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The map label for this gene is zraS [H]

Identifier: 170751447

GI number: 170751447

Start: 5381134

End: 5382621

Strand: Direct

Name: zraS [H]

Synonym: Mrad2831_5066

Alternate gene names: 170751447

Gene position: 5381134-5382621 (Clockwise)

Preceding gene: 170751446

Following gene: 170751451

Centisome position: 88.54

GC content: 74.6

Gene sequence:

>1488_bases
ATGCCCGCGCGGAGCGTGACCGGCGTGTCCGTCAAGTCCGATCAGGCCGCGGCACCGGCGACGCCGGCGCCCGCTCCGGC
CCGCGACCTGCCCGAGCGGCGCACGGCGCGCCTCGGCCTGTCCGGGCGGCTGTTCCTCGTGACCGTCGCGTTCGTGGTGG
TGGCCGAGGTGCTGACCTACGTGCCGGCGGTGGCCAACTACCGGATCGAGTGGATGTCCGACCGGCTGGCGGCCGCGCAG
GTCGCCGCCCTGGTCCTCGATGGCCGGACCGGCGAGCCGGTCTCCGAGCCGCTCGAGAGCCGGCTCCTGGCCGGCGTGAA
CGCCCGGGCGATCGCGGTCCGCGGGGGCGGCGCACAGCGCCTGCTCGCCATCGAGCCGATGCCCGAGCAGGTCGCCGACA
CCGTCGACCTGCGCGACGTCACGGCCCTGTCGGCGATCCGGGGCGCGTGGCGCACCCTCGTGGCGCCGGTCCACGAGCCG
ATCCGCGTGGTCGGGGAGGGCGGGATCGGCTTCGACCGTGTCGAGATCCTGCTCGACGAGGCGCCGCTGCGCACCGCCAT
GATCGACTACGCGCTGCGCCTGCTGGTCTCCTCGCTGATCATCGCGGCCGCCGCGGCCGGTCTCGTCTTCGTGGTGCTGC
AGGTTCTGATCGTGCGGCCGGTGCGGCGCCTCGCCACCAGCATCACGGTCTTCGCGGACGATCCGGAGGATGCCGGCCGG
ATCATCGCGCCGTCCCGCCGCAGCGACGAGATCGGCCAGGCCGAGCGGGCGCTCGGGCGGATGCAGCGCAGCCTCGCCGA
CCAGCTCCGGCAGAAGCGGCGTCTCGCCGAGCTCGGTCTCGCGGTCAGCAAGATCAGCCACGAGCTGCGCAACCTGCTGA
CCGGCGCGCAGCTCCTGGGCGACCGCCTGGAGGGTACCGAGGATCCGACGGTGCAGCGCGTGGCCCCCCGCCTCGTCGGG
ACGCTGGCTCGCGCGATCCGCTTCTGCGAGGCGACCCTCGCCTACGGGCGCGTCTCCGAGCGGACGCCGCTCCTGACCAG
CACGCCGCTGGCGCCGATCTTCGCGGAGCTCCCGGATCTCGCCGCGCTGGCGGCGCACCCGGTCAGCGTCCAGGTCGCGG
CGGGCGATCTCTCCGTGCAGGCCGATCCGGAGCAGCTCGGTCGGGCGCTGGCCAATCTCGTGCGCAACGCCGTGCAGGCG
CTGGACGGGGCCGCCGTGCCGGAGGCCACCGTGAGCGTGGTCGCCTCGCGCGCGGCGTCGGGCCGGATCACGATCCTGGT
CACCGATAACGGCCCCGGCCTGCCGGCGCGCGCCCGGGAGAACCTGTTCGCGCCGTTCCAGGGATCCATGCGGTCCGGCG
GCACGGGCCTCGGTCTGCCGATCGCCGCCGAACTGATCGGGATCAACGGCGGAACCCTCACCCTCGACGCCTGCCAGGAC
GAGGGGACGAGCGGGGCGCGCTTCCGGATCGTGCTGCCGGAGGGCTGA

Upstream 100 bases:

>100_bases
TATTCCCGCCTGCGAATCTGTGGCTTGCGAACATGTATCCCGCGAAGGCCGGACCCGGCTCGAGCTTTCTCAATCCTCTC
TCCGCCGATCCTCATCCGCG

Downstream 100 bases:

>100_bases
CGCGATCGCCCGCGCGCGACCGCCGTGAACCGGGAGGGGCCCGGTCGGGGGGCGATGCCGGGCTCCGTGGCGCCGCTGAG
GCGCCGCGCGCAGGGGCCGG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MPARSVTGVSVKSDQAAAPATPAPAPARDLPERRTARLGLSGRLFLVTVAFVVVAEVLTYVPAVANYRIEWMSDRLAAAQ
VAALVLDGRTGEPVSEPLESRLLAGVNARAIAVRGGGAQRLLAIEPMPEQVADTVDLRDVTALSAIRGAWRTLVAPVHEP
IRVVGEGGIGFDRVEILLDEAPLRTAMIDYALRLLVSSLIIAAAAAGLVFVVLQVLIVRPVRRLATSITVFADDPEDAGR
IIAPSRRSDEIGQAERALGRMQRSLADQLRQKRRLAELGLAVSKISHELRNLLTGAQLLGDRLEGTEDPTVQRVAPRLVG
TLARAIRFCEATLAYGRVSERTPLLTSTPLAPIFAELPDLAALAAHPVSVQVAAGDLSVQADPEQLGRALANLVRNAVQA
LDGAAVPEATVSVVASRAASGRITILVTDNGPGLPARARENLFAPFQGSMRSGGTGLGLPIAAELIGINGGTLTLDACQD
EGTSGARFRIVLPEG

Sequences:

>Translated_495_residues
MPARSVTGVSVKSDQAAAPATPAPAPARDLPERRTARLGLSGRLFLVTVAFVVVAEVLTYVPAVANYRIEWMSDRLAAAQ
VAALVLDGRTGEPVSEPLESRLLAGVNARAIAVRGGGAQRLLAIEPMPEQVADTVDLRDVTALSAIRGAWRTLVAPVHEP
IRVVGEGGIGFDRVEILLDEAPLRTAMIDYALRLLVSSLIIAAAAAGLVFVVLQVLIVRPVRRLATSITVFADDPEDAGR
IIAPSRRSDEIGQAERALGRMQRSLADQLRQKRRLAELGLAVSKISHELRNLLTGAQLLGDRLEGTEDPTVQRVAPRLVG
TLARAIRFCEATLAYGRVSERTPLLTSTPLAPIFAELPDLAALAAHPVSVQVAAGDLSVQADPEQLGRALANLVRNAVQA
LDGAAVPEATVSVVASRAASGRITILVTDNGPGLPARARENLFAPFQGSMRSGGTGLGLPIAAELIGINGGTLTLDACQD
EGTSGARFRIVLPEG
>Mature_494_residues
PARSVTGVSVKSDQAAAPATPAPAPARDLPERRTARLGLSGRLFLVTVAFVVVAEVLTYVPAVANYRIEWMSDRLAAAQV
AALVLDGRTGEPVSEPLESRLLAGVNARAIAVRGGGAQRLLAIEPMPEQVADTVDLRDVTALSAIRGAWRTLVAPVHEPI
RVVGEGGIGFDRVEILLDEAPLRTAMIDYALRLLVSSLIIAAAAAGLVFVVLQVLIVRPVRRLATSITVFADDPEDAGRI
IAPSRRSDEIGQAERALGRMQRSLADQLRQKRRLAELGLAVSKISHELRNLLTGAQLLGDRLEGTEDPTVQRVAPRLVGT
LARAIRFCEATLAYGRVSERTPLLTSTPLAPIFAELPDLAALAAHPVSVQVAAGDLSVQADPEQLGRALANLVRNAVQAL
DGAAVPEATVSVVASRAASGRITILVTDNGPGLPARARENLFAPFQGSMRSGGTGLGLPIAAELIGINGGTLTLDACQDE
GTSGARFRIVLPEG

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=253, Percent_Identity=28.4584980237154, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790861, Length=301, Percent_Identity=26.578073089701, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790300, Length=265, Percent_Identity=30.9433962264151, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=31.1111111111111, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787894, Length=266, Percent_Identity=27.4436090225564, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52017; Mature: 51886

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPARSVTGVSVKSDQAAAPATPAPAPARDLPERRTARLGLSGRLFLVTVAFVVVAEVLTY
CCCCCCCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VPAVANYRIEWMSDRLAAAQVAALVLDGRTGEPVSEPLESRLLAGVNARAIAVRGGGAQR
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCE
LLAIEPMPEQVADTVDLRDVTALSAIRGAWRTLVAPVHEPIRVVGEGGIGFDRVEILLDE
EEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCHHHHHHHHCC
APLRTAMIDYALRLLVSSLIIAAAAAGLVFVVLQVLIVRPVRRLATSITVFADDPEDAGR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCC
IIAPSRRSDEIGQAERALGRMQRSLADQLRQKRRLAELGLAVSKISHELRNLLTGAQLLG
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRLEGTEDPTVQRVAPRLVGTLARAIRFCEATLAYGRVSERTPLLTSTPLAPIFAELPDL
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCHH
AALAAHPVSVQVAAGDLSVQADPEQLGRALANLVRNAVQALDGAAVPEATVSVVASRAAS
HHHHCCCCEEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
GRITILVTDNGPGLPARARENLFAPFQGSMRSGGTGLGLPIAAELIGINGGTLTLDACQD
CEEEEEEECCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHEEECCCCEEEEECCCC
EGTSGARFRIVLPEG
CCCCCCEEEEEECCC
>Mature Secondary Structure 
PARSVTGVSVKSDQAAAPATPAPAPARDLPERRTARLGLSGRLFLVTVAFVVVAEVLTY
CCCCCCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VPAVANYRIEWMSDRLAAAQVAALVLDGRTGEPVSEPLESRLLAGVNARAIAVRGGGAQR
HHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCE
LLAIEPMPEQVADTVDLRDVTALSAIRGAWRTLVAPVHEPIRVVGEGGIGFDRVEILLDE
EEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCHHHHHHHHCC
APLRTAMIDYALRLLVSSLIIAAAAAGLVFVVLQVLIVRPVRRLATSITVFADDPEDAGR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCC
IIAPSRRSDEIGQAERALGRMQRSLADQLRQKRRLAELGLAVSKISHELRNLLTGAQLLG
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRLEGTEDPTVQRVAPRLVGTLARAIRFCEATLAYGRVSERTPLLTSTPLAPIFAELPDL
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCHH
AALAAHPVSVQVAAGDLSVQADPEQLGRALANLVRNAVQALDGAAVPEATVSVVASRAAS
HHHHCCCCEEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
GRITILVTDNGPGLPARARENLFAPFQGSMRSGGTGLGLPIAAELIGINGGTLTLDACQD
CEEEEEEECCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHEEECCCCEEEEECCCC
EGTSGARFRIVLPEG
CCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]