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The map label for this gene is ptxR [H]

Identifier: 170750184

GI number: 170750184

Start: 4027265

End: 4028173

Strand: Direct

Name: ptxR [H]

Synonym: Mrad2831_3786

Alternate gene names: 170750184

Gene position: 4027265-4028173 (Clockwise)

Preceding gene: 170750176

Following gene: 170750185

Centisome position: 66.26

GC content: 73.38

Gene sequence:

>909_bases
ATGGCCAGGACGGGGCCCAACTGGGACGACCTCCGCTTCTTCCTCGCGGTGGCGCGGACGGGAACGCTGAGCGCCGCCGG
GGCCCGCACCGGCACCGAGCACACCACGGTCGGGCGCCGGATCCGCGCCCTGGAGGAAGGGCTCGGCGCCCGGCTGTTCC
ACCGCAGCAACCTCGGCTACGCGCTCACCGAGGACGGCGCGAACCTGCTGGGCGTCGCGGAGGCCATGGAGAGCGCGTTC
CTGTCGGCGAGCGCCGCCACGGAGGCCGCGCAGACGGTCTCCGGCACGGTTCGGATCGGCGCGCCGGACGGGTTCGGCAG
CGTGTTCCTCGCACCCCGGATGCACCGGCTCACCGCCCGCCACCCGGGGCTGGAGGTCGAGATCATGGCGACCGCCCGGA
TCTTCAGCCTCTCGAAGCGCGAGGCCGACATCGTCATCAGCCTCTCGGGCCCGCAGCAGGCGCGGGTGGTGGCGCGCCGG
CTGACCGATTACCGGCTGCTCGTCTACGCGGCCGAAACCTACCTCGCGGGGGCCGCGCCGATCGCGGAGGTCGGGGACCT
CTCGGGGCATCCCTTCGTCGGCTACATCGAGGACATGCTGTTCACGCGCGAGCTGAACTATCTCGGCGCCCTGGGTCCGC
CGGTCTCCGCGCGGCTGCGCTCCACCAACCTCCTGGCCCAGGTCCACGCGACGCTCGGCGGCGCCGGCCTCTGCGTCCTG
CCGGCCTTCATCGCGGCGGCCCATCCGGGTCTCGTGCCGGTGCTGCCCGGGGCGGTGGCCCTGACACGCTCGTTCCACAT
GCACATCCACGAGGATCACCGGAAGGCGGCCCATATCCGCGCGGTGGCGGGCTTCATCGCGGGCGAGGTGGAGGCCGCCG
CCGCGCTGTTCGCCGGGCCGGCAGTGTAA

Upstream 100 bases:

>100_bases
TGTGGCGTTCGATTTTGGCGCACCCTATCAGGATCGCTTGAGCGATAAAGCCGGATGCGCTTACAGCCGTCGTGCATCGA
TGCACAGCGAGGGTGCGGCC

Downstream 100 bases:

>100_bases
GCGCCGGCAGTTTCGCCCGGCGCGCGCAGGTCCTAAGATCGCCGTCCCGGCGGACCAGCAGAGGCGCCGGGAGGGAGAAG
CAACAGAATGGTCGCCTCGA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MARTGPNWDDLRFFLAVARTGTLSAAGARTGTEHTTVGRRIRALEEGLGARLFHRSNLGYALTEDGANLLGVAEAMESAF
LSASAATEAAQTVSGTVRIGAPDGFGSVFLAPRMHRLTARHPGLEVEIMATARIFSLSKREADIVISLSGPQQARVVARR
LTDYRLLVYAAETYLAGAAPIAEVGDLSGHPFVGYIEDMLFTRELNYLGALGPPVSARLRSTNLLAQVHATLGGAGLCVL
PAFIAAAHPGLVPVLPGAVALTRSFHMHIHEDHRKAAHIRAVAGFIAGEVEAAAALFAGPAV

Sequences:

>Translated_302_residues
MARTGPNWDDLRFFLAVARTGTLSAAGARTGTEHTTVGRRIRALEEGLGARLFHRSNLGYALTEDGANLLGVAEAMESAF
LSASAATEAAQTVSGTVRIGAPDGFGSVFLAPRMHRLTARHPGLEVEIMATARIFSLSKREADIVISLSGPQQARVVARR
LTDYRLLVYAAETYLAGAAPIAEVGDLSGHPFVGYIEDMLFTRELNYLGALGPPVSARLRSTNLLAQVHATLGGAGLCVL
PAFIAAAHPGLVPVLPGAVALTRSFHMHIHEDHRKAAHIRAVAGFIAGEVEAAAALFAGPAV
>Mature_301_residues
ARTGPNWDDLRFFLAVARTGTLSAAGARTGTEHTTVGRRIRALEEGLGARLFHRSNLGYALTEDGANLLGVAEAMESAFL
SASAATEAAQTVSGTVRIGAPDGFGSVFLAPRMHRLTARHPGLEVEIMATARIFSLSKREADIVISLSGPQQARVVARRL
TDYRLLVYAAETYLAGAAPIAEVGDLSGHPFVGYIEDMLFTRELNYLGALGPPVSARLRSTNLLAQVHATLGGAGLCVLP
AFIAAAHPGLVPVLPGAVALTRSFHMHIHEDHRKAAHIRAVAGFIAGEVEAAAALFAGPAV

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789440, Length=205, Percent_Identity=28.2926829268293, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI145693193, Length=186, Percent_Identity=27.4193548387097, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87081978, Length=188, Percent_Identity=28.7234042553192, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789173, Length=221, Percent_Identity=24.4343891402715, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31744; Mature: 31613

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTGPNWDDLRFFLAVARTGTLSAAGARTGTEHTTVGRRIRALEEGLGARLFHRSNLGY
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCE
ALTEDGANLLGVAEAMESAFLSASAATEAAQTVSGTVRIGAPDGFGSVFLAPRMHRLTAR
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEECCHHHHHHHC
HPGLEVEIMATARIFSLSKREADIVISLSGPQQARVVARRLTDYRLLVYAAETYLAGAAP
CCCCEEEEEEEEHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCEEEEEEHHHHHCCCCC
IAEVGDLSGHPFVGYIEDMLFTRELNYLGALGPPVSARLRSTNLLAQVHATLGGAGLCVL
HHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
PAFIAAAHPGLVPVLPGAVALTRSFHMHIHEDHRKAAHIRAVAGFIAGEVEAAAALFAGP
HHHHHHCCCCCCCCCCCHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AV
CC
>Mature Secondary Structure 
ARTGPNWDDLRFFLAVARTGTLSAAGARTGTEHTTVGRRIRALEEGLGARLFHRSNLGY
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCE
ALTEDGANLLGVAEAMESAFLSASAATEAAQTVSGTVRIGAPDGFGSVFLAPRMHRLTAR
EEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEECCHHHHHHHC
HPGLEVEIMATARIFSLSKREADIVISLSGPQQARVVARRLTDYRLLVYAAETYLAGAAP
CCCCEEEEEEEEHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCEEEEEEHHHHHCCCCC
IAEVGDLSGHPFVGYIEDMLFTRELNYLGALGPPVSARLRSTNLLAQVHATLGGAGLCVL
HHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHH
PAFIAAAHPGLVPVLPGAVALTRSFHMHIHEDHRKAAHIRAVAGFIAGEVEAAAALFAGP
HHHHHHCCCCCCCCCCCHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AV
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]