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The map label for this gene is pdg [H]

Identifier: 170751703

GI number: 170751703

Start: 5643259

End: 5644020

Strand: Reverse

Name: pdg [H]

Synonym: Mrad2831_5333

Alternate gene names: 170751703

Gene position: 5644020-5643259 (Counterclockwise)

Preceding gene: 170751704

Following gene: 170751702

Centisome position: 92.86

GC content: 73.23

Gene sequence:

>762_bases
ATGCCCGCCGCCGACCTCAGAACCGCGACCGCCCCGCGCCCGCGCCGCAAGCCGACCCCCGCCGTCACGGATCCGGCCCT
CGCCGAGAAGGCGCTCGCCGTCCATGCCCGGTTGTGCCCGGTCTACGGCTGCCCGATCCCGTACTTCCACAGCCTGGATC
CGGTCAGCGAACTCGTCTCCTCGCTCCTGTCGCACCGGACGCGCAACGCCGAATCCGGCCGGGCCTTCAAGGCCCTGCGG
GCGCGCTTCCGCGACTGGGAGGCGGTGATCGACGCGGACGTGCCGGAGATCGAGGCTGCCATCGCGGGCGTGACCTGGCC
GGAGCTGAAGGCGCCGCGCATCCGCGACGTGCTCCGGGCGCTGCGCGACCGGTGCGGCGGCCTCGACCTCGCCTTCCTGG
CCGACATGGAGGTCGAGGCCGCGCGGGTGTGGCTGCAGGCGATCCCGGGCGTCGGGCCGAAGACCAGCGCGGCGGTCCTG
TCCTTCTCCACCCTGCGAATGCCGGCCCTGCCGGTCGACAGCCACCATCACCGGGTGGCGCAGCGCCTCGGGCTGATCGG
CAAGACGGTCGATGTCGGCCCGTCGCACCCGATCCTGCGGGCGCAGCTCCCCGCCGACTGGAGCGCGCAGGACCTCTACG
ACAATCACGAGATCCTGATGCTGCACGGCCAGAAGGTCTGCCATCATCGCCGCCCGGCCTGCGGGCGCTGCGTCCTGGTC
GACCTCTGCCCGAGCGCGAGGCTGCCCACGCGGGAGCCGTGA

Upstream 100 bases:

>100_bases
CCTGCTCTCCGCTGGAAGCGCGCGAACCCGACGAGGCGGACAGATCGCCGCTGCCCCGTACAGGCAGGAACAGGGGCATC
GGCTCGCGGATTCGCCCGAC

Downstream 100 bases:

>100_bases
GCGCGTCCTTGACCATTCCGGCCTACGGGTGCGAGTAACCCCGCGCCCGGACGGCGCGGAGCCCCGGTCTTCCCTTGCTC
AGGATCGGCGCCGATGGCCG

Product: helix-hairpin-helix DNA-binding motif-containing protein

Products: NA

Alternate protein names: Pyrimidine dimer glycosylase; UV-endonuclease [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MPAADLRTATAPRPRRKPTPAVTDPALAEKALAVHARLCPVYGCPIPYFHSLDPVSELVSSLLSHRTRNAESGRAFKALR
ARFRDWEAVIDADVPEIEAAIAGVTWPELKAPRIRDVLRALRDRCGGLDLAFLADMEVEAARVWLQAIPGVGPKTSAAVL
SFSTLRMPALPVDSHHHRVAQRLGLIGKTVDVGPSHPILRAQLPADWSAQDLYDNHEILMLHGQKVCHHRRPACGRCVLV
DLCPSARLPTREP

Sequences:

>Translated_253_residues
MPAADLRTATAPRPRRKPTPAVTDPALAEKALAVHARLCPVYGCPIPYFHSLDPVSELVSSLLSHRTRNAESGRAFKALR
ARFRDWEAVIDADVPEIEAAIAGVTWPELKAPRIRDVLRALRDRCGGLDLAFLADMEVEAARVWLQAIPGVGPKTSAAVL
SFSTLRMPALPVDSHHHRVAQRLGLIGKTVDVGPSHPILRAQLPADWSAQDLYDNHEILMLHGQKVCHHRRPACGRCVLV
DLCPSARLPTREP
>Mature_252_residues
PAADLRTATAPRPRRKPTPAVTDPALAEKALAVHARLCPVYGCPIPYFHSLDPVSELVSSLLSHRTRNAESGRAFKALRA
RFRDWEAVIDADVPEIEAAIAGVTWPELKAPRIRDVLRALRDRCGGLDLAFLADMEVEAARVWLQAIPGVGPKTSAAVLS
FSTLRMPALPVDSHHHRVAQRLGLIGKTVDVGPSHPILRAQLPADWSAQDLYDNHEILMLHGQKVCHHRRPACGRCVLVD
LCPSARLPTREP

Specific function: Has both, an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Initiates repair at cis-syn pyrimidine dimers. Proceeds via an imino enzyme:DNA intermediate [H]

COG id: COG0177

COG function: function code L; Predicted EndoIII-related endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Escherichia coli, GI1787920, Length=200, Percent_Identity=29, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17554540, Length=190, Percent_Identity=29.4736842105263, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI45550361, Length=199, Percent_Identity=29.1457286432161, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR005759
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 4.2.99.18

Molecular weight: Translated: 27761; Mature: 27630

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAADLRTATAPRPRRKPTPAVTDPALAEKALAVHARLCPVYGCPIPYFHSLDPVSELVS
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
SLLSHRTRNAESGRAFKALRARFRDWEAVIDADVPEIEAAIAGVTWPELKAPRIRDVLRA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHH
LRDRCGGLDLAFLADMEVEAARVWLQAIPGVGPKTSAAVLSFSTLRMPALPVDSHHHRVA
HHHHHCCCCEEEHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
QRLGLIGKTVDVGPSHPILRAQLPADWSAQDLYDNHEILMLHGQKVCHHRRPACGRCVLV
HHHHHHCCEECCCCCCCEEEEECCCCCCHHHHCCCCCEEEEECHHHHHCCCCCCCCEEEE
DLCPSARLPTREP
EECCCCCCCCCCC
>Mature Secondary Structure 
PAADLRTATAPRPRRKPTPAVTDPALAEKALAVHARLCPVYGCPIPYFHSLDPVSELVS
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
SLLSHRTRNAESGRAFKALRARFRDWEAVIDADVPEIEAAIAGVTWPELKAPRIRDVLRA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHH
LRDRCGGLDLAFLADMEVEAARVWLQAIPGVGPKTSAAVLSFSTLRMPALPVDSHHHRVA
HHHHHCCCCEEEHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
QRLGLIGKTVDVGPSHPILRAQLPADWSAQDLYDNHEILMLHGQKVCHHRRPACGRCVLV
HHHHHHCCEECCCCCCCEEEEECCCCCCHHHHCCCCCEEEEECHHHHHCCCCCCCCEEEE
DLCPSARLPTREP
EECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Carbon-Oxygen Lyase [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7559510 [H]