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The map label for this gene is serA [H]

Identifier: 170750604

GI number: 170750604

Start: 4463683

End: 4464636

Strand: Direct

Name: serA [H]

Synonym: Mrad2831_4214

Alternate gene names: 170750604

Gene position: 4463683-4464636 (Clockwise)

Preceding gene: 170750603

Following gene: 170750605

Centisome position: 73.44

GC content: 77.36

Gene sequence:

>954_bases
ATGCCCAAGGTCGTCATCAGCGAGTTCATGGACGAGGCCGCGATCGCGGCCGAGCTCGCCGGCCTCGACGTGGTGTACGA
TCCCGGCCTCGTCGACCGGCCGGAGGACCTCGCCGCCGCCGCCGCCCGGGCCGACGCCCTGATCGTGCGCAACCGGACGC
AGGTCCGCGGCGCCCTGCTCGACGCCGCCCGCGACCTCACGGTCGTCGGCCGCCTCGGCGTCGGCCTCGACAACATCGAC
CTCCCCGCCTGCCGGGCGCGCGGCATCGCGGTCTACCCGGCCACCGGCGCCAACGACGGCGCGGTCGCCGAGTACGTCAT
CGCCTCCGCGCTGCTGCTCCTGCGCGGCGCCTACGGGGCGAGCGCCGCCGTCGCCGCCGGCGCGTGGCCGCGCAACGCCC
TGATGGGCCGCGAGATCGCCGGCAAGCGCCTCGGCCTCGTGGGCTTCGGCGCGATCGCCCGCGAGACCGCCCGGCGGGCG
GCGGCGCTCGGCATGGCGGTCGCCGCCCACGACCCGTTCGTGGCCGCGGACGACCCGGCCTGGACCCAGACCTGGACCCC
GGCCTCCGGCCCGGTGGAACGGACCGCCCTCGACGCGCTGATCGCCGGCAGCGACGTGCTCTCGCTGCACGTGCCGCTCA
CCGACGCGACCCGCGGCCTGATCGACGCGGCGGCGCTGGCGCGGATGCCGACGGGCGCGATCCTGATCAACGCCGCCCGG
GGCGGCATCGTGGACGAGGCGGCCGTGGCCGCCGCGCTGCGCTCGGGCCATCTCGGCGGCGCGGCGCTGGACGTGTTCGA
GCGCGAGCCCCTCGACCCGGCCGCCGGCGCCGTGTTCGCGGGCGTGCCCAACCTGATCCTGACGCCCCACATCGCCGGCG
TGACCCGGGAATCGAACGTGCGCGTCTCCGCCGTAACCGCCGCGGCCGTCCGCCGCCACCTCACGGAGCGCTGA

Upstream 100 bases:

>100_bases
GCGGTCGCCTGAGGGCGGCAGGGCCGGGATCCGGGTTGCCACGCGGGTGCCAACGGCTCTAGCGGGGGACGACCACGCGG
AACCGGGACAGAGGCGCGCC

Downstream 100 bases:

>100_bases
ATGCGGGGGATCTGGGCCTTTCGGCCGGAGCGGGCTATCCACGGGAGCCGGCCGCGCGGGGACCGGGACGTCCGGTGCGG
GCCGGGAAGGAGCAGAGGAT

Product: NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MPKVVISEFMDEAAIAAELAGLDVVYDPGLVDRPEDLAAAAARADALIVRNRTQVRGALLDAARDLTVVGRLGVGLDNID
LPACRARGIAVYPATGANDGAVAEYVIASALLLLRGAYGASAAVAAGAWPRNALMGREIAGKRLGLVGFGAIARETARRA
AALGMAVAAHDPFVAADDPAWTQTWTPASGPVERTALDALIAGSDVLSLHVPLTDATRGLIDAAALARMPTGAILINAAR
GGIVDEAAVAAALRSGHLGGAALDVFEREPLDPAAGAVFAGVPNLILTPHIAGVTRESNVRVSAVTAAAVRRHLTER

Sequences:

>Translated_317_residues
MPKVVISEFMDEAAIAAELAGLDVVYDPGLVDRPEDLAAAAARADALIVRNRTQVRGALLDAARDLTVVGRLGVGLDNID
LPACRARGIAVYPATGANDGAVAEYVIASALLLLRGAYGASAAVAAGAWPRNALMGREIAGKRLGLVGFGAIARETARRA
AALGMAVAAHDPFVAADDPAWTQTWTPASGPVERTALDALIAGSDVLSLHVPLTDATRGLIDAAALARMPTGAILINAAR
GGIVDEAAVAAALRSGHLGGAALDVFEREPLDPAAGAVFAGVPNLILTPHIAGVTRESNVRVSAVTAAAVRRHLTER
>Mature_316_residues
PKVVISEFMDEAAIAAELAGLDVVYDPGLVDRPEDLAAAAARADALIVRNRTQVRGALLDAARDLTVVGRLGVGLDNIDL
PACRARGIAVYPATGANDGAVAEYVIASALLLLRGAYGASAAVAAGAWPRNALMGREIAGKRLGLVGFGAIARETARRAA
ALGMAVAAHDPFVAADDPAWTQTWTPASGPVERTALDALIAGSDVLSLHVPLTDATRGLIDAAALARMPTGAILINAARG
GIVDEAAVAAALRSGHLGGAALDVFEREPLDPAAGAVFAGVPNLILTPHIAGVTRESNVRVSAVTAAAVRRHLTER

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=301, Percent_Identity=35.8803986710963, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI145580578, Length=266, Percent_Identity=36.0902255639098, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI4557499, Length=266, Percent_Identity=36.0902255639098, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI145580575, Length=266, Percent_Identity=36.0902255639098, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI61743967, Length=272, Percent_Identity=33.0882352941176, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4557497, Length=272, Percent_Identity=33.0882352941176, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI6912396, Length=277, Percent_Identity=27.4368231046931, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1789279, Length=294, Percent_Identity=34.3537414965986, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI87082289, Length=272, Percent_Identity=33.4558823529412, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787645, Length=243, Percent_Identity=29.2181069958848, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI87081824, Length=246, Percent_Identity=29.6747967479675, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788660, Length=269, Percent_Identity=32.3420074349442, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=280, Percent_Identity=36.0714285714286, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=270, Percent_Identity=33.3333333333333, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320925, Length=327, Percent_Identity=30.8868501529052, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6322116, Length=294, Percent_Identity=31.2925170068027, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6324055, Length=207, Percent_Identity=29.951690821256, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324964, Length=236, Percent_Identity=30.5084745762712, Blast_Score=93, Evalue=4e-20,
Organism=Drosophila melanogaster, GI19921140, Length=304, Percent_Identity=35.1973684210526, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24646446, Length=263, Percent_Identity=34.6007604562738, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24646448, Length=263, Percent_Identity=34.6007604562738, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24646452, Length=263, Percent_Identity=34.6007604562738, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24646450, Length=263, Percent_Identity=34.6007604562738, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI62472511, Length=263, Percent_Identity=34.6007604562738, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28571528, Length=285, Percent_Identity=31.9298245614035, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24585516, Length=272, Percent_Identity=27.2058823529412, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28574286, Length=289, Percent_Identity=27.681660899654, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24585514, Length=265, Percent_Identity=26.7924528301887, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28574282, Length=265, Percent_Identity=26.7924528301887, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45552429, Length=265, Percent_Identity=26.7924528301887, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28574284, Length=265, Percent_Identity=26.7924528301887, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI45551003, Length=265, Percent_Identity=26.7924528301887, Blast_Score=95, Evalue=5e-20,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 32307; Mature: 32176

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVVISEFMDEAAIAAELAGLDVVYDPGLVDRPEDLAAAAARADALIVRNRTQVRGALL
CCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHCEEEECCCHHHHHHHH
DAARDLTVVGRLGVGLDNIDLPACRARGIAVYPATGANDGAVAEYVIASALLLLRGAYGA
HHHCCEEEEEHHCCCCCCCCCCHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCC
SAAVAAGAWPRNALMGREIAGKRLGLVGFGAIARETARRAAALGMAVAAHDPFVAADDPA
CHHHHCCCCCCHHHHCCHHCCCCCCEEEHHHHHHHHHHHHHHHHHHEECCCCEEECCCCC
WTQTWTPASGPVERTALDALIAGSDVLSLHVPLTDATRGLIDAAALARMPTGAILINAAR
CCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCC
GGIVDEAAVAAALRSGHLGGAALDVFEREPLDPAAGAVFAGVPNLILTPHIAGVTRESNV
CCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHCHHHHCCCCCEECCCCCCCCCCCCE
RVSAVTAAAVRRHLTER
EEEHHHHHHHHHHHCCC
>Mature Secondary Structure 
PKVVISEFMDEAAIAAELAGLDVVYDPGLVDRPEDLAAAAARADALIVRNRTQVRGALL
CCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHCEEEECCCHHHHHHHH
DAARDLTVVGRLGVGLDNIDLPACRARGIAVYPATGANDGAVAEYVIASALLLLRGAYGA
HHHCCEEEEEHHCCCCCCCCCCHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCC
SAAVAAGAWPRNALMGREIAGKRLGLVGFGAIARETARRAAALGMAVAAHDPFVAADDPA
CHHHHCCCCCCHHHHCCHHCCCCCCEEEHHHHHHHHHHHHHHHHHHEECCCCEEECCCCC
WTQTWTPASGPVERTALDALIAGSDVLSLHVPLTDATRGLIDAAALARMPTGAILINAAR
CCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCC
GGIVDEAAVAAALRSGHLGGAALDVFEREPLDPAAGAVFAGVPNLILTPHIAGVTRESNV
CCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHCHHHHCCCCCEECCCCCCCCCCCCE
RVSAVTAAAVRRHLTER
EEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]