCTGGTC
TTCTTCCTGATGATCGTCGC

Product: heme exporter protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MRLSVDNLACRRSGRRIFANLSFALGPGDALAITGRNGAGKSSLLAILSGRLRADAGRIDVADVGEASLPECLHAVGHRD
GLKSSLTAGENLLFAQRLLGAPRLDPRAALERLGLGHAHDLPVAYLSAGQRRRVALARLLVCARPLWLLDEPTAALDTAS
QAVLAELMEGHRAGGGLVIAATHQSLGLAGAAELRIETAAAAPVADLLEEWA

Sequences:

>Translated_212_residues
MRLSVDNLACRRSGRRIFANLSFALGPGDALAITGRNGAGKSSLLAILSGRLRADAGRIDVADVGEASLPECLHAVGHRD
GLKSSLTAGENLLFAQRLLGAPRLDPRAALERLGLGHAHDLPVAYLSAGQRRRVALARLLVCARPLWLLDEPTAALDTAS
QAVLAELMEGHRAGGGLVIAATHQSLGLAGAAELRIETAAAAPVADLLEEWA
>Mature_212_residues
MRLSVDNLACRRSGRRIFANLSFALGPGDALAITGRNGAGKSSLLAILSGRLRADAGRIDVADVGEASLPECLHAVGHRD
GLKSSLTAGENLLFAQRLLGAPRLDPRAALERLGLGHAHDLPVAYLSAGQRRRVALARLLVCARPLWLLDEPTAALDTAS
QAVLAELMEGHRAGGGLVIAATHQSLGLAGAAELRIETAAAAPVADLLEEWA

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI11967969, Length=201, Percent_Identity=33.8308457711443, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI105990541, Length=179, Percent_Identity=30.1675977653631, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI11967971, Length=195, Percent_Identity=31.2820512820513, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI46592971, Length=184, Percent_Identity=31.5217391304348, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI46592964, Length=184, Percent_Identity=31.5217391304348, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI31657092, Length=181, Percent_Identity=30.3867403314917, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI46592978, Length=184, Percent_Identity=31.5217391304348, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI9955968, Length=202, Percent_Identity=29.7029702970297, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI46592898, Length=184, Percent_Identity=31.5217391304348, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI46592915, Length=184, Percent_Identity=31.5217391304348, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI9955966, Length=202, Percent_Identity=29.7029702970297, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI45243524, Length=202, Percent_Identity=29.7029702970297, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI46592956, Length=184, Percent_Identity=31.5217391304348, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI27436953, Length=170, Percent_Identity=29.4117647058824, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082064, Length=202, Percent_Identity=42.0792079207921, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI48994997, Length=205, Percent_Identity=33.1707317073171, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788165, Length=168, Percent_Identity=32.1428571428571, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1787029, Length=200, Percent_Identity=30, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787182, Length=193, Percent_Identity=30.0518134715026, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789873, Length=183, Percent_Identity=32.2404371584699, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1787105, Length=199, Percent_Identity=34.1708542713568, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI87081791, Length=205, Percent_Identity=29.7560975609756, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789593, Length=195, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788053, Length=202, Percent_Identity=33.6633663366337, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1788897, Length=194, Percent_Identity=29.8969072164948, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI87081709, Length=160, Percent_Identity=30, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1786253, Length=155, Percent_Identity=34.1935483870968, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI2367384, Length=160, Percent_Identity=31.25, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790467, Length=175, Percent_Identity=29.7142857142857, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787712, Length=189, Percent_Identity=28.042328042328, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1787370, Length=179, Percent_Identity=29.0502793296089, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1790739, Length=197, Percent_Identity=29.4416243654822, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1787089, Length=200, Percent_Identity=29.5, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1788210, Length=203, Percent_Identity=27.5862068965517, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1786563, Length=186, Percent_Identity=27.4193548387097, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1787112, Length=188, Percent_Identity=34.0425531914894, Blast_Score=60, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI115533608, Length=175, Percent_Identity=32, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71992290, Length=188, Percent_Identity=29.7872340425532, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17565586, Length=158, Percent_Identity=31.6455696202532, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17567269, Length=201, Percent_Identity=28.3582089552239, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI115535101, Length=188, Percent_Identity=28.1914893617021, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193202349, Length=188, Percent_Identity=27.6595744680851, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193211015, Length=188, Percent_Identity=26.063829787234, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71996809, Length=188, Percent_Identity=26.063829787234, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193211017, Length=188, Percent_Identity=26.063829787234, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25146777, Length=183, Percent_Identity=27.8688524590164, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI212646699, Length=183, Percent_Identity=26.775956284153, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17569145, Length=185, Percent_Identity=27.5675675675676, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24641342, Length=177, Percent_Identity=36.1581920903955, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19920532, Length=186, Percent_Identity=31.1827956989247, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24580930, Length=186, Percent_Identity=31.1827956989247, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221500365, Length=164, Percent_Identity=31.0975609756098, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI116007184, Length=164, Percent_Identity=31.0975609756098, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI161076682, Length=186, Percent_Identity=30.6451612903226, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161076684, Length=186, Percent_Identity=30.6451612903226, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24581617, Length=186, Percent_Identity=30.6451612903226, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24581615, Length=186, Percent_Identity=30.6451612903226, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28574150, Length=195, Percent_Identity=29.2307692307692, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI116007328, Length=195, Percent_Identity=29.2307692307692, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 22079; Mature: 22079

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSVDNLACRRSGRRIFANLSFALGPGDALAITGRNGAGKSSLLAILSGRLRADAGRID
CCCCCHHHHHHHCCCEEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEE
VADVGEASLPECLHAVGHRDGLKSSLTAGENLLFAQRLLGAPRLDPRAALERLGLGHAHD
CCCCCCCCHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCC
LPVAYLSAGQRRRVALARLLVCARPLWLLDEPTAALDTASQAVLAELMEGHRAGGGLVIA
CCHHHHCCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEE
ATHQSLGLAGAAELRIETAAAAPVADLLEEWA
ECCCCCCCCCHHHEEEEHHHCCCHHHHHHHCC
>Mature Secondary Structure
MRLSVDNLACRRSGRRIFANLSFALGPGDALAITGRNGAGKSSLLAILSGRLRADAGRID
CCCCCHHHHHHHCCCEEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEE
VADVGEASLPECLHAVGHRDGLKSSLTAGENLLFAQRLLGAPRLDPRAALERLGLGHAHD
CCCCCCCCHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCC
LPVAYLSAGQRRRVALARLLVCARPLWLLDEPTAALDTASQAVLAELMEGHRAGGGLVIA
CCHHHHCCCCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEE
ATHQSLGLAGAAELRIETAAAAPVADLLEEWA
ECCCCCCCCCHHHEEEEHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA