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The map label for this gene is luxQ [H]

Identifier: 170749919

GI number: 170749919

Start: 3733007

End: 3734353

Strand: Direct

Name: luxQ [H]

Synonym: Mrad2831_3519

Alternate gene names: 170749919

Gene position: 3733007-3734353 (Clockwise)

Preceding gene: 170749918

Following gene: 170749920

Centisome position: 61.42

GC content: 71.86

Gene sequence:

>1347_bases
GTGACCCTGCACCCGAACGGCCTCGAGACCGACGCGTCCCTGCACCGGCGGATCGAGAAGCTCGAGCGCATCAACGCCGC
GCTGATGTCCCATGTCGAGCGCTCCATGGATCAGCGGGGCAGCGCCTACTCGCTGTTCCAGACGGCGATCATGCTCGAGG
GCCGGGTCCGCACCCGCACCGAGGAGCTGACCGGGCTCATGCACCGGCTGGAGCGCTCCAACGAGGCGCTGGCCGCGGCC
AAGGAGGAGGCCGAGACCGCCAACCGCTCGAAGACGCGGTTCCTGGCGGCGGCGAGCCACGACCTGCTGCAGCCGGTCAA
TGCCGCCCGCCTGTCGATCTCGGCGCTCGCCGACCTCGAGGTCCCGCCGGAAGCGCGTGCCATCGCCGGACAGGTGGAGC
GGGGCCTGCAGACCATCGAGGACCTGATCAAGACGCTGCTCGACATCTCGAAACTCGATGCCGGGGTCGTTCGACCGCAG
GTCCAGCCCGTCTTCCTGCCCGACCTGCTGGCGGAGCTCGCGGAGAGCTTCAAACCCTTCGCGCAGCGCAAGGGTCTGCG
CCTGTCGGTGCACTGTCCGGAGGTCACCGTCACCAGCGACGTGGTGCTCCTGCAGCGGATCCTCCAGAACCTCGTCTCCA
ACGCCGTCCGGTACACCCGCACCGGCGGGATCGTCCTGGCGGCCCGGCGCCGGTCCGGCGCTGTCCGGATCGAAGTGACC
GACACGGGCTGCGGCATCGCCGCCGAGGAATGCGACCTCGTCTTCGACGAGTTCTTCCGGGGCGGCGACCGGACCGGCAG
CGGCGAGGAGCCGGGCCTCGGCCTCGGCCTTTCGATCGTCCGCCGCATGGCCCTGGCCCTCGACCATCCCCTGCGGCTGC
GCTCCCGGGTCGGCCACGGCACCCGGGTCGCGCTGACGCTGCCCCTGAGCGCGGTCCCGGCCGCGGCCGCGCCGCCCGCC
CCGGTGGCGACCCGGCTCTCGGGAGCGCACGTCCTCGTCGTGGAGAACGACGCCTCGACGGCCGACGCCCTCGCGCGCCT
CCTCCAGAACTGGGATGCCCGGGTCTCGACCTTCCGCGACCTCGCGGGGGTGAAGGCCTCCGTCGAGGCGGGCGCCGGGG
CGCCGGACATCCTGGTGCTCGACTATCATCTCGACGAGGGCGCCTGCGGCCTCGACGTGGCCGCCTATCTCCGCGCGCTG
CGGGCCGAGCCGCTCCCGGTCATCGTCACCACCGCCGACCATTCCAGCGCGGTCGAGGATCGCGTCACAGCCGCCGGAGC
GGAACTCGTGCACAAGCCGATCAAGCCGGCCCAGCTCCGCTCCCTGCTGACCTACATGCTGGCTTGA

Upstream 100 bases:

>100_bases
AGTACCGGGCGATGCACCTGAACCAGACCTTCACGGGCATCGCCATCGGCAAGACCCTCGCCGCGGGCGCGCCGGCCGCG
GCCGCCGCCCCGGTCGCGTC

Downstream 100 bases:

>100_bases
TCCCGGTCGGGACCCGCGACGCTCCGGGTCGCGCCCGGCGCGCGCCGCGCGCTCCCGAACCGATCGAGCGCCCGGGCCGC
GCGGCGTGCTGCCGACGGCG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTLHPNGLETDASLHRRIEKLERINAALMSHVERSMDQRGSAYSLFQTAIMLEGRVRTRTEELTGLMHRLERSNEALAAA
KEEAETANRSKTRFLAAASHDLLQPVNAARLSISALADLEVPPEARAIAGQVERGLQTIEDLIKTLLDISKLDAGVVRPQ
VQPVFLPDLLAELAESFKPFAQRKGLRLSVHCPEVTVTSDVVLLQRILQNLVSNAVRYTRTGGIVLAARRRSGAVRIEVT
DTGCGIAAEECDLVFDEFFRGGDRTGSGEEPGLGLGLSIVRRMALALDHPLRLRSRVGHGTRVALTLPLSAVPAAAAPPA
PVATRLSGAHVLVVENDASTADALARLLQNWDARVSTFRDLAGVKASVEAGAGAPDILVLDYHLDEGACGLDVAAYLRAL
RAEPLPVIVTTADHSSAVEDRVTAAGAELVHKPIKPAQLRSLLTYMLA

Sequences:

>Translated_448_residues
MTLHPNGLETDASLHRRIEKLERINAALMSHVERSMDQRGSAYSLFQTAIMLEGRVRTRTEELTGLMHRLERSNEALAAA
KEEAETANRSKTRFLAAASHDLLQPVNAARLSISALADLEVPPEARAIAGQVERGLQTIEDLIKTLLDISKLDAGVVRPQ
VQPVFLPDLLAELAESFKPFAQRKGLRLSVHCPEVTVTSDVVLLQRILQNLVSNAVRYTRTGGIVLAARRRSGAVRIEVT
DTGCGIAAEECDLVFDEFFRGGDRTGSGEEPGLGLGLSIVRRMALALDHPLRLRSRVGHGTRVALTLPLSAVPAAAAPPA
PVATRLSGAHVLVVENDASTADALARLLQNWDARVSTFRDLAGVKASVEAGAGAPDILVLDYHLDEGACGLDVAAYLRAL
RAEPLPVIVTTADHSSAVEDRVTAAGAELVHKPIKPAQLRSLLTYMLA
>Mature_447_residues
TLHPNGLETDASLHRRIEKLERINAALMSHVERSMDQRGSAYSLFQTAIMLEGRVRTRTEELTGLMHRLERSNEALAAAK
EEAETANRSKTRFLAAASHDLLQPVNAARLSISALADLEVPPEARAIAGQVERGLQTIEDLIKTLLDISKLDAGVVRPQV
QPVFLPDLLAELAESFKPFAQRKGLRLSVHCPEVTVTSDVVLLQRILQNLVSNAVRYTRTGGIVLAARRRSGAVRIEVTD
TGCGIAAEECDLVFDEFFRGGDRTGSGEEPGLGLGLSIVRRMALALDHPLRLRSRVGHGTRVALTLPLSAVPAAAAPPAP
VATRLSGAHVLVVENDASTADALARLLQNWDARVSTFRDLAGVKASVEAGAGAPDILVLDYHLDEGACGLDVAAYLRALR
AEPLPVIVTTADHSSAVEDRVTAAGAELVHKPIKPAQLRSLLTYMLA

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=373, Percent_Identity=27.3458445040214, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI145693157, Length=378, Percent_Identity=27.2486772486773, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1789149, Length=310, Percent_Identity=28.3870967741935, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788713, Length=391, Percent_Identity=26.3427109974425, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87081816, Length=336, Percent_Identity=28.8690476190476, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1788393, Length=219, Percent_Identity=30.5936073059361, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082128, Length=224, Percent_Identity=29.0178571428571, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786783, Length=230, Percent_Identity=27.8260869565217, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786912, Length=244, Percent_Identity=27.8688524590164, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786600, Length=221, Percent_Identity=27.6018099547511, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1788279, Length=197, Percent_Identity=25.3807106598985, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48153; Mature: 48022

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLHPNGLETDASLHRRIEKLERINAALMSHVERSMDQRGSAYSLFQTAIMLEGRVRTRT
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHH
EELTGLMHRLERSNEALAAAKEEAETANRSKTRFLAAASHDLLQPVNAARLSISALADLE
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
VPPEARAIAGQVERGLQTIEDLIKTLLDISKLDAGVVRPQVQPVFLPDLLAELAESFKPF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AQRKGLRLSVHCPEVTVTSDVVLLQRILQNLVSNAVRYTRTGGIVLAARRRSGAVRIEVT
HHCCCCEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCEEEEEEE
DTGCGIAAEECDLVFDEFFRGGDRTGSGEEPGLGLGLSIVRRMALALDHPLRLRSRVGHG
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCC
TRVALTLPLSAVPAAAAPPAPVATRLSGAHVLVVENDASTADALARLLQNWDARVSTFRD
CEEEEEECHHHCCCCCCCCCCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
LAGVKASVEAGAGAPDILVLDYHLDEGACGLDVAAYLRALRAEPLPVIVTTADHSSAVED
HHCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHH
RVTAAGAELVHKPIKPAQLRSLLTYMLA
HHHHHHHHHHHCCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
TLHPNGLETDASLHRRIEKLERINAALMSHVERSMDQRGSAYSLFQTAIMLEGRVRTRT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHH
EELTGLMHRLERSNEALAAAKEEAETANRSKTRFLAAASHDLLQPVNAARLSISALADLE
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCC
VPPEARAIAGQVERGLQTIEDLIKTLLDISKLDAGVVRPQVQPVFLPDLLAELAESFKPF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AQRKGLRLSVHCPEVTVTSDVVLLQRILQNLVSNAVRYTRTGGIVLAARRRSGAVRIEVT
HHCCCCEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCEEEEEEE
DTGCGIAAEECDLVFDEFFRGGDRTGSGEEPGLGLGLSIVRRMALALDHPLRLRSRVGHG
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCC
TRVALTLPLSAVPAAAAPPAPVATRLSGAHVLVVENDASTADALARLLQNWDARVSTFRD
CEEEEEECHHHCCCCCCCCCCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
LAGVKASVEAGAGAPDILVLDYHLDEGACGLDVAAYLRALRAEPLPVIVTTADHSSAVED
HHCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHH
RVTAAGAELVHKPIKPAQLRSLLTYMLA
HHHHHHHHHHHCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]