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The map label for this gene is czcD [H]

Identifier: 170750676

GI number: 170750676

Start: 4536735

End: 4537736

Strand: Reverse

Name: czcD [H]

Synonym: Mrad2831_4286

Alternate gene names: 170750676

Gene position: 4537736-4536735 (Counterclockwise)

Preceding gene: 170750677

Following gene: 170750675

Centisome position: 74.66

GC content: 71.56

Gene sequence:

>1002_bases
TTGGCCGGACACGATCATTCGCACGGCGGCCACGGGCACGGGAGCCATGCCCACGGAAGTCATGCCCACGGGGGCCACGC
CCATGGCGGCCTCGGCGGCCACGCGCACGCGCCGAAGGATTTCGGCACGGCCTTCGCCATCGGCATCGTGCTCAACACCG
CCTTCGTGGTGATCGAGGCGGTCTACGGCTATCTCAGCAACTCGATGTCGCTGGTGGCCGATGCCGGCCACAACCTGTCG
GACGTTCTGGGCCTCGCGGCCGCCTGGATCGCCGCGATCCTGGTGCGCCGCCGCGCGAGCGCGCGCTTCACCTACGGCTA
CCGCGGCTCCTCGATCCTGGCGGCCCTGTTCAACGCCGTGTTCCTGCTCATCGCCATGGGAGCGGTGATCTGGGAGGCGC
TGGTCCGGCTGGTCCACCCGGAGCCCGTCGCGGGCACGACCGTGATGGTGGTGGCCGCGGTGGGGATCCTGGTCAACGGC
CTCACCGCGTGGCTCTTCGCCAGCGGAGCCAAGGGCGACATCAACGTCCGCGGGGCGTTCCTCCACATGGTGGCCGACGC
CGCCGTCTCGGCCGGGGTCGTGGTGGCGGGCCTCGTGATCCAGCTCACCGGCCTCGCCTGGCTCGACCCGGCGGTCAGCC
TCGTCATCGCCGCCCTAGTGGTCTGGGCGACCTGGGGCCTGCTGCGCGACAGCGTGGCCATGTCCCTCGACGCCGTGCCG
CCGGAGATCTCCCCGGACGCGGTGACCGACTTCCTCCTCGAACGGCCGGGCGTCGCCGGCCTCCACGACCTGCATATCTG
GCCCATGAGCACCACCAGCGTCGCCCTCACGGTCCATCTCGTGATGCAGGAGGGTCATCAGGCCCACCGCCTGCCCGGCA
ACGGCTTCCTCACCGACACCGCCGAGGGCCTGCGCGCTCGGTTCGGCATCGGCCACGCCACCCTCCAGGTCGAGGAGGCC
GGCGGTCCGGCCTGCCGCCTCGCGCAGGATTGCGCGGCGTGA

Upstream 100 bases:

>100_bases
CGGTGGCCGGGGACCACAGCACCGTGCTGGGCCTGCCGCTGCTGCCGCTCCTCGCGCGGCTCCGCGCCGCCGGCTACTTG
GCCTTCTGAGGGAAAAGCTC

Downstream 100 bases:

>100_bases
GCGTCGCGACCCCCCGCGCCTTCGTGGTCGGCCACCCGATCGCCCACTCGCGCTCGCCGCTGATCCACGGCCACTGGCTC
GCCGTGCACGGGATCCCGGG

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MAGHDHSHGGHGHGSHAHGSHAHGGHAHGGLGGHAHAPKDFGTAFAIGIVLNTAFVVIEAVYGYLSNSMSLVADAGHNLS
DVLGLAAAWIAAILVRRRASARFTYGYRGSSILAALFNAVFLLIAMGAVIWEALVRLVHPEPVAGTTVMVVAAVGILVNG
LTAWLFASGAKGDINVRGAFLHMVADAAVSAGVVVAGLVIQLTGLAWLDPAVSLVIAALVVWATWGLLRDSVAMSLDAVP
PEISPDAVTDFLLERPGVAGLHDLHIWPMSTTSVALTVHLVMQEGHQAHRLPGNGFLTDTAEGLRARFGIGHATLQVEEA
GGPACRLAQDCAA

Sequences:

>Translated_333_residues
MAGHDHSHGGHGHGSHAHGSHAHGGHAHGGLGGHAHAPKDFGTAFAIGIVLNTAFVVIEAVYGYLSNSMSLVADAGHNLS
DVLGLAAAWIAAILVRRRASARFTYGYRGSSILAALFNAVFLLIAMGAVIWEALVRLVHPEPVAGTTVMVVAAVGILVNG
LTAWLFASGAKGDINVRGAFLHMVADAAVSAGVVVAGLVIQLTGLAWLDPAVSLVIAALVVWATWGLLRDSVAMSLDAVP
PEISPDAVTDFLLERPGVAGLHDLHIWPMSTTSVALTVHLVMQEGHQAHRLPGNGFLTDTAEGLRARFGIGHATLQVEEA
GGPACRLAQDCAA
>Mature_332_residues
AGHDHSHGGHGHGSHAHGSHAHGGHAHGGLGGHAHAPKDFGTAFAIGIVLNTAFVVIEAVYGYLSNSMSLVADAGHNLSD
VLGLAAAWIAAILVRRRASARFTYGYRGSSILAALFNAVFLLIAMGAVIWEALVRLVHPEPVAGTTVMVVAAVGILVNGL
TAWLFASGAKGDINVRGAFLHMVADAAVSAGVVVAGLVIQLTGLAWLDPAVSLVIAALVVWATWGLLRDSVAMSLDAVPP
EISPDAVTDFLLERPGVAGLHDLHIWPMSTTSVALTVHLVMQEGHQAHRLPGNGFLTDTAEGLRARFGIGHATLQVEEAG
GPACRLAQDCAA

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=326, Percent_Identity=26.3803680981595, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI21359890, Length=324, Percent_Identity=25.6172839506173, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI20070323, Length=312, Percent_Identity=27.5641025641026, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI21361112, Length=310, Percent_Identity=27.4193548387097, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI289803013, Length=324, Percent_Identity=24.6913580246914, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI289803009, Length=324, Percent_Identity=24.6913580246914, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI289803007, Length=324, Percent_Identity=24.6913580246914, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI289803003, Length=324, Percent_Identity=24.6913580246914, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI64762489, Length=324, Percent_Identity=24.6913580246914, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI14210520, Length=238, Percent_Identity=27.3109243697479, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI52351208, Length=129, Percent_Identity=38.7596899224806, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786966, Length=289, Percent_Identity=33.5640138408304, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17555794, Length=346, Percent_Identity=28.0346820809249, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193210990, Length=298, Percent_Identity=29.8657718120805, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17555796, Length=303, Percent_Identity=28.7128712871287, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI32564488, Length=313, Percent_Identity=26.517571884984, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323899, Length=120, Percent_Identity=35.8333333333333, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320411, Length=178, Percent_Identity=34.2696629213483, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324892, Length=120, Percent_Identity=35.8333333333333, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24583858, Length=350, Percent_Identity=26, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24645863, Length=106, Percent_Identity=33.9622641509434, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24585900, Length=148, Percent_Identity=31.0810810810811, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24585898, Length=148, Percent_Identity=31.0810810810811, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24585896, Length=148, Percent_Identity=31.0810810810811, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19921672, Length=148, Percent_Identity=31.0810810810811, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24656728, Length=164, Percent_Identity=28.0487804878049, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24656724, Length=164, Percent_Identity=28.0487804878049, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24656720, Length=164, Percent_Identity=28.0487804878049, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24656715, Length=164, Percent_Identity=28.0487804878049, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21357035, Length=164, Percent_Identity=28.0487804878049, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28574430, Length=148, Percent_Identity=27.027027027027, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24584409, Length=148, Percent_Identity=27.027027027027, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34347; Mature: 34216

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGHDHSHGGHGHGSHAHGSHAHGGHAHGGLGGHAHAPKDFGTAFAIGIVLNTAFVVIEA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VYGYLSNSMSLVADAGHNLSDVLGLAAAWIAAILVRRRASARFTYGYRGSSILAALFNAV
HHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHH
FLLIAMGAVIWEALVRLVHPEPVAGTTVMVVAAVGILVNGLTAWLFASGAKGDINVRGAF
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHH
LHMVADAAVSAGVVVAGLVIQLTGLAWLDPAVSLVIAALVVWATWGLLRDSVAMSLDAVP
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PEISPDAVTDFLLERPGVAGLHDLHIWPMSTTSVALTVHLVMQEGHQAHRLPGNGFLTDT
CCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCC
AEGLRARFGIGHATLQVEEAGGPACRLAQDCAA
HHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCC
>Mature Secondary Structure 
AGHDHSHGGHGHGSHAHGSHAHGGHAHGGLGGHAHAPKDFGTAFAIGIVLNTAFVVIEA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
VYGYLSNSMSLVADAGHNLSDVLGLAAAWIAAILVRRRASARFTYGYRGSSILAALFNAV
HHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHH
FLLIAMGAVIWEALVRLVHPEPVAGTTVMVVAAVGILVNGLTAWLFASGAKGDINVRGAF
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHH
LHMVADAAVSAGVVVAGLVIQLTGLAWLDPAVSLVIAALVVWATWGLLRDSVAMSLDAVP
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PEISPDAVTDFLLERPGVAGLHDLHIWPMSTTSVALTVHLVMQEGHQAHRLPGNGFLTDT
CCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCC
AEGLRARFGIGHATLQVEEAGGPACRLAQDCAA
HHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA