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The map label for this gene is crt [H]

Identifier: 170749320

GI number: 170749320

Start: 3070282

End: 3071094

Strand: Reverse

Name: crt [H]

Synonym: Mrad2831_2913

Alternate gene names: 170749320

Gene position: 3071094-3070282 (Counterclockwise)

Preceding gene: 170749321

Following gene: 170749315

Centisome position: 50.53

GC content: 71.46

Gene sequence:

>813_bases
ATGACCGCCAAGCCCGCGACCGACGAGCTGCTGTTCACCATCGACGAGGCCGGCATCGCCCGCATCGTCCTGAACCGCCC
GCAGGCGCGCAACGCGCTCACCTTCGCGATGTATCAGGGCCTGATCACCTGCTGCGAGGCGATCGCCGAGAATCCGGCGG
TCAAGGCGCTGATCATCACCGGCGCGGGCGACAAGGCCTTCGCGGCCGGGACCGACATCGCCCAGTTCCGCGACTTCAGC
ACCGCCGAGGACGCGCTGGGCTACGAGCGCTTCATGGACAAGGTGCTGGGCTCCCTGGAGCGGCTGCGGGTGCCGACCAT
CGCGGCGATCGCCGGGGCCTGCACGGGCGGCGGCGCGGCCATCGCGGCAGCCTGCGACCTGCGGATCGCCACCCGCGACG
CGCGATTCGGCTTCCCGATCGCCCGCACCCTCGGCAACTGCCTGAGCCAGGGCAACCTCAAGCGCCTCTCCGGCCTGATC
GGCCCGGCGCGGGTCAAGGACATCATCTTCACCGCCCGCCTCGTCGGCGCCGAGGAGGCGCTCGGCATCGGGCTCATCGG
CGAGATGGTGGACGATCGCGCCGCGCTCACCGAGCGGGTGGACACCCTGGCGCAGCTGCTGGCCAACCACGCGCCGCTGA
CCATGCAGGCGACCAAGGAGGGGCTGCGGCGCCTCGCCGAGGAGGAGGCCGGCGCCGAGGGCGCCCCGCATCCCGGCGAT
GACCTGATCCTCATGTGCTACATGAGCCAGGACTTCCGCGAGGGCATGGAGGCCTTCCTCGGCAAGCGCACGCCCAACTG
GACCGGGCGCTAG

Upstream 100 bases:

>100_bases
GGCCGAGGCCGGGTACGCGCCGGCCGAGATCGACGCGCTGATCGCGCGGGGCGTGGTCCGCGAGACCGCGGCCTGACGCC
GCCACCCGGAGACGCCGCGC

Downstream 100 bases:

>100_bases
GACCGCTCCCGGTCGTGCCGCGACAGTCCGGAGGGAAGGCGTCTTCGGTGTCGAGACAGTGGCGCCATGCCCCCTCTCTC
GTGCGGGAGAGGGTTGGGGT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTAKPATDELLFTIDEAGIARIVLNRPQARNALTFAMYQGLITCCEAIAENPAVKALIITGAGDKAFAAGTDIAQFRDFS
TAEDALGYERFMDKVLGSLERLRVPTIAAIAGACTGGGAAIAAACDLRIATRDARFGFPIARTLGNCLSQGNLKRLSGLI
GPARVKDIIFTARLVGAEEALGIGLIGEMVDDRAALTERVDTLAQLLANHAPLTMQATKEGLRRLAEEEAGAEGAPHPGD
DLILMCYMSQDFREGMEAFLGKRTPNWTGR

Sequences:

>Translated_270_residues
MTAKPATDELLFTIDEAGIARIVLNRPQARNALTFAMYQGLITCCEAIAENPAVKALIITGAGDKAFAAGTDIAQFRDFS
TAEDALGYERFMDKVLGSLERLRVPTIAAIAGACTGGGAAIAAACDLRIATRDARFGFPIARTLGNCLSQGNLKRLSGLI
GPARVKDIIFTARLVGAEEALGIGLIGEMVDDRAALTERVDTLAQLLANHAPLTMQATKEGLRRLAEEEAGAEGAPHPGD
DLILMCYMSQDFREGMEAFLGKRTPNWTGR
>Mature_269_residues
TAKPATDELLFTIDEAGIARIVLNRPQARNALTFAMYQGLITCCEAIAENPAVKALIITGAGDKAFAAGTDIAQFRDFST
AEDALGYERFMDKVLGSLERLRVPTIAAIAGACTGGGAAIAAACDLRIATRDARFGFPIARTLGNCLSQGNLKRLSGLIG
PARVKDIIFTARLVGAEEALGIGLIGEMVDDRAALTERVDTLAQLLANHAPLTMQATKEGLRRLAEEEAGAEGAPHPGDD
LILMCYMSQDFREGMEAFLGKRTPNWTGR

Specific function: Could Possibly Oxidizes Fatty Acids Using Specific Components (By Similarity). [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI70995211, Length=228, Percent_Identity=30.2631578947368, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI194097323, Length=249, Percent_Identity=30.5220883534137, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI157694516, Length=222, Percent_Identity=28.3783783783784, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI213417737, Length=222, Percent_Identity=28.3783783783784, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4502327, Length=272, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI31542718, Length=257, Percent_Identity=28.4046692607004, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI157694520, Length=182, Percent_Identity=29.6703296703297, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI45643119, Length=241, Percent_Identity=24.4813278008299, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI260275230, Length=241, Percent_Identity=24.4813278008299, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI260274832, Length=241, Percent_Identity=24.4813278008299, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI20127408, Length=176, Percent_Identity=26.1363636363636, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI150378541, Length=262, Percent_Identity=26.3358778625954, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1787659, Length=249, Percent_Identity=31.3253012048193, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI221142681, Length=270, Percent_Identity=34.0740740740741, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788597, Length=264, Percent_Identity=27.6515151515151, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI87082183, Length=261, Percent_Identity=28.735632183908, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1787660, Length=266, Percent_Identity=28.9473684210526, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790281, Length=185, Percent_Identity=34.0540540540541, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788682, Length=201, Percent_Identity=28.3582089552239, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17536985, Length=269, Percent_Identity=31.9702602230483, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17534483, Length=214, Percent_Identity=32.2429906542056, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17554946, Length=256, Percent_Identity=30.46875, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17560910, Length=218, Percent_Identity=33.4862385321101, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI25145438, Length=252, Percent_Identity=30.1587301587302, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17540714, Length=223, Percent_Identity=26.457399103139, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17558304, Length=163, Percent_Identity=31.2883435582822, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17535521, Length=223, Percent_Identity=26.9058295964126, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17540306, Length=251, Percent_Identity=24.3027888446215, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24653139, Length=272, Percent_Identity=29.0441176470588, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI20129971, Length=251, Percent_Identity=31.4741035856574, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653477, Length=251, Percent_Identity=31.4741035856574, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19920382, Length=259, Percent_Identity=29.7297297297297, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45550169, Length=182, Percent_Identity=29.6703296703297, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921000, Length=190, Percent_Identity=28.9473684210526, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583077, Length=190, Percent_Identity=28.9473684210526, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583079, Length=190, Percent_Identity=28.9473684210526, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922422, Length=265, Percent_Identity=22.6415094339623, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24650670, Length=267, Percent_Identity=28.4644194756554, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357171, Length=185, Percent_Identity=30.2702702702703, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583165, Length=210, Percent_Identity=27.6190476190476, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 28713; Mature: 28582

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKPATDELLFTIDEAGIARIVLNRPQARNALTFAMYQGLITCCEAIAENPAVKALIIT
CCCCCCCCCEEEEECCCCHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
GAGDKAFAAGTDIAQFRDFSTAEDALGYERFMDKVLGSLERLRVPTIAAIAGACTGGGAA
CCCCCCHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHH
IAAACDLRIATRDARFGFPIARTLGNCLSQGNLKRLSGLIGPARVKDIIFTARLVGAEEA
HHHHHHEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHCHHHH
LGIGLIGEMVDDRAALTERVDTLAQLLANHAPLTMQATKEGLRRLAEEEAGAEGAPHPGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
DLILMCYMSQDFREGMEAFLGKRTPNWTGR
CEEEEEECCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TAKPATDELLFTIDEAGIARIVLNRPQARNALTFAMYQGLITCCEAIAENPAVKALIIT
CCCCCCCCEEEEECCCCHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
GAGDKAFAAGTDIAQFRDFSTAEDALGYERFMDKVLGSLERLRVPTIAAIAGACTGGGAA
CCCCCCHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHH
IAAACDLRIATRDARFGFPIARTLGNCLSQGNLKRLSGLIGPARVKDIIFTARLVGAEEA
HHHHHHEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHCHHHH
LGIGLIGEMVDDRAALTERVDTLAQLLANHAPLTMQATKEGLRRLAEEEAGAEGAPHPGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
DLILMCYMSQDFREGMEAFLGKRTPNWTGR
CEEEEEECCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]