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The map label for this gene is hemE [H]

Identifier: 170750688

GI number: 170750688

Start: 4548256

End: 4549434

Strand: Reverse

Name: hemE [H]

Synonym: Mrad2831_4298

Alternate gene names: 170750688

Gene position: 4549434-4548256 (Counterclockwise)

Preceding gene: 170750690

Following gene: 170750687

Centisome position: 74.85

GC content: 75.66

Gene sequence:

>1179_bases
ATGGGAGCGACCATGACGGGGACGGAGCGCGAGCCCGAGCGGGAGACGTCCGGGACGACGTCCGAGCGCAAGGTGCTGCG
CGTCCTCGAGGGCGAGGCGATCGGGCCGCCCCCCGCCTGGATGATGCGCCAGGCCGGGCGCTACCTGCCGGAATACCGGG
CGACCCGCGCCGAGGCCGGCTCGTTCCTCGACCTCTGCTACAGCCCGGACTTCGCCGTCGAGGTGACGCTCCAGCCGATC
CGCCGCTTCGGCTTCGACGCGGCGATCCTGTTCTCCGACATCCTGGTCGTCCCCCACGCGCTCGGCCAGGACGTGCGCTT
CGTGGAGGGCGAGGGCCCCCGGCTCGACCCCCTCGACGGACGGGCGGCGTTCGCGCGCCTGCGCGAGGCCGGCGACCCGG
CGGTGATGAGCCACCTCGCGCCGGTCTTCGAGACCGTGACGCGGCTGCGCGCCGAGCTGCCGGGCGAGACCACGCTGCTC
GGCTTCTGCGGCGCCCCCTGGACGGTGGCGAGCTACATGATCGGCGGCCGCGGCACGCCGGACCTCGCCCCCGCGCGGGC
GCTGGCCGAGGGCGACACCGCCCTGGTCGACACCCTGATCGACCGCCTCGTCGCCGTGCAGACCGAGTACCTCGTGCGCC
AGCTCGAGGCCGGCGCCGACGCGGTGCAGATCTTCGAGTCCCACGCCGGCACCTTGCCGCTTGCCGTTCTGGCTCCCGGC
GGCACGGTCGAGCCCGTCGGCGACGTCGCCGAGAGCGCCCTGCCGGGTGCGGCCGCGGCGGACGCCCTCACCCGCTGGTC
GCTGCGGCCGATCGCCCGGATGGTGGCGGGCGTCCGCGCCCGGGTGCCGGGGGCCAAGATCATCGTGTTCGCCCGCGGCT
CGGGCCTCGACGGCCACGCCCGGGTGGTGCCGGAGACCGGCGCCGACGCCGTCGGCGTCGACTGGGGCGTGGATCTGAAG
GCCCTGCGGCAGACGGTGCCGGCCGCGACGGTGACGCAGGGCAACCTGCATCCCGAAACGCTGATCGCGGGCGGCGCGGC
CCTCGACGCGGCGGTGGACGCGGTGCTCGAGGCGACCGCCGGCCTGCCGCACATCTTCAACCTCGGCCACGGCATCACGC
CGCAGACGCCGGTGGCCCATGTCGAGCGGATGCTCGCGCGGCTGCGCGGCCAGGGCTGA

Upstream 100 bases:

>100_bases
AAGATTCTCTCTTATCTTTTCGAAGGGGCCTGTGTGGGGATCGGCGCGCCTCGACTCGACAGGACGCCCGCCGACGGGCA
TGCGGGGTGAGGGATACGGG

Downstream 100 bases:

>100_bases
GGTCGGGCGCGTGCTGTACGACTGGATCAAGGCCCTCCACGTCATCAGCCTGATCGCCTGGATGGCCGGGATGCTCTACC
TGCCCCGGCTGTTCGTCTAC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MGATMTGTEREPERETSGTTSERKVLRVLEGEAIGPPPAWMMRQAGRYLPEYRATRAEAGSFLDLCYSPDFAVEVTLQPI
RRFGFDAAILFSDILVVPHALGQDVRFVEGEGPRLDPLDGRAAFARLREAGDPAVMSHLAPVFETVTRLRAELPGETTLL
GFCGAPWTVASYMIGGRGTPDLAPARALAEGDTALVDTLIDRLVAVQTEYLVRQLEAGADAVQIFESHAGTLPLAVLAPG
GTVEPVGDVAESALPGAAAADALTRWSLRPIARMVAGVRARVPGAKIIVFARGSGLDGHARVVPETGADAVGVDWGVDLK
ALRQTVPAATVTQGNLHPETLIAGGAALDAAVDAVLEATAGLPHIFNLGHGITPQTPVAHVERMLARLRGQG

Sequences:

>Translated_392_residues
MGATMTGTEREPERETSGTTSERKVLRVLEGEAIGPPPAWMMRQAGRYLPEYRATRAEAGSFLDLCYSPDFAVEVTLQPI
RRFGFDAAILFSDILVVPHALGQDVRFVEGEGPRLDPLDGRAAFARLREAGDPAVMSHLAPVFETVTRLRAELPGETTLL
GFCGAPWTVASYMIGGRGTPDLAPARALAEGDTALVDTLIDRLVAVQTEYLVRQLEAGADAVQIFESHAGTLPLAVLAPG
GTVEPVGDVAESALPGAAAADALTRWSLRPIARMVAGVRARVPGAKIIVFARGSGLDGHARVVPETGADAVGVDWGVDLK
ALRQTVPAATVTQGNLHPETLIAGGAALDAAVDAVLEATAGLPHIFNLGHGITPQTPVAHVERMLARLRGQG
>Mature_391_residues
GATMTGTEREPERETSGTTSERKVLRVLEGEAIGPPPAWMMRQAGRYLPEYRATRAEAGSFLDLCYSPDFAVEVTLQPIR
RFGFDAAILFSDILVVPHALGQDVRFVEGEGPRLDPLDGRAAFARLREAGDPAVMSHLAPVFETVTRLRAELPGETTLLG
FCGAPWTVASYMIGGRGTPDLAPARALAEGDTALVDTLIDRLVAVQTEYLVRQLEAGADAVQIFESHAGTLPLAVLAPGG
TVEPVGDVAESALPGAAAADALTRWSLRPIARMVAGVRARVPGAKIIVFARGSGLDGHARVVPETGADAVGVDWGVDLKA
LRQTVPAATVTQGNLHPETLIAGGAALDAAVDAVLEATAGLPHIFNLGHGITPQTPVAHVERMLARLRGQG

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=370, Percent_Identity=38.6486486486486, Blast_Score=205, Evalue=5e-53,
Organism=Escherichia coli, GI2367337, Length=361, Percent_Identity=37.6731301939058, Blast_Score=217, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6320252, Length=363, Percent_Identity=33.8842975206612, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI19921920, Length=366, Percent_Identity=33.879781420765, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI221330099, Length=366, Percent_Identity=33.879781420765, Blast_Score=194, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 41213; Mature: 41081

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00626 RCC1_2 ; PS00906 UROD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGATMTGTEREPERETSGTTSERKVLRVLEGEAIGPPPAWMMRQAGRYLPEYRATRAEAG
CCCCCCCCCCCCCHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCC
SFLDLCYSPDFAVEVTLQPIRRFGFDAAILFSDILVVPHALGQDVRFVEGEGPRLDPLDG
CCHHHHCCCCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCC
RAAFARLREAGDPAVMSHLAPVFETVTRLRAELPGETTLLGFCGAPWTVASYMIGGRGTP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCC
DLAPARALAEGDTALVDTLIDRLVAVQTEYLVRQLEAGADAVQIFESHAGTLPLAVLAPG
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCC
GTVEPVGDVAESALPGAAAADALTRWSLRPIARMVAGVRARVPGAKIIVFARGSGLDGHA
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCE
RVVPETGADAVGVDWGVDLKALRQTVPAATVTQGNLHPETLIAGGAALDAAVDAVLEATA
EECCCCCCCCCCCCCCCCHHHHHHHCCCCEEECCCCCHHHHEECCHHHHHHHHHHHHHHC
GLPHIFNLGHGITPQTPVAHVERMLARLRGQG
CCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GATMTGTEREPERETSGTTSERKVLRVLEGEAIGPPPAWMMRQAGRYLPEYRATRAEAG
CCCCCCCCCCCCHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCC
SFLDLCYSPDFAVEVTLQPIRRFGFDAAILFSDILVVPHALGQDVRFVEGEGPRLDPLDG
CCHHHHCCCCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCC
RAAFARLREAGDPAVMSHLAPVFETVTRLRAELPGETTLLGFCGAPWTVASYMIGGRGTP
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCC
DLAPARALAEGDTALVDTLIDRLVAVQTEYLVRQLEAGADAVQIFESHAGTLPLAVLAPG
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCC
GTVEPVGDVAESALPGAAAADALTRWSLRPIARMVAGVRARVPGAKIIVFARGSGLDGHA
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCE
RVVPETGADAVGVDWGVDLKALRQTVPAATVTQGNLHPETLIAGGAALDAAVDAVLEATA
EECCCCCCCCCCCCCCCCHHHHHHHCCCCEEECCCCCHHHHEECCHHHHHHHHHHHHHHC
GLPHIFNLGHGITPQTPVAHVERMLARLRGQG
CCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA