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The map label for this gene is phoQ [H]

Identifier: 170751371

GI number: 170751371

Start: 5309840

End: 5311258

Strand: Direct

Name: phoQ [H]

Synonym: Mrad2831_4990

Alternate gene names: 170751371

Gene position: 5309840-5311258 (Clockwise)

Preceding gene: 170751370

Following gene: 170751372

Centisome position: 87.36

GC content: 71.46

Gene sequence:

>1419_bases
ATGATCGACCTCATCGGCCTCTTCTCCCTGCGCCGCCGCTCCATCGCGGTGCGGCTCGCCGTGTCGGCGTTCCTGTCGAG
CTCCGCGATCCTGCTGATCGCGGCCTGGATCCTCACGACCCTCTACCGCGAGAACACCGAGCGCTCCTTCGACAGCCGGC
TCCTCGTCTTCGCCAACAATCTCGCCACCGACCTCGTCTCGCCCAACGATCCCGAGAGCCGGACCTTCTCGCTCGGCGAC
CCGCGCTTCGACCTGCCCCTGTCGGGCTGGTACTGGCAGGTCGGCAAGCCCGACGCGAAGCCGCGCGACGTGCGCACCTC
CCGCTCCCTCGTGGGTGTGCCGCTCCCGCCCGCCACCGATTCGGACGGCAAGGTCGGGGTCGGGCAGATCCGTCAGGGCT
ACGGCAAGGGGCAGGACGGACGCCTCCTGCGCATCATGGAGCGCGACGTCGATCTCGGCGAGGAGGGCCGCTACACGGTC
CGGGTCGCCGGCCCCGCCGACGAGATCGTCAACGACGTCGACCGGTTCCGGAACTCGCTGACCATCACCTTCGGCCTGCT
CGGGCTGTCGCTGGCGATCACCACCCTGCTGCAGATCCGGTTCGGCCTCGCGCCGCTCAAGAAGATGCGCGCCGCGCTGG
GCGCCGTCCGCCGGGGCGAGGCCGACCGCATCACCGGCACCTATCCCCGCGACATCGCGCCGCTCACCGGCGAGGTGAAC
CTCCTGATCGAGACCAACCGCGAGATCCTGGAGCGCGCCCGGACCCAGGTCGGCAACCTGGCCCACGCCCTGAAGACGCC
GCTCTCGATCATCGTCAACGAGGTCGGCGCCTCCGACGCCCCCGAGGAGCTCGCGCAGAAGATCCGCGAGCAGGCCGCGG
TCATGCGCGATCAGGTCAACTACCACCTCGACCGCGCCCGGGCCGCCGCCCTCGCCGGCACGCTCGGCACCTCGACAGAG
GTGGAGCCGGCGCTCGCGGGCCTCGTGCGCACCTTCGGGAAGATCTACCGGGACAAGGACATCGCCTACGACGTCCACGT
GCCGCCGGGCCTGCGCTTCCGCGGCGAGCGCCAGGATTTCGAGGAGATGGTCGGCAACCTCGTCGACAACGCGTCGAAAT
GGGCCCACGGCCGCGTCGCGATCCGGGCCGAGGCGGTGAACACGAACGATTATCCCCATCTCGTCGTCGCCATCGAGGAT
GACGGCCCCGGCCTGCCCCCGGAGGCCCGCCAGGCCGTGCTCGGCCGCGGGCGGCGCCTCGACGAATCGAAGCCCGGCTC
CGGCCTCGGCCTGTCGATCGTGGCCGACCTCGCCGCCCTGTACCGGGGACGCTTCACCCTGGAGGAGGCGGCGCTCGGCG
GCCTGCGGGCGGTGCTGGAGGTGCCGGGCGACCTGCCGGTCGGCACCCCGACCCACTGA

Upstream 100 bases:

>100_bases
GCGGGCCGAGCGCGGCGCCTTCTTCCGCACGGCGCGCCCGCTGATGCGTGGCGCGGTGTTCTACGACGCGCCGCCGCCCG
TCTGAGCGACCGACGCAACC

Downstream 100 bases:

>100_bases
GGCCGTCCGCCGCCTCCGGGTACGGGCCGGGCACGGATCGAGCTGCGGGACGCGGCCTCATGGCTCCGCCCGGCCCCTTG
TCTTCGCAACAGAGTTGCGT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MIDLIGLFSLRRRSIAVRLAVSAFLSSSAILLIAAWILTTLYRENTERSFDSRLLVFANNLATDLVSPNDPESRTFSLGD
PRFDLPLSGWYWQVGKPDAKPRDVRTSRSLVGVPLPPATDSDGKVGVGQIRQGYGKGQDGRLLRIMERDVDLGEEGRYTV
RVAGPADEIVNDVDRFRNSLTITFGLLGLSLAITTLLQIRFGLAPLKKMRAALGAVRRGEADRITGTYPRDIAPLTGEVN
LLIETNREILERARTQVGNLAHALKTPLSIIVNEVGASDAPEELAQKIREQAAVMRDQVNYHLDRARAAALAGTLGTSTE
VEPALAGLVRTFGKIYRDKDIAYDVHVPPGLRFRGERQDFEEMVGNLVDNASKWAHGRVAIRAEAVNTNDYPHLVVAIED
DGPGLPPEARQAVLGRGRRLDESKPGSGLGLSIVADLAALYRGRFTLEEAALGGLRAVLEVPGDLPVGTPTH

Sequences:

>Translated_472_residues
MIDLIGLFSLRRRSIAVRLAVSAFLSSSAILLIAAWILTTLYRENTERSFDSRLLVFANNLATDLVSPNDPESRTFSLGD
PRFDLPLSGWYWQVGKPDAKPRDVRTSRSLVGVPLPPATDSDGKVGVGQIRQGYGKGQDGRLLRIMERDVDLGEEGRYTV
RVAGPADEIVNDVDRFRNSLTITFGLLGLSLAITTLLQIRFGLAPLKKMRAALGAVRRGEADRITGTYPRDIAPLTGEVN
LLIETNREILERARTQVGNLAHALKTPLSIIVNEVGASDAPEELAQKIREQAAVMRDQVNYHLDRARAAALAGTLGTSTE
VEPALAGLVRTFGKIYRDKDIAYDVHVPPGLRFRGERQDFEEMVGNLVDNASKWAHGRVAIRAEAVNTNDYPHLVVAIED
DGPGLPPEARQAVLGRGRRLDESKPGSGLGLSIVADLAALYRGRFTLEEAALGGLRAVLEVPGDLPVGTPTH
>Mature_472_residues
MIDLIGLFSLRRRSIAVRLAVSAFLSSSAILLIAAWILTTLYRENTERSFDSRLLVFANNLATDLVSPNDPESRTFSLGD
PRFDLPLSGWYWQVGKPDAKPRDVRTSRSLVGVPLPPATDSDGKVGVGQIRQGYGKGQDGRLLRIMERDVDLGEEGRYTV
RVAGPADEIVNDVDRFRNSLTITFGLLGLSLAITTLLQIRFGLAPLKKMRAALGAVRRGEADRITGTYPRDIAPLTGEVN
LLIETNREILERARTQVGNLAHALKTPLSIIVNEVGASDAPEELAQKIREQAAVMRDQVNYHLDRARAAALAGTLGTSTE
VEPALAGLVRTFGKIYRDKDIAYDVHVPPGLRFRGERQDFEEMVGNLVDNASKWAHGRVAIRAEAVNTNDYPHLVVAIED
DGPGLPPEARQAVLGRGRRLDESKPGSGLGLSIVADLAALYRGRFTLEEAALGGLRAVLEVPGDLPVGTPTH

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=266, Percent_Identity=29.6992481203008, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790346, Length=249, Percent_Identity=24.0963855421687, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1786600, Length=254, Percent_Identity=26.3779527559055, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51382; Mature: 51382

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLIGLFSLRRRSIAVRLAVSAFLSSSAILLIAAWILTTLYRENTERSFDSRLLVFANN
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHCEEEEEECH
LATDLVSPNDPESRTFSLGDPRFDLPLSGWYWQVGKPDAKPRDVRTSRSLVGVPLPPATD
HHHHCCCCCCCCCCEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCEEECCCCCCCC
SDGKVGVGQIRQGYGKGQDGRLLRIMERDVDLGEEGRYTVRVAGPADEIVNDVDRFRNSL
CCCCCCHHHHHHCCCCCCCCCEEEEEHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCE
TITFGLLGLSLAITTLLQIRFGLAPLKKMRAALGAVRRGEADRITGTYPRDIAPLTGEVN
EEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEE
LLIETNREILERARTQVGNLAHALKTPLSIIVNEVGASDAPEELAQKIREQAAVMRDQVN
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
YHLDRARAAALAGTLGTSTEVEPALAGLVRTFGKIYRDKDIAYDVHVPPGLRFRGERQDF
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHH
EEMVGNLVDNASKWAHGRVAIRAEAVNTNDYPHLVVAIEDDGPGLPPEARQAVLGRGRRL
HHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCC
DESKPGSGLGLSIVADLAALYRGRFTLEEAALGGLRAVLEVPGDLPVGTPTH
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MIDLIGLFSLRRRSIAVRLAVSAFLSSSAILLIAAWILTTLYRENTERSFDSRLLVFANN
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHCEEEEEECH
LATDLVSPNDPESRTFSLGDPRFDLPLSGWYWQVGKPDAKPRDVRTSRSLVGVPLPPATD
HHHHCCCCCCCCCCEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCEEECCCCCCCC
SDGKVGVGQIRQGYGKGQDGRLLRIMERDVDLGEEGRYTVRVAGPADEIVNDVDRFRNSL
CCCCCCHHHHHHCCCCCCCCCEEEEEHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCE
TITFGLLGLSLAITTLLQIRFGLAPLKKMRAALGAVRRGEADRITGTYPRDIAPLTGEVN
EEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEE
LLIETNREILERARTQVGNLAHALKTPLSIIVNEVGASDAPEELAQKIREQAAVMRDQVN
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
YHLDRARAAALAGTLGTSTEVEPALAGLVRTFGKIYRDKDIAYDVHVPPGLRFRGERQDF
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHH
EEMVGNLVDNASKWAHGRVAIRAEAVNTNDYPHLVVAIEDDGPGLPPEARQAVLGRGRRL
HHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCC
DESKPGSGLGLSIVADLAALYRGRFTLEEAALGGLRAVLEVPGDLPVGTPTH
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]