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The map label for this gene is trxA [C]

Identifier: 170749779

GI number: 170749779

Start: 3587469

End: 3587792

Strand: Direct

Name: trxA [C]

Synonym: Mrad2831_3378

Alternate gene names: 170749779

Gene position: 3587469-3587792 (Clockwise)

Preceding gene: 170749778

Following gene: 170749784

Centisome position: 59.03

GC content: 66.98

Gene sequence:

>324_bases
ATGGCGACGGTGAAAGTAACCGACGCGAGCTTCGAGCAGGACGTTCTCAAGTCCGCCGAGCCCGTCGTGGTGGATTTCTG
GGCGGAGTGGTGCGGCCCGTGCCGTCAGATCGGCCCGGCCCTCGAGGAGATCGCGACCGACCTGCAGGGCAAGGTGAAGA
TCGCCAAGGTCAACGTCGACGAGAACCCGCAGATCGCCGCCCAGTACGGCATCCGCTCGATCCCGACGCTGCTGCTCTTC
AAGAACGGCGAGCGGGTGGACCAGAAGGTCGGCGCCGCCCCGAAGGGCGACCTGTCGCGCTGGATCGGCGCCCAGACTGC
CTGA

Upstream 100 bases:

>100_bases
CTTGACCGCGCGCCGGGCCGTCGCCAATTCTGACGGGACCGCGCGGGCCTCTGCCCGTTCGACGCCGCCCGACGGGCGGC
GGATTCCGAAAGGTGACGTT

Downstream 100 bases:

>100_bases
AGCGCCTTCGAGGCCCTGAACGACGAAAAGAAAGCCCGGCCGCGAGGCCGGGCTTTCTCGGTTTCGAGCCCAAGATTGTT
CTTGAGGGATCCCGGAGCGA

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MATVKVTDASFEQDVLKSAEPVVVDFWAEWCGPCRQIGPALEEIATDLQGKVKIAKVNVDENPQIAAQYGIRSIPTLLLF
KNGERVDQKVGAAPKGDLSRWIGAQTA

Sequences:

>Translated_107_residues
MATVKVTDASFEQDVLKSAEPVVVDFWAEWCGPCRQIGPALEEIATDLQGKVKIAKVNVDENPQIAAQYGIRSIPTLLLF
KNGERVDQKVGAAPKGDLSRWIGAQTA
>Mature_106_residues
ATVKVTDASFEQDVLKSAEPVVVDFWAEWCGPCRQIGPALEEIATDLQGKVKIAKVNVDENPQIAAQYGIRSIPTLLLFK
NGERVDQKVGAAPKGDLSRWIGAQTA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=103, Percent_Identity=39.8058252427184, Blast_Score=89, Evalue=6e-19,
Organism=Homo sapiens, GI5031973, Length=99, Percent_Identity=36.3636363636364, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI21361657, Length=83, Percent_Identity=38.5542168674699, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI24308127, Length=78, Percent_Identity=35.8974358974359, Blast_Score=66, Evalue=7e-12,
Organism=Homo sapiens, GI20070125, Length=98, Percent_Identity=30.6122448979592, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=56.7307692307692, Blast_Score=130, Evalue=2e-32,
Organism=Escherichia coli, GI1788936, Length=89, Percent_Identity=47.1910112359551, Blast_Score=102, Evalue=4e-24,
Organism=Escherichia coli, GI87081747, Length=93, Percent_Identity=37.6344086021505, Blast_Score=72, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI212646193, Length=92, Percent_Identity=45.6521739130435, Blast_Score=95, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI115532378, Length=95, Percent_Identity=38.9473684210526, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=76, Percent_Identity=42.1052631578947, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71980562, Length=85, Percent_Identity=36.4705882352941, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI115532380, Length=95, Percent_Identity=38.9473684210526, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17544108, Length=95, Percent_Identity=38.9473684210526, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=85, Percent_Identity=35.2941176470588, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=80, Percent_Identity=37.5, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=79, Percent_Identity=39.2405063291139, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=80, Percent_Identity=38.75, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=105, Percent_Identity=32.3809523809524, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=71, Percent_Identity=39.4366197183099, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25144092, Length=87, Percent_Identity=34.4827586206897, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=87, Percent_Identity=42.5287356321839, Blast_Score=72, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=93, Percent_Identity=32.258064516129, Blast_Score=69, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321648, Length=73, Percent_Identity=42.4657534246575, Blast_Score=68, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=39.5833333333333, Blast_Score=93, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24664269, Length=71, Percent_Identity=47.887323943662, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=46.1538461538462, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=46.1538461538462, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24639826, Length=81, Percent_Identity=41.9753086419753, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21358065, Length=94, Percent_Identity=36.1702127659575, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19921434, Length=77, Percent_Identity=37.6623376623377, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24639068, Length=92, Percent_Identity=30.4347826086957, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24658597, Length=98, Percent_Identity=36.734693877551, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11609; Mature: 11478

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVKVTDASFEQDVLKSAEPVVVDFWAEWCGPCRQIGPALEEIATDLQGKVKIAKVNVD
CCEEEECCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
ENPQIAAQYGIRSIPTLLLFKNGERVDQKVGAAPKGDLSRWIGAQTA
CCCCHHHHHCHHCCCEEEEECCCCHHHHHHCCCCCCHHHHHHCCCCC
>Mature Secondary Structure 
ATVKVTDASFEQDVLKSAEPVVVDFWAEWCGPCRQIGPALEEIATDLQGKVKIAKVNVD
CEEEECCCCHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
ENPQIAAQYGIRSIPTLLLFKNGERVDQKVGAAPKGDLSRWIGAQTA
CCCCHHHHHCHHCCCEEEEECCCCHHHHHHCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]