Click here to switch to the map view.

The map label for this gene is cyaA [H]

Identifier: 170750608

GI number: 170750608

Start: 4466679

End: 4468085

Strand: Reverse

Name: cyaA [H]

Synonym: Mrad2831_4218

Alternate gene names: 170750608

Gene position: 4468085-4466679 (Counterclockwise)

Preceding gene: 170750609

Following gene: 170750607

Centisome position: 73.51

GC content: 75.2

Gene sequence:

>1407_bases
ATGTCCGCTCCAGCCACCGCGCCCGCAGCGGACGGGAGCGAGGCCGCGACGCGTGCCTCCGTCCGGGCACGCGTCGCGGC
GCGGGTGCAGCGGTCCCTGCGCTCGCGCACCGTGGCGTGGATGACGGTGGGCCTCGCCACGATCCTGGTGATGACCGCCA
TCGCGCTGGGCGCCTTCGTGTACCAGCAGCGCGGCGTCGACGCCGTGCGCCACACCGTGGCGGTGGACGGGCGCCTCGCC
CGGGTGCTGTCGGCGGTGCAGGACGCCGAGACCGGCCAGCGCGGCTACCTGCTCACCGGCGACGCGGCCTTCCTGATGCC
CTTCACCGAGGGGCGGGTGAACGTCGACCGGCAGCTCGACCTCCTGCGCGACCTCGTCCAGGACGATCCCGACCAGCGGG
GCGAGCTCGACACCCTGGCCGGGCTGATCCGCCGGAAACTCGACGAGCTCGGCGCCAGCGTCGCCCTCATGCGCGCCGGC
GACGGCGCCGCGGCCCGCGCCTCCGTGGCGGACGGGCGCGGCAAGCAGGTGATGGACGCGATCCGCGACCGCGTGCGCCG
CATGGAGGCGCACGAGGCGGACCGGATGGAGCGGCGGCAGGCGACGGTGTCGCGGATCGCCCTGGCCATCTGGGTCATGG
TCGGCGCCCTCGCCGTCCTGTTCGTGCTGTTCGCCGCCTCGGCCCTGCGGGAGGCGACCCGGCGCAACCGGCTGTCGCGG
TTCCTGCCGCAGGAGCTGGTCCTGCGTCTCGCCGACGGCGACGGCAGCCTGAAGGCCGGCCGCCGCCAGCAGGCCGCCAT
CGTGTTCGTCGACATGCGCGGCTCGACCACCCTGGCCGAGAGCCTCGATCCGCACCGGCTCTCCGAGTTCCTGTCCGCCT
TCCGGCGGCGGGTGACGCGCCTCGCCCGCCTGCGGGGCGGGGTGGTCGACAAGTTCATCGGCGACGGCGCCCTGGTGGTG
TTCGGCCTGCCCGAGCCGCGGCCCGACGATGCCGCCCGCGCCCTCGCCTTCGCCCAGGACCTCGTCGCGGTGATCGCCCG
CTGGACCGACAGGAGCGGGCCCGCGCGGACCGTGCGCATCGGCGTCGGGGTGCATTACGGCGAGGTGTTCTGCGGGATCA
TCGGCGAGGCGGCGCGCTACGAGTTCACCGTGCTGGGCGACGCCGTCAACGTCGCCGCCCGCCTCGAGCAGGCGACCAAG
CTCCACGGCGTCCCGATCCTGGTCTCGGAGGCCGCGCGCCGCGCCGCCGGGGCGCCGGCCGAGGCGTGGCGCGAAGTCAG
CCGCGAGCCCCTGCGGGGACGCCGGGAGCGCATGGCCTACCACACGCCCGCCGATCCCGGATCGGCCGGATCCGACCCCC
ATCGGGAAGAAGATATCGCGTCCTCGGCGGTCGAAGCGGCTCTCTGA

Upstream 100 bases:

>100_bases
ACGGCGCGGGCGACCATCGCGGATTGCCGGGCGCGGGCGGCCGGGGACGGGGGGCGGACCGGGCGCGCCGTCCGGCTGCA
CGGCGCGGGCGGGGCCTGAC

Downstream 100 bases:

>100_bases
GAAGAACCTGTCTGTCACTGAGACCGGATGGAGAACAAGCATCTCCACGCGCGGCGAAATTCGAAAGACGCCTCCATTGC
GAACGGGCCGGCCGAGCGCG

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSAPATAPAADGSEAATRASVRARVAARVQRSLRSRTVAWMTVGLATILVMTAIALGAFVYQQRGVDAVRHTVAVDGRLA
RVLSAVQDAETGQRGYLLTGDAAFLMPFTEGRVNVDRQLDLLRDLVQDDPDQRGELDTLAGLIRRKLDELGASVALMRAG
DGAAARASVADGRGKQVMDAIRDRVRRMEAHEADRMERRQATVSRIALAIWVMVGALAVLFVLFAASALREATRRNRLSR
FLPQELVLRLADGDGSLKAGRRQQAAIVFVDMRGSTTLAESLDPHRLSEFLSAFRRRVTRLARLRGGVVDKFIGDGALVV
FGLPEPRPDDAARALAFAQDLVAVIARWTDRSGPARTVRIGVGVHYGEVFCGIIGEAARYEFTVLGDAVNVAARLEQATK
LHGVPILVSEAARRAAGAPAEAWREVSREPLRGRRERMAYHTPADPGSAGSDPHREEDIASSAVEAAL

Sequences:

>Translated_468_residues
MSAPATAPAADGSEAATRASVRARVAARVQRSLRSRTVAWMTVGLATILVMTAIALGAFVYQQRGVDAVRHTVAVDGRLA
RVLSAVQDAETGQRGYLLTGDAAFLMPFTEGRVNVDRQLDLLRDLVQDDPDQRGELDTLAGLIRRKLDELGASVALMRAG
DGAAARASVADGRGKQVMDAIRDRVRRMEAHEADRMERRQATVSRIALAIWVMVGALAVLFVLFAASALREATRRNRLSR
FLPQELVLRLADGDGSLKAGRRQQAAIVFVDMRGSTTLAESLDPHRLSEFLSAFRRRVTRLARLRGGVVDKFIGDGALVV
FGLPEPRPDDAARALAFAQDLVAVIARWTDRSGPARTVRIGVGVHYGEVFCGIIGEAARYEFTVLGDAVNVAARLEQATK
LHGVPILVSEAARRAAGAPAEAWREVSREPLRGRRERMAYHTPADPGSAGSDPHREEDIASSAVEAAL
>Mature_467_residues
SAPATAPAADGSEAATRASVRARVAARVQRSLRSRTVAWMTVGLATILVMTAIALGAFVYQQRGVDAVRHTVAVDGRLAR
VLSAVQDAETGQRGYLLTGDAAFLMPFTEGRVNVDRQLDLLRDLVQDDPDQRGELDTLAGLIRRKLDELGASVALMRAGD
GAAARASVADGRGKQVMDAIRDRVRRMEAHEADRMERRQATVSRIALAIWVMVGALAVLFVLFAASALREATRRNRLSRF
LPQELVLRLADGDGSLKAGRRQQAAIVFVDMRGSTTLAESLDPHRLSEFLSAFRRRVTRLARLRGGVVDKFIGDGALVVF
GLPEPRPDDAARALAFAQDLVAVIARWTDRSGPARTVRIGVGVHYGEVFCGIIGEAARYEFTVLGDAVNVAARLEQATKL
HGVPILVSEAARRAAGAPAEAWREVSREPLRGRRERMAYHTPADPGSAGSDPHREEDIASSAVEAAL

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI4557257, Length=154, Percent_Identity=31.8181818181818, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551720, Length=136, Percent_Identity=30.8823529411765, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281366320, Length=145, Percent_Identity=33.1034482758621, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221330470, Length=169, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330468, Length=169, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161084260, Length=145, Percent_Identity=33.1034482758621, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24642014, Length=185, Percent_Identity=28.1081081081081, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 50529; Mature: 50398

Theoretical pI: Translated: 10.82; Mature: 10.82

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPATAPAADGSEAATRASVRARVAARVQRSLRSRTVAWMTVGLATILVMTAIALGAFV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YQQRGVDAVRHTVAVDGRLARVLSAVQDAETGQRGYLLTGDAAFLMPFTEGRVNVDRQLD
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEECCCCCCCHHHHHH
LLRDLVQDDPDQRGELDTLAGLIRRKLDELGASVALMRAGDGAAARASVADGRGKQVMDA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHCCCCCCCCHHHHHH
IRDRVRRMEAHEADRMERRQATVSRIALAIWVMVGALAVLFVLFAASALREATRRNRLSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLPQELVLRLADGDGSLKAGRRQQAAIVFVDMRGSTTLAESLDPHRLSEFLSAFRRRVTR
HCHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHCCCHHHHHHHHHHHHHHHHH
LARLRGGVVDKFIGDGALVVFGLPEPRPDDAARALAFAQDLVAVIARWTDRSGPARTVRI
HHHHHCCHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
GVGVHYGEVFCGIIGEAARYEFTVLGDAVNVAARLEQATKLHGVPILVSEAARRAAGAPA
ECCCHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCH
EAWREVSREPLRGRRERMAYHTPADPGSAGSDPHREEDIASSAVEAAL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAPATAPAADGSEAATRASVRARVAARVQRSLRSRTVAWMTVGLATILVMTAIALGAFV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YQQRGVDAVRHTVAVDGRLARVLSAVQDAETGQRGYLLTGDAAFLMPFTEGRVNVDRQLD
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEECCCCCCCHHHHHH
LLRDLVQDDPDQRGELDTLAGLIRRKLDELGASVALMRAGDGAAARASVADGRGKQVMDA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHCCCCCCCCHHHHHH
IRDRVRRMEAHEADRMERRQATVSRIALAIWVMVGALAVLFVLFAASALREATRRNRLSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLPQELVLRLADGDGSLKAGRRQQAAIVFVDMRGSTTLAESLDPHRLSEFLSAFRRRVTR
HCHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHCCCHHHHHHHHHHHHHHHHH
LARLRGGVVDKFIGDGALVVFGLPEPRPDDAARALAFAQDLVAVIARWTDRSGPARTVRI
HHHHHCCHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
GVGVHYGEVFCGIIGEAARYEFTVLGDAVNVAARLEQATKLHGVPILVSEAARRAAGAPA
ECCCHHHHHHHHHHHHHHHEEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCH
EAWREVSREPLRGRRERMAYHTPADPGSAGSDPHREEDIASSAVEAAL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]