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The map label for this gene is lpxD

Identifier: 170749838

GI number: 170749838

Start: 3651415

End: 3652476

Strand: Reverse

Name: lpxD

Synonym: Mrad2831_3438

Alternate gene names: 170749838

Gene position: 3652476-3651415 (Counterclockwise)

Preceding gene: 170749839

Following gene: 170749837

Centisome position: 60.1

GC content: 73.92

Gene sequence:

>1062_bases
ATGTCAGATCCCGTTTTCTTCACCGCCGCCGCCACAGGCCTCACCCTGGCCGAGATCGCGGCGGCCGCCGGCACCGGCCT
CCCCGAGGGGGCGGACCCGGACCGCCGATTCAGTGGCGCGGCCTCCCTGGAGAGCGCCGGCCCGGACCACCTCGCCTACA
TGGACAACGCCCGCTACGGCGACGCCCTCGCGGCGACGCGGGCGGGCGCGTGCCTCGTCTCACCCCGTTTCGCGGCGCGC
TGTCCCGCCGGCACGGTCGCCCTCGTCAGCCGCGACCCCTACCGCGCTTACGCGGCGCTGCTCGGCCGCCTGCATCCGGA
CGCCCTGCGTCCCGGCTCGCAATTCGCCGTCCGCGGCGTCGCCCCCGGCGCCCACGTCCATCCCGAGGCCCGTCTCGAGG
ACGGCGTCACGGTCGATCCCGGCGCGGTGATCGGGCCGGGGGCCGAGATCGGCGCCGGAACGGTGGTCGGACCCAACGCC
GTGATCGGACCGGGCGTCCGGATCGGGCGCGACTGCGCGATCGGCGCCGGCACGACCCTGAGCCACGCCCTCCTCGGAAA
CCGGGTGATCGTCCATCCCGGGGCGCGGCTCGGGCAGGACGGGTTCGGCTTCGCTATGGGCGCCACCCATCTCAAGGTCC
CGCAGGTCGGGCGCGTCATCGTGCAGGACGACGTCGAGATCGGCGCCAACACCACGGTCGACCGCGGCGCCTCGCGCGAC
ACGGTGATCGGGGAGGGCACCAAGATCGACAACCTCGTGCAGATCGCCCACAACGTCGTGATCGGGCGCCACTGCGTCAT
CGTGTCGGGGGTCGGCATCTCCGGCTCGACGACGCTGGAGGACTACGTCGTCCTGGGCGGGCAGGTCGGCGTCGTCGGCC
ACCTGCGCATCGGCCGCGGCTCGCAGATCGCCGGCTCGTCCAACGTCAACCGCGACGTGCCGCCGGGAAGCCGCTGGGGC
GGGACTCCCGCCAAGCCGGTGCGGGCGTGGTTCCGCGAGCTGACGACGCTCGCGCGTCTCGCCGAACGCTCGGGCAAGGA
CCAAGCGGGAGACGACGCCTGA

Upstream 100 bases:

>100_bases
GCGCGGATCAGGTCCAGGCGTTCCGCTTCTCCGGCGGCTCGCGCTTCTGATAAAAATCCCGCGCGCCGGCCGGATTGTCC
CGGCCGGCGCGTTGTCGAAC

Downstream 100 bases:

>100_bases
CCGGGAAGGCCTTGCGCTTCCGGCGATTTCTTCCGAAGAGGGCGGTCGGCGCGCCGGAGGCGGCCGGATTGCGGGCCGCC
GAAGGCGGCAAGTCGAGGTG

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSDPVFFTAAATGLTLAEIAAAAGTGLPEGADPDRRFSGAASLESAGPDHLAYMDNARYGDALAATRAGACLVSPRFAAR
CPAGTVALVSRDPYRAYAALLGRLHPDALRPGSQFAVRGVAPGAHVHPEARLEDGVTVDPGAVIGPGAEIGAGTVVGPNA
VIGPGVRIGRDCAIGAGTTLSHALLGNRVIVHPGARLGQDGFGFAMGATHLKVPQVGRVIVQDDVEIGANTTVDRGASRD
TVIGEGTKIDNLVQIAHNVVIGRHCVIVSGVGISGSTTLEDYVVLGGQVGVVGHLRIGRGSQIAGSSNVNRDVPPGSRWG
GTPAKPVRAWFRELTTLARLAERSGKDQAGDDA

Sequences:

>Translated_353_residues
MSDPVFFTAAATGLTLAEIAAAAGTGLPEGADPDRRFSGAASLESAGPDHLAYMDNARYGDALAATRAGACLVSPRFAAR
CPAGTVALVSRDPYRAYAALLGRLHPDALRPGSQFAVRGVAPGAHVHPEARLEDGVTVDPGAVIGPGAEIGAGTVVGPNA
VIGPGVRIGRDCAIGAGTTLSHALLGNRVIVHPGARLGQDGFGFAMGATHLKVPQVGRVIVQDDVEIGANTTVDRGASRD
TVIGEGTKIDNLVQIAHNVVIGRHCVIVSGVGISGSTTLEDYVVLGGQVGVVGHLRIGRGSQIAGSSNVNRDVPPGSRWG
GTPAKPVRAWFRELTTLARLAERSGKDQAGDDA
>Mature_352_residues
SDPVFFTAAATGLTLAEIAAAAGTGLPEGADPDRRFSGAASLESAGPDHLAYMDNARYGDALAATRAGACLVSPRFAARC
PAGTVALVSRDPYRAYAALLGRLHPDALRPGSQFAVRGVAPGAHVHPEARLEDGVTVDPGAVIGPGAEIGAGTVVGPNAV
IGPGVRIGRDCAIGAGTTLSHALLGNRVIVHPGARLGQDGFGFAMGATHLKVPQVGRVIVQDDVEIGANTTVDRGASRDT
VIGEGTKIDNLVQIAHNVVIGRHCVIVSGVGISGSTTLEDYVVLGGQVGVVGHLRIGRGSQIAGSSNVNRDVPPGSRWGG
TPAKPVRAWFRELTTLARLAERSGKDQAGDDA

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=319, Percent_Identity=33.5423197492163, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1786378, Length=241, Percent_Identity=30.7053941908714, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_METRJ (B1LTP6)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001756098.1
- ProteinModelPortal:   B1LTP6
- SMR:   B1LTP6
- GeneID:   6139486
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_3438
- HOGENOM:   HBG469615
- OMA:   AKIMKSA
- ProtClustDB:   PRK00892
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 35892; Mature: 35761

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPVFFTAAATGLTLAEIAAAAGTGLPEGADPDRRFSGAASLESAGPDHLAYMDNARYG
CCCCEEEEEHHCCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCCEEEECCCCCC
DALAATRAGACLVSPRFAARCPAGTVALVSRDPYRAYAALLGRLHPDALRPGSQFAVRGV
CHHHHHHCCEEEECCCHHHHCCCCEEEEEECCHHHHHHHHHHCCCHHHCCCCCCEEEEEC
APGAHVHPEARLEDGVTVDPGAVIGPGAEIGAGTVVGPNAVIGPGVRIGRDCAIGAGTTL
CCCCCCCCCCHHCCCCEECCCCEECCCCCCCCCEEECCCCEECCCCEECCCCCCCCCCHH
SHALLGNRVIVHPGARLGQDGFGFAMGATHLKVPQVGRVIVQDDVEIGANTTVDRGASRD
HHHHHCCEEEECCCCCCCCCCCCEEECCCEECCCCCCEEEEECCCCCCCCCCCCCCCCCC
TVIGEGTKIDNLVQIAHNVVIGRHCVIVSGVGISGSTTLEDYVVLGGQVGVVGHLRIGRG
CEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEECCCEEEEEEEEECCC
SQIAGSSNVNRDVPPGSRWGGTPAKPVRAWFRELTTLARLAERSGKDQAGDDA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SDPVFFTAAATGLTLAEIAAAAGTGLPEGADPDRRFSGAASLESAGPDHLAYMDNARYG
CCCEEEEEHHCCHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCCEEEECCCCCC
DALAATRAGACLVSPRFAARCPAGTVALVSRDPYRAYAALLGRLHPDALRPGSQFAVRGV
CHHHHHHCCEEEECCCHHHHCCCCEEEEEECCHHHHHHHHHHCCCHHHCCCCCCEEEEEC
APGAHVHPEARLEDGVTVDPGAVIGPGAEIGAGTVVGPNAVIGPGVRIGRDCAIGAGTTL
CCCCCCCCCCHHCCCCEECCCCEECCCCCCCCCEEECCCCEECCCCEECCCCCCCCCCHH
SHALLGNRVIVHPGARLGQDGFGFAMGATHLKVPQVGRVIVQDDVEIGANTTVDRGASRD
HHHHHCCEEEECCCCCCCCCCCCEEECCCEECCCCCCEEEEECCCCCCCCCCCCCCCCCC
TVIGEGTKIDNLVQIAHNVVIGRHCVIVSGVGISGSTTLEDYVVLGGQVGVVGHLRIGRG
CEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEECCCEEEEEEEEECCC
SQIAGSSNVNRDVPPGSRWGGTPAKPVRAWFRELTTLARLAERSGKDQAGDDA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA