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The map label for this gene is mmgC [H]

Identifier: 170749663

GI number: 170749663

Start: 3453733

End: 3454884

Strand: Direct

Name: mmgC [H]

Synonym: Mrad2831_3260

Alternate gene names: 170749663

Gene position: 3453733-3454884 (Clockwise)

Preceding gene: 170749662

Following gene: 170749664

Centisome position: 56.83

GC content: 73.35

Gene sequence:

>1152_bases
ATGCACAGCTTCCGCTTCAGCGCCGAGCCGCTCCCGCCCGAGGTCGAGGCCGCGCGCGCGTCCGTCCGCGCCTTCCTCGA
CGCGGAACGGGCGGCCGGGCATTTCGTGCCGCACCGGACCTCGTGGACGACCTTCGACGCCGCCTTCAGCCGGCGCGCGG
GGGCGGCGGGCCTCATCGGCCTGACCGTGCCGGAGGCCTATGGCGGCCACGGCCGCTCCGGCCTCGTCCGCTTCGTCGTC
ACCGAGGAGATGCTGGCGGCGGGCGCACCCTGCGGCGCGCACTGGATCGCCGACCGCCAGTCGGGCCCGCAGATCCTGCG
GCACGGCACCGAGGCGGCCAAGCGGGCGATCCTGCCGCGCATCTGCCGGGGCGCGTGCGCCTTCGGCATCGGCATGAGCG
AGCCGAATTCCGGCTCGGACCTCGCCGCCGTGCGGACCCGCGCGGTGCGCGACGGCGACGATTGGGTCATCAACGGCTCC
AAGATCTGGACGACGAACGCCCATCAGGTCGATTACCTGCTGGCCCTGGTCCGGACCGGTGAGCCGGGACCGGACCGCCA
CGGCGGGCTGACCCAGTTCATCGTCGACATGGCCGCCCCCGGGGTGACGGTGCGGCCGATCCTCGACCTGTCGGGCCATC
ACGAGTTCAACGAGGTGTTCTTCACCGACTACCGCGTTCCCGACGCGATGCGGGTCGGCGCGGAGGACGATGGCTGGAAC
CTCGTCACGGAGGAGCTCGCCTTCGAGCGCTCGGGACCCGACCGGTTCCTGTCGGATTACCGCCTGCTCGTCGAACTCGT
CGACCGGATCGGGCCGGAACCGGACCGTTTCCAGGCGGTCGAGACCGGGCGGATGGTGGCGCAGCTCACCGCGCTGCTGG
GCATGTCGGCCTCGGTGGCCCGTCTCCTCGACCAGGGAATCGTGCCGGGCGTCGAGGCGGCCCTGGTCAAGGACGTCGGC
AACGGCTTCGAGCGCGCGGTGCCGGAGATCGCCCGGCGGCTCGTGCCGGTCGAGCCGAGCCTGTCGGCGCAGGGCGACGC
CTTCCGCGAGGCGCTCGGCGGCGTGACCCTGCGGGCGCCGTCCTTCACCCTGCGCGGCGGGACCCGCGAGGTCCTGCGCG
GCGTCATCGCCCGGGGGCTGGGGCTGCGATGA

Upstream 100 bases:

>100_bases
ACTGGCAGGAGATCTTCTTCCCCGGCCTCCAGGGCCGCGACGGGAGCTGAGCGACGCGGATCCGGCGCCGCCCACACATC
CCATCGCTCACGGAACCCGG

Downstream 100 bases:

>100_bases
GCCGGATGGACCACGCGGCGGAGGCCGGCGACGATGTCGACGGGATCGTCCTCGATCAGGTCGAGCGGTTGCTCGCCCAG
CACCTCACGCCGGCGCTGCT

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MHSFRFSAEPLPPEVEAARASVRAFLDAERAAGHFVPHRTSWTTFDAAFSRRAGAAGLIGLTVPEAYGGHGRSGLVRFVV
TEEMLAAGAPCGAHWIADRQSGPQILRHGTEAAKRAILPRICRGACAFGIGMSEPNSGSDLAAVRTRAVRDGDDWVINGS
KIWTTNAHQVDYLLALVRTGEPGPDRHGGLTQFIVDMAAPGVTVRPILDLSGHHEFNEVFFTDYRVPDAMRVGAEDDGWN
LVTEELAFERSGPDRFLSDYRLLVELVDRIGPEPDRFQAVETGRMVAQLTALLGMSASVARLLDQGIVPGVEAALVKDVG
NGFERAVPEIARRLVPVEPSLSAQGDAFREALGGVTLRAPSFTLRGGTREVLRGVIARGLGLR

Sequences:

>Translated_383_residues
MHSFRFSAEPLPPEVEAARASVRAFLDAERAAGHFVPHRTSWTTFDAAFSRRAGAAGLIGLTVPEAYGGHGRSGLVRFVV
TEEMLAAGAPCGAHWIADRQSGPQILRHGTEAAKRAILPRICRGACAFGIGMSEPNSGSDLAAVRTRAVRDGDDWVINGS
KIWTTNAHQVDYLLALVRTGEPGPDRHGGLTQFIVDMAAPGVTVRPILDLSGHHEFNEVFFTDYRVPDAMRVGAEDDGWN
LVTEELAFERSGPDRFLSDYRLLVELVDRIGPEPDRFQAVETGRMVAQLTALLGMSASVARLLDQGIVPGVEAALVKDVG
NGFERAVPEIARRLVPVEPSLSAQGDAFREALGGVTLRAPSFTLRGGTREVLRGVIARGLGLR
>Mature_383_residues
MHSFRFSAEPLPPEVEAARASVRAFLDAERAAGHFVPHRTSWTTFDAAFSRRAGAAGLIGLTVPEAYGGHGRSGLVRFVV
TEEMLAAGAPCGAHWIADRQSGPQILRHGTEAAKRAILPRICRGACAFGIGMSEPNSGSDLAAVRTRAVRDGDDWVINGS
KIWTTNAHQVDYLLALVRTGEPGPDRHGGLTQFIVDMAAPGVTVRPILDLSGHHEFNEVFFTDYRVPDAMRVGAEDDGWN
LVTEELAFERSGPDRFLSDYRLLVELVDRIGPEPDRFQAVETGRMVAQLTALLGMSASVARLLDQGIVPGVEAALVKDVG
NGFERAVPEIARRLVPVEPSLSAQGDAFREALGGVTLRAPSFTLRGGTREVLRGVIARGLGLR

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=272, Percent_Identity=29.7794117647059, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI226958414, Length=272, Percent_Identity=29.7794117647059, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI4501857, Length=245, Percent_Identity=29.3877551020408, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI4557233, Length=213, Percent_Identity=30.5164319248826, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI7656849, Length=214, Percent_Identity=28.0373831775701, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4557231, Length=208, Percent_Identity=28.8461538461538, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI187960098, Length=208, Percent_Identity=28.8461538461538, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4501859, Length=274, Percent_Identity=27.7372262773723, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI4557235, Length=289, Percent_Identity=29.757785467128, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI76496475, Length=289, Percent_Identity=29.757785467128, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI21361497, Length=285, Percent_Identity=27.719298245614, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786223, Length=321, Percent_Identity=24.6105919003115, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081958, Length=242, Percent_Identity=26.8595041322314, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=257, Percent_Identity=30.7392996108949, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17506239, Length=194, Percent_Identity=34.020618556701, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71990804, Length=200, Percent_Identity=33.5, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17508101, Length=200, Percent_Identity=34.5, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17570075, Length=214, Percent_Identity=28.5046728971963, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17505929, Length=201, Percent_Identity=31.3432835820896, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI32563615, Length=192, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17551932, Length=203, Percent_Identity=29.5566502463054, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17534899, Length=194, Percent_Identity=28.8659793814433, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17569725, Length=218, Percent_Identity=28.8990825688073, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71982178, Length=205, Percent_Identity=30.7317073170732, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71985184, Length=206, Percent_Identity=31.5533980582524, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71985192, Length=206, Percent_Identity=31.5533980582524, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21355753, Length=347, Percent_Identity=30.5475504322767, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI281363737, Length=319, Percent_Identity=27.5862068965517, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24666513, Length=288, Percent_Identity=27.0833333333333, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24660351, Length=205, Percent_Identity=30.2439024390244, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24646207, Length=236, Percent_Identity=26.6949152542373, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21356377, Length=206, Percent_Identity=27.6699029126214, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41231; Mature: 41231

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSFRFSAEPLPPEVEAARASVRAFLDAERAAGHFVPHRTSWTTFDAAFSRRAGAAGLIG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCEEE
LTVPEAYGGHGRSGLVRFVVTEEMLAAGAPCGAHWIADRQSGPQILRHGTEAAKRAILPR
EECCCCCCCCCCCCCEEHEEHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHH
ICRGACAFGIGMSEPNSGSDLAAVRTRAVRDGDDWVINGSKIWTTNAHQVDYLLALVRTG
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCEEEECCCHHHHHHHHHHHCC
EPGPDRHGGLTQFIVDMAAPGVTVRPILDLSGHHEFNEVFFTDYRVPDAMRVGAEDDGWN
CCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCCHHCCCCCCCCCH
LVTEELAFERSGPDRFLSDYRLLVELVDRIGPEPDRFQAVETGRMVAQLTALLGMSASVA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
RLLDQGIVPGVEAALVKDVGNGFERAVPEIARRLVPVEPSLSAQGDAFREALGGVTLRAP
HHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCEEEECC
SFTLRGGTREVLRGVIARGLGLR
CEEECCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHSFRFSAEPLPPEVEAARASVRAFLDAERAAGHFVPHRTSWTTFDAAFSRRAGAAGLIG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCEEE
LTVPEAYGGHGRSGLVRFVVTEEMLAAGAPCGAHWIADRQSGPQILRHGTEAAKRAILPR
EECCCCCCCCCCCCCEEHEEHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHH
ICRGACAFGIGMSEPNSGSDLAAVRTRAVRDGDDWVINGSKIWTTNAHQVDYLLALVRTG
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCEEEECCCHHHHHHHHHHHCC
EPGPDRHGGLTQFIVDMAAPGVTVRPILDLSGHHEFNEVFFTDYRVPDAMRVGAEDDGWN
CCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCCHHCCCCCCCCCH
LVTEELAFERSGPDRFLSDYRLLVELVDRIGPEPDRFQAVETGRMVAQLTALLGMSASVA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
RLLDQGIVPGVEAALVKDVGNGFERAVPEIARRLVPVEPSLSAQGDAFREALGGVTLRAP
HHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCEEEECC
SFTLRGGTREVLRGVIARGLGLR
CEEECCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]