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The map label for this gene is trpE [H]

Identifier: 170749507

GI number: 170749507

Start: 3279621

End: 3281141

Strand: Reverse

Name: trpE [H]

Synonym: Mrad2831_3102

Alternate gene names: 170749507

Gene position: 3281141-3279621 (Counterclockwise)

Preceding gene: 170749508

Following gene: 170749506

Centisome position: 53.99

GC content: 72.06

Gene sequence:

>1521_bases
ATGGCCGAAGCGCCCGATTACGCGGCCTTCGCGGCGCGCTACGAGGCCGGGCAGCCGAGCCTCGTGGCGGTAAGCCTCGT
CGCGGACCTCGAGACGCCGGTCGCGGCGTTCCTCAAGCTGCGCGCCGGCCATTCCGGGCCGGCCTTCCTGCTCGAATCGG
TCGAGGGCGGCGCTGTCCGCGGCCGGTACTCGATGATCGGACTCGATCCGGACCTGATCTGGCGCTGCCGGGCGGGCGCG
CCCGCGATCGCGCGCGGGGCAGACCTCACGCGGTTCGAGCCGGATTCCCGGGCGCCGCTCGCGAGCCTGCGCGCCCTGAT
CGCCGAGAGCGCCATCGGCGAGTCGGATGGCCAGGACCTGCCGCCGATGGCCGCCGGCCTGTTCGGCTATCTCGGCTACG
ACATGGTCCGCGCCATGGAGCGGCTGCCGGAGCCGAACCCGGACCCGCTCGGCGTGCCGGACGCGATCCTTGTGCGCCCC
CGGGTGATGGTGGTCTTCGACTCCATCCGCGACGTCATCACCGTCGTGTCGCCGGTCCGGCCCGGCCCAGGCGTCGCGGC
TCGGGCCGCCTACGAGGACGCGCTGCAGCGCGTCGACCGGGTAGCCGCCGCCCTCGAGGGGCCGCTGCCGATCGAGGCGC
GGGTCGACCTGTCGGCGGTCGCCCATCCCGAGCCGGTCTCGAACACGCCGCCGGCCGACTTCTTCGCCATGGTGGCGCGC
GCCAAGGAGTACATCGTCGCGGGCGACGTGTTCCAGGTGGTGCTGTCCCAGCGCTTCTCGGCGCCGTTCACGCTGCCGGC
CTTCAGCCTGTACCGCTCGCTGCGGCGGACGAACCCGGCGCCGTTCCTGTGCTACCTCGATTTCGAGGATTTCCAGATCG
TCTGCTCCTCGCCGGAGATCCTGGTGCGGGTGCGGGACGGGGTAGTCACGGTCCGCCCGATCGCCGGCACGCGCCGCCGC
GGCGCGACCCCGGCCGAGGATGCCGCCCTGGCCGAGGAGCTGCTCGCCGATCCGAAGGAGCGGGCCGAGCACCTGATGCT
GCTCGATCTCGGCCGCAACGACGCCGGGCGGGTGTCGCGGATCGGCAGCGTCCGGGTGACCGACTCGTTCTTCATCGAGC
GCTACAGCCAGGTCATGCACATCGTGTCGAACGTCGAGGGTGACCTCGACCCGCGCCACGATCCCCTGGAGGCTCTGGCC
GCGGGATTTCCGGCCGGCACGGTCTCGGGTGCCCCGAAGGTGCGGGCCATGGAGATCATCGACGAGCTGGAGCGCGAGAA
GCGCGGGCCGTACGCGGGCTGCATCGGCTATTTCGGCGCGCGTGGCGAGATGGACACCTGCATCGTCCTGCGCACCGCGG
TGGTGAAGGACGGGACGATGCACGTCCAGGCCGGGGCGGGGATCGTCTACGATTCGGACCCGGCCTCCGAGCAGCAGGAA
TGCGTCAACAAGGCCAAGGCGCTGTTCCGAGCCGCCGAGGAGGCGGTGCGCTTCGCCGCGCAGGCCAAGCGCGGGCAGTA
G

Upstream 100 bases:

>100_bases
TGACGTGCTGTCCCAGTACATCAGCGAGGTCCAGAAGAACGCGGGCGTGAAGGTCGACCCGGCGGCCCTGCGGCGCGCCA
TCGGCGGCGAGTACTGAGGC

Downstream 100 bases:

>100_bases
GGCGGACGCGCGGCTGCGCCGCCGTCCGACGCCGACGGTTGACCGCGCGGGTGCGAGCGGTCACATCGCCTGCATGCCCG
AGCGTGCCGCCGCGATGCCC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MAEAPDYAAFAARYEAGQPSLVAVSLVADLETPVAAFLKLRAGHSGPAFLLESVEGGAVRGRYSMIGLDPDLIWRCRAGA
PAIARGADLTRFEPDSRAPLASLRALIAESAIGESDGQDLPPMAAGLFGYLGYDMVRAMERLPEPNPDPLGVPDAILVRP
RVMVVFDSIRDVITVVSPVRPGPGVAARAAYEDALQRVDRVAAALEGPLPIEARVDLSAVAHPEPVSNTPPADFFAMVAR
AKEYIVAGDVFQVVLSQRFSAPFTLPAFSLYRSLRRTNPAPFLCYLDFEDFQIVCSSPEILVRVRDGVVTVRPIAGTRRR
GATPAEDAALAEELLADPKERAEHLMLLDLGRNDAGRVSRIGSVRVTDSFFIERYSQVMHIVSNVEGDLDPRHDPLEALA
AGFPAGTVSGAPKVRAMEIIDELEREKRGPYAGCIGYFGARGEMDTCIVLRTAVVKDGTMHVQAGAGIVYDSDPASEQQE
CVNKAKALFRAAEEAVRFAAQAKRGQ

Sequences:

>Translated_506_residues
MAEAPDYAAFAARYEAGQPSLVAVSLVADLETPVAAFLKLRAGHSGPAFLLESVEGGAVRGRYSMIGLDPDLIWRCRAGA
PAIARGADLTRFEPDSRAPLASLRALIAESAIGESDGQDLPPMAAGLFGYLGYDMVRAMERLPEPNPDPLGVPDAILVRP
RVMVVFDSIRDVITVVSPVRPGPGVAARAAYEDALQRVDRVAAALEGPLPIEARVDLSAVAHPEPVSNTPPADFFAMVAR
AKEYIVAGDVFQVVLSQRFSAPFTLPAFSLYRSLRRTNPAPFLCYLDFEDFQIVCSSPEILVRVRDGVVTVRPIAGTRRR
GATPAEDAALAEELLADPKERAEHLMLLDLGRNDAGRVSRIGSVRVTDSFFIERYSQVMHIVSNVEGDLDPRHDPLEALA
AGFPAGTVSGAPKVRAMEIIDELEREKRGPYAGCIGYFGARGEMDTCIVLRTAVVKDGTMHVQAGAGIVYDSDPASEQQE
CVNKAKALFRAAEEAVRFAAQAKRGQ
>Mature_505_residues
AEAPDYAAFAARYEAGQPSLVAVSLVADLETPVAAFLKLRAGHSGPAFLLESVEGGAVRGRYSMIGLDPDLIWRCRAGAP
AIARGADLTRFEPDSRAPLASLRALIAESAIGESDGQDLPPMAAGLFGYLGYDMVRAMERLPEPNPDPLGVPDAILVRPR
VMVVFDSIRDVITVVSPVRPGPGVAARAAYEDALQRVDRVAAALEGPLPIEARVDLSAVAHPEPVSNTPPADFFAMVARA
KEYIVAGDVFQVVLSQRFSAPFTLPAFSLYRSLRRTNPAPFLCYLDFEDFQIVCSSPEILVRVRDGVVTVRPIAGTRRRG
ATPAEDAALAEELLADPKERAEHLMLLDLGRNDAGRVSRIGSVRVTDSFFIERYSQVMHIVSNVEGDLDPRHDPLEALAA
GFPAGTVSGAPKVRAMEIIDELEREKRGPYAGCIGYFGARGEMDTCIVLRTAVVKDGTMHVQAGAGIVYDSDPASEQQEC
VNKAKALFRAAEEAVRFAAQAKRGQ

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=371, Percent_Identity=37.1967654986523, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1788114, Length=460, Percent_Identity=31.5217391304348, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI87082077, Length=260, Percent_Identity=27.6923076923077, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786809, Length=260, Percent_Identity=26.5384615384615, Blast_Score=75, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320935, Length=469, Percent_Identity=38.1663113006397, Blast_Score=278, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6324361, Length=396, Percent_Identity=25.2525252525253, Blast_Score=120, Evalue=6e-28,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54421; Mature: 54290

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAPDYAAFAARYEAGQPSLVAVSLVADLETPVAAFLKLRAGHSGPAFLLESVEGGAVR
CCCCCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCEE
GRYSMIGLDPDLIWRCRAGAPAIARGADLTRFEPDSRAPLASLRALIAESAIGESDGQDL
CEEEEEECCHHHEEEECCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
PPMAAGLFGYLGYDMVRAMERLPEPNPDPLGVPDAILVRPRVMVVFDSIRDVITVVSPVR
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCC
PGPGVAARAAYEDALQRVDRVAAALEGPLPIEARVDLSAVAHPEPVSNTPPADFFAMVAR
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHCCCCCCCCCCCCHHHHHHHHH
AKEYIVAGDVFQVVLSQRFSAPFTLPAFSLYRSLRRTNPAPFLCYLDFEDFQIVCSSPEI
HHHHEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCEE
LVRVRDGVVTVRPIAGTRRRGATPAEDAALAEELLADPKERAEHLMLLDLGRNDAGRVSR
EEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHCEEEEEECCCCCCCHHHH
IGSVRVTDSFFIERYSQVMHIVSNVEGDLDPRHDPLEALAAGFPAGTVSGAPKVRAMEII
CCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHH
DELEREKRGPYAGCIGYFGARGEMDTCIVLRTAVVKDGTMHVQAGAGIVYDSDPASEQQE
HHHHHHHCCCCCHHHHHCCCCCCCCHHHEEHHHHHCCCCEEEEECCEEEECCCCCHHHHH
CVNKAKALFRAAEEAVRFAAQAKRGQ
HHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AEAPDYAAFAARYEAGQPSLVAVSLVADLETPVAAFLKLRAGHSGPAFLLESVEGGAVR
CCCCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCEE
GRYSMIGLDPDLIWRCRAGAPAIARGADLTRFEPDSRAPLASLRALIAESAIGESDGQDL
CEEEEEECCHHHEEEECCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
PPMAAGLFGYLGYDMVRAMERLPEPNPDPLGVPDAILVRPRVMVVFDSIRDVITVVSPVR
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCC
PGPGVAARAAYEDALQRVDRVAAALEGPLPIEARVDLSAVAHPEPVSNTPPADFFAMVAR
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHCCCCCCCCCCCCHHHHHHHHH
AKEYIVAGDVFQVVLSQRFSAPFTLPAFSLYRSLRRTNPAPFLCYLDFEDFQIVCSSPEI
HHHHEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCEE
LVRVRDGVVTVRPIAGTRRRGATPAEDAALAEELLADPKERAEHLMLLDLGRNDAGRVSR
EEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHCEEEEEECCCCCCCHHHH
IGSVRVTDSFFIERYSQVMHIVSNVEGDLDPRHDPLEALAAGFPAGTVSGAPKVRAMEII
CCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHH
DELEREKRGPYAGCIGYFGARGEMDTCIVLRTAVVKDGTMHVQAGAGIVYDSDPASEQQE
HHHHHHHCCCCCHHHHHCCCCCCCCHHHEEHHHHHCCCCEEEEECCEEEECCCCCHHHHH
CVNKAKALFRAAEEAVRFAAQAKRGQ
HHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA