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The map label for this gene is cheA [H]

Identifier: 170751198

GI number: 170751198

Start: 5141719

End: 5143827

Strand: Direct

Name: cheA [H]

Synonym: Mrad2831_4815

Alternate gene names: 170751198

Gene position: 5141719-5143827 (Clockwise)

Preceding gene: 170751197

Following gene: 170751199

Centisome position: 84.6

GC content: 75.3

Gene sequence:

>2109_bases
ATGACTGCCCTGGATCCGGCGGAGATCTTCCGCGCCGAGGCCGCCGAGCTGCTCGCCTGCCTGGAGACGACCCTGCTCGA
CCTCGGCGACCGGCCCGAGGACCGGACCCTGATCGACACCGCCTTCCGCGCCCTGCACACCATCAAGGGCTCGGGCGCCA
TGTTCGGCTTCGAGCAGGTCGCCGCCTTCACCCACGACTTCGAGACCGCCTTCGACCGCGTCCGCCGCGGCGAGGTCCCG
GTCGGCCGCGACCTCGTCAACGTCTCCCTCTCGGCCAAGGACTTCATCCGCGGCCTCATCGAGGAGCCCGAGGTCAGCGC
GCCCATCATCGGCGAGGCCATCCTGGCCGAGCTCGAGCAGCTCCTCGGCGCCGCGGGCGCCGACGCGGCCCAGGCCGCTG
CCGATACCGCTGCCGATACCGCCGCCGATACCGCCGCCGCTTCCGACGCCCCGCCCGCCGAGGCCGGCTGGCGGATCGGC
ATCGCCTTCGCCCCGGACGTCCTGCGCAACGGCACCAACCCGCTCGCCCTCCTCGACGAGCTGCGCGACCTCGGCGCCTG
CACGGTCGTGCCGCGGCTCGAGGCCCTGCCCGAGCTGCCCGGCCTCGATCCCGAGAGCCTCGCCCTCGGCTGGGACGTCA
CGCTGCGCGGGCCCGTCAGCCGCGCGGCGGTCGAGGACGTGTTCCTGTTCGTGCGCGACGAGATGGTCCTGACCCTGGAG
CCGGCCGGCCCGGCGTTGCCGGACGCCGCCCCGCCCGAGCCGGTGCCGGTCCAGGCGCGCGCGCCCGCTCCGGTCGCGGC
GGAGCCGGCACCACCGGCCGCGCCCGCTGCCGCGCCCGCTGCCGCTGCCACCCCGGCCGTCGCCGCTGCCGCGCCGGCCG
ATGCCCGGGCGCCGGCGCGGCGGGCCGAGGACCGGCCGGCCAGCAGCGTGCGGGTCGAGGCCGAGCGGCTCGACGAGCTG
ATGGACCGGGTCGGCGAACTCGTCATCGCCCAGGCCCGCCTCGGCCAGCTCGCCGGCTTGCACGCCGATCCCGGCCTCAA
GACCGTCGCGGAGGAGATCGAGCGCCTCTCGGCGCGCCTGCGCGACACCACGATGAGCATCCGCATGGTCGCCATCGGCG
CCCTGTTCGGCCGCTTCCGCCGCCTCGTCCACGACCTCGCGCGCGACCTCGGCAAGCCGGTCGAGTTCGTCACCGGCGGC
GAGGAGACCGAGCTCGACAAGACCGTGATCGAGCGCCTGGCCGACCCGCTCGTCCACCTGATCCGCAACGCCATCGACCA
CGGCATCGAGGCGCCCGCGCAGCGCGCGGCCGCCGCCAAGCCCGCCACGGGCCGGATCACGCTCACCGCCGAGCATGTCG
GCGCCCAGGTGCTGGTGAGCGTGCGCGACGACGGCGCCGGGCTCGACGCGGCGCGCATCCGCGCCAAGGCCGAGGAGCGG
GGCCTGTGCGCGCCCGGCGCGGTGCTGAGCGACCAGCAGATCTACCAGTTCCTGTTCGCGCCGGGCTTCTCGACCGCGCC
GACGATCTCGGCGCTGTCGGGGCGCGGGGTCGGCATGGACGTGGTCAAGAAGACGATCGAGAGCCTGCGCGGCACGATCG
ACATCACCACCGAGCCGGGGGGCGGGACCTGCGTGGCGCTGCGCCTGCCGCTGACCCTGGCGATCATCGAGGGGCTGCTG
ATCCGGGTCGGCGCGGGGCGCTACGTGATCCCGCTGGCGGCGGTGGAGGAGTGCGTCGCGCTGCCCGCGGGCGAGCGCGG
CGGGCGCGGGCGGGACTTCCTGAACATCCGCGGCGCGCTGGTGCCGTTCCTGCGGCTGCGCGACCTGTTCGGGGCGCCGG
GCGAGCCGGAGGAGCACCAGAAGGTGATCGTGGTGTCGGCGGGCGAGGCGCGGGTCGGCCTGGTGGCGGACCAGATCATC
GGCAACCACCAGACGGTGATCAAGTCGCTGTCGAAGCTGCACGCGGACGTGGCGACGTTCTCGGGGGCGACGATCCTGGG
CGACGGCACGGCCGCGCTGATCGTCGATGTCGGCCGGCTCGTGGGCGGCGGCGAGCGGGCGCACGAGAGCCCGCGCGAGA
GCCCGCGCGCCTACCAGGAGGTGGCGTGA

Upstream 100 bases:

>100_bases
CGAAGGAAACGGCCCGCGTTCGGAGCTGGAATCTCGCCCCGCTCGGGATGGGGCGCTTCATTCTGTATCTGCGTGCTGTG
TGCGAGGGTCCGATCGTCCC

Downstream 100 bases:

>100_bases
TGAGCGGCGGCGTGACGAGCGGCGTGACGAGCGGTGTGACGCGCGGCGTGACGCGCGGGTCTCCCGGGTCCGGGCCGCAG
GCGGGCGCGCAGTCTGGCGC

Product: CheA signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 702; Mature: 701

Protein sequence:

>702_residues
MTALDPAEIFRAEAAELLACLETTLLDLGDRPEDRTLIDTAFRALHTIKGSGAMFGFEQVAAFTHDFETAFDRVRRGEVP
VGRDLVNVSLSAKDFIRGLIEEPEVSAPIIGEAILAELEQLLGAAGADAAQAAADTAADTAADTAAASDAPPAEAGWRIG
IAFAPDVLRNGTNPLALLDELRDLGACTVVPRLEALPELPGLDPESLALGWDVTLRGPVSRAAVEDVFLFVRDEMVLTLE
PAGPALPDAAPPEPVPVQARAPAPVAAEPAPPAAPAAAPAAAATPAVAAAAPADARAPARRAEDRPASSVRVEAERLDEL
MDRVGELVIAQARLGQLAGLHADPGLKTVAEEIERLSARLRDTTMSIRMVAIGALFGRFRRLVHDLARDLGKPVEFVTGG
EETELDKTVIERLADPLVHLIRNAIDHGIEAPAQRAAAAKPATGRITLTAEHVGAQVLVSVRDDGAGLDAARIRAKAEER
GLCAPGAVLSDQQIYQFLFAPGFSTAPTISALSGRGVGMDVVKKTIESLRGTIDITTEPGGGTCVALRLPLTLAIIEGLL
IRVGAGRYVIPLAAVEECVALPAGERGGRGRDFLNIRGALVPFLRLRDLFGAPGEPEEHQKVIVVSAGEARVGLVADQII
GNHQTVIKSLSKLHADVATFSGATILGDGTAALIVDVGRLVGGGERAHESPRESPRAYQEVA

Sequences:

>Translated_702_residues
MTALDPAEIFRAEAAELLACLETTLLDLGDRPEDRTLIDTAFRALHTIKGSGAMFGFEQVAAFTHDFETAFDRVRRGEVP
VGRDLVNVSLSAKDFIRGLIEEPEVSAPIIGEAILAELEQLLGAAGADAAQAAADTAADTAADTAAASDAPPAEAGWRIG
IAFAPDVLRNGTNPLALLDELRDLGACTVVPRLEALPELPGLDPESLALGWDVTLRGPVSRAAVEDVFLFVRDEMVLTLE
PAGPALPDAAPPEPVPVQARAPAPVAAEPAPPAAPAAAPAAAATPAVAAAAPADARAPARRAEDRPASSVRVEAERLDEL
MDRVGELVIAQARLGQLAGLHADPGLKTVAEEIERLSARLRDTTMSIRMVAIGALFGRFRRLVHDLARDLGKPVEFVTGG
EETELDKTVIERLADPLVHLIRNAIDHGIEAPAQRAAAAKPATGRITLTAEHVGAQVLVSVRDDGAGLDAARIRAKAEER
GLCAPGAVLSDQQIYQFLFAPGFSTAPTISALSGRGVGMDVVKKTIESLRGTIDITTEPGGGTCVALRLPLTLAIIEGLL
IRVGAGRYVIPLAAVEECVALPAGERGGRGRDFLNIRGALVPFLRLRDLFGAPGEPEEHQKVIVVSAGEARVGLVADQII
GNHQTVIKSLSKLHADVATFSGATILGDGTAALIVDVGRLVGGGERAHESPRESPRAYQEVA
>Mature_701_residues
TALDPAEIFRAEAAELLACLETTLLDLGDRPEDRTLIDTAFRALHTIKGSGAMFGFEQVAAFTHDFETAFDRVRRGEVPV
GRDLVNVSLSAKDFIRGLIEEPEVSAPIIGEAILAELEQLLGAAGADAAQAAADTAADTAADTAAASDAPPAEAGWRIGI
AFAPDVLRNGTNPLALLDELRDLGACTVVPRLEALPELPGLDPESLALGWDVTLRGPVSRAAVEDVFLFVRDEMVLTLEP
AGPALPDAAPPEPVPVQARAPAPVAAEPAPPAAPAAAPAAAATPAVAAAAPADARAPARRAEDRPASSVRVEAERLDELM
DRVGELVIAQARLGQLAGLHADPGLKTVAEEIERLSARLRDTTMSIRMVAIGALFGRFRRLVHDLARDLGKPVEFVTGGE
ETELDKTVIERLADPLVHLIRNAIDHGIEAPAQRAAAAKPATGRITLTAEHVGAQVLVSVRDDGAGLDAARIRAKAEERG
LCAPGAVLSDQQIYQFLFAPGFSTAPTISALSGRGVGMDVVKKTIESLRGTIDITTEPGGGTCVALRLPLTLAIIEGLLI
RVGAGRYVIPLAAVEECVALPAGERGGRGRDFLNIRGALVPFLRLRDLFGAPGEPEEHQKVIVVSAGEARVGLVADQIIG
NHQTVIKSLSKLHADVATFSGATILGDGTAALIVDVGRLVGGGERAHESPRESPRAYQEVA

Specific function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY [H]

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HPt domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=700, Percent_Identity=34.8571428571429, Blast_Score=347, Evalue=2e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR015162
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR004105
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF01584 CheW; PF09078 CheY-binding; PF02895 H-kinase_dim; PF02518 HATPase_c; PF01627 Hpt [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 73362; Mature: 73231

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALDPAEIFRAEAAELLACLETTLLDLGDRPEDRTLIDTAFRALHTIKGSGAMFGFEQV
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
AAFTHDFETAFDRVRRGEVPVGRDLVNVSLSAKDFIRGLIEEPEVSAPIIGEAILAELEQ
HHHHHHHHHHHHHHHCCCCCCCCHHEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LLGAAGADAAQAAADTAADTAADTAAASDAPPAEAGWRIGIAFAPDVLRNGTNPLALLDE
HHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHCCCCHHHHHHH
LRDLGACTVVPRLEALPELPGLDPESLALGWDVTLRGPVSRAAVEDVFLFVRDEMVLTLE
HHHCCCEEECHHHHHCCCCCCCCHHHEEEEECEEECCCHHHHHHHHHHHHEECCEEEEEC
PAGPALPDAAPPEPVPVQARAPAPVAAEPAPPAAPAAAPAAAATPAVAAAAPADARAPAR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHCCCCCCCCCHH
RAEDRPASSVRVEAERLDELMDRVGELVIAQARLGQLAGLHADPGLKTVAEEIERLSARL
HCCCCCCCHHEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
RDTTMSIRMVAIGALFGRFRRLVHDLARDLGKPVEFVTGGEETELDKTVIERLADPLVHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
IRNAIDHGIEAPAQRAAAAKPATGRITLTAEHVGAQVLVSVRDDGAGLDAARIRAKAEER
HHHHHHHCCCCHHHHHHCCCCCCCEEEEEHHHCCEEEEEEECCCCCCCCHHHHHHHHHHC
GLCAPGAVLSDQQIYQFLFAPGFSTAPTISALSGRGVGMDVVKKTIESLRGTIDITTEPG
CCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCEEEEEECCC
GGTCVALRLPLTLAIIEGLLIRVGAGRYVIPLAAVEECVALPAGERGGRGRDFLNIRGAL
CCEEEEEEHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
VPFLRLRDLFGAPGEPEEHQKVIVVSAGEARVGLVADQIIGNHQTVIKSLSKLHADVATF
HHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
SGATILGDGTAALIVDVGRLVGGGERAHESPRESPRAYQEVA
CCCEEECCCCHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHCC
>Mature Secondary Structure 
TALDPAEIFRAEAAELLACLETTLLDLGDRPEDRTLIDTAFRALHTIKGSGAMFGFEQV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
AAFTHDFETAFDRVRRGEVPVGRDLVNVSLSAKDFIRGLIEEPEVSAPIIGEAILAELEQ
HHHHHHHHHHHHHHHCCCCCCCCHHEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LLGAAGADAAQAAADTAADTAADTAAASDAPPAEAGWRIGIAFAPDVLRNGTNPLALLDE
HHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHCCCCHHHHHHH
LRDLGACTVVPRLEALPELPGLDPESLALGWDVTLRGPVSRAAVEDVFLFVRDEMVLTLE
HHHCCCEEECHHHHHCCCCCCCCHHHEEEEECEEECCCHHHHHHHHHHHHEECCEEEEEC
PAGPALPDAAPPEPVPVQARAPAPVAAEPAPPAAPAAAPAAAATPAVAAAAPADARAPAR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHCCCCCCCCCHH
RAEDRPASSVRVEAERLDELMDRVGELVIAQARLGQLAGLHADPGLKTVAEEIERLSARL
HCCCCCCCHHEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
RDTTMSIRMVAIGALFGRFRRLVHDLARDLGKPVEFVTGGEETELDKTVIERLADPLVHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
IRNAIDHGIEAPAQRAAAAKPATGRITLTAEHVGAQVLVSVRDDGAGLDAARIRAKAEER
HHHHHHHCCCCHHHHHHCCCCCCCEEEEEHHHCCEEEEEEECCCCCCCCHHHHHHHHHHC
GLCAPGAVLSDQQIYQFLFAPGFSTAPTISALSGRGVGMDVVKKTIESLRGTIDITTEPG
CCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCEEEEEECCC
GGTCVALRLPLTLAIIEGLLIRVGAGRYVIPLAAVEECVALPAGERGGRGRDFLNIRGAL
CCEEEEEEHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
VPFLRLRDLFGAPGEPEEHQKVIVVSAGEARVGLVADQIIGNHQTVIKSLSKLHADVATF
HHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
SGATILGDGTAALIVDVGRLVGGGERAHESPRESPRAYQEVA
CCCEEECCCCHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3278311; 11677609 [H]