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The map label for this gene is baiF [H]

Identifier: 170750524

GI number: 170750524

Start: 4387035

End: 4388276

Strand: Direct

Name: baiF [H]

Synonym: Mrad2831_4131

Alternate gene names: 170750524

Gene position: 4387035-4388276 (Clockwise)

Preceding gene: 170750523

Following gene: 170750525

Centisome position: 72.18

GC content: 71.1

Gene sequence:

>1242_bases
ATGACCGAGCGCGAACTGCACCGGCGCGCCTACCGACCCGAGGCCCGGGGTATCCTCGACGGGGTGCGCATCCTCGACCT
CTCCCGGCTCTTCGCCGGCAACGTCCTGACGCAGATGCTCGGCGATTTCGGTGCCGAGGTGATCAAGGTCGAGCCCCCCG
AGGGCGACACCCTGCGCGCCTGGAAGACCGAGGGCGTCGAGACCCACTGGAAGATCTACGCCCGCAACAAGAAGAGCCTG
TGCCTGTCGCTGCGCGATCCCCGCGCCGTCGAGGTGCTCCGCGCGCTCGTGCCCTCCTGCCAGATGCTGATCGAAAGCTT
CCGCCCCGGGGTGCTGGAAGCGATGGGCCTCGCGCCGGAGTCTCTGCACGCCCTCAATCCCGGATTGACGATCATCCGCA
TCTCCGGCTGGGGGCAGGACGGGCCCTACGCGCAGCGGCCCGGCTTCGGCACGGTCATCGAGGGCTTCTCGGGCTTCGCC
GCCATGAACGGCTTCGCCGACCGCGAGCCCGTGCTGCCGCCGATGTACCTCGCGGACGGCGTCGCCGGACTCACCGGCGC
CTCGGCCGCCATGATCGCCCTGCGCGAGGTCGAGGTGAACGGCGGCCGGGGGCAGGTGATCGATCTGCCGCTTCTGGATC
CGCTCTTCGCGATCCTCAGCCCGCAGGCCGCCCATTACCGGCTCACCGGCAAGGGAAAGCCGCGGACCGGCTCGCGCTCG
ACGAACTCGGCGCCGCGCAACGCCTACCGGTGCAGCGACGGGCTCTATGTCGGCCTGTCGGGCTCGATCCAGAAGATGGC
CGAGCGCCTGTTCCGGGCGATCGGGCGCCCCGACCTCGTGGACGATCCGCGCTTCCGCACCAACGCCGACCGGCTGCGCC
ACGTGGACGAGCTCGACGCGATCATCGGCGCCTTCATCGCGGAGCGGACGCAGGACGAGAACGTCGCGTTCTTCGAGGCC
GCCGAGGTGACGATCGGCCCGATCAACGATGCGGCCAAGCTCGTCGCCGACCCGCACGTGGTCGAGCGCGAACTCATCGC
CGACTATCCCGACCCCGACATGGGGCTCATCCCCATGCACGCCGTCGTGCCGCGGCTCCACGACCGGCCGGGCGCGATCC
GCACGCCCGCGCCCACCCTCGGCCAGCACAACCGCGAGGTGCTGGGGCAGATCGGCATCGCGGGCGCGGCCTTTGACGAC
CTCGTCGCCGCGGGCGTGGTCCGCAGCGGCGACGCCCGCTGA

Upstream 100 bases:

>100_bases
GCGCCATCCTCGTGGACGGGCGGATGATCGATCCGCCCTTCCTGGCCCGCGCCCGCGCCGTCGTGGCGCTGTCCGATCTC
CACACCGCGACGGAAGTCCC

Downstream 100 bases:

>100_bases
CGACAATGACAGGGAGGCTGGGAATGCCCACGCTGACACGCCGCGGCTTCGTCGCGGCCGCCATGGCCGGCATGGCCGGC
ATGGCCGGCATGGCAACGTC

Product: L-carnitine dehydratase/bile acid-inducible protein F

Products: NA

Alternate protein names: Bile acid-coenzyme A hydrolase; Bile acid-inducible operon protein F [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MTERELHRRAYRPEARGILDGVRILDLSRLFAGNVLTQMLGDFGAEVIKVEPPEGDTLRAWKTEGVETHWKIYARNKKSL
CLSLRDPRAVEVLRALVPSCQMLIESFRPGVLEAMGLAPESLHALNPGLTIIRISGWGQDGPYAQRPGFGTVIEGFSGFA
AMNGFADREPVLPPMYLADGVAGLTGASAAMIALREVEVNGGRGQVIDLPLLDPLFAILSPQAAHYRLTGKGKPRTGSRS
TNSAPRNAYRCSDGLYVGLSGSIQKMAERLFRAIGRPDLVDDPRFRTNADRLRHVDELDAIIGAFIAERTQDENVAFFEA
AEVTIGPINDAAKLVADPHVVERELIADYPDPDMGLIPMHAVVPRLHDRPGAIRTPAPTLGQHNREVLGQIGIAGAAFDD
LVAAGVVRSGDAR

Sequences:

>Translated_413_residues
MTERELHRRAYRPEARGILDGVRILDLSRLFAGNVLTQMLGDFGAEVIKVEPPEGDTLRAWKTEGVETHWKIYARNKKSL
CLSLRDPRAVEVLRALVPSCQMLIESFRPGVLEAMGLAPESLHALNPGLTIIRISGWGQDGPYAQRPGFGTVIEGFSGFA
AMNGFADREPVLPPMYLADGVAGLTGASAAMIALREVEVNGGRGQVIDLPLLDPLFAILSPQAAHYRLTGKGKPRTGSRS
TNSAPRNAYRCSDGLYVGLSGSIQKMAERLFRAIGRPDLVDDPRFRTNADRLRHVDELDAIIGAFIAERTQDENVAFFEA
AEVTIGPINDAAKLVADPHVVERELIADYPDPDMGLIPMHAVVPRLHDRPGAIRTPAPTLGQHNREVLGQIGIAGAAFDD
LVAAGVVRSGDAR
>Mature_412_residues
TERELHRRAYRPEARGILDGVRILDLSRLFAGNVLTQMLGDFGAEVIKVEPPEGDTLRAWKTEGVETHWKIYARNKKSLC
LSLRDPRAVEVLRALVPSCQMLIESFRPGVLEAMGLAPESLHALNPGLTIIRISGWGQDGPYAQRPGFGTVIEGFSGFAA
MNGFADREPVLPPMYLADGVAGLTGASAAMIALREVEVNGGRGQVIDLPLLDPLFAILSPQAAHYRLTGKGKPRTGSRST
NSAPRNAYRCSDGLYVGLSGSIQKMAERLFRAIGRPDLVDDPRFRTNADRLRHVDELDAIIGAFIAERTQDENVAFFEAA
EVTIGPINDAAKLVADPHVVERELIADYPDPDMGLIPMHAVVPRLHDRPGAIRTPAPTLGQHNREVLGQIGIAGAAFDDL
VAAGVVRSGDAR

Specific function: Involved in bile acid dehydration reactions in the human intestine. Active on cholyl-CoA, 3-dehydrocholyl-CoA and chenodeoxycholoyl-CoA; as substrates. No hydrolytic activity on acetyl-CoA, isovaleryl-CoA, palmitoyl-CoA, or phenylacetyl-CoA as substrates

COG id: COG1804

COG function: function code C; Predicted acyl-CoA transferases/carnitine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CaiB/BaiF CoA-transferase family [H]

Homologues:

Organism=Homo sapiens, GI300863128, Length=394, Percent_Identity=33.756345177665, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI300863124, Length=420, Percent_Identity=31.6666666666667, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI300863126, Length=394, Percent_Identity=30.2030456852792, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI13376042, Length=420, Percent_Identity=28.8095238095238, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI266456254, Length=403, Percent_Identity=27.5434243176179, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI42794625, Length=404, Percent_Identity=27.2277227722772, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI266458393, Length=259, Percent_Identity=30.8880308880309, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI266458397, Length=258, Percent_Identity=30.6201550387597, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI266458395, Length=130, Percent_Identity=36.9230769230769, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI42822893, Length=130, Percent_Identity=36.9230769230769, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI87082093, Length=338, Percent_Identity=28.1065088757396, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788717, Length=413, Percent_Identity=24.9394673123487, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1786222, Length=406, Percent_Identity=26.1083743842365, Blast_Score=108, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI115535051, Length=331, Percent_Identity=24.1691842900302, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI32564160, Length=340, Percent_Identity=25.8823529411765, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24648431, Length=384, Percent_Identity=31.25, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24585488, Length=394, Percent_Identity=26.9035532994924, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003673 [H]

Pfam domain/function: PF02515 CoA_transf_3 [H]

EC number: =3.1.2.26 [H]

Molecular weight: Translated: 44768; Mature: 44637

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERELHRRAYRPEARGILDGVRILDLSRLFAGNVLTQMLGDFGAEVIKVEPPEGDTLRA
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEE
WKTEGVETHWKIYARNKKSLCLSLRDPRAVEVLRALVPSCQMLIESFRPGVLEAMGLAPE
EECCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHH
SLHALNPGLTIIRISGWGQDGPYAQRPGFGTVIEGFSGFAAMNGFADREPVLPPMYLADG
HHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCC
VAGLTGASAAMIALREVEVNGGRGQVIDLPLLDPLFAILSPQAAHYRLTGKGKPRTGSRS
CCCCCCCHHHHEEEEEEEECCCCCCEEECCHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
TNSAPRNAYRCSDGLYVGLSGSIQKMAERLFRAIGRPDLVDDPRFRTNADRLRHVDELDA
CCCCCCCCEECCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
IIGAFIAERTQDENVAFFEAAEVTIGPINDAAKLVADPHVVERELIADYPDPDMGLIPMH
HHHHHHHHCCCCCCEEEEEEEEEEEECCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHH
AVVPRLHDRPGAIRTPAPTLGQHNREVLGQIGIAGAAFDDLVAAGVVRSGDAR
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TERELHRRAYRPEARGILDGVRILDLSRLFAGNVLTQMLGDFGAEVIKVEPPEGDTLRA
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEE
WKTEGVETHWKIYARNKKSLCLSLRDPRAVEVLRALVPSCQMLIESFRPGVLEAMGLAPE
EECCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHH
SLHALNPGLTIIRISGWGQDGPYAQRPGFGTVIEGFSGFAAMNGFADREPVLPPMYLADG
HHHHCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCC
VAGLTGASAAMIALREVEVNGGRGQVIDLPLLDPLFAILSPQAAHYRLTGKGKPRTGSRS
CCCCCCCHHHHEEEEEEEECCCCCCEEECCHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
TNSAPRNAYRCSDGLYVGLSGSIQKMAERLFRAIGRPDLVDDPRFRTNADRLRHVDELDA
CCCCCCCCEECCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
IIGAFIAERTQDENVAFFEAAEVTIGPINDAAKLVADPHVVERELIADYPDPDMGLIPMH
HHHHHHHHCCCCCCEEEEEEEEEEEECCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCCHH
AVVPRLHDRPGAIRTPAPTLGQHNREVLGQIGIAGAAFDDLVAAGVVRSGDAR
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254270; 3170477; 2448288 [H]