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The map label for this gene is nhaA [H]

Identifier: 170750891

GI number: 170750891

Start: 4784299

End: 4785501

Strand: Reverse

Name: nhaA [H]

Synonym: Mrad2831_4502

Alternate gene names: 170750891

Gene position: 4785501-4784299 (Counterclockwise)

Preceding gene: 170750892

Following gene: 170750890

Centisome position: 78.74

GC content: 74.73

Gene sequence:

>1203_bases
ATGACGTCGCCCACCCCCGACAGCCCCCCGCCGCGGCGCGGCCCGCGCCCCCTCTCGATCATCCGCACGCTGCTCGCCGG
CGAGGCGGCGGGCGGGCTGATCCTGATGGCGGCGGCGGCCCTGGCGCTGGTGGTCGCCAACGGCCCGCTGGCCGGGACCT
ACGCGCACGCCCTCCACGCCGAACTCGGCCCGTTGAGCGTCCAGCACTGGATCAACGACGGCCTGATGGCCGGCTTCTTC
CTGCTGGTCGGGCTGGAGATCAAGCGCGAGGCGCTGGACGGGCGGCTGCGCACCTGGCCCGACCGGGTCCTGCCCGGCTT
CGCGGCGCTCGGCGGCATGGCGGTTCCGGCCGCGTTCTACGCGCTCGCCAACCTCGGCGCCGGCACCCTGCGGGGCTGGG
CTATTCCCGCGGCCACCGACATCGCCTTCGCGCTGGGCGTCCTGGCGCTCCTCGGGTCGCGGGTGCCGGTCTCCCTCAAG
ATCTTCCTCAGCGCGGTCGCCATCGTCGACGACCTCGGCGCCGTCGTGGTGATCGCGCTGTTCTACAGCTCCGGCCTCGA
CCTCGCCGCGCTGGGGCTCGCCGCCCTGGTGCTGGCCGGCCTCTACGGCCTCAACCGGGCGGGGATCGGGTGGCTTCCGG
CCTACGGGCTCCTCGGCCTCGTGCTCTGGGTCCTCGTGCTGCGCTCCGGGATCCACGCGACGATCGCGGGCGTGCTGCTC
GCGCTCACCGTCCCGATCCGGGTCAGCCCGGGCCGGCCGGAGGACGCGCACTCGCCCCTGCACCGGCTGGAGCACGCCCT
CGCGCCCTGGATCACCTACGGGGTGGTGCCGGTCTTCGGCTTCGCCAATGCAGGCGTGGACCTCTCCGGCCTCACCCCCG
AGGCCCTGCTCCAGCCGGTGACGCTCGGCATCGCGGCGGGCCTGTTCCTGGGCAAGCAGGCCGGCGTGTTCGCGAGCCTG
CGGCTGGCGGTGGCGCTGGGATGGGCCAAGCGCCCGGCCGGGGCCGGCTGGGGGCAGGTCTACGGGGTCGCGGTGCTGTG
CGGCATCGGCTTCACCATGAGCCTGTTCATCGGCGGCCTCGCCTTCCCGGACCCGCAGCACGAGACCGCCGTGAAGCTCG
GCGTGCTCGCGGGCTCGGCCCTGTCGGGACTCGCCGGCGCGGCGATCCTTCTCGTCACGAAGCGCCGCGCCACCCCGCAC
TAG

Upstream 100 bases:

>100_bases
CGCTGATCCGCGCTGCCCTGGGGCGGACGTCGTAGGGCTTCGAGCGGGACTTCGGCCAGTCGCTTGCGCGTCCCCGCGAT
GCGCGGCAAGGCCTGCCGCG

Downstream 100 bases:

>100_bases
CGGGCGGCTGTCGGCACCTCTCTCACGTGCCGGGCTCCGTCCGGCGCGAAAATGCGCTAGGCCGCGTCGACATGCGCTTC
TATCTCGGCCTCGCCACCAC

Product: Na+/H+ antiporter NhaA

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MTSPTPDSPPPRRGPRPLSIIRTLLAGEAAGGLILMAAAALALVVANGPLAGTYAHALHAELGPLSVQHWINDGLMAGFF
LLVGLEIKREALDGRLRTWPDRVLPGFAALGGMAVPAAFYALANLGAGTLRGWAIPAATDIAFALGVLALLGSRVPVSLK
IFLSAVAIVDDLGAVVVIALFYSSGLDLAALGLAALVLAGLYGLNRAGIGWLPAYGLLGLVLWVLVLRSGIHATIAGVLL
ALTVPIRVSPGRPEDAHSPLHRLEHALAPWITYGVVPVFGFANAGVDLSGLTPEALLQPVTLGIAAGLFLGKQAGVFASL
RLAVALGWAKRPAGAGWGQVYGVAVLCGIGFTMSLFIGGLAFPDPQHETAVKLGVLAGSALSGLAGAAILLVTKRRATPH

Sequences:

>Translated_400_residues
MTSPTPDSPPPRRGPRPLSIIRTLLAGEAAGGLILMAAAALALVVANGPLAGTYAHALHAELGPLSVQHWINDGLMAGFF
LLVGLEIKREALDGRLRTWPDRVLPGFAALGGMAVPAAFYALANLGAGTLRGWAIPAATDIAFALGVLALLGSRVPVSLK
IFLSAVAIVDDLGAVVVIALFYSSGLDLAALGLAALVLAGLYGLNRAGIGWLPAYGLLGLVLWVLVLRSGIHATIAGVLL
ALTVPIRVSPGRPEDAHSPLHRLEHALAPWITYGVVPVFGFANAGVDLSGLTPEALLQPVTLGIAAGLFLGKQAGVFASL
RLAVALGWAKRPAGAGWGQVYGVAVLCGIGFTMSLFIGGLAFPDPQHETAVKLGVLAGSALSGLAGAAILLVTKRRATPH
>Mature_399_residues
TSPTPDSPPPRRGPRPLSIIRTLLAGEAAGGLILMAAAALALVVANGPLAGTYAHALHAELGPLSVQHWINDGLMAGFFL
LVGLEIKREALDGRLRTWPDRVLPGFAALGGMAVPAAFYALANLGAGTLRGWAIPAATDIAFALGVLALLGSRVPVSLKI
FLSAVAIVDDLGAVVVIALFYSSGLDLAALGLAALVLAGLYGLNRAGIGWLPAYGLLGLVLWVLVLRSGIHATIAGVLLA
LTVPIRVSPGRPEDAHSPLHRLEHALAPWITYGVVPVFGFANAGVDLSGLTPEALLQPVTLGIAAGLFLGKQAGVFASLR
LAVALGWAKRPAGAGWGQVYGVAVLCGIGFTMSLFIGGLAFPDPQHETAVKLGVLAGSALSGLAGAAILLVTKRRATPH

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=387, Percent_Identity=48.578811369509, Blast_Score=283, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 40842; Mature: 40711

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPTPDSPPPRRGPRPLSIIRTLLAGEAAGGLILMAAAALALVVANGPLAGTYAHALHA
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
ELGPLSVQHWINDGLMAGFFLLVGLEIKREALDGRLRTWPDRVLPGFAALGGMAVPAAFY
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHCCHHHHHHHHHHHHHHH
ALANLGAGTLRGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSAVAIVDDLGAVVVIAL
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FYSSGLDLAALGLAALVLAGLYGLNRAGIGWLPAYGLLGLVLWVLVLRSGIHATIAGVLL
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
ALTVPIRVSPGRPEDAHSPLHRLEHALAPWITYGVVPVFGFANAGVDLSGLTPEALLQPV
HHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
TLGIAAGLFLGKQAGVFASLRLAVALGWAKRPAGAGWGQVYGVAVLCGIGFTMSLFIGGL
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
AFPDPQHETAVKLGVLAGSALSGLAGAAILLVTKRRATPH
CCCCCCCHHHHHHHHHHCHHHHHHHHHHHEEEECCCCCCC
>Mature Secondary Structure 
TSPTPDSPPPRRGPRPLSIIRTLLAGEAAGGLILMAAAALALVVANGPLAGTYAHALHA
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
ELGPLSVQHWINDGLMAGFFLLVGLEIKREALDGRLRTWPDRVLPGFAALGGMAVPAAFY
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHCCHHHHHHHHHHHHHHH
ALANLGAGTLRGWAIPAATDIAFALGVLALLGSRVPVSLKIFLSAVAIVDDLGAVVVIAL
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FYSSGLDLAALGLAALVLAGLYGLNRAGIGWLPAYGLLGLVLWVLVLRSGIHATIAGVLL
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
ALTVPIRVSPGRPEDAHSPLHRLEHALAPWITYGVVPVFGFANAGVDLSGLTPEALLQPV
HHHCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
TLGIAAGLFLGKQAGVFASLRLAVALGWAKRPAGAGWGQVYGVAVLCGIGFTMSLFIGGL
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
AFPDPQHETAVKLGVLAGSALSGLAGAAILLVTKRRATPH
CCCCCCCHHHHHHHHHHCHHHHHHHHHHHEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]