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The map label for this gene is thrB

Identifier: 170750703

GI number: 170750703

Start: 4562795

End: 4563760

Strand: Direct

Name: thrB

Synonym: Mrad2831_4313

Alternate gene names: 170750703

Gene position: 4562795-4563760 (Clockwise)

Preceding gene: 170750702

Following gene: 170750710

Centisome position: 75.07

GC content: 71.84

Gene sequence:

>966_bases
GTGGCCGTCTACACCGAGGTATCCGACGCGGCGCTCGCCGAGTTCCTGTCCGCCTACGCGATCGGCAGCCTGCTCTCCTT
CAAGGGCATCGCGGAGGGTGTCGAGAACTCGAACTTCTTCCTGCACACCACCGAGGGCGCCTACATCCTGACGCTCTACG
AGAAGCGCGTCCGGGAACAGGACCTGCCGTTCTTCATCGGGCTGATGGAGCACCTCTCGGCCCGCGGCCTCGCCTGCCCG
CAACCCGTGCGCGACCGGGCCGGCCAGGCCCTCGGCCAGCTCTGCGGCCGGCCCGCCGCCATCGTCAGCTTCCTGGAGGG
CGTCTCGGTCAAGGCGCCGGGCGCCGAGCATTGCCGGGAACTCGGCCGGGCGCTCGCGGAGCTGCACGCCGCCGGCCGGG
ACTTCCCGATGGTGCGGGAGAACAACCTCTCGGTGTCCGCGTGGCGCCCGCTCTTCGCGCAAGCGGAGGCCCAGGCCGAT
TCGGTCGAGCCCGGCCTCGCGGCGCGCACCCGGTCGGACCTCGCTGTCCTGGAGGCGCACTGGCCCCGGGACCTGCCGGG
CGGCGTGATCCACGCGGACCTGTTCACCGACAACGTCTTCTTCATCGGCGACGCCCTGTCGGGCCTGATCGACTTCTACT
TCGCCTGCACGGACGCCTTCGCGTACGACCTCGCGGTCTGCCTGAACGCGTGGTGCTTCGACCCCGACGGCACCTTCCAC
CGGGACATGGCCGCCGCGCTGATCGCCGGCTACGAGGCCGTGCGGCCCCTGGAGGCCGCCGAGGTCGCGGCCCTGCCGAT
CCTGTGCCGGGGCGCCGCCCTCCGCTTCATGCTCACCCGGCTGGTCGACTGGCTGAACGTGCCCCCGGGCGCCCTGGTGA
AGCCGAAGGACCCGCGGGAATTCGATCGCCGGCTCACCTTCCACCGGCAGGCGCGGGACGCGCGGGATTACGGGCGGCCC
CACTGA

Upstream 100 bases:

>100_bases
CGGGACCGACGCCTCGGTCTCGGGGCGCGCGGCAGGCTTTGTGCGGGGGCGCTTCGGCGCCCCTTGCCGTATCGAACTTC
CGACATCAGAGCGCAGACAC

Downstream 100 bases:

>100_bases
GGGCCCGGTGAGCGCTGACGGGACCGGGCAGCCGAGGCGCGATCCTGAGTCATCGTCGACACCCGCGTGGCGCTCTCAGG
GGGCGAAGCCCGCACCACCG

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MAVYTEVSDAALAEFLSAYAIGSLLSFKGIAEGVENSNFFLHTTEGAYILTLYEKRVREQDLPFFIGLMEHLSARGLACP
QPVRDRAGQALGQLCGRPAAIVSFLEGVSVKAPGAEHCRELGRALAELHAAGRDFPMVRENNLSVSAWRPLFAQAEAQAD
SVEPGLAARTRSDLAVLEAHWPRDLPGGVIHADLFTDNVFFIGDALSGLIDFYFACTDAFAYDLAVCLNAWCFDPDGTFH
RDMAAALIAGYEAVRPLEAAEVAALPILCRGAALRFMLTRLVDWLNVPPGALVKPKDPREFDRRLTFHRQARDARDYGRP
H

Sequences:

>Translated_321_residues
MAVYTEVSDAALAEFLSAYAIGSLLSFKGIAEGVENSNFFLHTTEGAYILTLYEKRVREQDLPFFIGLMEHLSARGLACP
QPVRDRAGQALGQLCGRPAAIVSFLEGVSVKAPGAEHCRELGRALAELHAAGRDFPMVRENNLSVSAWRPLFAQAEAQAD
SVEPGLAARTRSDLAVLEAHWPRDLPGGVIHADLFTDNVFFIGDALSGLIDFYFACTDAFAYDLAVCLNAWCFDPDGTFH
RDMAAALIAGYEAVRPLEAAEVAALPILCRGAALRFMLTRLVDWLNVPPGALVKPKDPREFDRRLTFHRQARDARDYGRP
H
>Mature_320_residues
AVYTEVSDAALAEFLSAYAIGSLLSFKGIAEGVENSNFFLHTTEGAYILTLYEKRVREQDLPFFIGLMEHLSARGLACPQ
PVRDRAGQALGQLCGRPAAIVSFLEGVSVKAPGAEHCRELGRALAELHAAGRDFPMVRENNLSVSAWRPLFAQAEAQADS
VEPGLAARTRSDLAVLEAHWPRDLPGGVIHADLFTDNVFFIGDALSGLIDFYFACTDAFAYDLAVCLNAWCFDPDGTFHR
DMAAALIAGYEAVRPLEAAEVAALPILCRGAALRFMLTRLVDWLNVPPGALVKPKDPREFDRRLTFHRQARDARDYGRPH

Specific function: Unknown

COG id: COG2334

COG function: function code R; Putative homoserine kinase type II (protein kinase fold)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pseudomonas-type thrB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_METRJ (B1M3E0)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001756963.1
- ProteinModelPortal:   B1M3E0
- SMR:   B1M3E0
- GeneID:   6140372
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_4313
- HOGENOM:   HBG309377
- OMA:   ADLFRDN
- ProtClustDB:   CLSK2331237
- HAMAP:   MF_00301
- InterPro:   IPR002575
- InterPro:   IPR005280
- InterPro:   IPR011009
- TIGRFAMs:   TIGR00938

Pfam domain/function: PF01636 APH; SSF56112 Kinase_like

EC number: =2.7.1.39

Molecular weight: Translated: 35192; Mature: 35061

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVYTEVSDAALAEFLSAYAIGSLLSFKGIAEGVENSNFFLHTTEGAYILTLYEKRVREQ
CCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEHHHHHHHHC
DLPFFIGLMEHLSARGLACPQPVRDRAGQALGQLCGRPAAIVSFLEGVSVKAPGAEHCRE
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHH
LGRALAELHAAGRDFPMVRENNLSVSAWRPLFAQAEAQADSVEPGLAARTRSDLAVLEAH
HHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHCC
WPRDLPGGVIHADLFTDNVFFIGDALSGLIDFYFACTDAFAYDLAVCLNAWCFDPDGTFH
CCCCCCCCEEEEEEHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
RDMAAALIAGYEAVRPLEAAEVAALPILCRGAALRFMLTRLVDWLNVPPGALVKPKDPRE
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
FDRRLTFHRQARDARDYGRPH
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AVYTEVSDAALAEFLSAYAIGSLLSFKGIAEGVENSNFFLHTTEGAYILTLYEKRVREQ
CEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEHHHHHHHHC
DLPFFIGLMEHLSARGLACPQPVRDRAGQALGQLCGRPAAIVSFLEGVSVKAPGAEHCRE
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHH
LGRALAELHAAGRDFPMVRENNLSVSAWRPLFAQAEAQADSVEPGLAARTRSDLAVLEAH
HHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHCC
WPRDLPGGVIHADLFTDNVFFIGDALSGLIDFYFACTDAFAYDLAVCLNAWCFDPDGTFH
CCCCCCCCEEEEEEHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHH
RDMAAALIAGYEAVRPLEAAEVAALPILCRGAALRFMLTRLVDWLNVPPGALVKPKDPRE
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
FDRRLTFHRQARDARDYGRPH
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA