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The map label for this gene is deoA [H]

Identifier: 170750320

GI number: 170750320

Start: 4173658

End: 4174986

Strand: Reverse

Name: deoA [H]

Synonym: Mrad2831_3923

Alternate gene names: 170750320

Gene position: 4174986-4173658 (Counterclockwise)

Preceding gene: 170750321

Following gene: 170750315

Centisome position: 68.69

GC content: 76.82

Gene sequence:

>1329_bases
GTGCCGCTTCCCCAGGAGAGGCTTCCCCAGGAGAGGCTGCCCCAGGAGACGATCCGGGCCAAGCGCGACGGCCAGCCCCT
CGAGCCGGAGGCGATCGACGCCTTCATCCGCGGCCTCACCGACGGCACGGTCGGGGAGGGTCAGGCGGCGGCCTTCGCCA
TGGCGGTGTTCTTCCGCGGCCTGTCGCTGCCGGAGCGGGTGGCGCTGACCCGGGCCATGGCCGAGTCGGGCCGGGTCCTC
GCCTGGGACCTGCCCGGGCCCGTCCTCGACAAGCACTCCACCGGCGGCATCGGCGACGCGGTGAGCCTGCCGCTCGCCCC
GATGGTCGCGGCCTGCGGCGGCTACGTGCCGATGATCTCGGGGCGCGGCCTCGGCCATACCGGCGGGACGCTGGACAAGC
TCGGCAGCATCCCGGGCTACGACGCGACGCCGGGCCTCGACGCGTTCCGCCGGGTCGTCGGCACGGTCGGCTGCGCCATC
ATCGGCCAGACTGCCGAGCTCGCGCCCGCGGACCGGCGCCTCTACGCGATCCGCGACGTCACCGGCACGGTCGAGTCCCG
CGACCTGATCACCGCCTCGATCCTGTCGAAGAAGCTCGCCGCCGGGCTGGACGGGCTCGTGATGGACGTGAAGCAGGGCT
CCGGCGCCTTCATGGCAACGCTGCCCGAGGCGCGCGCCCTGGCGGGGAGCATCGTCACGGTGGCGGAGGGGGCCGGCCTG
CACACCGCCGCGCTGATCACCGACATGGACGCGCCGCTCGCCAGCGCGGCCGGCAACGCCGTCGAGGTCGCCTACGCGAT
CGACTACCTGACGGGCGCGCGCCGCGAGCCGCGCTTCCACGCGGTCACGGTGGCCCTGGGCGCGGAGATGCTGGTCGTCG
GCGGCCTCGCGCCGGACCGCGACAGCGCCGCGGAGCGGCTGGAGCGGGCCCTCGCGTCGGGCCGGGCGGCCGAGGGCTTC
GGCCGCATGGTCGCGGCCCTGGGCGGGCCGGGCGATCTCCTGGAGCGGCCGGCGGCGCATCTGCCGGCGGCACCGGTGCG
CCGGGCGGTGCGTCAGGACGGGACCGTCGCGGGGATCGCGACGCGGGCGCTGGGCCTGGCGGTGATCGGACTCGGGGGCG
GACGCACGCGGCCGGAGGATCCCGTCGACCCGCGCGTCGGCTTCACGGACCTCGCCGGTCCGGGATCGTCCGGCGGCCTG
CTCGGGATCGTCCACGCGGCCGACGAGGCCGCCGCGGACCGGGCCGAGGCCGCGCTGCGGGCGGCCTACCGGATGGGCGA
CGCGCCGACGGAGCGGCCGCCCGTCCTGGAGCGGGTGGACGCCGGTTAG

Upstream 100 bases:

>100_bases
CCGACCGGCTCATGGGGCCCGGCTGGGTGAGCCCCGCAACCTTCCGGCTCGGAGCGAGCAGCCTGTTCGGGACCCTGATC
CAGGCGCGGGAGCTGTGAGC

Downstream 100 bases:

>100_bases
GGGCCGCGCCCGGTCGGGACCGGGCGCGCGGACTAGCTGTTACCAGCGGCCGTAGCCGTGACGGTGGCCCCAGTCACCGT
GGTGATGGTGACGCGGCCCG

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MPLPQERLPQERLPQETIRAKRDGQPLEPEAIDAFIRGLTDGTVGEGQAAAFAMAVFFRGLSLPERVALTRAMAESGRVL
AWDLPGPVLDKHSTGGIGDAVSLPLAPMVAACGGYVPMISGRGLGHTGGTLDKLGSIPGYDATPGLDAFRRVVGTVGCAI
IGQTAELAPADRRLYAIRDVTGTVESRDLITASILSKKLAAGLDGLVMDVKQGSGAFMATLPEARALAGSIVTVAEGAGL
HTAALITDMDAPLASAAGNAVEVAYAIDYLTGARREPRFHAVTVALGAEMLVVGGLAPDRDSAAERLERALASGRAAEGF
GRMVAALGGPGDLLERPAAHLPAAPVRRAVRQDGTVAGIATRALGLAVIGLGGGRTRPEDPVDPRVGFTDLAGPGSSGGL
LGIVHAADEAAADRAEAALRAAYRMGDAPTERPPVLERVDAG

Sequences:

>Translated_442_residues
MPLPQERLPQERLPQETIRAKRDGQPLEPEAIDAFIRGLTDGTVGEGQAAAFAMAVFFRGLSLPERVALTRAMAESGRVL
AWDLPGPVLDKHSTGGIGDAVSLPLAPMVAACGGYVPMISGRGLGHTGGTLDKLGSIPGYDATPGLDAFRRVVGTVGCAI
IGQTAELAPADRRLYAIRDVTGTVESRDLITASILSKKLAAGLDGLVMDVKQGSGAFMATLPEARALAGSIVTVAEGAGL
HTAALITDMDAPLASAAGNAVEVAYAIDYLTGARREPRFHAVTVALGAEMLVVGGLAPDRDSAAERLERALASGRAAEGF
GRMVAALGGPGDLLERPAAHLPAAPVRRAVRQDGTVAGIATRALGLAVIGLGGGRTRPEDPVDPRVGFTDLAGPGSSGGL
LGIVHAADEAAADRAEAALRAAYRMGDAPTERPPVLERVDAG
>Mature_441_residues
PLPQERLPQERLPQETIRAKRDGQPLEPEAIDAFIRGLTDGTVGEGQAAAFAMAVFFRGLSLPERVALTRAMAESGRVLA
WDLPGPVLDKHSTGGIGDAVSLPLAPMVAACGGYVPMISGRGLGHTGGTLDKLGSIPGYDATPGLDAFRRVVGTVGCAII
GQTAELAPADRRLYAIRDVTGTVESRDLITASILSKKLAAGLDGLVMDVKQGSGAFMATLPEARALAGSIVTVAEGAGLH
TAALITDMDAPLASAAGNAVEVAYAIDYLTGARREPRFHAVTVALGAEMLVVGGLAPDRDSAAERLERALASGRAAEGFG
RMVAALGGPGDLLERPAAHLPAAPVRRAVRQDGTVAGIATRALGLAVIGLGGGRTRPEDPVDPRVGFTDLAGPGSSGGLL
GIVHAADEAAADRAEAALRAAYRMGDAPTERPPVLERVDAG

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=393, Percent_Identity=43.5114503816794, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4503445, Length=393, Percent_Identity=43.5114503816794, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI166158922, Length=393, Percent_Identity=43.5114503816794, Blast_Score=244, Evalue=1e-64,
Organism=Escherichia coli, GI1790842, Length=436, Percent_Identity=55.9633027522936, Blast_Score=441, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 45174; Mature: 45043

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLPQERLPQERLPQETIRAKRDGQPLEPEAIDAFIRGLTDGTVGEGQAAAFAMAVFFRG
CCCCHHCCCHHHCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
LSLPERVALTRAMAESGRVLAWDLPGPVLDKHSTGGIGDAVSLPLAPMVAACGGYVPMIS
CCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHCCHHHHHHHHCCCEEECC
GRGLGHTGGTLDKLGSIPGYDATPGLDAFRRVVGTVGCAIIGQTAELAPADRRLYAIRDV
CCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHCCCCCCEEEEEECC
TGTVESRDLITASILSKKLAAGLDGLVMDVKQGSGAFMATLPEARALAGSIVTVAEGAGL
CCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCHHHHHHCCEEEEECCCCC
HTAALITDMDAPLASAAGNAVEVAYAIDYLTGARREPRFHAVTVALGAEMLVVGGLAPDR
HHHHHHHCCCCCHHHHCCCCEEHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECCCCCH
DSAAERLERALASGRAAEGFGRMVAALGGPGDLLERPAAHLPAAPVRRAVRQDGTVAGIA
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHCCHHHCCHHHHHHHHHCCCCCHHHH
TRALGLAVIGLGGGRTRPEDPVDPRVGFTDLAGPGSSGGLLGIVHAADEAAADRAEAALR
HHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
AAYRMGDAPTERPPVLERVDAG
HHHHCCCCCCCCCCHHHHCCCC
>Mature Secondary Structure 
PLPQERLPQERLPQETIRAKRDGQPLEPEAIDAFIRGLTDGTVGEGQAAAFAMAVFFRG
CCCHHCCCHHHCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHC
LSLPERVALTRAMAESGRVLAWDLPGPVLDKHSTGGIGDAVSLPLAPMVAACGGYVPMIS
CCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHCCHHHHHHHHCCCEEECC
GRGLGHTGGTLDKLGSIPGYDATPGLDAFRRVVGTVGCAIIGQTAELAPADRRLYAIRDV
CCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHCCCCCCEEEEEECC
TGTVESRDLITASILSKKLAAGLDGLVMDVKQGSGAFMATLPEARALAGSIVTVAEGAGL
CCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCHHHHHHCCEEEEECCCCC
HTAALITDMDAPLASAAGNAVEVAYAIDYLTGARREPRFHAVTVALGAEMLVVGGLAPDR
HHHHHHHCCCCCHHHHCCCCEEHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEECCCCCH
DSAAERLERALASGRAAEGFGRMVAALGGPGDLLERPAAHLPAAPVRRAVRQDGTVAGIA
HHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHCCHHHCCHHHHHHHHHCCCCCHHHH
TRALGLAVIGLGGGRTRPEDPVDPRVGFTDLAGPGSSGGLLGIVHAADEAAADRAEAALR
HHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
AAYRMGDAPTERPPVLERVDAG
HHHHCCCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA