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The map label for this gene is appC [H]

Identifier: 170751146

GI number: 170751146

Start: 5075262

End: 5076185

Strand: Reverse

Name: appC [H]

Synonym: Mrad2831_4762

Alternate gene names: 170751146

Gene position: 5076185-5075262 (Counterclockwise)

Preceding gene: 170751147

Following gene: 170751145

Centisome position: 83.52

GC content: 72.19

Gene sequence:

>924_bases
ATGAGCGCCCTCGCCGCGGCCGAACCGGCGGTGCGGCCCCAGCCGGTGCGATCCGAGACCGCGCCACCGATGCCGCGCCC
GGCGGCGGATCCCGGCCTCGCCGCCTTGCGCCTCTTCCTGCGCAACCCGAGCGGGCTCCTGGGCCTGGCCATCCTGATCG
GCCTGCTGTTCGCCGCGCTGGCGGGCCCGCACCTCTACGGGGTCGACCCGTTCGAGATCGTCGGCGCCCCGTTCCAGCCA
CCCGGCGGCGACCCGGTGCTGGGCACCGATTACCTGGGTCAGGATATCCTGGCGGCCCTGCTCCAGGGCGGCCGCGCGAC
CCTGCTGGTCGGGTTCTCGGCGGCGCTCATCACCGTGGTGATCGGCGTGACCTTCGGGGCGCTCGCGGGCTTCTTCGGCG
GCCGGGTCGACGCGGCGCTGATGAAGGTCACCGAGTTCTTCCAGGTGCTGCCGACCCTGCTGTTCGCGATGGTTCTGGTC
ACCCTGTTCGGCCAGAAGATCGCCATCACCACGATCGCGATCGGCATCGTGTCGTGGCCGCCGACCGCCCGGTTGACCCG
GGCCGAGTTCCTGCGCCTGCGCGGCCTCGACTTCGTCAAGGCAGCCCGGGCGGCCGGTGCCGGACCGCTCTACCTGATCG
GACGGGTGATCCTGCCGAACGCCGCGCCGCCGATCGTGGTCTCCGCGACGCTGGCGATCGGCACCGCCGTGCTGTTCGAG
GGGGCCTTGAGTTTCCTCGGCCTGGGCGACCCCAACGTGATGAGCTGGGGGCTGATGATCGGGCAGAACCGCGCCTACGC
CCTGGAGGCGTGGTGGACCGTGCTGCTGCCCGGCGCGGCGATCTTCCTCGCGGTCCTCGGCGTCAGCCTCGTGGGCGACG
CGGTCAACGACGCGGTCAATCCGCGCCTGCGCAAGCGGAGCTGA

Upstream 100 bases:

>100_bases
GCATCCTGTTCTGCTCGGCGCTGCTGGTCATCGCCGCGAACCTCGTCACCGACCTCCTCTACCGCCTGATCGACCCGCGG
ATCCGCGCCGGGAGGCCGGC

Downstream 100 bases:

>100_bases
GCGATGGCCCCCGTACTCGCCGTCGAGGACCTGACCGTGACCCTGACGCGGCCGGGCGGCCGCGTGCCGGTCCTGGAGCG
GCTCAGCTTCTCCGTCGAGG

Product: binding-protein-dependent transport systems inner membrane component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MSALAAAEPAVRPQPVRSETAPPMPRPAADPGLAALRLFLRNPSGLLGLAILIGLLFAALAGPHLYGVDPFEIVGAPFQP
PGGDPVLGTDYLGQDILAALLQGGRATLLVGFSAALITVVIGVTFGALAGFFGGRVDAALMKVTEFFQVLPTLLFAMVLV
TLFGQKIAITTIAIGIVSWPPTARLTRAEFLRLRGLDFVKAARAAGAGPLYLIGRVILPNAAPPIVVSATLAIGTAVLFE
GALSFLGLGDPNVMSWGLMIGQNRAYALEAWWTVLLPGAAIFLAVLGVSLVGDAVNDAVNPRLRKRS

Sequences:

>Translated_307_residues
MSALAAAEPAVRPQPVRSETAPPMPRPAADPGLAALRLFLRNPSGLLGLAILIGLLFAALAGPHLYGVDPFEIVGAPFQP
PGGDPVLGTDYLGQDILAALLQGGRATLLVGFSAALITVVIGVTFGALAGFFGGRVDAALMKVTEFFQVLPTLLFAMVLV
TLFGQKIAITTIAIGIVSWPPTARLTRAEFLRLRGLDFVKAARAAGAGPLYLIGRVILPNAAPPIVVSATLAIGTAVLFE
GALSFLGLGDPNVMSWGLMIGQNRAYALEAWWTVLLPGAAIFLAVLGVSLVGDAVNDAVNPRLRKRS
>Mature_306_residues
SALAAAEPAVRPQPVRSETAPPMPRPAADPGLAALRLFLRNPSGLLGLAILIGLLFAALAGPHLYGVDPFEIVGAPFQPP
GGDPVLGTDYLGQDILAALLQGGRATLLVGFSAALITVVIGVTFGALAGFFGGRVDAALMKVTEFFQVLPTLLFAMVLVT
LFGQKIAITTIAIGIVSWPPTARLTRAEFLRLRGLDFVKAARAAGAGPLYLIGRVILPNAAPPIVVSATLAIGTAVLFEG
ALSFLGLGDPNVMSWGLMIGQNRAYALEAWWTVLLPGAAIFLAVLGVSLVGDAVNDAVNPRLRKRS

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787760, Length=289, Percent_Identity=33.9100346020761, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789964, Length=277, Percent_Identity=37.9061371841155, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1787054, Length=308, Percent_Identity=32.1428571428571, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1787498, Length=277, Percent_Identity=34.2960288808664, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1789889, Length=224, Percent_Identity=35.2678571428571, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1787549, Length=298, Percent_Identity=31.2080536912752, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788505, Length=241, Percent_Identity=34.0248962655602, Blast_Score=98, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 31845; Mature: 31714

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALAAAEPAVRPQPVRSETAPPMPRPAADPGLAALRLFLRNPSGLLGLAILIGLLFAAL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AGPHLYGVDPFEIVGAPFQPPGGDPVLGTDYLGQDILAALLQGGRATLLVGFSAALITVV
CCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHH
IGVTFGALAGFFGGRVDAALMKVTEFFQVLPTLLFAMVLVTLFGQKIAITTIAIGIVSWP
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
PTARLTRAEFLRLRGLDFVKAARAAGAGPLYLIGRVILPNAAPPIVVSATLAIGTAVLFE
CCCHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHH
GALSFLGLGDPNVMSWGLMIGQNRAYALEAWWTVLLPGAAIFLAVLGVSLVGDAVNDAVN
HHHHHHCCCCCCHHEEHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRLRKRS
CHHHCCC
>Mature Secondary Structure 
SALAAAEPAVRPQPVRSETAPPMPRPAADPGLAALRLFLRNPSGLLGLAILIGLLFAAL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH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CHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]