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The map label for this gene is hisI [H]

Identifier: 170751027

GI number: 170751027

Start: 4935027

End: 4935449

Strand: Reverse

Name: hisI [H]

Synonym: Mrad2831_4638

Alternate gene names: 170751027

Gene position: 4935449-4935027 (Counterclockwise)

Preceding gene: 170751028

Following gene: 170751026

Centisome position: 81.2

GC content: 73.52

Gene sequence:

>423_bases
ATGACCGCGCGCGACATCGCCTTCGATCCCCCCGGCACCCGCGCCGAGGTCGAGGAGGGCGCGGCCCTCACGCCGCGCTT
CGACCGCGACGGCCTCGTCGCCTGCATCGCGGTGGACGCGCGGGACGGGCAGGTGCTGATGCTCGCCCACATGAACGCCG
AATCGCTGGCGCGCACCCTCGAGACCGGCGAGGCGTGGTACTGGTCGCGCTCGCGCCGGGAACTCTGGCACAAGGGGGCG
ACCAGCGGCCAGATCCAGCGCATCGTCGAGATGCGGGTCGACTGCGACCAGGACGCCCTGCTGATCCGCGTCGAGGTCGG
CGGCGACGGCGGCTGCTGCCACACCGGCCGGCGCGACTGCTTCTACCGCAGCGTCGTCCGGGAGGCGGACGGCCGGGTGG
TCCTGAAAGCCGCCGGGCGATGA

Upstream 100 bases:

>100_bases
GCGGCGTCTTCAAGGACAACGCCAACGAGCAGGTCCGCTTCCTGACCCTGGTGCGCGGCGGCGCCAAGTAGCTCCGACGA
GCGAGCCGGATCACCCTGCC

Downstream 100 bases:

>100_bases
GCCGCCCTCTTGCCACCCGGTGGCAAGACGAGTCCGCCGACCCGCATTTCCCGCCCGGAACCGTCGAGCCGCTCCGGCCG
CCGCCGAGCCCCGGTCCGCT

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MTARDIAFDPPGTRAEVEEGAALTPRFDRDGLVACIAVDARDGQVLMLAHMNAESLARTLETGEAWYWSRSRRELWHKGA
TSGQIQRIVEMRVDCDQDALLIRVEVGGDGGCCHTGRRDCFYRSVVREADGRVVLKAAGR

Sequences:

>Translated_140_residues
MTARDIAFDPPGTRAEVEEGAALTPRFDRDGLVACIAVDARDGQVLMLAHMNAESLARTLETGEAWYWSRSRRELWHKGA
TSGQIQRIVEMRVDCDQDALLIRVEVGGDGGCCHTGRRDCFYRSVVREADGRVVLKAAGR
>Mature_139_residues
TARDIAFDPPGTRAEVEEGAALTPRFDRDGLVACIAVDARDGQVLMLAHMNAESLARTLETGEAWYWSRSRRELWHKGAT
SGQIQRIVEMRVDCDQDALLIRVEVGGDGGCCHTGRRDCFYRSVVREADGRVVLKAAGR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=92, Percent_Identity=43.4782608695652, Blast_Score=86, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319819, Length=97, Percent_Identity=40.2061855670103, Blast_Score=71, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 15492; Mature: 15360

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARDIAFDPPGTRAEVEEGAALTPRFDRDGLVACIAVDARDGQVLMLAHMNAESLARTL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHH
ETGEAWYWSRSRRELWHKGATSGQIQRIVEMRVDCDQDALLIRVEVGGDGGCCHTGRRDC
HCCCCEEECCHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCHHH
FYRSVVREADGRVVLKAAGR
HHHHHHHCCCCEEEEEECCC
>Mature Secondary Structure 
TARDIAFDPPGTRAEVEEGAALTPRFDRDGLVACIAVDARDGQVLMLAHMNAESLARTL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHH
ETGEAWYWSRSRRELWHKGATSGQIQRIVEMRVDCDQDALLIRVEVGGDGGCCHTGRRDC
HCCCCEEECCHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCHHH
FYRSVVREADGRVVLKAAGR
HHHHHHHCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA