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The map label for this gene is kefBC [H]

Identifier: 170750348

GI number: 170750348

Start: 4203073

End: 4205046

Strand: Direct

Name: kefBC [H]

Synonym: Mrad2831_3951

Alternate gene names: 170750348

Gene position: 4203073-4205046 (Clockwise)

Preceding gene: 170750347

Following gene: 170750349

Centisome position: 69.15

GC content: 72.8

Gene sequence:

>1974_bases
ATGGCGAGCCCCGTCGAACATGCGAGCTTCCTGCCGCCGGTCCTGACCTTCCTCACCGCGGCTGTGATCGGCGTGCCGAT
CTTCCGGCTGATCGGGCAGAGCGCCGTGCTCGGCTACCTCGTGGCCGGCGTGCTGATCGGGCCCTCCGGCCTGTCGCTGA
TCGCCGAGCCCGAGACGGCGGCGAGCGTCGCCGAGATCGGCGTGGTGCTCCTGCTCTTCATCGTCGGCCTGGAGCTGCAC
CTGTCGCAGCTCGTCTCCATGCGCCGCGACATCTTCGGCCTCGGCACCGCGCAGCTCGTCGTCTGCGCGCTGGTGCTCGG
CGGCGCCGGAATCCTGGCCGGCCTCAGTTTCGGCGCCGCCGCGGTGATCGGCCTCGCGCTCGCCCTCTCGGCCACCGCGG
TGGCCCTGCAACTCCTGGAGGAGCGGGGCGATCTCGGCAGCGCCTACGGCGCGCGCGCCTTCGCGGTGCTGCTGTTCCAG
GACCTGTCGGTGGTCGGCATCCTGGCGCTGATGCCGCTGCTGGCCTCGGCCGGCGAGGCGACCGACGTCTCCTGGCTCGG
GGAGGCGGCGGTCTCCACCGGCAAGGCGCTCGCGGCGATCCTCGCGGTGGTGCTGGTCGGCCGCTACGGCCTGAACCCGT
TCTTCCGGCTGCTCGCGGCGAGCGGCGCCCGCGAGGTGATGACCGCCGCGGCACTCCTGGTGGTGCTCGGCACCGCGCTG
CTCATGGAGCAGGTCGGCCTGTCGATGGCGATGGGCGCGTTCCTCGCCGGCATCCTGCTGGCCGAGTCGAACTTCCGCCA
CCAGCTGGAGGCCGATATCGAGCCGTTCCGCGGCATGCTGCTCGGCCTGTTCTTCATGAGCGTCGGCATGTCGATCGACG
GCAACCTCGTGCGCGAGGTCTGGCCGGCCCTGTTCGGCGCGACCCTGGCGGCGATCCTGGTCAAGGTCGCCATCGTGGCC
GGCCTGTTCCGGCTGTTCGGCTCGGACACCCTCGGGGCCCTGCGGGGCGCCGCGGTCCTGGCGCCCGCGGGCGAGTTCGC
CTTCGTGCTGCTGCCGCAGGCCCAGGATCTCGGCCTCACCGGCGTCACGGCGACGCGCTTCGCGGTGGCGCTCGCCGCGC
TGACCATGCTGATCGGCCCCATCGCCGCCAAGGGTCTCGACAAGCTGATCGAGCGGCGCAACGCGCGCAGCACCTTCGCG
CTGGAGGAGCCCTCCAGCGAGCTCTCCGAGAGCGGCGACGCCCGGGTGCTGGTGATCGGCTTCGGCCGGTTCGGGCAGGT
GCTGACCCACGTGCTGATGGCCGAGGGCATCCCGGTCACGGTGATCGACAAGGACGTGGAGCAGCTGCGCGCCGCCTCGC
GCTTCGGCTTCCGCATCTACTACGGCGACGGCACGCGCCTCGACGTGCTGCGCGCCGCCGGGATCGGTCGGGTCGAGCTG
GTCTGCATCTGCGTCGACGACCGGGAGGGCGCCCTCAAGATCGTCGACATCGTCCACGAGGAGTTCTCCAGCGTGCGCAC
CTTCGTGCGGGCCTACGACCGCCTGCACGCGGTGGAGCTGATGAACCGGGACGTCGACTACCAGATCCGCGAGACCGCCG
AATCCGCCCTCGCCTTCGGGCGGGCGGCCCTCGAGGGACTCGGCCTGTCGCCGGAGGCCGCCACCGCCCGGACCGACGAT
GTGCGCAAGCGCGACATCGCGCGGCTGGTCCTGCAGCAGGCTGGCGCCCTGCCGGACGGGTCCAGCTGGATGCGCGGCGC
CGCGGCGGGCCTGAAGCCCGAGCCGCTGACCGCCCCGGTCCGGCCGGCCCGGGCGCTCAGCACCGAGACCCGCGACCTCG
TGGGCAGCGACCGGCGCGAGGCCGCCGAGCGGCTCCTGGAGAAGCCCGCCCTGGCCCCGCAGGAGACGGAGGCCGCCGAG
GAATCCGATCCGGAGACCGAGCTCGAAGCGGAAGGCAGCGCCCGGGATGCGTGA

Upstream 100 bases:

>100_bases
GTGCCGAACGGCACCCGCATACGGCTCGCATCGCGGCCGCGCGCGCGCTAAGCGGGGACCTCACCTGCGCCGATCCAGCA
GAACCGCCGGGACGATCACC

Downstream 100 bases:

>100_bases
CGGGCCGGATGTCTGACCTGTCCGACGGGCCGCCCCCGGCGGAGGCGGGCCGCTTCGTCACCGGCTCGATCCTCCGCCAC
GTCGTCGTGATGGCCGCCAC

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MASPVEHASFLPPVLTFLTAAVIGVPIFRLIGQSAVLGYLVAGVLIGPSGLSLIAEPETAASVAEIGVVLLLFIVGLELH
LSQLVSMRRDIFGLGTAQLVVCALVLGGAGILAGLSFGAAAVIGLALALSATAVALQLLEERGDLGSAYGARAFAVLLFQ
DLSVVGILALMPLLASAGEATDVSWLGEAAVSTGKALAAILAVVLVGRYGLNPFFRLLAASGAREVMTAAALLVVLGTAL
LMEQVGLSMAMGAFLAGILLAESNFRHQLEADIEPFRGMLLGLFFMSVGMSIDGNLVREVWPALFGATLAAILVKVAIVA
GLFRLFGSDTLGALRGAAVLAPAGEFAFVLLPQAQDLGLTGVTATRFAVALAALTMLIGPIAAKGLDKLIERRNARSTFA
LEEPSSELSESGDARVLVIGFGRFGQVLTHVLMAEGIPVTVIDKDVEQLRAASRFGFRIYYGDGTRLDVLRAAGIGRVEL
VCICVDDREGALKIVDIVHEEFSSVRTFVRAYDRLHAVELMNRDVDYQIRETAESALAFGRAALEGLGLSPEAATARTDD
VRKRDIARLVLQQAGALPDGSSWMRGAAAGLKPEPLTAPVRPARALSTETRDLVGSDRREAAERLLEKPALAPQETEAAE
ESDPETELEAEGSARDA

Sequences:

>Translated_657_residues
MASPVEHASFLPPVLTFLTAAVIGVPIFRLIGQSAVLGYLVAGVLIGPSGLSLIAEPETAASVAEIGVVLLLFIVGLELH
LSQLVSMRRDIFGLGTAQLVVCALVLGGAGILAGLSFGAAAVIGLALALSATAVALQLLEERGDLGSAYGARAFAVLLFQ
DLSVVGILALMPLLASAGEATDVSWLGEAAVSTGKALAAILAVVLVGRYGLNPFFRLLAASGAREVMTAAALLVVLGTAL
LMEQVGLSMAMGAFLAGILLAESNFRHQLEADIEPFRGMLLGLFFMSVGMSIDGNLVREVWPALFGATLAAILVKVAIVA
GLFRLFGSDTLGALRGAAVLAPAGEFAFVLLPQAQDLGLTGVTATRFAVALAALTMLIGPIAAKGLDKLIERRNARSTFA
LEEPSSELSESGDARVLVIGFGRFGQVLTHVLMAEGIPVTVIDKDVEQLRAASRFGFRIYYGDGTRLDVLRAAGIGRVEL
VCICVDDREGALKIVDIVHEEFSSVRTFVRAYDRLHAVELMNRDVDYQIRETAESALAFGRAALEGLGLSPEAATARTDD
VRKRDIARLVLQQAGALPDGSSWMRGAAAGLKPEPLTAPVRPARALSTETRDLVGSDRREAAERLLEKPALAPQETEAAE
ESDPETELEAEGSARDA
>Mature_656_residues
ASPVEHASFLPPVLTFLTAAVIGVPIFRLIGQSAVLGYLVAGVLIGPSGLSLIAEPETAASVAEIGVVLLLFIVGLELHL
SQLVSMRRDIFGLGTAQLVVCALVLGGAGILAGLSFGAAAVIGLALALSATAVALQLLEERGDLGSAYGARAFAVLLFQD
LSVVGILALMPLLASAGEATDVSWLGEAAVSTGKALAAILAVVLVGRYGLNPFFRLLAASGAREVMTAAALLVVLGTALL
MEQVGLSMAMGAFLAGILLAESNFRHQLEADIEPFRGMLLGLFFMSVGMSIDGNLVREVWPALFGATLAAILVKVAIVAG
LFRLFGSDTLGALRGAAVLAPAGEFAFVLLPQAQDLGLTGVTATRFAVALAALTMLIGPIAAKGLDKLIERRNARSTFAL
EEPSSELSESGDARVLVIGFGRFGQVLTHVLMAEGIPVTVIDKDVEQLRAASRFGFRIYYGDGTRLDVLRAAGIGRVELV
CICVDDREGALKIVDIVHEEFSSVRTFVRAYDRLHAVELMNRDVDYQIRETAESALAFGRAALEGLGLSPEAATARTDDV
RKRDIARLVLQQAGALPDGSSWMRGAAAGLKPEPLTAPVRPARALSTETRDLVGSDRREAAERLLEKPALAPQETEAAEE
SDPETELEAEGSARDA

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=352, Percent_Identity=26.9886363636364, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1786232, Length=561, Percent_Identity=40.8199643493761, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI1789749, Length=566, Percent_Identity=40.9893992932862, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1786685, Length=490, Percent_Identity=31.8367346938775, Blast_Score=161, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 68778; Mature: 68647

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPVEHASFLPPVLTFLTAAVIGVPIFRLIGQSAVLGYLVAGVLIGPSGLSLIAEPETA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHH
ASVAEIGVVLLLFIVGLELHLSQLVSMRRDIFGLGTAQLVVCALVLGGAGILAGLSFGAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHH
AVIGLALALSATAVALQLLEERGDLGSAYGARAFAVLLFQDLSVVGILALMPLLASAGEA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TDVSWLGEAAVSTGKALAAILAVVLVGRYGLNPFFRLLAASGAREVMTAAALLVVLGTAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LMEQVGLSMAMGAFLAGILLAESNFRHQLEADIEPFRGMLLGLFFMSVGMSIDGNLVREV
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHH
WPALFGATLAAILVKVAIVAGLFRLFGSDTLGALRGAAVLAPAGEFAFVLLPQAQDLGLT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHEECCCCEEEEEECCCCCCCCC
GVTATRFAVALAALTMLIGPIAAKGLDKLIERRNARSTFALEEPSSELSESGDARVLVIG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHCCCCCEEEEEE
FGRFGQVLTHVLMAEGIPVTVIDKDVEQLRAASRFGFRIYYGDGTRLDVLRAAGIGRVEL
CCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHCCEEEEECCCCEEHHHHHCCCCCEEE
VCICVDDREGALKIVDIVHEEFSSVRTFVRAYDRLHAVELMNRDVDYQIRETAESALAFG
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
RAALEGLGLSPEAATARTDDVRKRDIARLVLQQAGALPDGSSWMRGAAAGLKPEPLTAPV
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCC
RPARALSTETRDLVGSDRREAAERLLEKPALAPQETEAAEESDPETELEAEGSARDA
CCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ASPVEHASFLPPVLTFLTAAVIGVPIFRLIGQSAVLGYLVAGVLIGPSGLSLIAEPETA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHH
ASVAEIGVVLLLFIVGLELHLSQLVSMRRDIFGLGTAQLVVCALVLGGAGILAGLSFGAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHH
AVIGLALALSATAVALQLLEERGDLGSAYGARAFAVLLFQDLSVVGILALMPLLASAGEA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TDVSWLGEAAVSTGKALAAILAVVLVGRYGLNPFFRLLAASGAREVMTAAALLVVLGTAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LMEQVGLSMAMGAFLAGILLAESNFRHQLEADIEPFRGMLLGLFFMSVGMSIDGNLVREV
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHH
WPALFGATLAAILVKVAIVAGLFRLFGSDTLGALRGAAVLAPAGEFAFVLLPQAQDLGLT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHEECCCCEEEEEECCCCCCCCC
GVTATRFAVALAALTMLIGPIAAKGLDKLIERRNARSTFALEEPSSELSESGDARVLVIG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHCCCCCEEEEEE
FGRFGQVLTHVLMAEGIPVTVIDKDVEQLRAASRFGFRIYYGDGTRLDVLRAAGIGRVEL
CCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHCCEEEEECCCCEEHHHHHCCCCCEEE
VCICVDDREGALKIVDIVHEEFSSVRTFVRAYDRLHAVELMNRDVDYQIRETAESALAFG
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
RAALEGLGLSPEAATARTDDVRKRDIARLVLQQAGALPDGSSWMRGAAAGLKPEPLTAPV
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCC
RPARALSTETRDLVGSDRREAAERLLEKPALAPQETEAAEESDPETELEAEGSARDA
CCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]