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The map label for this gene is lpxA

Identifier: 170749836

GI number: 170749836

Start: 3650014

End: 3650832

Strand: Reverse

Name: lpxA

Synonym: Mrad2831_3436

Alternate gene names: 170749836

Gene position: 3650832-3650014 (Counterclockwise)

Preceding gene: 170749837

Following gene: 170749835

Centisome position: 60.07

GC content: 71.18

Gene sequence:

>819_bases
GTGACCGCGCCCGCCATCCACCCGAGCGCCGTGATCGAGTCCGGCGCCCGGATCGGCGACGGGGCGCGGATCGGCCCCTT
CTGCCATGTCGGGCCCGAGGTCGTGCTCGGCGCGGATTGCGAGCTCATCAGCCACGTGGTCCTCGCGGGCCGGACCACGA
TCGGCCCCCGCACCCGGATCTTCCCCTTCGCGTCGATCGGCCACCAGCCGCAGGACCTGAAGTACCGGGGCGAGGCCTCG
ACCCTGACGATCGGCGCCGATTGCCTGATCCGCGAAGGCGTCACCATGAACCCGGGCACGAGCGGCGGCGGCCTGGAGAC
CCTGGTCGGCGACCACTGCACCTTCCTGGCCAACTCGCATGTCGGCCACGATTGTCGGGTCGGCGCCCACGTGATCTTCT
CCAACAACGTCATGCTGGCGGGCCATTGCAGCGTCGGCGACTACGCGATCCTGGGTGGCGGCGCCGCCGTGATCCAGTTC
GCGCGGGTCGGCGCGCACGCCTTCGTGGGCGGCCTGTCGGGCCTGGAGAACGACTGCATCCCCTACGGCATGGTGCTCGG
CAACCGGGCCTACCTGTCGGGGCTCAACATCATCGGCCTGCAGCGCCGCGGCTTCGCCCGCGAGGACATCCACGCGCTGC
GGCGCGCCTACCGCCTGCTCTTCGCCCCAGAGGGCACGCTGATGGAGCGGGTGGAGGACGTGGCCGCGACCTTCGAATCC
CACGCGGCGGTCGCCGAGATCCTCGACTTCATCCGCCTCGGCGGCAAGCGCTCGATCTGCACGCCGCGCGAGGTTCCGAC
CCCGATCAGCGCCGCCTGA

Upstream 100 bases:

>100_bases
AGCTGAACCAGCGCCGGACCATGTGGTGGTTCCGCGGCGAGGCCCGGGTCGACGGCACGCTGGTCGCCGAGGCCGAGATC
AGCGCCATGCTGGTGACGGA

Downstream 100 bases:

>100_bases
GCGGCCGGGCCGTGACCGAGGCCGATCCCGCCCCCGAGGGGGCCCTGGTCCTGATCGCGGGGGCGGGGCGCCTGCCCGAA
CTCGTCGCCGAGTCGCTCCG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MTAPAIHPSAVIESGARIGDGARIGPFCHVGPEVVLGADCELISHVVLAGRTTIGPRTRIFPFASIGHQPQDLKYRGEAS
TLTIGADCLIREGVTMNPGTSGGGLETLVGDHCTFLANSHVGHDCRVGAHVIFSNNVMLAGHCSVGDYAILGGGAAVIQF
ARVGAHAFVGGLSGLENDCIPYGMVLGNRAYLSGLNIIGLQRRGFAREDIHALRRAYRLLFAPEGTLMERVEDVAATFES
HAAVAEILDFIRLGGKRSICTPREVPTPISAA

Sequences:

>Translated_272_residues
MTAPAIHPSAVIESGARIGDGARIGPFCHVGPEVVLGADCELISHVVLAGRTTIGPRTRIFPFASIGHQPQDLKYRGEAS
TLTIGADCLIREGVTMNPGTSGGGLETLVGDHCTFLANSHVGHDCRVGAHVIFSNNVMLAGHCSVGDYAILGGGAAVIQF
ARVGAHAFVGGLSGLENDCIPYGMVLGNRAYLSGLNIIGLQRRGFAREDIHALRRAYRLLFAPEGTLMERVEDVAATFES
HAAVAEILDFIRLGGKRSICTPREVPTPISAA
>Mature_271_residues
TAPAIHPSAVIESGARIGDGARIGPFCHVGPEVVLGADCELISHVVLAGRTTIGPRTRIFPFASIGHQPQDLKYRGEAST
LTIGADCLIREGVTMNPGTSGGGLETLVGDHCTFLANSHVGHDCRVGAHVIFSNNVMLAGHCSVGDYAILGGGAAVIQFA
RVGAHAFVGGLSGLENDCIPYGMVLGNRAYLSGLNIIGLQRRGFAREDIHALRRAYRLLFAPEGTLMERVEDVAATFESH
AAVAEILDFIRLGGKRSICTPREVPTPISAA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=245, Percent_Identity=48.5714285714286, Blast_Score=217, Evalue=5e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_METRJ (B1LTP4)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001756096.1
- ProteinModelPortal:   B1LTP4
- SMR:   B1LTP4
- GeneID:   6139484
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_3436
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- ProtClustDB:   PRK05289
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28560; Mature: 28429

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPAIHPSAVIESGARIGDGARIGPFCHVGPEVVLGADCELISHVVLAGRTTIGPRTRI
CCCCCCCHHHHHHCCCCCCCCCCCCCEEECCCCEEECCCHHHHHHHHHHCCCCCCCCCEE
FPFASIGHQPQDLKYRGEASTLTIGADCLIREGVTMNPGTSGGGLETLVGDHCTFLANSH
EEHHHCCCCCCCCEECCCCCEEEECCHHHEECCCEECCCCCCCCHHHHHCCCEEEEECCC
VGHDCRVGAHVIFSNNVMLAGHCSVGDYAILGGGAAVIQFARVGAHAFVGGLSGLENDCI
CCCCCCCCEEEEEECCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCC
PYGMVLGNRAYLSGLNIIGLQRRGFAREDIHALRRAYRLLFAPEGTLMERVEDVAATFES
CCHHHCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
HAAVAEILDFIRLGGKRSICTPREVPTPISAA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAPAIHPSAVIESGARIGDGARIGPFCHVGPEVVLGADCELISHVVLAGRTTIGPRTRI
CCCCCCHHHHHHCCCCCCCCCCCCCEEECCCCEEECCCHHHHHHHHHHCCCCCCCCCEE
FPFASIGHQPQDLKYRGEASTLTIGADCLIREGVTMNPGTSGGGLETLVGDHCTFLANSH
EEHHHCCCCCCCCEECCCCCEEEECCHHHEECCCEECCCCCCCCHHHHHCCCEEEEECCC
VGHDCRVGAHVIFSNNVMLAGHCSVGDYAILGGGAAVIQFARVGAHAFVGGLSGLENDCI
CCCCCCCCEEEEEECCEEEEECCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCC
PYGMVLGNRAYLSGLNIIGLQRRGFAREDIHALRRAYRLLFAPEGTLMERVEDVAATFES
CCHHHCCCHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
HAAVAEILDFIRLGGKRSICTPREVPTPISAA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA